DRUG STUDY

Name of the Patient: Age: 52 Sex: Female Name of Student Casilao, Mike Arone H.
Civil Status: Religion: Rm/Bed No. _________________ Area: __________________________ Level/ Block: BSNII-B
Address: Date Submitted: 19/02/2022
Date of Admission: _____________________ Diagnosis: Diabetes Mellitus Type 2 Rating: ___________________________________________________

MEDICATION Classification/ Action Indications Contraindications Side Effects Adverse Effects Nursing Responsibilities
 Hypersensitivity
Generic name: Pharmacotherapeutic: Antifungal This drug is reaction  Exfoliative skin Before:
prophylaxis in pts contraindicated to  Dizziness disorders, serious  Verify doctor’s order in
Fluconazole Synthetic azole undergoing bone patients with: hepatic injury, blood regards to the medication.
marrow transplant;  Drowsiness The order should include the
 Headache dyscrasias
candidiasis  Hypersensitivity to drug name, dosage,
Brand name: Clinical: (esophageal, (eosinophilia, frequency and route of
fluconazole  Constipation
oropharyngeal,  Concomitant thrombocytopenia, administration. If any element
 Diarrhea
Diflucan Anti-fungal agent urinary tract, administration of anemia, leukopenia) is missing, check with the
vaginal); systemic  Nausea practitioner.
QT-prolonging have been reported
Usual dosage/ Candida infections medications  Vomiting  Obtain diet history esp. fat
rarely
frequency: Drug action: (e.g., candidemia); Use cautiously in:  Abdominal pain consumption
 May increase risk of QT
treatment of  Check the patient's medical
Interferes with fungal prolongation, torsades
150 mg once or cryptococcal  Hepatic/Renal record for an allergy or
loading dose: 200-800 cytochrome P-450 activity, meningitis. de pointes. contraindication to the
impairment
mg. an enzyme necessary for  Skin disorders including prescribed medication. If an
 Hypokalemia
Maintenance: 200-800 ergosterol formation  Hypersensitivity to Stevens-Johnson allergy or contraindications
mg once daily (principal sterol in fungal other triazoles, syndrome, toxic exist, don't administer the
Usual route: cell membrane). imidazoles medication and notify the
epidermal necrolysis
Oral Therapeutic Effect:  Medications or practitioner.
may occur.  Observe the ten (10) rights of
Directly damages fungal conditions known to
cause arrythmias medication administration
membrane, altering its  Obtain and record vital signs
Drug order: function. Fungistatic  Educate and explain the
medication to the client and
Fluconazole 150 mg Pharmacokinetics: SO.
orally every 72 hours  Use fluconazole cautiously
for 3 doses in patients with potentially
Absorption: Well-absorbed proarrhythmic conditions
Drug interactions: from GI tract. because drug may prolong
Distribution: Widely the QT interval, which can
 Increases distributed including to lead to life-threatening
concentration/ CSF torsades de pointes
effect of  Expect to obtain BUN and
Protein Binding: 11%
calcium serum creatinine levels and
Metabolism: Partially culture and sensitivity and
channel
blockers, metabolized in the liver liver function test results
celecoxib, Excretion: Excreted before therapy starts
cyclosporine, unchanged primarily in
midazolam, urine During:
methadone, Half-life: 20-30hrs
NSAIDS,  Take the full course
rifabutin, prescribed.
Pharmacodynamics:
sirolimus,  Give without regard to food.
tacrolimus,  Take with full glass of water.
theophylline, Onset: Unknown  Monitor hepatic and renal
tofacitinib, Peak: Unknown function periodically during
zidovudine Duration: Unknown therapy, and notify prescriber
 HCTZ may if you detect signs of
increase dysfunction
concentration/  Stay with patient throughout
effect. whole duration of
Cimetidine, administration.
rifampin may
decrease After:
concentration/  Monitor the effect of the
effect. drugs that are administered
 May increase to the patient
concentration/  Discontinue drug if
effect of oral hypersensitivity reactions
hypoglycemic occur.
 s, phenytoin  Immediately report any side
 May further or adverse effects such as
prolong fatigue, dizziness, and
prothrombin diarrhea
time of  Obtain and record vital signs.
warfarin.  Document the time, location,
 Quinidine may dose, and medication given
increase QT to the client.
prolongation;
risk of Patient Teaching
torsades de  Instruct patient to take
pointes fluconazole tablets or oral
 May increase suspension 30 minutes
Concentration before or 2 hours after
effect, risk of meals. Inform her that tablets
myopathy of may be crushed for easier
HMG-CoA swallowing if needed.
reductase  Advise patient to complete
inhibitors entire course of therapy,
even if she feels better.
 If patient takes an oral
antidiabetic, urge her to
monitor blood glucose level
often because of increased
risk of hypoglycemia
 Alert patient that fluconazole
may change the taste of
food.
 Encourage patient to notify
prescriber immediately about
diarrhea, headache, nausea,
rash, right-upper-quadrant
abdominal pain, yellow skin
or whites of eyes, or
vomiting.
 Suggest that breast-feeding
patient consult prescriber
because breast-feeding may
 need to be stopped during
therapy.

References:
 Vallerand, A. H., & Sanoski, C. A. (2019) Davis’s Drug Guide for Nurses (6th Edition). F.A Davis Company.
 Kizior, R. J., & Hodgson, K. J. (2020). Saunders Nursing Drug Handbook 2020. Elsevier.