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M.SC Integrated Biotechnology AY 2019 2020

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SCHOOL OF BIOSCIENCES AND

TECHNOLOGY

M.Sc Integrated Biotechnology


(5yr.)
Curriculum
(2019-2020 admitted students)

M.Sc Intg Biotechnology (5yr.) Page 1


VISION STATEMENT OF VELLORE INSTITUTE OF TECHNOLOGY

Transforming life through excellence in education and research.

MISSION STATEMENT OF VELLORE INSTITUTE OF


TECHNOLOGY

World class Education: Excellence in education, grounded in ethics and


critical thinking, for improvement of life.
Cutting edge Research: An innovation ecosystem to extend knowledge and
solve critical problems.
Impactful People: Happy, accountable, caring and effective workforce and
students.
Rewarding Co-creations: Active collaboration with national & international
industries & universities for productivity and economic development.
Service to Society: Service to the region and world through knowledge and
compassion.

VISION STATEMENT OF THE SCHOOL OF BIOSCIENCES AND


TECHNOLOGY

To nurture high-quality bioengineers and science graduates with the potential to


innovate, invent and disseminate knowledge for the benefit of society and
environment.

MISSION STATEMENT OF THE SCHOOL OF BIOSCIENCES AND


TECHNOLOGY

• To create opportunities for multi-disciplinary education, training and


research in biotechnology and bio-sciences.
• To instill a spirit of innovation and creativity in young minds from across
the globe with sound research aptitude.
• To foster ethically strong biologists who effectively contribute towards
the growth of the nation.

M.Sc Intg Biotechnology (5yr.) Page 2


M.Sc Integrated Biotechnology (5yr.)

PROGRAMME EDUCATIONAL OBJECTIVES (PEOs)

1. Graduates will be practitioners and leaders in their chosen field.


2. Graduates will function in their profession with social awareness
and responsibility
3. Graduates will interact with their peers in other disciplines in their
work place and society and contribute to the economic growth of the
country
4. Graduates will be successful in pursuing higher studies in their
chosen field
5. Graduates will pursue career paths in teaching or research.

M.Sc Intg Biotechnology (5yr.) Page 3


M.Sc Integrated Biotechnology (5yr.)

PROGRAMME OUTCOMES (POs)

PO_02: Having a clear understanding of the subject related concepts and of


contemporary issues and apply them to identify, formulate and analyse complex
engineering problems.

PO_04: Having an ability to design and conduct experiments, as well as to


analyse and interpret data, and synthesis of information

PO_05: Having an ability to use techniques, skills, resources and modern


engineering and IT tools necessary for engineering practice

PO_06: Having problem solving ability- to assess social issues (societal, health,
safety, legal and cultural) and engineering problems

PO_07: Having adaptive thinking and adaptability in relation to environmental


context and sustainable development

PO_08: Having a clear understanding of professional and ethical responsibility

PO_09: Having cross cultural competency exhibited by working as a member or


in teams

PO_10: Having a good working knowledge of communicating in English –


communication with engineering community and society

PO_11: Having a good cognitive load management skills related to project


management and finance

PO_12: Having interest and recognise the need for independent and lifelong
learning

M.Sc Intg Biotechnology (5yr.) Page 4


M.Sc Integrated Biotechnology (5yr.)

ADDITIONAL PROGRAMME OUTCOMES (APOs)

APO_01: Having an ability to be socially intelligent with good SIQ (Social


Intelligence Quotient) and EQ (Emotional Quotient)

APO_02: Having Sense-Making Skills of creating unique insights in what is


being seen or observed (Higher level thinking skills which cannot be codified)
(University Elective)

APO_03: Having design thinking capability


APO_04: Having computational thinking (Ability to translate vast data in to
abstract concepts and to understand database reasoning

APO_05: Having Virtual Collaborating ability

APO_06: Having an ability to use the social media effectively for productive
use

APO_07: Having critical thinking and innovative skills

APO_08: Having a good digital footprint

M.Sc Intg Biotechnology (5yr.) Page 5


M.Sc Integrated Biotechnology (5yr.)

PROGRAMME SPECIFIC OUTCOMES (PSOs)

On completion of M.Sc Integrated Biotechnology (5yr.) programme,


graduates will be able to

• PSO1: Gain and apply knowledge to plan, analyze and find


innovative solutions in the field of biological sciences.

• PSO2: Explore problems and provide valid solutions through the


industry-academia interactions.

• PSO3: Acquire interdisciplinary knowledge in the areas of


biological, chemical, environmental and technical sciences for
the benefit of society.

M.Sc Intg Biotechnology (5yr.) Page 6


M.Sc Integrated Biotechnology (5yr.)

CREDIT STRUCTURE

Category-wise Credit distribution

Category Credits
University core (UC) 66
Programme core (PC) 70
Programmme elective (PE) 62
University elective (UE) 12
Bridge course (BC) 0
Total credits 210

M.Sc Intg Biotechnology (5yr.) Page 7


M.Sc Integrated Biotechnology (5yr.)

DETAILED CURRICULUM
University Core

S. No. Course Course Title T P J C


Code L
1 BIY4098 Comprehensive Examination 0 0 0 0 2
2 BIY6099 Masters Thesis 0 0 0 0 16
3 CHY1003 Environmental Studies 2 0 0 4 3
4 CHY1005 Allied Chemistry 3 0 0 0 3
5 CSE1012 Introduction to Computers and their 2 0 2 0 3
Applications
6 CSE2009 Computer Programming for Biologists 2 0 2 0 3
7 ENG1911 General English - I 1 0 2 0 2
8 ENG1912 General English - II 1 0 2 0 2
9 ENG1913 Effective Communication Skills 1 0 2 0 2
10 HUM1032 Ethics and Values 1 0 0 4 2
11 MAT1001 Fundamentals of Mathematics 3 1 0 0 4
12 MAT1012 Statistical Applications 2 0 2 0 3
13 MGT1022 Lean Start-up Management 1 0 0 4 2
14 PHY1003 Physics 3 0 2 4 5
16 FLC4097 Foreign Language Course Basket 0 0 0 0 2
17 SET4001 Science, Engineering and Technology Project 0 0 0 0 2
-I
18 SET4002 Science, Engineering and Technology Project 0 0 0 0 2
- II
19 EXC4097 Co-Extra Curricular Basket 0 0 0 0 2
20 STS5097 Soft Skills Course Basket 0 0 0 0 8

M.Sc Intg Biotechnology (5yr.) Page 8


M.Sc Integrated Biotechnology (5yr.)

Programme Core

S. No. Course Course Title L T P J C


Code
1 BIY1001 Biochemistry 3 0 2 0 4
2 BIY1002 Cell Biology 3 0 2 0 4
3 BIY1003 Biodiversity and Conservation Biology 2 0 0 4 3
4 BIY1004 Genetics 2 0 0 4 3
5 BIY1005 General Microbiology 2 0 2 4 4
6 BIY1006 Human Anatomy and Physiology 3 0 0 0 3
7 BIY1007 Molecular Biology 3 0 2 0 4
8 BIY1008 Research Methodology 3 0 2 0 4
9 BIY1009 Analytical Techniques 3 0 2 0 4
10 BIY1010 Immunology 3 0 2 0 4
11 BIY1011 Fundamentals of Chemical Engineering 3 0 0 0 3
12 BIY1012 Bioinformatics 2 0 2 4 4
13 BIY1013 Bioresource Management 2 0 0 4 3
14 BIY1014 Bio-Business and IPR 2 0 0 4 3
15 BIY2001 Microbial Genetics 3 0 0 0 3
16 BIY2002 Genetic Engineering 3 0 2 0 4
17 BIY2003 Bioprocess Principles 3 0 0 0 3
18 BIY2009 Genomics 3 0 0 0 3
19 BIY2011 Proteomics 3 0 0 0 3
20 BIY3001 Downstream Processing 3 0 2 0 4

M.Sc Intg Biotechnology (5yr.) Page 9


M.Sc Integrated Biotechnology (5yr.)

Programme Elective

S. No. Course Course Title L T P J C


Code
1 BIY1015 Environmental Health 2 0 0 4 3
2 BIY1016 Behavioral Sciences 2 0 0 4 3
3 BIY1017 Pharmaceutical Biotechnology 3 0 0 0 3
4 BIY1018 Industrial Biotechnology 2 0 0 4 3
5 BIY1019 Nanobiotechnology 2 0 0 4 3
6 BIY1020 Vaccinology 3 0 0 0 3
7 BIY1021 Epidemiology 2 0 0 4 3
8 BIY1022 Nutraceuticals 3 0 0 0 3
9 BIY1023 Nutrition and Health 3 0 0 0 3
10 BIY1024 Computational Biochemistry and 3 0 0 0 3
Biomedicine
11 BIY1025 Plant Biology 3 0 0 0 3
12 BIY1026 Forensic Science 3 0 0 0 3
13 BIY2004 Biophysics 3 0 0 0 3
14 BIY2005 Advanced Biochemistry 3 0 0 0 3
15 BIY2006 Clinical Biochemistry 2 0 0 4 3
16 BIY2007 Developmental Biology 3 0 0 0 3
17 BIY2008 Biological Databases 2 0 2 4 4
18 BIY2010 Plant Biotechnology 2 0 2 4 4
19 BIY2012 Enzymology 2 0 2 4 4
20 BIY2013 Molecular Endocrinology 3 0 0 0 3
21 BIY2014 Aquatic Biotechnology 2 0 0 4 3
22 BIY2015 Biological Spectroscopy 3 0 0 0 3
23 BIY2016 Stem Cell Technology 3 0 0 0 3

M.Sc Intg Biotechnology (5yr.) Page 10


24 BIY2017 Neurobiology 3 0 0 0 3
25 BIY2018 Bioremediation 2 0 0 4 3
26 BIY2019 Molecular Evolution and Phylogeny 3 0 2 0 4
27 BIY3002 Environmental Genetics 3 0 0 0 3
28 BIY3003 Protein Engineering 2 0 0 4 3
29 BIY3004 Molecular Modeling and Drug Design 3 0 2 0 4
30 BIY4001 Cancer Biology 3 0 0 0 3
31 BIY4002 Food Science 2 0 2 4 4
32 BIY5001 Animal Biotechnology 3 0 0 0 3
33 BIY5002 Gene Therapy 3 0 0 0 3
34 BIY5003 Enzyme Technology 2 0 0 4 3
35 BIY5004 Food Biotechnology 2 0 0 4 3
36 BIY5005 Environmental Biotechnology 2 0 0 4 3
37 BIY5006 Medical Biotechnology 3 0 0 0 3

M.Sc Intg Biotechnology (5yr.) Page 11


M.Sc Integrated Biotechnology (5yr.)

