SAFETY DATA SHEET Version 8.

2
Revision Date 20.03.2023
according to Regulation (EC) No. 1907/2006 Print Date 05.07.2023
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA

SECTION 1: Identification of the substance/mixture and of the company/undertaking

1.1 Product identifiers
Product name : Dichloromethane
Product Number : 270997
Brand : Sigma-Aldrich
Index-No. : 602-004-00-3
REACH No. : 01-2119480404-41-XXXX
CAS-No. : 75-09-2

1.2 Relevant identified uses of the substance or mixture and uses advised against
Identified uses : Laboratory chemicals, Manufacture of substances
1.3 Details of the supplier of the safety data sheet
Company : Sigma-Aldrich Pte Ltd
(Co. Registration No. 199403788W)
2 Science Park Drive
#05-01/12 Ascent Building
SINGAPORE 118222
SINGAPORE
Telephone : +65 6890 6633
Fax : +65 6890 6639
E-mail address : TechnicalService@merckgroup.com
1.4 Emergency telephone
Emergency Phone # : 1-800-262-8200

SECTION 2: Hazards identification

2.1 Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008
Skin irritation (Category 2), H315
Eye irritation (Category 2), H319
Carcinogenicity (Category 2), H351
Specific target organ toxicity - single exposure (Category 3), Central nervous system, H336
For the full text of the H-Statements mentioned in this Section, see Section 16.
2.2 Label elements
Labelling according Regulation (EC) No 1272/2008

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 Pictogram

Signal Word Warning

Hazard statement(s)
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H336 May cause drowsiness or dizziness.
H351 Suspected of causing cancer.
Precautionary statement(s)
P202 Do not handle until all safety precautions have been read and
understood.
P261 Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray.
P264 Wash skin thoroughly after handling.
P302 + P352 IF ON SKIN: Wash with plenty of water.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes.
Remove contact lenses, if present and easy to do. Continue
rinsing.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
Supplemental Hazard none
Statements

Reduced Labeling (<= 125 ml)

Pictogram

Signal Word Warning

Hazard statement(s)
H351 Suspected of causing cancer.
Precautionary statement(s)
P202 Do not handle until all safety precautions have been read and
understood.
P308 + P313 IF exposed or concerned: Get medical advice/ attention.
Supplemental Hazard none
Statements
2.3 Other hazards
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.

SECTION 3: Composition/information on ingredients

3.1 Substances
Synonyms : Methylene chloride
DCM

Formula : CH2Cl2
Molecular weight : 84,93 g/mol
CAS-No. : 75-09-2
EC-No. : 200-838-9
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 Index-No. : 602-004-00-3
Component Classification Concentration
Dichloromethane
CAS-No. 75-09-2 Skin Irrit. 2; Eye Irrit. 2; <= 100 %
EC-No. 200-838-9 Carc. 2; STOT SE 3; H315,
Index-No. 602-004-00-3 H319, H351, H336
Concentration limits:
20 %: STOT SE 3, H336;

For the full text of the H-Statements mentioned in this Section, see Section 16.

SECTION 4: First aid measures

4.1 Description of first-aid measures
General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with
water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Call in ophthalmologist. Remove contact
lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a
physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: Firefighting measures

5.1 Extinguishing media
Suitable extinguishing media
Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Hydrogen chloride gas
Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.

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5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by
keeping a safe distance or by wearing suitable protective clothing.
5.4 Further information
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire
extinguishing water from contaminating surface water or the ground water system.

SECTION 6: Accidental release measures

6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance
contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency
procedures, consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions
(see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb® ).
Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.