University Elective Baskets


Management courses
Sl.No Code Title L T P J C
1 MGT1001 Basic Accounting 3 0 0 0 3
2 MGT1002 Principles of Management 2 0 0 4 3
3 MGT1003 Economics for Engineers 2 0 0 4 3
4 MGT1004 Resource Management 2 0 0 4 3
5 MGT1005 Design, Systems and Society 2 0 0 4 3
6 MGT1006 Environmental and Sustainability Assessment 2 0 0 4 3
7 MGT1007 Gender, Culture and Technology 2 0 0 4 3
8 MGT1008 Impact of Information Systems on Society 2 0 0 4 3
9 MGT1009 Technological Change and Entrepreneurship 2 0 0 4 3
10 MGT1010 Total Quality Management 2 2 0 0 3
11 MGT1014 Supply Chain Management 3 0 0 0 3
12 MGT1015 Business Mathematics 3 0 0 0 3
13 MGT1016 Intellectual Property Rights 3 0 0 0 3
14 MGT1017 Business Regulatory Framework For Start- 3 0 0 0 3
ups
15 MGT1018 Consumer Behaviour 3 0 0 0 3
16 MGT1019 Services Marketing 3 0 0 0 3
17 MGT1020 Marketing Analytics 2 0 2 0 3
18 MGT1021 Digital and Social Media Marketing 3 0 0 0 3
19 MGT1022 Lean Start-up Management 1 0 0 4 2
20 MGT1023 Fundamentals of Human Resource 3 0 0 4 4
Management

M.Sc Intg Biotechnology (5yr.) Page 12


21 MGT1024 Organizational Behaviour 3 0 0 4 4
22 MGT1025 Foundations of Management And 3 0 0 4 4
Organizational Behaviour
23 MGT1026 Information Assurance and Auditing 2 0 0 4 3
24 MGT1028 Accounting and Financial Management 2 2 0 4 4
25 MGT1029 Financial Management 2 1 0 4 4
26 MGT1030 Entrepreneurship Development 3 0 0 4 4
27 MGT1031 International Business 3 0 0 4 4
28 MGT1032 Managing Asian Business 3 0 0 4 4
29 MGT1033 Research Methods in Management 2 1 0 4 4
30 MGT1034 Project Management 3 0 0 4 4
31 MGT1035 Operations Management 3 0 0 0 3
32 MGT1036 Principles of Marketing 3 0 0 4 4
33 MGT1037 Financial Accounting and Analysis 2 1 0 4 4
34 MGT1038 Financial Econometrics 2 0 0 4 3
35 MGT1039 Financial Markets and Institutions 2 0 0 4 3
36 MGT1040 Personal Financial Planning 2 0 0 4 3
37 MGT1041 Financial Derivatives 2 1 0 4 4
38 MGT1042 Investment Analysis and Portfolio 2 0 0 4 3
Management
39 MGT1043 Applications in Neuro Marketing 3 0 0 4 4
40 MGT1044 Global Brand Marketing Strategies 3 0 0 4 4
41 MGT1045 Industrial Marketing 3 0 0 4 4
42 MGT1046 Sales and Distribution Management 3 0 0 4 4
43 MGT1047 Social Marketing 3 0 0 4 4
44 MGT1048 Political Economy of Globalization 3 0 0 4 4
45 MGT1049 Sustainable Business Models 3 0 0 4 4
46 MGT1050 Software Engineering Management 2 0 0 4 3
47 MGT1051 Business Analytics for Engineers 2 2 0 0 3

M.Sc Intg Biotechnology (5yr.) Page 13


48 MGT1052 Bottom of the Pyramid Operations 3 0 0 0 3
49 MGT1053 Entrepreneurship Development, Business 1 0 2 0 2
Communication and IPR
50 MGT1054 Product Planning and Strategy 2 2 0 0 3
51 MGT1055 Design Management 2 2 0 0 3
52 MGT1056 Accounting and Financial Management 3 0 0 4 4
53 MGT6001 Organizational Behaviour 2 0 0 4 3

Humanities courses
Sl.No Code Title L T P J C
1 HUM1001 Fundamentals of Cyber Laws 3 0 0 0 3
2 HUM1002 Business Laws 3 0 0 0 3
3 HUM1003 Basic Taxation for Engineers 3 0 0 0 3
4 HUM1004 Corporate Law for Engineers 3 0 0 0 3
5 HUM1005 Cost Accounting for Engineers 3 0 0 0 3
6 HUM1006 Business Accounting for Engineers 3 0 0 0 3
7 HUM1007 Contemporary Legal Framework for Business 3 0 0 0 3
8 HUM1009 International Business 3 0 0 0 3
9 HUM1010 Foreign Trade Environment 3 0 0 0 3
10 HUM1011 Export Business 3 0 0 0 3
11 HUM1012 Introduction to Sociology 3 0 0 0 3
12 HUM1013 Population Studies 3 0 0 0 3
13 HUM1021 Ethics and Values 2 0 0 0 2
14 HUM1022 Psychology in Everyday Life 2 0 0 4 2
15 HUM1023 Indian Heritage and Culture 2 0 0 4 2
16 HUM1024 India and Contemporary World 2 0 0 4 2
17 HUM1025 Indian Classical Music 1 0 2 4 1
18 HUM1033 Micro Economics 3 0 0 0 3
19 HUM1034 Macro Economics 3 0 0 0 3

M.Sc Intg Biotechnology (5yr.) Page 14


20 HUM1035 Introductory Econometrics 2 0 2 0 2
21 HUM1036 Engineering Economics and Decision 2 0 0 4 2
Analysis
22 HUM1037 Applied Game Theory 2 0 0 4 2
23 HUM1038 International Economics 3 0 0 0 3
24 HUM1039 Community Development in India 2 0 0 4 2
25 HUM1040 Indian Social Problems 3 0 0 0 3
26 HUM1041 Indian Society Structure and Change 3 0 0 0 3
27 HUM1042 Industrial Relations and Labour Welfare in 3 0 0 0 3
India
28 HUM1043 Mass Media and Society 2 0 0 4 2
29 HUM1044 Network Society 3 0 0 0 3
30 HUM1045 Introduction to Psychology 2 0 2 0 2
31 HUM1706 Business Accounting for Engineers 3 0 0 0 3

M.Sc Intg Biotechnology (5yr.) Page 15


UNIVERSITY CORES

M.Sc Intg Biotechnology (5yr.) Page 16


BIY6099 Masters Thesis L T P J C
0 0 0 0 14
Pre-requisite As per the academic regulations Syllabus version
1.0
Course Objectives:
To provide sufficient hands-on learning experience related to the area of specialization with a
focus on research orientation

Expected Course Outcome:


At the end of the course, the student will be able to

1. Formulate specific problem statements for ill-defined real-life problems with


reasonable assumptions and constraints.
2. Perform a literature search and/or patent search in the area of interest.
3. Design and Conduct experiments
4. Perform error analysis /benchmarking/costing
5. Synthesize the results and arrive at scientific conclusions
6. Document the results in the form of technical report/presentation

Student Learning Outcomes (SLO): 9, 20


9. Having problem-solving ability- solving social issues and engineering problems
20. Having a good digital footprint

Contents
1. It can be a theoretical analysis, modeling & simulation, experimentation & analysis,
prototype design, correlation and analysis of data, software development, applied
research, and any other related activities.
2. The project can be for one or two semesters based on the completion of the required
number of credits as per the academic regulations.

3. It should be individual work.

4. Carried out inside or outside the university, in any relevant industry or research
institution.

5. Publications in the peer-reviewed journals / International Conferences will be an


added advantage

Mode of Evaluation: Periodic reviews, Presentation, Final oral viva, Poster submission
Recommended by Board of 04.03.2016
Studies
Approved by Academic Council 40th AC Date 18.03.2016

M.Sc Intg Biotechnology (5yr.) Page 17


Course code Comprehensive Examination L T P J C
BIY4098 0 0 0 0 2
Pre-requisite Syllabus version
1.00
Student Learning Outcomes (SLO): 2
[2] Having a clear understanding of the subject related concepts and of contemporary issues

Module 1:

Biochemistry: Foundation of biochemistry, Carbohydrates, Amino acids and Proteins, Lipids and
Nucleic acids. Analytical Techniques in Biotechnology: Lab Practices and Sampling, Analytical
Lab, Standard Operating Procedures, Physico-chemical analyses, Spectrometry, Electrophoresis
and chromatography, Mass Spectrometry and NMR.

Module 2:
Cell Biology and Genetics: Cell structure and function, Transport across cell membranes, Cell
signalling, motility and integration, Mechanisms of inheritance, Evolution and genetic
applications. Molecular Biology: Chromosomes, DNA, Transcription, translation, Retroviruses
and recombination - transformation, conjugation, transduction.

Module 3:
Immunology: The Immune System, Humoral Immune responses, Cellular Immune responses,
Immunity to infection, Immunology of transplantation. Genetic Engineering: Concepts of
Recombinant DNA technology, Tool enzymes, Vectors, Gene cloning strategies, Polymerase
chain reaction.

Module 4:
Animal Biotechnology: Introduction to Physiology, Neurotransmitters and Nervous system,
Animal Cell Technology and its applications, Animal Reproductive Biotechnology, Transgenic
animals & transgenic engineering.

Module 5:
Microbiology: Tools in Microbiology, Morphology and Taxonomy, metabolisms of
microorganism, Microbial growth, Applied Microbiology. Plant Biotechnology: Plant growth and
development, Plant genome Organization and Tissue culture, Plant transformation, transgenic
plants, Marker technology.

M.Sc Intg Biotechnology (5yr.) Page 18


Module 6:
Pharmaceutical Biotechnology: General pharmacology, Pharmacology, Formulating Biotech
drugs, Biotech drugs, Clinical Trials & Regulations.

Module 7
Plant Biotechnology: Plant growth and development, Plant genome Organization and Tissue
culture, Plant transformation, transgenic plants, Marker technology.
Recommended by Board of Studies 04.03.2016
Approved by Academic Council 40th AC 40th AC 18-03-2016

M.Sc Intg Biotechnology (5yr.) Page 19


Course code Course title L T P J C
CHY1003 Environmental Studies 3 0 0 0 3
Pre-requisite None Syllabus version
1.1
Course Objectives: (C Ob) The course is aimed at
• To make students understand and appreciate the unity of life in all its forms and the
implications of lifestyle on the environment.
• To broaden the understanding of global climate changes and the importance of renewable
sources of energy.
• To give students a basic understanding of the major causes of environmental degradation
on the planet, with specific reference to the Indian situation.
• To inspire students to find ways in which they can contribute personally and professionally
to prevent and rectify environmental problems.

Course Outcomes: (CO):


At the end of the course, the student should be able to
[1] Know the importance of environment and awareness on natural resources to find the causes,
effects, and consequences if not protected.
[2] Acquire knowledge of renewable and non-renewable energy resources to solve future problems
on energy demand.
[3] Enriching the understanding of the need for eco-balance and the importance of biodiversity
conservation.
[4] Identify the numerous causes for environmental pollutions, hazards, their management, and
control methods.
[5] Find ways to protect the environment on global climatic changes and their mitigation.
[6] Recognise some of the social issues and gaining knowledge on the protection of the
environment.
[7] Develop adequate knowledge of population, which enabling them to make better in life
decisions as well as enter a career in an environmental profession or higher education.

Student Learning Outcomes (SLO) involved:2,10,11


2. Having a clear understanding of the subject related concepts and contemporary issues
10. Having a clear understanding of professional and ethical responsibility
11. Having an interest in lifelong learning

Module:1 Environment and Natural Resources 7 hours


Definition, scope, importance, the need for public awareness on natural resources Forest resources
– use, exploitation, causes, and consequences of deforestation. Water resources – use of surface
and subsurface water; dams - effect of drought, water conflicts. Land resources - Land
degradation, soil erosion, and desertification. Indian Case studies. Food resources – Definition,
world food problems, Traditional and modern agriculture, and its impacts and remedies.

Module:2 Energy Resources 7 hours


Definition of renewable and non-renewable energy resources. Non-renewable energy resources -
oil, Natural gas, Coal, Nuclear energy. Renewable energy - Solar energy, Hydroelectric power,
Ocean thermal energy, wind, and geothermal energy. Biomass energy and Bio Gas.

M.Sc Intg Biotechnology (5yr.) Page 20


Module:3 Ecosystem and Biodiversity 5 hours
Concept of ecosystem, Structure, and functions of an ecosystem, Food chains, food webs. Energy
flow in an ecosystem, ecological pyramids, and ecological succession. Case studies:
Biomagnification of DDT. Biodiversity-Bio-geographical classification of India, hotspots, values
of biodiversity. Threats to biodiversity - a Case study. Conservation of biodiversity. GM Crops
.
Module:4 Environmental changes and Remediation 6 hours
Air, water, soil, Thermal Pollution: Causes, effects and control measures; Nuclear hazard. Solid
waste Management- Causes, Effects and control measures. Floods, earthquakes, cyclones,
tsunami and landslides, Case studies.

Module:5 Global Climatic Change and Mitigation 5 hours


Global climate change and the greenhouse effect – Kyoto Protocol, Carbon sequestration, Acid
rain, Ozone depletion problem – Montreal Protocol.
Module:6 Social Issues and the Environment 6 hours
Urban problems related to energy and sustainable development, Water conservation, Rainwater
harvesting, Wasteland Reclamation. Environment Protection Act - Prevention and control of
Pollution of Air and Water. Wildlife protection and Forest Conservation Acts.

Module:7 Human Population and the Environment 7 hours


Population growth, variation among nations, population explosion, Family Welfare Programme,
Environment, Women and Child Welfare, Human rights, HIV/AIDS, Role of information
technology on the environment and human health. Discussion on current environmental
issues/topics by an Industrial expert or faculty

Module:8 Contemporary issues 2 hours


Industry Expert Lectures
Total Lecture hours: 45 hours
Text Book(s)
1. Anubha Kaushik and C.P. Kaushik, Environmental Science and Engineering, 2016, 5th
Edition, ISBN: 978-81-224-4013-3, New Age International.
2. G. Tyler Miller Jr and Scott E. Spoolman, Living in the Environment, 2012. 17th Edition,
ISBN-13: 978-0-538-73534-6, Brooks / Cole.
Reference Books
1. Environmental Science and Engineering by Anjali Bagad, 2014, 1st Edition, ISBN-10:
9350997088, Technical Publications.
2. Introduction to Environmental Engineering by Masters, 2015, 3rd Edition, ISBN-10:
9332549761, Pearson Education India.
3. Basic Environmental Sciences For Undergraduates by Dr. Tanu Allen, Dr. Richa K. Tyagi Dr.
Sohini Singh, 2014, 1st Edition, ISBN-10: 938375827, Vayu Education of India.
Mode of Evaluation: Internal Assessment (CAT, Quizzes, Digital Assignments) & FAT
Recommended by Board of Studies 12-8-2017
Approved by Academic Council No.47 Date 05-10-2017

M.Sc Intg Biotechnology (5yr.) Page 21


Course code Course Title L T P J C
CHY1005 Allied Chemistry 3 0 0 0 3
th
Pre-requisite Chemistry at 12 standard or equivalent Syllabus version
2.0
Course Objectives

The course is aimed at


• To understand the interdependency of chemistry and biological systems and the relationship
between chemical structure and biological activity
• To introduce analytical and separation techniques essential for biologists

Expected Course Outcomes:


At the end of the course, the students will
1. be able to acquire knowledge about the stereochemistry of organic and biomolecules
2. be able to acquire knowledge on various electronic effects in biological systems.
3. be familiar with the fundamental chemistry of the biomolecules
4. be familiar with the fundamental chemistry of chlorophyll and Haemoglobin
5. be able to acquire knowledge on the various functions of several metal ions and the complexes in the
biological systems.
6. be able to acquire knowledge about the uses, mechanism of action of essential drugs, and their SAR.
7. Demonstrate basic knowledge of the separation and analytical techniques.

Student Learning Outcomes involved: 2,18


2. Having a clear understanding of the subject related concepts and contemporary issues
18. Having critical thinking and innovative skills

Module:1 Introduction to Stereochemistry 6 hours


Isomerism in organic compounds – structural, stereo, geometrical and optical isomerism-Chirality-
Racemisation–Specific optical rotation-Enantiomeric Excess-Optical purity-Resolution–R-S notation–E-Z
nomenclature

Module:2 Electronic effects 6 hours


Intermolecular bonding forces-ionic bonds, hydrogen bonds, Van der Waals interactions, Dipole-dipole
and Ion-dipole interactions, Repulsive interactions, water, and hydrophobic interactions –Importance of
these effects in biological systems.

Module:3 Chemistry of Biomolecules 6 hours


Amino acids, Proteins, and Enzymes - Chemical structure and function.

Module:4 Molecules of Life 4 hours


Structure and functions of Haemoglobin and Chlorophyll

Module:5 Role of metal ions in Biology 6 hours

M.Sc Intg Biotechnology (5yr.) Page 22


Essential and toxic metals – metal ions deficiency and its treatment – metal ion toxicity – Fe, Cu,
Cr, Pb, As, Hg, Cd – Natural detoxification – chelating drugs for detoxification – examples for
Chelating drugs – Anti-arthritic gold drugs – psychiatric drug – Lithium – Anticancer drugs –
platinum complexes
Module:6 Antibiotics, Anti-ulcer and Analgesic drugs 9 hours
Structure-activity relationship (SAR) – cell wall synthesis inhibitors - Penicillins, Cephalosporin-Protein
synthesis inhibitors– tetracycline, chloramphenicol. SAR–H2 antagonist–Ranitidine–Proton pump inhibitors
– Pantoprazole –Omeprazole. NSAID- SAR – paracetamol – diclofenac sodium – ibuprofen.

Module:7 Separation and Analytical Techniques 6 hours


Chromatography – Adsorption, Absorption, Partition- HPLC, GC -Spectroscopy – the interaction of
electromagnetic radiation with matter, type of interaction, the origin of IR, UV – Visible, Emission
spectroscopy (fluorescence) and applications.

Module:8 Contemporary issues: 2 hours


Industry Expert Lecture

Total Lecture hours: 45 hours


Text Book(s)
1. An Introduction to Medicinal Chemistry, Graham L. Patrick, VIth edition, Oxford
University Press, 2017.
2. Organic Chemistry, Solomon, and Fryhle. Eighth Edition, Wiley India (P) Ltd. 2009.
3. Bioinorganic Chemistry, Asim K. Das, Books and Allied (P) Ltd, 2010.
4. Fundamentals of Analytical Chemistry, D. A. Skoog, D. M. West, and F. J. Holler, S.R.
Crouch,9th Edition, Thomson Asia (P) Ltd., Singapore, 2014.
Reference Books
1. Stereochemistry of Organic Compounds by L. Eliel, Samuel H. Wilen, Wiley India (P) Ltd,
2010.
2. Instrumental Methods of Chemical Analysis, B. K. Sharma, Goel Publishing House, 24th
edition,2005.
3. Basic Concepts of Analytical Chemistry, S. M. Khopkar, New Age International Publishers,
2009.
Mode of evaluation: Internal assessment (CAT, Quizzes, Digital Assignment) and FAT
Recommended by Board of Studies 12.08.2017
Approved by Academic Council No.46 Date 24.08.2017

M.Sc Intg Biotechnology (5yr.) Page 23


Course code Introduction to Computers and their Applications L T P J C
CSE1012 2 0 2 0 3
Pre-requisite None Syllabus version
1.1
Course Objectives:
1. Gaining foundation in the fundamentals of computers concerning computer components and
their usage
2. Making students understand different web technologies and computer networks
3. Exploring the application suite of software for the betterment of presentation and management
of data

Expected Course Outcome:


1. The students will have the knowledge and skills to describe the software and hardware
components
2. Explain some of the web technologies and illustrate how these can be used to manage scientific
data
3. Obtain and analyze information and data relating to specific word applications for fine
document preparation and report writing.
4. Data computation using spreadsheet application and presentation application for scientific
findings.
5. Perform practical data management techniques, including DDL and DML and database
querying.

Student Learning Outcomes (SLO): 2,8


2. Having a clear understanding of the subject related concepts and contemporary issues
8. Having a clear understanding of professional and ethical responsibility

Module:1 History of Computers 4 hours


History of Computers, Basic Components of Computer Systems, CPU, Memory, I/O Devices,
Operating system, DOS and Unix system commands

Module:2 Web Technologies 4 hours


Introduction to Internet - URL, WWW, HTML, Internet Protocols- HTTP, TCP/IP, E-Mail &
FTP.

Module:3 Computer Networks 3 hours


Networks and Data Communications: LAN, MAN & WAN – Network Topologies. Basics of
Network, Uses of the network, types of networks, Network topologies.

Module:4 Word Processing 4 hours


Word basics, Editing and formatting a document, layout and inserting and managing graphics,
formatting tables

Module:5 Spreadsheets 4 hours


Spreadsheet basics, Editing worksheets, Form cells – formatting worksheets, formulas and
function, data filtering and sorting, chart, and graphs.

M.Sc Intg Biotechnology (5yr.) Page 24


Module:6 Presentation 5hours
Presentation basics, Creation of Presentation, editing presentation, formatting presentation,
working with multimedia.

Module:7 Database Management 4 hours


Database basics, advantages of Database, create a database, updating and manipulating data, DDL
and DML command, database querying.
Module:8 Recent trends 2 hours
Total Lecture hours: 30 hours

Text Book(s)
1. Peter Norton, 2017, Introduction to Computers, 7th Edition, Tata McGraw Hill Publications.

2. Joan Lambert, and Curtis Frye, 2017 Microsoft Office 2016 Step by Step, Microsoft Press
Reference Books
1. Rajaraman V, and Adabala N, 2014, Fundamentals of Computers, PHI Publication

Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.
List of Experiments SLO: 2,8
1. Unix and DOS commands
2. Creating and Formatting Word document
3. Creating and Manipulating Tables in a document
4. Inserting any Graphics in a document
5. Create a Personal Resume
6. Using the Excel Formula and Functions
7. Representing Data in a Chart
8. Excel Using Pivot Table
9. Excel Using Functions
10. Working with Design Templates and Auto Content wizards by using
PowerPoint
11. Formatting and editing slides
12. PowerPoint Slide design
13. Slide transition effects

M.Sc Intg Biotechnology (5yr.) Page 25


14. Creating and querying a recipe database using a database program
15. Updating and manipulating database
Total Laboratory Hours 30 hours

Mode of Evaluation: Assignments, Continuous assessment tests and Final


assessment test.
Recommended by Board of 12-8-2017
Studies
Approved by Academic Council No. 5. Date 13-12-2018

M.Sc Intg Biotechnology (5yr.) Page 26


Course code Course Title L T P J C
CSE2009 Computer Programming for Biologists 2 0 2 0 3
Pre-requisite Introduction to Computers and their Applications Syllabus version
1.1
Course Objectives:
Course Objectives:
1. To make students understand and practice beginning and advanced skills in the areas of
computer command line mode operations.
2. To broaden the understanding of Bash shell scripting to automate the workflow process,
including pattern search.
3. To give a biology-specific programming language to concentrate on the string data structure.
4. To inspire students to find ways in which they can contribute to features prediction from
biological sequences.

Course Outcomes: (CO):


At the end of the course, the student should be able to
[1] Know the importance of the bash environment and awareness on command line operations.
[2] Acquire knowledge on automating a list of command-line process.
[3] Enriching the understanding of regular expression in string data structure pattern finding.
[4] Identify the appropriate and essential functions to debug or troubleshoot programs.
[5] Find ways to protect the environment on global climatic changes and their mitigation.
[6] Recognise improved computational proficiency.
[7] Apply the powerful combination of shell and python programing to get expedite on the big
data analysis.

Student Learning Outcomes (SLO) 2,7


2. Having a clear understanding of the subject related concepts and contemporary issues
7. Having computational thinking (Ability to translate vast data into abstract concepts and to
understand database reasoning)

Module:1 Shell Scripting 4 hours CO: 1, 2


Bash and Bash Scripts – Common Shell programs, Executing commands, Developing Good
Scripts, Creating and running a script, Scripts basics, and Debugging bash scripts.

Module:2 The Bash Environment and statements 4 hours CO: 2, 3


Shell initialization file, Variables, Quoting characters, Shell expansion, and Aliases, variables,
condition statements, and loop statements.

Module:3 Python Programming 3 hours CO: 3, 6


Python environment, printing and manipulating text- comments to annotate your code, error
message and debugging, storing strings in variables, and manipulating strings.

Module:4 List and Loops 4 hours CO: 4, 5


Creating a list and retrieving elements, list elements, loop, indentation error, splitting strings,
iterating, and looping with ranges.

M.Sc Intg Biotechnology (5yr.) Page 27


Module:5 Functions and Conditional statements 5 hours CO: 4, 5
Function definition, calling and encapsulation, function argument and return value, Decision-
making programs, if statements, if...else...elif statements, and while loops.

Module:6 Regular expression and Dictionaries 4 hours CO: 1, 6


Patterns in Biology, modules, patterns in a string, searching and extracting patterns and
Positions, creating, and iterating dictionaries.

Module:7 Reading and writing files 4 hours CO: 1, 7

Reading text from files, file content and file name, dealing with newlines, writing text to files,
closing files.

Module: Recent trends 2 hours


8
Industry Expert Lectures

Total Lecture hours: 30 hours

Text Book(s)
1. Jason Cannon, 2014, Command Line Kung Fu: Bash Scripting Tricks, Linux Shell
Programming, First edition, Create Space Independent Publishing Platform.

2. Dr. Martin Jones, 2013, Python for Biologists: A complete programming course for
beginners, First edition, Create Space Independent Publishing Platform.
Reference Books
1. Martin C, 2018, Python: The Complete Reference, 4 edition, McGraw Hill Publisher.