SECTION 7: Handling and storage

7.1 Precautions for safe handling
Advice on safe handling
Work under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands
and face after working with substance.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditions
Tightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only
to qualified or authorized persons.
Heat sensitive. Handle and store under inert gas.
Storage class
Storage class (TRGS 510): 6.1D: Non-combustible, acute toxic Cat.3 / toxic hazardous
materials or hazardous materials causing chronic effects
7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated

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SECTION 8: Exposure controls/personal protection
8.1 Control parameters
Ingredients with workplace control parameters
Derived No Effect Level (DNEL)
Application Area Routes of Health effect Value
exposure
Workers Inhalation Acute systemic effects 706 mg/m3
Workers Inhalation Long-term systemic effects 353 mg/m3
Workers Skin contact Long-term systemic effects 4750mg/kg BW/d
Consumers Ingestion Long-term systemic effects 0,06mg/kg BW/d
Consumers Inhalation Long-term systemic effects 88,3 mg/m3
Consumers Skin contact Long-term systemic effects 2395mg/kg BW/d
Consumers Inhalation Acute systemic effects 353 mg/m3
Predicted No Effect Concentration (PNEC)
Compartment Value
Soil 0,583 mg/kg
Sea water 0,194 mg/l
Fresh water 0,54 mg/l
Sea sediment 1,61 mg/kg
Fresh water sediment 4,47 mg/kg
Onsite sewage treatment plant 26 mg/l
Aquatic intermittent release 0,27 mg/l
8.2 Exposure controls
Personal protective equipment

Eye/face protection
Use equipment for eye protection tested and approved under appropriate
government standards such as NIOSH (US) or EN 166(EU). Safety glasses
Skin protection
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN374 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Viton®
Minimum layer thickness: 0,7 mm
Break through time: 120 min
Material tested:Vitoject® (KCL 890 / Aldrich Z677698, Size M)
Body Protection
protective clothing
Respiratory protection
Recommended Filter type: Filter AX (EN 371)
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory
protective devices are carried out according to the instructions of the producer.
These measures have to be properly documented.

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 Control of environmental exposure
Do not let product enter drains.

SECTION 9: Physical and chemical properties

9.1 Information on basic physical and chemical properties
a) Physical state liquid
b) Color colorless
c) Odor ether-like
d) Melting Melting point/range: -97 °C
point/freezing point
e) Initial boiling point 39,8 - 40 °C
and boiling range
f) Flammability (solid, No data available
gas)
g) Upper/lower Upper explosion limit: 22 %(V)
flammability or Lower explosion limit: 13 %(V)
explosive limits
h) Flash point - closed cupdoes not flash
i) Autoignition 605 °C
temperature at 1.013 hPa - DIN 51794
j) Decomposition No data available
temperature
k) pH No data available
l) Viscosity Viscosity, kinematic: No data available
Viscosity, dynamic: 0,42 mPa.s at 25 °C
m) Water solubility 13,2 g/l at 25 °C
n) Partition coefficient: log Pow: 1,25 at 20 °C - Bioaccumulation is not expected.
n-octanol/water
o) Vapor pressure 584 hPa at 25 °C
p) Density 1,325 g/mL at 25 °C
Relative density No data available
q) Relative vapor No data available
density
r) Particle No data available
characteristics

s) Explosive properties No data available

t) Oxidizing properties none
9.2 Other safety information
Relative vapor 2,93
density
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SECTION 10: Stability and reactivity
10.1 Reactivity
No data available
10.2 Chemical stability
Sensitivity to light
The product is chemically stable under standard ambient conditions (room temperature) .
Contains the following stabilizer(s):
2-methyl-2-butene (>0,005 - <0,015 %)
10.3 Possibility of hazardous reactions
Risk of explosion with:
Alkali metals
nitrogen oxides
nitrogen dioxide
Potassium
sodium azide
perchloric acid
Nitric acid
aluminium chloride
Amines
Oxygen
(as liquefied gas)
powdered aluminium
sodium
aromatic hydrocarbons
with
powdered aluminium
Exothermic reaction with:
Alkaline earth metals
Powdered metals
amides
alcoholates
nonmetallic oxides
potassium tert-butanolate
sodium amide
Lithium

10.4 Conditions to avoid

no information available
10.5 Incompatible materials
rubber, various plastics, Light metals, Metals, Mild steel
10.6 Hazardous decomposition products
In the event of fire: see section 5

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SECTION 11: Toxicological information
11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - male and female - > 2.000 mg/kg
(OECD Test Guideline 401)
LC50 Inhalation - Mouse - 4 h - 86 mg/l - vapor

Remarks: (ECHA)
Symptoms: Possible damages:, mucosal irritations
LD50 Dermal - Rat - male and female - > 2.000 mg/kg
(OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: Irritations - 4 h
(OECD Test Guideline 404)
Remarks: Repeated or prolonged exposure may cause skin irritation and dermatitis, due to
degreasing properties of the product.
Serious eye damage/eye irritation
Eyes - Rabbit
Result: Eye irritation
Remarks: (ECHA)
Remarks: Risk of corneal clouding.
Respiratory or skin sensitization
Local lymph node assay (LLNA) - Mouse
Result: negative
(OECD Test Guideline 429)
Germ cell mutagenicity
Test Type: Mutagenicity (mammal cell test): chromosome aberration.
Test system: Chinese hamster ovary cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 473
Result: positive
Test Type: Ames test
Test system: Salmonella typhimurium
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 471
Result: positive

Test Type: In vivo micronucleus test

Species: Mouse
Cell type: Bone marrow
Application Route: Oral
Method: OECD Test Guideline 474
Result: negative
Carcinogenicity
Limited evidence of carcinogenicity in animal studies
Suspected human carcinogens
Reproductive toxicity
No data available

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 Specific target organ toxicity - single exposure
Inhalation - May cause drowsiness or dizziness. - Central nervous system
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain
components considered to have endocrine
disrupting properties according to REACH Article
57(f) or Commission Delegated regulation (EU)
2017/2100 or Commission Regulation (EU)
2018/605 at levels of 0.1% or higher.
Repeated dose toxicity - Rat - male and female - Oral - 104 Weeks - NOAEL (No observed
adverse effect level) - 6 mg/kg

Repeated dose toxicity - Rat - male and female - Inhalation - 104 Weeks

RTECS: PA8050000
Dizziness, Nausea, Vomiting, narcosis, Cough, irritant effects, Unconsciousness, Shortness
of breath, respiratory paralysis, somnolence, depressed respiration, CNS disorders,
inebriation
Risk of corneal clouding.
The following applies to aliphatic halogenated hydrocarbons in general: systemic effect:
narcosis, cardiovascular disorders. Toxic effect on liver, kidneys.
Dichloromethane is metabolized in the body producing carbon monoxide which increases
and sustains carboxyhemoglobin levels in the blood, reducing the oxygen-carrying capacity
of the blood.
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.

SECTION 12: Ecological information

12.1 Toxicity
Toxicity to fish flow-through test LC50 - Pimephales promelas (fathead minnow) -
193,00 mg/l - 96 h
Remarks: (ECHA)

Toxicity to daphnia static test LC50 - Daphnia magna (Water flea) - 27 mg/l - 48 h
and other aquatic (US-EPA)
invertebrates
Toxicity to bacteria static test EC50 - activated sludge - 2.590 mg/l - 40 min
(OECD Test Guideline 209)
Toxicity to flow-through test LC50 - Pimephales promelas (fathead minnow) -
fish(Chronic toxicity) 471 mg/l - 8 d

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 Remarks: (ECHA)

12.2 Persistence and degradability

Biodegradability aerobic - Exposure time 28 d
Result: 68 % - Readily biodegradable.
(OECD Test Guideline 301D)
12.3 Bioaccumulative potential
Bioaccumulation Cyprinus carpio (Carp) - 6 Weeks
- 250 µg/l(Dichloromethane)

Bioconcentration factor (BCF): 2 - 5,4

(OECD Test Guideline 305)

Cyprinus carpio (Carp) - 6 Weeks

- 25 µg/l(Dichloromethane)

Bioconcentration factor (BCF): 6 - 40

(OECD Test Guideline 305)

12.4 Mobility in soil

No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
12.6 Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components
considered to have endocrine disrupting properties
according to REACH Article 57(f) or Commission
Delegated regulation (EU) 2017/2100 or Commission
Regulation (EU) 2018/605 at levels of 0.1% or higher.

12.7 Other adverse effects

No data available

SECTION 13: Disposal considerations

13.1 Waste treatment methods
Product
See www.retrologistik.com for processes regarding the return of chemicals and
containers, or contact us there if you have further questions.