2. Richard Blum & Christine Bresnahan, 2015, Linux Command Line and Shell Scripting
Bible, 3ed Wiley publisher.
List of Challenging Experiments
1. Basic Bash Shell commands
2. Creating Bash Script
3. Understanding Shell configuration files
4. Control Statements
5. Conditional Statements
6. Python program to calculate AT content and Complement of a DNA
Sequence.
7. Splitting of Genomic DNA
8. Processing DNA in a file

M.Sc Intg Biotechnology (5yr.) Page 28


9. Percentage of amino acid residue
10. Printing out gene names for all genes between a specific length ranges.
11. Printing accession names and double digestion
12. DNA translation using python Dictionaries
Total Lab Hours - 30
Mode of Evaluation: Internal Assessment (CAT, Quizzes, Digital Assignments) & FAT
Recommended by Board of Studies 12-8-2017
Approved by Academic Council No.53 Date 13-12-2018

M.Sc Intg Biotechnology (5yr.) Page 29


Course code Course title L T P J C
ENG1911 General English-I 1 0 2 0 2
Pre-requisite Cleared EPT/English for Beginners Syllabus version
1
Course Objectives:
1. To synthesize information, analyze simple arguments, generate and express their own
opinions on a limited range of technical as well as general-interest topics inside as well as
outside the classroom.
2. To develop competencies in all the areas of LSRW skills
3. To speak and write in grammatically error-free English with the aid of active vocabulary.
Expected Course Outcome:
1. Develop communicative competence to express himself/herself in English in all
challenging situations
2. Apply knowledge, ideas and concepts in the technicalities of proper pronunciation,
Grammatical structure
3. Have better grasp over appropriate use and style of the English Language as well as the
application areas of English communication
4. Write all types of official Letters/Emails used in the corporate world
5. Interpret text, diagram etc. which helps them in their academic as well as professional
career.
Student Learning Outcomes (SLO): 16, 18
16. Having a good working knowledge of communicating in English
18. Having critical thinking and innovative skills

THEORY

Module:1 Grammar and Vocabulary 4 Hours


Grammatical & structural aspects covering -Types of sentences, Active & Passive Voice, Tenses,
WH- Question Tags, Gerund, Auxiliaries & Modal Verbs, Preposition
Vocabulary: Synonyms, Antonyms, Homonyms, Homophones
Activity: Solving Worksheets of Grammar; Enhancing the knowledge of vocabulary through
written interpretation and reading English newspapers/magazines

Module:2 Text-based Analysis 6 Hours


Two short-stories-i) A Tiger in the House by Ruskin Bond; ii) Real Time by Amit Chaudhury
Activity: Understanding sentence structures and enriching vocabulary by analyzing a text

Module:3 Job-related Communication 3 Hours


Writing resumes, Job-application & Thank-you letters.
Activity: An in-depth discussion on the different types of resumes, Job- application and Thank-
you letters.
Module-4 Reading Skills 2 Hours
Skimming, scanning, guessing unfamiliar words from context, understanding text organization,
recognizing argument and counter-argument; distinguishing between main information and
supporting detail, fact and opinion, hypothesis versus evidence; summarizing and note-taking

M.Sc Intg Biotechnology (5yr.) Page 30


Activity: Reading of Newspapers & Articles in the class
PRACTICE SESSIONS

Activity-1 Listening Comprehensions 4 hours


Listening & Note Making: Short speeches/ news clips from Indian TV channels in English with
interpretive questions
Session: Summarizing/ note-making and drawing inferences

Activity-2 Introduction to Phonetics 4 hours


Speech Sounds – Vowels and Consonants – Minimal Pairs- Consonant Clusters- Past Tense
Marker and Plural Marker
Session: Learning varied types of speech sounds

Activity-3 Public Speaking: Two Models 6 hours


i) The interactional model of public speaking which includes encoding, decoding and
feedback.
ii) The transactional model of public speaking takes on a more mutual communication
effort between the sender and receiver wherein both seek to find mutual meaning in the
message.
Session: The learners watch different videos on Public speaking and accordingly engage
themselves in planning and preparing speeches that inform, persuade, or fulfill the needs of a
special occasion.

Activity-4 Skit on Social issues / Debate 6 hours


To highlight the use of functional English which helps the students to learn the usage of language
in different occasions
Session: Under the supervision of the Instructor and the audio-visual materials, the students will
enact small skit on social issues and learn different expressions used for various situations like
getting to know someone, introducing someone etc.; they will also hone their oratory power and
argumentative skills by taking part in debates

Activity-5 Reading E-books through Intonation 4 hours


Intonation refers to the way the reader varies the voice in tone, pitch, and volume to reflect the
meaning of the text--sometimes called "expression."
Session: Students learn to read E-books properly with the appropriate use of intonation

Activity-6 Information Transfer 6 hours


Information transfer, or presenting verbal account of facts and processes in pictorial form and,
conversely, changing Web-based graphic representations to writing, involves learning how to
restate a given body of material in different ways.
Session: The learners will be interpreting the information in different forms like tree diagrams, bar
charts, pie charts

Textbook/ Workbook

M.Sc Intg Biotechnology (5yr.) Page 31


1. Wren & Martin, (Re-Printed 2018), High School English Grammar & Composition (Revised
by Dr. N.D.V. Prasada Rao); New Delhi, S. Chand & Company Ltd.,
Reference Books
1. Parul Popat (2015) Communication Skills, Noida, Pearson Education.
2. Aruna Koneru, (2015) Professional Speaking Skills, New Delhi, OUP.
Mode of Evaluation: Quizzes, Presentations, Discussions, Role Play, Assignments and FAT.
List of Challenging Experiments (Indicative)
1 Vocabulary building through reading a newspaper article 5 hours
2 Reading the prescribed text and writing a summary 10 hours
3 Writing a resume 5 hours
4 Listening to speeches/news clips and making inferences 5 hours
5 Public speaking 10 hours
6 Debates on current issues 10 hours
Total Laboratory Hours 45 Hours
Mode of Evaluation: Quizzes, Presentations, Discussions, Role Play, Assignments and FAT.
Recommended by Board of Studies 08.06.2019
Approved by Academic Council No. 55 Date 13-06-2019

M.Sc Intg Biotechnology (5yr.) Page 32


Course code Course title L T P J C
ENG1912 General English-II 1 0 2 0 2
Pre-requisite General English-I Syllabus version
1
Course Objectives:
1. To provide resources for the students to learn pronunciation of the English sounds through
the knowledge of syllable-break-up and stress; and to know the advance level English
grammar and vocabulary
2. To learn to appear for personal interview and to participate in Group Discussions
3. To develop the students' reading skills to enable them to skim an adapted text for main
idea, to scan the text for specific information, to interpret and for inferences
Course Outcome:
1. Communicate effectively in medium level interview and group-discussions;
2. Develop the listening skills so as to understand and apply specific information from the
source;
3. Use English appropriately in their professional and academic environment
4. Improve the Grammar writing skills to enable the students to respond to input provided
through training so as to stimulate, to select and to summarize information in Technical
Reports and apply acquired information to a specified task like Transcoding, writing letters
etc.
5. Develop the overall personality and to hone the leadership qualities of the learners

Student Learning Outcomes (SLO): 16, 18


16. Having a good working knowledge of communicating in English
18. Having critical thinking and innovative skills

THEORY

Module:1 Advanced-level Grammar 5 hours


Simple, Compound and Complex Sentences, Phrases-Adjective Phrases, Adverb Phrases, Noun
Phrases, Direct and Indirect Speech, Conditionals, Concord, Punctuation
Vocabulary building: Idioms
Activity: Grammar Worksheet

Module:2 Professional Dialogues 2 hours


Formal Conversations – at the office with the CEO/ with the Registrar of a University/ Introducing
oneself at an interview panel
Activity: Role play [students practice short formal conversations in pairs/groups of 5-6]

Module:3 Drafting 4 hours


Notice, Circular, Resolution & Minutes, Business letter writing- Offer letter, quotation, status
enquiry, Confirmation, Execution, Refusal and cancellation of order, recommendation, credit
collection, claim, bank loan
Activity: Worksheets

M.Sc Intg Biotechnology (5yr.) Page 33


Module:4 Text-based Analysis 4 hours
You Can Win by Shiv Khera
Activity: Skimming, scanning, guessing unfamiliar words from context; summarizing/note making
& drawing inferences from the Text

PRACTICE SESSIONS:

Activity-1 Listening Comprehension for General Details 2 hours


Listening Comprehension Tests; Testing Exercises
Session: Students will reflect back what they hear from the videos, which help them to be
understood.
Activity-2 Syllable structure; Word stress 4 hours
Structure of Syllables – Word Stress– Weak Forms and Strong Forms –Tone & Rhythm
Session: Practicing basic rules of word accent - Stress shift - Weak forms and Strong forms-
Sentence Stress

Activity-3 Verbal & Non-Verbal Communication 6 hours


Exposure to videos of structured talks delivered by leaders across all domain - Presentation Skills-
Non-verbal Communication
Session: Students will make short speeches by watching relevant TED-Talk videos –PPT
presentations by students communicating non-verbally in a pair/group

Activity-4 Features of Good Conversation 4 hours


Strategies for effective Communication and the use of polite language through the aid of audio-
visual materials.
Session: Making requests and seeking permissions, Telephone etiquette, Participating in Case-
study based Group Discussions

Activity-5 Report Writing & Transcoding 8 hours


Report writing format; Essential qualities of technical writing; Data interpretation & Transcoding;
logical and analytical reasoning questions
Session: Students write a Report; they interpret graphs of medium level difficulty

Activity-6 Leadership Development 6 hours


The focus will be on individual, group and organization factors associated with leadership.
Session: Students will be acquainted with the development of the conception of leadership and in
the process would hone their vocabulary and conversational power, by watching videos of leaders
delivering Lectures; Seminars conducted by Administrative Heads of various Schools/
Departments within the University.

Total Practical hours: 45 hours


Text Book/ Work Book

M.Sc Intg Biotechnology (5yr.) Page 34


1 Wren & Martin, (Re-Printed 2018) High School English Grammar & Composition (Revised
by Dr. N.D.V. Prasada Rao); New Delhi, S. Chand & Company Ltd.,

Reference Books
1. Maclean Joan and Lynch Tony (2013) Study Speaking, CUP.
2. Thill John and L. Bove Courtland (2016) Excellence in Business Communication, Pearson
Publications
3 Khera Shiv 2013 (Reprint 2019) You Can Win: New Delhi, Bloomsbury India, New Delhi
Mode of Evaluation: Quizzes, Presentation, Discussion, Role play, Assignments and FAT
List of Challenging Experiments (Indicative)
1 Error detection in paragraph 6 hours
2 Role plays on professional situations 10 hours
3 Discussing a Case on communication skills 7 hours
4 Academic listening and note taking 7 hours
5 Report Writing 10 hours
6 Guessing unfamiliar words from the prescribed text 5 hours
Total Laboratory Hours 45 hours
Mode of Evaluation: Quizzes, Presentation, Discussion, Role Play, Assignments & FAT
Recommended by Board of Studies 08-06-2019
Approved by Academic Council No. 55 Date 13-06-2019

M.Sc Intg Biotechnology (5yr.) Page 35


Course code Course title L T P J C
ENG1913 Effective Communication Skills 1 0 2 0 2
Pre-requisite General English-II Syllabus version
v.1
Course Objectives:
1. To be an independent/ a competent speaker in all areas of written and spoken communication
for successful business/ professional interactions.
2. To organize, compare and contrast, categorize and describe complex content.
3. To speak and write with fluency and confidence, with minor grammatical errors and with a
fairly wide active vocabulary.
Course Outcome:
• Acquire an effective command over the language, though with minor inaccuracies
• Understand complex theories of varied subjects and understand detailed logic & reasoning
• Perform well in middle to upper-end placement interviews/ competitive exams/ general
social situations
• Participate actively and independently in seminars/discussions
• Understand the requisite proficiency for difficult/ varied levels of communications in
BBC/UK & CNN/US accents
Student Learning Outcomes (SLO): 16, 18
16. Having a good working knowledge of communicating in English
18. Having critical thinking and innovative skills

THEORY
Module:1 Verbal-Logic & Reasoning 4 hours
Verbal reasoning tests assess the learner’s understanding and comprehension skills.
Activity: Interpreting short texts.
Module:2 The Art of Paraphrasing 2 hours
A restatement of the meaning of a text or passage using other words.
Activity: Paraphrasing different articles & Research papers
Module:3 Text-based Analysis 6 hours
The Thousand Faces of Night by Githa Hariharan
Activity: Summarizing/ note making & drawing inferences from the text
Module:4 Research Paper Writing 3 hours
Structure of a Research paper; Plagiarism
Activity: Practice on Research Paper writing.
PRACTICE-SESSIONS
Activity-1 Vocalics 4 hours
The learners will undergo training in vocalics which are rate, or speed at which the person speaks,
pitch, inflection and variety in the voice, volume, being loud or soft, and articulation and
pronunciation, or how correctly and clearly the person speaks.
Session: Type the learners will undergo training in vocalics
Activity-2 Travel blogs / E-Travel Diary 6 hours
Briefing on the art of writing travel blogs.
Session: The learners will engage in writing relevant blogs

M.Sc Intg Biotechnology (5yr.) Page 36


Activity-3 Video-conference and Interview 8 hours
Preparing the students for Interviews.
Session: Students will participate in mock-Interviews and real-time video-conference
Activity-4 Language Sensitivity & Cross Cultural Communication 4 hours
Meaning & importance of Cross Cultural Communication; Understanding Inter and Cross-Cultural
Communication Nuances through relevant videos & case-studies
Session: Students will attempt a case study on cross-cultural communication
Activity-5 Mass-Media Communication 2 hours
Briefing on the constituents of mass media such as newspapers, magazines, films/documentaries,
radio, television, the mechanism of conveying information to a mass-audience and an academic
investigation of the different methods of mass correspondence
Activity: An advanced understanding of news media and their role in the society and relevant media
education through the mode of note-making & interpretive exercises
Activity-6 Writing Abstract/Summary/Articles 6 hours
Equip participants with skills in writing and presenting effective and successful Abstract/ Summary.
The participants will also acquire skills in writing quality Articles which can engage the audience.
Session: Each individual student will submit an Article under the guidance of the course-Instructor
Total Lecture hours: 45 hours
Text Book/Work Book
1 Krizan, Merrier, Logan, Williams (Eight Edition) 2012 Business Communication, New Delhi,
Cengage Learning

Reference Books
1. Githa Hariharan (2013) The Thousand Faces of Night, Royal New Zealand Foundation of the
Blind
2. O’ Brien, Terry, (2011) Effective English Skills, Nd: Rupa
3. Kumar, Sanjay & Puspalata, (2015-2nd Ed) Communication Skills,Nd: OUP
Mode of Evaluation: Quizzes, Presentation, Discussion, Role play, Assignments & FAT
List of Challenging Experiments (Indicative)
1 Interpreting short texts and writing a paragraph 8 hours
2 Writing an abstracts 10 hours
3 Mock Interviews through video conferencing 12 hours

4 Analysing and discussing a case on cross cultural communication 6 hours


5 Listening and paraphrasing 4 hours
6 Reading aloud travel blogs or E-travel diary with focus on vocalics 5 hours
Total Laboratory Hours 45 hours
Mode of Evaluation: Quizzes, Presentation, Discussion, Role play, Assignments & FAT
Recommended by Board of Studies 08.06.2019
Approved by Academic Council No.55 Date 13-06-2019

M.Sc Intg Biotechnology (5yr.) Page 37


Course code Course title L T P J C
HUM1021 / Ethics and values 2 0 0 0 2
HUM1032
Pre-requisite None Syllabus version
1.1
Course Objectives:
1. To understand and appreciate the ethical issues faced by an individual in profession, society,
and polity
2. To understand the negative health impacts of certain unhealthy behaviors
3. To appreciate the need and importance of physical, emotional health and social health

Expected Course Outcome:


Students will be able to:
1. Follow sound morals and ethical values scrupulously to prove as good citizens
2. Understand various social problems and learn to act ethically
3. Understand the concept of addiction and how it will affect the physical and mental health
4. Identify ethical concerns in research and intellectual contexts, including academic integrity,
use, and citation of sources, the objective presentation of data, and the treatment of human
subjects
5. Identify the main typologies, characteristics, activities, actors, and forms of cybercrime

Student Learning Outcomes (SLO): 2,10,11,12


2. Having a clear understanding of the subject related concepts and contemporary issues
10. Having a clear understanding of professional and ethical responsibility
11. Having an interest in lifelong learning
12. Having adaptive thinking and adaptability

Module:1 Being Good and Responsible 5 hours


Gandhian values such as truth and non-violence – Comparative analysis on leaders of past and
present – Society’s interests versus self-interests - Personal Social Responsibility: Helping the
needy, charity and serving the society

Module:2 Social Issues 1 4 hours


Harassment – Types - Prevention of harassment, Violence, and Terrorism

Module:3 Social Issues 2 4 hours


Corruption: Ethical values, causes, impact, laws, prevention – Electoral malpractices;
White collar crimes - Tax evasions – Unfair trade practices

Module:4 Addiction and Health 5 hours


Peer pressure - Alcoholism: Ethical values, causes, impact, laws, prevention – Ill effects of
smoking - Prevention of Suicides;
Sexual Health: Prevention and impact of pre-marital pregnancy and Sexually Transmitted
Diseases

Module:5 Drug Abuse 3 hours

M.Sc Intg Biotechnology (5yr.) Page 38


Abuse of different types of legal and illegal drugs: Ethical values, causes, impact, laws, and
prevention

Module:6 Personal and Professional Ethics 4 hours


Dishonesty - Stealing - Malpractices in Examinations – Plagiarism

Module:7 Abuse of Technologies 3 hours


Hacking and other cybercrimes, Addiction to mobile phone usage, Video games and Social
networking websites

Module:8 Contemporary issues: 2 hours


Guest lectures by Experts

Total Lecture hours: 30 hours

Reference Books
1. Dhaliwal, K.K, “Gandhian Philosophy of Ethics: A Study of Relationship between his
Presupposition and Precepts,2016, Writers Choice, New Delhi, India.
2. Vittal, N, “Ending Corruption? - How to Clean up India?” 2012, Penguin Publishers, UK.
3. Pagliaro, L.A., and Pagliaro, A.M, “Handbook of Child and Adolescent Drug and
Substance Abuse: Pharmacological, Developmental and Clinical Considerations,”
4. 2012Wiley Publishers, U.S.A.
Pandey, P. K (2012), “Sexual Harassment and Law in India,” 2012, Lambert Publishers,
Germany.

Mode of Evaluation: CAT, Assignment, Quiz, FAT, and Seminar


Recommended by Board of Studies 26-07-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 39


Course Code Course title L T P J C
MAT-1001 Fundamentals of Mathematics 3 2 0 0 4
Pre-requisite None Syllabus Version
1.0
Course Objectives
The course is aimed at providing
[1] necessary and relevant background to understand the other important engineering
mathematics courses
[2] basic knowledge for the non-mathematics students to learn further topics and apply it in
solving real-world engineering problems

Course Outcomes
At the end of the course, the student should be able to
[1] Solve a system of linear equations by matrix method
[2] Apply the techniques of differentiation to find maxima and minima, and techniques of
integration to evaluate areas and volumes of revolution
[3] Understand the concept of ordinary differential equations, and first and second-order linear
differential equations
[4] Have a clear understanding of analytic geometry and vector algebra
[5] Apply concepts of mathematical logic and elementary probability to real-life problems

Student Learning Outcomes 2, 7,9


2. Having a clear understanding of the subject related concepts and contemporary issues
7. Having computational thinking (Ability to translate vast data into abstract concepts and to
understand database reasoning
9. Having problem-solving ability- solving social issues and engineering problems

Module:1 Matrices 5 hours


Matrices - types of matrices - operations on matrices - determinants - adjoint matrix –
Inverse of a matrix - solution of a system of linear equations by inversion method –
elementary transformations – the rank of a matrix - consistency, and inconsistency of the system
of equations

Module:2 Differential Calculus 6 hours


Differentiation of functions of a single variable – differentiation techniques physical
interpretations - differentiation of implicit functions – higher-order derivatives – Taylor’s,
McClaurin’s series - maxima and minima of functions of a single variable

Module:3 Integral Calculus 6 hours


Partial fractions - Integration- integration techniques- integration by parts- definite integrals –
properties- evaluation of area and volume by integration

Module:4 Linear Ordinary Differential Equations 6 hours

M.Sc Intg Biotechnology (5yr.) Page 40


Differential equations-definition and examples- formation of the differential equation- solving
differential equations of the first order - solving second order homogenous differential equations
with constant coefficients

Module:5 Analytic geometry 5 hours


Analytic geometry of three dimensions - direction cosines and direction ratios - plane, straight line and
sphere, distance between points, distance to a plane

Module:6 Vector Algebra 7 hours


Vectors–operations on vectors-angle between two vectors-projection of one vector on another vector –
equations of the plane, straight line, and sphere in vector forms-shortest distance between two skew lines -
equation of a tangent plane to a sphere

Module:7 Logic and Probability 8 hours


Mathematical logic – propositions – truth table – connectives– tautology – contradiction.
Permutations and combinations – probability – classical approach – addition law - conditional probability -
multiplicative law - Bayes' theorem and applications

Module:8 Contemporary Issues 2 hours


Industry Expert Lecture

Total Lecture hours: 45 hours

• A minimum of 10 problems to be
worked out by students in every
Tutorial Class
• Another 5 problems per Tutorial Class
Tutorial 30 hours
to be given as homework

Mode: Individual Exercises, Team Exercises,


Online Quizzes, Online Discussion Forums
Text Book(s)
• Engineering Mathematics, K. A. Stroud, and Dexter J. Booth, 7th Edition, Palgrave Macmillan (2013).

Reference Books
• Elementary Engineering Mathematics, B. S. Grewal, 43rd edition, Khanna Publications, (2015).
• Discrete Mathematics, Seymour Lipschutz and Marc Lipson, 6th Edition, Tata McGraw -Hill (2017).
• Introduction to Probability and Statistics, Seymour Lipschutz and John Schiller, 3rd Indian Edition,
Tata McGraw -Hill (2017).

Mode of Evaluation
Digital Assignments (Solutions by using a soft skill), Quiz, Continuous Assessments, Final
Assessment Test
Recommended by Board of Studies 25-02-2017
Approved by Academic Council No. 47 Date 05-10-2017

M.Sc Intg Biotechnology (5yr.) Page 41


Course Code Course title L T P J C
MAT-1012 Statistical Applications 2 0 2 0 3
Pre-requisite None Syllabus Version
1.0
Course Objectives:
[1] This course provides the meaning and scope of Statistical Applications.
[2] This enables the students to understand and use statistics in real-world problems.
[3] This course imparts comprehensive knowledge on data collection, presentation of data,
pictorial representation, and measures of central tendency, measures of dispersion, control
charts, correlation, regression, time series, probability, estimation, and inference.

Expected Course Outcome :


After completion of the course, a student will be able to
[1] Organize, present, and interpret statistical data, both numerically and graphically.
[2] Perform regression analysis and compute and interpret the coefficient of correlation
[3] Use various methods to compute the probabilities of events
[4] Analyse and interpret data using appropriate statistical hypothesis and parametric testing
techniques.
[5] apply statistical quality control techniques
[6] implement SPSS code for statistical data

Student Learning Outcomes 2, 7


2. Having a clear understanding of the subject related concepts and contemporary issues
7. Having computational thinking (Ability to translate vast data into abstract concepts and to
understand database reasoning)

Module:1 Introduction to Statistics and Data Collection: 5 hours


Importance of statistics, concepts of statistical population, and a sample - Methods of
Random and Non -Random Sampling - quantitative and qualitative data - Measurement
scales - nominal, ordinal, interval, and ratio - Primary and secondary data- Classification and
tabulation of data. Diagrammatic and graphical representation of data-Histograms and
Frequency Polygons.

Module:2 Describing Business Data: 5 hours


Measures of Central tendency- Mean, median, and mode- Measures of Dispersion, Range,
Quartile deviation, Mean Deviation, Standard Deviation-The coefficient of Variation.

Module:3 Correlation and Regression Analysis: 4 hours


The Scatter Plot- Correlation-Types-Karl Pearson’s Coefficient of Correlation-Spearman’s
Rank Correlation –Regression lines and coefficients- the coefficient of Determination-
Residuals-the standard error of Estimate.

M.Sc Intg Biotechnology (5yr.) Page 42


Module:4 Probability 4 hours
Probability, Random experiments, trial, sample space, events. Approaches to probability -
classical, empirical, subjective, and axiomatic. Theorems on probabilities of events. Addition
rule of probability. Conditional probability, independence of events, and multiplication rule
of probability. Bayes theorem and its applications.

Module:5 Testing of Hypothesis 5 hours


Testing of Hypothesis – Z- test, Student’s t-test, F-test, Chi-square test.

Module:6 Statistical Quality Control Charts 5 hours


Statistical Quality Control Charts- Introduction - Types of Control Charts – Setting up a
Control Procedure – X bar (Mean) Chart and R Chart–c Chart–p Chart–Advantages and
Limitations of Control Charts.