SECTION 14: Transport information

14.1 UN number
ADR/RID: 1593 IMDG: 1593 IATA: 1593

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14.2 UN proper shipping name
ADR/RID: DICHLOROMETHANE
IMDG: DICHLOROMETHANE
IATA: Dichloromethane
14.3 Transport hazard class(es)
ADR/RID: 6.1 IMDG: 6.1 IATA: 6.1
14.4 Packaging group
ADR/RID: III IMDG: III IATA: III
14.5 Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
Further information : No data available

SECTION 15: Regulatory information

15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
Authorisations and/or restrictions on use
REACH - Restrictions on the manufacture, : Dichloromethane
placing on the market and use of certain
dangerous substances, mixtures and articles
(Annex XVII)

Other regulations
Observe work restrictions regarding maternity protection in accordance to Dir 92/85/EEC or
stricter national regulations where applicable.
Take note of Dir 94/33/EC on the protection of young people at work.
15.2 Chemical Safety Assessment
A Chemical Safety Assessment has been carried out for this substance.

SECTION 16: Other information

Full text of H-Statements referred to under sections 2 and 3.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H336 May cause drowsiness or dizziness.
H351 Causes skin irritation.

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 Full text of other abbreviations
ADN - European Agreement concerning the International Carriage of Dangerous Goods
by Inland Waterways; ADR - Agreement concerning the International Carriage of
Dangerous Goods by Road; AIIC - Australian Inventory of Industrial Chemicals; ASTM -
American Society for the Testing of Materials; bw - Body weight; CMR - Carcinogen,
Mutagen or Reproductive Toxicant; DIN - Standard of the German Institute for
Standardisation; DSL - Domestic Substances List (Canada); ECx - Concentration
associated with x% response; ELx - Loading rate associated with x% response; EmS -
Emergency Schedule; ENCS - Existing and New Chemical Substances (Japan); ErCx -
Concentration associated with x% growth rate response; GHS - Globally Harmonized
System; GLP - Good Laboratory Practice; IARC - International Agency for Research on
Cancer; IATA - International Air Transport Association; IBC - International Code for the
Construction and Equipment of Ships carrying Dangerous Chemicals in Bulk; IC50 - Half
maximal inhibitory concentration; ICAO - International Civil Aviation Organization;
IECSC - Inventory of Existing Chemical Substances in China; IMDG - International
Maritime Dangerous Goods; IMO - International Maritime Organization; ISHL - Industrial
Safety and Health Law (Japan); ISO - International Organisation for Standardization;
KECI - Korea Existing Chemicals Inventory; LC50 - Lethal Concentration to 50 % of a
test population; LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose);
MARPOL - International Convention for the Prevention of Pollution from Ships; n.o.s. -
Not Otherwise Specified; NO(A)EC - No Observed (Adverse) Effect Concentration;
NO(A)EL - No Observed (Adverse) Effect Level; NOELR - No Observable Effect Loading
Rate; NZIoC - New Zealand Inventory of Chemicals; OECD - Organization for Economic
Co-operation and Development; OPPTS - Office of Chemical Safety and Pollution
Prevention; PBT - Persistent, Bioaccumulative and Toxic substance; PICCS - Philippines
Inventory of Chemicals and Chemical Substances; (Q)SAR - (Quantitative) Structure
Activity Relationship; REACH - Regulation (EC) No 1907/2006 of the European
Parliament and of the Council concerning the Registration, Evaluation, Authorisation and
Restriction of Chemicals; RID - Regulations concerning the International Carriage of
Dangerous Goods by Rail; SADT - Self-Accelerating Decomposition Temperature; SDS -
Safety Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TECI - Thailand
Existing Chemicals Inventory; TSCA - Toxic Substances Control Act (United States); UN
- United Nations; UNRTDG - United Nations Recommendations on the Transport of
Dangerous Goods; vPvB - Very Persistent and Very Bioaccumulative

Further information
The above information is believed to be correct but does not purport to be all inclusive
and shall be used only as a guide. The information in this document is based on the
present state of our knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any guarantee of the properties of
the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any
damage resulting from handling or from contact with the above product. See
www.sigma-aldrich.com and/or the reverse side of invoice or packing slip for additional
terms and conditions of sale.

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