Module:7 Contemporary Issues 2 hours

Industry Expert Lecture


Total Lecture hours: 30 hours
Text Book(s)
1. Statistics for managers using MS-Excel, David. M. Levin, David. F. Stephen, and
Cathryn. A. Szadat 7th Edition, Pearson Education (India), (2013).
Reference Books
1. Business Statistics and Statistical Methods, S. P. Gupta, S. Chand Publication, New
Delhi,2014.
2. Probability and Statistics for Engineers and Scientists, Ronald E. Walpole, Raymond H.
Myers, Sharon L. Myers, Keying E. Ye, (9th Edition), Pearson Education (2015)
3. Statistics For Management, Levin Richard and Rubin David, 7th Edition, Pearson
Education, Dorling Kindersley,( 2008, 2011-reprint).
4. Discovering Statistics Using IBM SPSS Statistics, Andy Field, 4th Edition, Sage
Publication, (2013).
Mode of Evaluation
Digital Assignments, Continuous Assessments, Final Assessment Test
List of Challenging Experiments (Indicative)
1 Tabulation and Pictorial representations of Various data types using Excel 2 hours
or SPSS.
2 Calculation of Mean, Median, Mode, location measures, Variance and 2 hours
Box-Plot representations, calculation using Excel or SPSS.
3 Plotting scatter diagram, computing correlation 2 hours
4 Fitting of linear regression 2 hours
5 Fitting of Multiple linear regression 2 hours
6 Plotting Mean and Range Charts, C chart, using Excel or SPSS. 2 hours
7 Plotting P chart, np chart, and C chart using Excel or SPSS. 2 hours

M.Sc Intg Biotechnology (5yr.) Page 43


8 Z-test for means and Proportions-One sample and Two-sample tests 2 hours
9 t-test for single mean, a difference of Means and Proportions 2 hours
10 Test for variance and Contingency (Chi-Square -Cross Tab) Test Excel or 2 hours
SPSS.
Total Laboratory Hours 20 hours
Mode of Evaluation
Weekly Assessments, Final Assessment Test
Recommended by Board of Studies 12-06-2016
Approved by Academic Council No. 37 Date 16-06-2015

M.Sc Intg Biotechnology (5yr.) Page 44


Course code Course title L T P J C
MGT1022 Lean Start up Management 1 0 0 4 2
Pre-requisite None Syllabus version
v.1.0
Course Objectives: To develop the ability to
1. Learn methods of company formation and management.
2. Gain practical skills in and experience of stating business using a pre-set collection of
business ideas.
3. Learn the basics of entrepreneurial skills.

Expected Course Outcome: On the completion of this course, the student will be able to:
1. Understand developing business models and growth drivers
2. Use the business model canvas to map out key components of the enterprise
3. Analyze market size, cost structure, revenue streams, and value chain
4. Understand build-measure-learn principles
Foreseeing and quantifying business and financial risks

Student Learning Outcomes (SLO): 2,3, 5


2. Having a clear understanding of the subject related concepts and contemporary issues
3. Having an ability to be socially intelligent with good SIQ (Social Intelligence Quotient) and EQ
(Emotional Quotient)
5. Having design thinking capability

Module:1 2 Hours
Creativity and Design Thinking (identify the vertical for business opportunity, understand your
customers, accurately assess market opportunity)

Module:2 3 Hours
Minimum Viable Product (Value Proposition, Customer Segments, Build- measure-learn process)

Module:3 3 Hours
Business Model Development(Channels and Partners, Revenue Model and streams, Key
Resources, Activities and Costs, Customer Relationships and Customer Development Processes,
Business model canvas –the lean model- templates)

Module:4 3 Hours
Business Plan and Access to Funding(visioning your venture, taking the product/ service to
market, a Market plan including Digital & Viral Marketing, start-up finance - Costs/Profits &
Losses/cash flow, Angel/VC,/Bank Loans and Key elements of raising money)

Module:5 3 Hours
Legal, Regulatory, CSR, Standards, Taxes

Module:6 2 Hours
Lectures by Entrepreneurs
M.Sc Intg Biotechnology (5yr.) Page 45
Total Lecture 15 hours
Text Book(s)
1. The Startup Owner's Manual: The Step-By-Step Guide for Building a Great Company, Steve
Blank, K & S Ranch; 1st edition (March 1, 2012)
2
The Four Steps to the Epiphany, Steve Blank, K&S Ranch; 2nd edition (July 17, 2013)
3 The Lean Startup: How Today's Entrepreneurs Use Continuous Innovation to Create Radically
Successful Businesses, Eric Ries, Crown Business; (13 September 2011)
Reference Books
1. Holding a Cat by the Tail, Steve Blank, K&S Ranch Publishing LLC (August 14, 2014)
2 Product Design and Development, Karal T Ulrich, SD Eppinger, McGraw Hill
3 Zero to One: Notes on Startups, or How to Build the Future, Peter Thiel, Crown
Business(2014)
4 Lean Analytics: Use Data to Build a Better Startup Faster (Lean Series), Alistair Croll &
Benjamin Yoskovitz, O'Reilly Media; 1st Edition (March 21, 2013)
5 Inspired: How To Create Products Customers Love, Marty Cagan, SVPG Press; 1st edition
(June 18, 2008)
6 Website References:
1. http://theleanstartup.com/
2. https://www.kickstarter.com/projects/881308232/only-on-kickstarter-the-leaders-guide-
by-eric-ries
3. http://businessmodelgeneration.com/
4. https://www.leanstartupmachine.com/
5. https://www.youtube.com/watch?v=fEvKo90qBns
6. http://thenextweb.com/entrepreneur/2015/07/05/whats-wrong-with-the-lean-startup-
methodology/#gref
7. http://www.businessinsider.in/Whats-Lean-about-Lean-Startup/articleshow/53615661.cms
8. https://steveblank.com/tools-and-blogs-for-entrepreneurs/
9. https://hbr.org/2013/05/why-the-lean-start-up-changes-everything
10. chventures.blogspot.in/ platformsandnetworks.blogspot.in/p/saas-model.html
Mode of Evaluation: Assignments; Field Trips, Case Studies; e-learning; Learning through
research, TED Talks
Project
1. Project 60 hours
Total Project 60 hours
Recommended by Board of Studies 08-06-2015
Approved by Academic Council 37 Date 16-06-2015

M.Sc Intg Biotechnology (5yr.) Page 46


Course code Course title L T P J C
PHY1003 Physics 3 0 2 4 5

Pre-requisite None Syllabus version


1.0
Course Objectives:
To enable the student to understand the basic principles of Physics behind (a) those latest areas of
biotechnology such as nanobiotechnology and (b) medical applications involving lasers, ultrasound
and fiber optics

Expected Course Outcome: Students will be able to


1. Understand the concept of dual nature of the electromagnetic radiation and its verification
2. Understand the quantum physics concept by studying the behavior of the particle in a box.
3. Study the material properties as a function of particle size, especially at the nano level.
4. Explore the properties and types of LASERs and its application.
5. Understand the properties, production, and detection of Ultrasonic waves.
6. Get insight into the communication system through fiber optics.
7. Learn the applications of LASER, Ultrasonic and Fiber optics in the medical field and to
appreciate the contemporary issues.
8. Demonstrate the ideas of quantum nature and ultrasonic waves-LAB
9. Carry out a mini project in the abovementioned topics-J COMPONENT

Student Learning Outcomes (SLO): 2,9,14,18


2. Having a clear understanding of the subject related concepts and contemporary issues
4. Having problem-solving ability- solving social issues and engineering problems
14. Having an ability to design and conduct experiments, as well as to analyze and interpret data
18. Having critical thinking and innovative skills

Module:1 Quantum Physics 7 hours


Dual nature of electromagnetic radiation, Compton effect (Qualitative), experimental verification-
deBroglie waves- Davisson-Germer Experiment, Heisenberg uncertainty principle - Schrödinger
equation.

Module:2 Applications of Quantum Physics 6 hours


Particle in a 1-D box (Eigen Value and Eigen Function), 3-D Analysis (Qualitative), Tunneling
Effect (Qualitative), Scanning Tunneling Microscope, Atomic Force Microscope.

Module:3 Nanotechnology 6 hours


Introduction to Nano-materials, Properties of Nano-materials, Bionanomaterials, membranes,
electrical properties of nano membranes, CNT, Applications of nanobiotechnology- longer-lasting
medical implants, nanodrugs
Module:4 Lasers 6 hours

M.Sc Intg Biotechnology (5yr.) Page 47


Laser characteristics, Einstein’s theory of stimulated emission, pumping mechanisms-population
inversion, three-level, four-level lasers, Nd-YAG, He-Ne-laser, CO2 laser.

Module:5 Ultrasonics 6 hours


Properties of ultrasonics, generation- Magnetostriction method, Piezoelectric method, detection of
ultrasonics.

Module:6 Fiber Optics 6 hours


Light propagation through fiber, Acceptance angle, numerical aperture, types of fiber.

Module:7 Application of Lasers, Ultrasonics and Fiber 6 hours


Optics
Laser in surgery, ophthalmology, dentistry, ultrasonogram, POT-sensors- fiber-optic- biosensors,
keyhole surgery.

Module:8 Contemporary issues: 2 hours


Current Topics - Industry Experts Talk

Total Lecture hours: 45


hours
Text Book(s)
1. Concepts of Modern Physics, Arthur Besier, Shobhit Mahajan, S. Rai Choudhury, 7th
2. Edition, Tata - McGraw Laser Fundamentals, William Silfvast, 2nd edition, Cambridge
University Press, Cambridge. 2008 [a Classic book on the subject of Laser]
3. Fiber Optic Communication Technology, Djafar K. Mynbaev, and Lowell L. Scheiner,
Addison Wesley Longman, Singapore, 2011
4. Ultrasonics: Fundamentals, Technologies, and Application, Dale Ensminger, Leonard J.
Bond, 3rd Edition, CRC Press, London, 2011
Reference Books
1. Modern Physics, Raymond A. Serway, Clement J. Mosses, Curt A. Moyer, 3rd Edition,
Cengage Learning, Boston, 2010
2. Laser Systems and Applications, Nityanand Choudhary and Richa Verma, PHI Learning
Private Ltd., New Delhi, 2011
3. Lasers and Optical Instrumentation, S. Nagabhushana and B. Sathyanarayana, I.K.
International Publishing House Pvt. Ltd., New Delhi, 2010
4. Fundamentals and Applications of Ultrasonic Waves, J. David N. Cheeke, 2nd Edition, CRC
Press, London, 2012
Mode of Evaluation: Quizzes, Digital Assignments, CAT-I and II and FAT
Recommended by Board of Studies 13.05.2017
Approved by Academic Council No. 45 Date 15.06.2017
List of Challenging Experiments (Indicative)
1. Calculation of interplanar spacing of polycrystalline graphite from electron 2 hrs
diffraction pattern (Module 1)
2. Fabry Perot Interferometer: Determination of wavelength of the laser beam and 2 hrs
finding spacing of the etalon (Module 4)

M.Sc Intg Biotechnology (5yr.) Page 48


3. Determination of wavelength of the laser source (He-Ne laser and diode lasers of 2 hrs
different wavelengths) using diffraction technique (Module 4)
4. Integrated optics: Determination of refractive index of the prism (Module 6) 2 hrs
5. Determination of refractive index of various liquids (Module 6) 2 hrs
6. Optical Fiber Characterization: determination of numerical aperture of a given 2 hrs
multimode optical fiber (Module 6)
7. Determination of the size of the fine particle using laser diffraction (Module 4) 2 hrs
8. Determination of the track width (periodicity) in a written CD (Module 4) 2 hrs
9. Analysis of crystallite size and strain in a nano-crystalline film using a given X- 2 hrs
ray diffraction pattern (Module 3)
10. Ultrasonic interferometer: Determination of velocity of the ultrasonic wave in 2 hrs
different liquids and its adiabatic compressibility (Module 5)
11. Numerical solutions of Schrödinger equation (e.g., particle in a box problem) (can 2 hrs
be given as an assignment) (Module 1)
12. Exploring the link between quantum confinement and Heisenberg's uncertainty 2 hrs
principle (can be given as assignment). (Module 1+3)
Total Laboratory Hours 24 hrs
Recommended by Board of Studies 13.05.2017
Approved by Academic Council No. 45 Date 15.06.2017

M.Sc Intg Biotechnology (5yr.) Page 49


Course code Course title L T P J C
ESP1001 ESPAÑOL FUNDAMENTAL 2 0 0 0 2
Pre-requisite None Syllabus version
v.
Course Objectives:
The course gives students the necessary background to:
• Demonstrate proficiency in reading, writing, and speaking in basic Spanish. Learning
vocabulary related to profession, education centers, day-today activities, food, culture,
sports and hobby, the family set up, workplace, market, and classroom activities is
essential.
• Demonstrate the ability to describe things and will be able to translate into English and
vice versa.
• Describe in simple terms (both in written and oral form) aspects of their background,
immediate environment, and matters in areas of immediate need.

Expected Course Outcome:


The students will be able to
• Remember greetings, giving personal details and Identify genders by using correct articles
• Apply the correct use of SER, ESTAR and TENER verb for describing people, place, and
things
• Create opinion about time and weather conditions by knowing months, days and seasons in
Spanish
• Create opinion about people and places by using regular verbs
• Apply reflexive verbs for writing about the daily routine and create small paragraphs about
hometown, best friend and family

Student Learning Outcomes (SLO): 2, 11


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning
Module:1 Abecedario, Saludos y Datos personales: Origen, 3 hours
Nacionalidad, Profesión

Competencia Gramática: Vocales y Consonantes. Artículos definidos e indefinidos (Numero y


Genero).
Competencia Escrita: Saludos y Datos personales
Module:2 Edad y posesión. Números (1-20) 3 hours
Competencia Gramática: Pronombres personales. Adjetivos. Los verbos SER y TENER.
Competencia Escrita: Escribe sobre mismo/a y los compañeros de la clase
Module:3 Vocabulario de Mi habitación. Colores. 5 hours
Descripción de lugares y cosas.
Competencia Gramática: Adjetivos posesivos. El uso del verbo ESTAR. Diferencia entre SER y
ESTAR.
Competencia Escrita: Mi habitación
Module:4 Mi familia. Números (21-100). Direcciones. 4 hours
Expresar la hora. Los meses del año.
Competencia Gramática: Frases preposicionales. Uso del HAY. La diferencia entre MUY y
MUCHO. Uso del verbo GUSTAR

M.Sc Intg Biotechnology (5yr.) Page 50


Competencia Escrita: Mi familia. Dar opiniones sobre tiempo
Module:5 Expresar fechas y el tiempo. Dar opiniones 5 hours
sobre personas y lugares.
Competencia Gramática: Los verbos regulares (-AR, -ER, -IR) en el presente. Adjetivos
demostrativos.
Competencia Escrita: Mi mejor amigo/a. Expresar fechas. Traducción ingles a español y Español
a Ingles.
Module:6 Describir el diario. Las actividades cotidianas. 3 hours
Competencia Gramática: Los Verbos y pronombres reflexivos. Los verbos pronominales con e/ie,
o/ue, e/i, u/ue.
Competencia Escrita: El horario. Traducción ingles a español y Español a Ingles.
Module:7 Dar opiniones sobre comidas y bebidas. Decir lo 5 hours
que está haciendo. Describir mi ciudad y Ubicar
los sitios en la ciudad.
Competencia Gramática: Los verbos irregulares. Estar + gerundio. Poder + Infinitivo.
Competencia Escrita: Conversación en un restaurante. Traducción ingles a español y Español a
Ingles. Mi ciudad natal. Mi Universidad. La clase. Mi fiesta favorita.
Module:8 Guest Lectures/ Native Speakers 2 hours

Total Lecture hours: 30 hours

Text Book(s)
1. Text Book:“Aula Internacional 1”, Jaime Corpas, Eva Garcia, Agustin Garmendia,
Carmen Soriano Goyal Publication ; reprinted Edition, (2010)
Reference Books
1 “¡AcciónGramática!”, Phil Turk and Mike Zollo, Hodder Murray, London 2006.
“Practice makes perfect: Spanish Vocabulary,” Dorothy Richmond, McGraw Hill
Contemporary, USA,2012.
2 “Practice makes perfect: Basic Spanish,” Dorothy Richmond, McGraw Hill Contemporary,
USA 2009.
3 “Pasaporte A1 Foundation”, Matilde Cerrolaza Aragón, Óscar Cerrolaza Gili, Begoña Llovet
Barquero, Edelsa Grupo, España, 2010.

Recommended by Board of Studies DD-MM-YYYY


Approved by Academic Council No. xx Date DD-MM-YYYY

M.Sc Intg Biotechnology (5yr.) Page 51


Course code Français Progressif L T P J C
FRE2001
2 0 1 0 3
Pre-requisite Français quotidien Syllabus version
v.1
Course Objectives:
The course gives students the necessary background to:
1. Understand isolated sentences and frequently used expressions in relation to immediate
priority areas (personal or family information, shopping, close environment, work).
2. Communicate in simple and routine tasks requiring only a simple and direct exchange of
information on familiar and habitual topics.
3. Enable students to describe with simply means his training, his immediate environment and
evoke familiar and habitual subjects, evoke subjects that correspond to immediate needs.

Expected Course Outcome:


The students will be able to :
1. Understand expressions in French.
2. Create sentences by using frequent lexicon related to himself, his family, his close
environment (family, shopping, work, school, etc).
3. Understand simple, clear messages on the internet, authentic documents.
4. Analyze predictable information in common documents, such as advertisements, flyers,
menus, schedules, simple personal letters.
5. Create simple and routine tasks.
6. Create a simple and direct exchange of information on familiar activities and topics.

Student Learning Outcomes (SLO): 2,11


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning

Module:1 Expressions simples 8 hours


La vie quotidiennes - Le verbe pronominal - Le passé composé avec l’auxiliaire - avoir et être- le
passé récent : venir de + infinitif - Le comparatif - Le superlatif - Les mots interrogatifs (les trois
formes)
Savoir-faire pour : Faire des achats, faire des commandes dans un restaurant, poser des questions.

Module:2 Les activitiés quotidiennes 6 hours


La vie privée et publique (Les achats, Les voyages, les transports-La nourriture, etc.) - Les lieux de
la ville - Les mots du savoir-vivre - Les pronoms indéfinis - Les pronoms démonstratifs - Les
pronoms compléments objets directs/ indirects - La formation du future simple et future proche

M.Sc Intg Biotechnology (5yr.) Page 52


Savoir-faire pour : Réserver les billets pour le voyage, réserver les chambres dans un hôtel,
S’informer sur les lieux de la ville, indiquer la direction à un étranger.

Module:3 Les activités de loisirs 7 hours


Les loisirs (sports/spectacles/activités) - Les moments de la journée, de l’année- La fête indienne
et française – Les goûts - L’impératif - La négation de l’impératif-La place du pronom à
l’impératif avec un verbe pronominal.
Savoir-faire pour : Parler de ses goûts, raconter les vacances, formuler des phrases plus
compliquées, Raconter les souvenirs de l’enfance, parler sur la tradition de son pays natal.

Module:4 La Francophonie 7 hours


L’espace francophone - Première approche de la société française – La consommation alimentaire
– caractériser un objet – décrire une tenue - Le pronom relatif (qui/que/dont/où)
Savoir-faire pour :
Articles de la presse-Portrait d’une personne-Cartes et messages d’invitation, d’acceptation ou de
refus -Article de presse - rédaction d’un événement.

Module:5 La culture française 5 hours


Parler de ses activités quotidiennes - les fêtes en France – Parler de sa famille – réserver un billet à
l’agence - la gastronomie française

Module:6 La description 5 hours


Décrire physiquement une personne – les vacances – les achats – réserver une chambre dans un
hôtel – les plus grands français - raconter des évènements passés

Module:7 S’exprimer 5 hours


Parler du climat - parcours francophone – placer une commande au restaurant –- la mode - parler
de son projet d’avenir.
Module:8 Guest lecures 2 hours

Guest lecures/ Natives speakers

Total Lecture hours: 45 hours

Text Book(s)

M.Sc Intg Biotechnology (5yr.) Page 53


1. Alter Ego 1, Méthode de français, Annie Berthet, Hachette, Paris 2010.
2. Alter Ego 1, Cahier d’exercices, Annie Berthet, Hachette, Paris 2010.
Reference Books
1. CONNEXIONS 1, Méthode de français, Régine Mérieux, Yves Loiseau,Les Éditions Didier,
2010.
2 CONNEXIONS 1, Le cahier d’exercices, Régine Mérieux, Yves Loiseau, Les Éditions
Didier, 2010
3 Fréquence jeunes-1, Méthode de français, G. Capelle et N.Gidon, Hachette, Paris, 2010.
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies DD-MM-YYYY
Approved by Academic Council No. xx Date DD-MM-YYYY

M.Sc Intg Biotechnology (5yr.) Page 54


Course code Grundstufe Deutsch L T P J C
Course code 2 0 0 0 2
Pre-requisite None Syllabus
version
v.1
Course Objectives:
The course gives students the necessary background to:
1. Demonstrate proficiency in reading, writing, and speaking in basic German. Learning
vocabulary related to profession, education centers, day-to-day activities, food, culture,
sports and hobby, the family set up, workplace, market, and classroom activities are
essential.
2. Make the student's industry-oriented and make them adapt to the German culture.

Expected Course Outcome:


The students will be able to
1. Remember greeting people, introducing oneself, and understanding basic expressions in
German.
2. Understand necessary grammar skills to use these in a meaning way.
3. Remember beginner's level vocabulary
4. Create sentences in German on a variety of topics with significant precision and detail.
5. Apply good comprehension of written discourse in areas of special interests.

Student Learning Outcomes (SLO): 2, 11


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning

Module:1 3 hours
Begrüssung, Landeskunde, Alphabet, Personalpronomen, Verben- heissen, kommen, wohnen,
lernen, Zahlen (1-100), W-Fragen, Aussagesätze, Nomen- Singular und Plural, der Artikel -
Bestimmter- Unbestimmter Artikel)
Lernziel :
Sich vorstellen, Grundlegendes Verständnis von Deutsch, Deutschland in Europa

Module:2 3 hours
Konjugation der Verben (regelmässig /unregelmässig),das Jahr- Monate, Jahreszeiten und die
Woche, Hobbys, Berufe, Artikel, Zahlen (Hundert bis eine Million), Ja-/Nein- Frage, Imperativ
mit ,,Sie’’
Lernziel:
Sätze schreiben, über Hobbys, Berufe erzählen, usw

Module:3 6 hours
Possessivpronomen, Negation, Kasus (Bestimmter- Unbestimmter Artikel) Trennbareverben,
Modalverben, Uhrzeit, Präpositionen, Lebensmittel, Getränkeund Essen, Farben, Tiere
Lernziel :
Sätze mit Modalverben, Verwendung von Artikel, Adjektiv beim Verb

M.Sc Intg Biotechnology (5yr.) Page 55


Module:4 4 hours
Übersetzung: (Deutsch – Englisch / Englisch – Deutsch)
Lernziel :
Die Übung von Grammatik und Wortschatz

Module:5 5 hours
Leserverständnis. Mindmap machen, Korrespondenz- Briefe und Email
Lernziel:
Übung der Sprache, Wortschatzbildung

Module:6 5 hours
Aufsätze :Die Familie, Bundesländer in Deutschland, Ein Fest in Deutschland,
Lernziel :
Aktiver, selbständiger Gebrauch der Sprache

Module:7 4 hours
Dialoge:
a) Gespräche mit einem/einer Freund /Freundin.
b) Gespräche beim Einkaufen ; in einem Supermarkt ; in einer Buchhandlung ;
c) in einem Hotel - an der Rezeption ; ein Termin beim Arzt.
d) Ein Telefongespräch ; Einladung–Abendessen

Module:8 2 hours
Guest Lectures/ Native Speakers ( Einleitung in die deustche Kultur und Politik
Total Lecture hours: 30 hours

Text Book(s)
1. Netzwerk Deutsch als Fremdsprache A1, Stefanie Dengler, Paul Rusch, Helen Schmtiz, Tanja
Sieber, Klett-Langenscheidt Verlag, München : 2013
Reference Books
1. Lagune, Hartmut Aufderstrasse, Jutta Müller, Thomas Storz, 2012.
2 Deutsche Sprachlehre für Ausländer, Heinz Griesbach, Dora Schulz, 2013
3 Studio d A1, Hermann Funk, Christina Kuhn, CorneslenVerlag, Berlin :2010
4 Tangram Aktuell-I, Maria-Rosa, SchoenherrTil, Max Hueber Verlag, Muenchen :2012
www.goethe.de
wirtschaftsdeutsch.de
hueber.de
klett-sprachen.de
www.deutschtraning.org
Mode of Evaluation: CAT / Assignment / Quiz / FAT
Recommended by Board of Studies DD-MM-YYYY
Approved by Academic Council No. xx Date DD-MM-YYYY

M.Sc Intg Biotechnology (5yr.) Page 56


Course code Course title L T P J C
ESP2001 ESPAÑOL INTERMEDIO 2 0 2 0 3
Pre-requisite Syllabus version
v.
Course Objectives:
The course gives students the necessary background to:
• Enable students to read, listen and communicate in Spanish in their day to day life.
• Enable students to describe situations by using present, past, and future tenses in Spanish.
• Enable to develop comprehension skill in Spanish language.

Expected Course Outcome:


The students will be able to
• Create sentences in near future and future tenses and correctly using the prepositions like
POR and PARA
• Create sentences in preterito perfecto and correctly use the direct and indirect object
pronouns
• Create sentences related to likes and dislikes and also give commands in a formal and
informal way
• Create sentences in past tense by using imperfecto and idefinido forms and describe past
events
• Create conversations in Spanish at places like restaurants, hotels, Shops and Railway
stations
• Understand different Spanish speaking countries and its culture and traditions.

Student Learning Outcomes (SLO): 2, 11


2. Having a clear understanding of the subject related concepts and of contemporary issues
11. Having interest in lifelong learning

Module:1 Números (101 – 1 millón). Expresar los planes 7 hours


futuros. Los números ordinales.
Competencia Gramática: Futuros cercanos (Ir+a+Infinitivo). Futuros (Verbos regulares e
irregulares). Uso del POR y PARA.
Competencia Escrita: Traducción ingles a español y español a Ingles.
Comprensión - Los textos y Videos

Module:2 Las ropas, colores y tamaños. Costar, valer, 8 hours


descuentos y rebajas
Competencia Gramática: Pronombres objetivos directos e indirectos. El verbo Gustar y Disgustar.
Competencia Escrita: Traducción ingles a español y español a Ingles. Comprensión - Los textos y
Videos

Module:3 Escribir un Correo electrónico formal e 7 hours


informal.
Competencia Gramática: Imperativos formales e informales. Pretérito perfecto.
Competencia Escrita: Traducción ingles a español y español a Ingles.
Comprensión - Los textos y Videos

M.Sc Intg Biotechnology (5yr.) Page 57


Module:4 Currículo Vitae. Presentarse en una 6 hours
entrevista informal.
Competencia Gramática: Pretérito imperfecto. Pretérito indefinido.
Competencia Escrita: Traducción ingles a español y español a Ingles.
Comprensión - Los textos y Videos

Module:5 Introducción personal, Expresar los 5 hours


planes futuros.
Comprensión oral: Introducción personal, Expresar los planes futuros. ¿Qué vas a hacer en las
próximas vacaciones?
Comprensión auditiva: Las preguntas sobre un cuento auditivo. Relacionar el audio con las
imágenes. Las preguntas basadas en canciones.
Medio de transporte: Comprar y Reservar billetes.

Module:6 Diálogos entre dos 5 hours


Comprensión oral: Diálogos entre dos (cliente y tendero de ropas, pasajero y empleado, en un
restaurante, Reservación de habitación en un hotel). Presentación en una entrevista.
Comprensión auditiva: Las preguntas basadas en canciones. Las preguntas basadas en diálogos.

Module:7 Presentación de los países hispánicos. 5 hours


Comprensión oral: Dialogo entre un médico y paciente. Presentación de los países hispánicos.
Describir su infancia. Describir vacaciones últimas o las actividades de último fin de semana.
Comprensión auditiva: Rellenar los blancos del cuento en pasado. Las preguntas basadas en el
cuento. Las preguntas basadas en un anuncio

Module:8 Guest Lectures/ Native Speakers 2 hours


Total Lecture hours: 45 hours

Text Book(s)
1. “Aula Internacional 1”, Jaime Corpas, Eva Garcia, Agustin Garmendia, Carmen Soriano
Goyal Publication; reprinted Edition, Delhi (2010)
Reference Books
1. “¡AcciónGramática!”, Phil Turk and Mike Zollo, Hodder Murray, London 2006.
2. “Practice makes perfect: Spanish Vocabulary”, Dorothy Richmond, McGraw Hill
Contemporary, USA,2012.
3. “Practice makes perfect: Basic Spanish”, Dorothy Richmond, McGraw Hill Contemporary,
USA 2009.
4. “Pasaporte A1 Foundation”, Matilde Cerrolaza Aragón, Óscar Cerrolaza Gili, Begoña Llovet
Barquero, Edelsa Grupo, España, 2010.
Authors, book title, year of publication, edition number, press, place
Recommended by Board of Studies DD-MM-YYYY
Approved by Academic Council No. xx Date DD-MM-YYYY

M.Sc Intg Biotechnology (5yr.) Page 58


Course code Course title L T P J C
STS 1021 Introduction to Softskills 3 0 0 0 1
Pre-requisite None Syllabus version

Course Objectives:
• To enhance critical thinking and innovative skills
• To have a working knowledge of communicating in English
• To have critical thinking and innovative skills

Expected Course Outcome:


• Students will be able to exhibit appropriate presentation skills
• Students will be able to exhibit appropriate analytical skills
• The students will be able to deliver impactful presentations

Student Learning Outcomes (SLO): 10, 11, 12, 13


10.Having a clear understanding of professional and ethical responsibility
11. Having an interest in lifelong learning
12. Having adaptive thinking and adaptability
13.Having cross-cultural competency exhibited by working in teams

Module:1 Lessons on excellence 10 hours


Ethics and integrity
Importance of ethics in life, Intuitionism vs. Consequentialism, Non-consequentialism, Virtue
ethics vs. situation ethics, Integrity - listen to conscience, Stand up for what is right
Change management
Who moved my cheese?, Tolerance of change and uncertainty, Joining the bandwagon, Adapting
change for growth - overcoming inhibition
How to pick up skills faster?
Knowledge vs. skill, Skill introspection, Skill acquisition, "10,000 hours rule" and the converse
Habit formation
Know your habits? How habits work? - The scientific approach, How habits work? - The
psychological approach, Habits and professional success, "The Habit Loop," Domino effect,
Unlearning a bad habit
Analytic and research skills.
Focused and targeted information seeking, How to make Google work for you, Data assimilation

Module:2 Team skills 11 hours


Goal setting
SMART goals, Action plans, Obstacles -Failure management
Motivation
Rewards and other motivational factors, Maslow's hierarchy of needs, Internal and external
motivation

M.Sc Intg Biotechnology (5yr.) Page 59


Facilitation
Planning and sequencing, Challenge by choice, Full Value Contract (FVC), Experiential learning
cycle, Facilitating the Debrief
Introspection
Identify your USP, Recognize your strengths and weakness, Nurture strengths, Fixing weakness,
Overcoming your complex, Confidence building
Trust and collaboration
Virtual Team building, Flexibility, Delegating, Shouldering responsibilities

Module:3 Emotional Intelligence 12 hours

Transactional Analysis
Introduction, Contracting, Ego states, Life positions
Brain storming
Individual Brainstorming, Group Brainstorming, Stepladder Technique, Brain writing, Crawford's
Slip writing approach, Reverse brainstorming, Star bursting, Charlette procedure, Round robin
brainstorming
Psychometric Analysis
Skill Test, Personality Test
Rebus Puzzles/Problem Solving
More than one answer, Unique ways

Module:4 Adaptability 12 hours

Theatrix
Motion Picture, Drama, Role Play, Different kinds of expressions
Creative expression
Writing, Graphic Arts, Music, Art and Dance
Flexibility of thought
The 5'P' framework (Profiling, prioritizing, problem analysis, problem-solving, planning)
Adapt to changes(tolerance of change and uncertainty)
Adaptability Curve, Survivor syndrome

Total Lecture hours: 45 hours

Text Book(s)
1. Chip Heath, How to Change Things When Change Is Hard (Hardcover), 2010, First Edition,
Crown Business.

2. Karen Kindrachuk, Introspection, 2010, 1st Edition.

Karen Hough, The Improvisation Edge: Secrets to Building Trust and Radical Collaboration
3. at Work, 2011, Berrett-Koehler Publishers

Reference Books

M.Sc Intg Biotechnology (5yr.) Page 60


1. Gideon Mellenbergh, A Conceptual Introduction to Psychometrics: Development, Analysis,
and Application of Psychological and Educational Tests, 2011, Boom Eleven International.

2. Phil Lapworth, An Introduction to Transactional Analysis, 2011, Sage Publications (CA)

Mode of Evaluation: FAT, Assignments, Projects, Case studies, Roleplays,3 Assessments with
Term End FAT (Computer Based Test)

M.Sc Intg Biotechnology (5yr.) Page 61


Course code Course title L T P J C
STS 1022 Introduction to Business Communication 3 0 0 0 1
Pre-requisite Syllabus version
1
Course Objectives:
• To enhance critical thinking and innovative skills
• To have a working knowledge of communicating in English
• To have critical thinking and innovative skills

Expected Course Outcome:


• Students will be able to exhibit appropriate presentation skills
• Students will be able to exhibit appropriate analytical skills
• The students will be able to deliver impactful presentations

Student Learning Outcomes (SLO): 16, 18


16. Having a good working knowledge of communicating in English
18.Having critical thinking and innovative skills

Module:1 Presentation skills – Preparing presentation 7 hours


and Organizing materials and Maintaining
and preparing visual aids and Dealing with
questions

10 Tips to prepare PowerPoint presentation, Outlining the content, Passing the Elevator Test, Blue
sky thinking, Introduction, body and conclusion, Use of Font, Use of Color, Strategic presentation,
Importance and types of visual aids, Animation to captivate your audience, Design of posters,
Setting out the ground rules, Dealing with interruptions, Staying in control of the questions,
Handling difficult questions

Module:2 Analytical Writing – Articulate and support 6 hours


complex ideas

30 minute - Analyse an Issue, 30 minute - Analyse an Argument, Construct and Evaluate


arguments¸ Focused and Coherent discussion

Module:3 Business Etiquette 9 hours

Social and Cultural Etiquette


Value, Manners, Customs, Language, Tradition
Writing Company Blogs
Building a blog, Developing brand message, FAQs', Assessing Competition
Internal Communications

M.Sc Intg Biotechnology (5yr.) Page 62


Open and objective Communication, Two-way dialogue, Understanding the audience
Planning
Identifying, Gathering Information, Analysis, Determining, Selecting plan, Progress check, Types
of planning
Writing a press release and meeting notes

Write a short, catchy headline, Get to the Point –summarize your subject in the first paragraph,
Body – Make it relevant to your audience
Module:4 Listening and speaking skills 10 hours
Debate, Idea generation, Research, Articulating, Style, Preparation of arguments –Rebuttal, Use of
statistics, Types of Listening, Hearing, Focus, Voice, Verbal and Non-verbal messages Practice
rounds, How to present a JAM, Public speaking.

Module:5 PEST Analysis & Lean Concepts 7 hours


SLEPT, STEEPLE, 360 Feedback, Product life cycle, Waste reduction, Technology change,
Product support

Module:6 Non Verbal Communication 6 hours


Proximecs :Types of proximecs, Rapport building
Reports and Data Transcoding: Types of reports
Negotiation Skill :Effective negotiation strategies
Conflict Resolution :Types of conflicts

Total Lecture hours: 45 hours

Reference Books
1. Dale Carnegie,(1936) How to Win Friends and Influence People. New York City. Gallery
Books
2. Joyce Aemstrong and Carroll(1992) Integrated Teaching of Reading, Writing, Listening,
Speaking, Viewing and Thinking. Korea. Libraries Unlimited Inc.
3. Theo Theobald(2011) Develop your Presentation Skills. New Delhi. Kogan Page Limited.
Websites:
1. www.chalkstreet.com

2. www.skillsyouneed.com

3. www.mindtools.com

4. www.thebalance.com

M.Sc Intg Biotechnology (5yr.) Page 63


5. www.eguru.ooo

Mode of Evaluation: FAT, Assignments, Projects, Case studies, Roleplays,


3 Assessments with Term End FAT (Computer Based Test)

M.Sc Intg Biotechnology (5yr.) Page 64


Course code Course title L T P J C
STS 2021 Fundamentals of Aptitude 3 0 0 0 1
Pre-requisite None Syllabus version
1
Course Objectives:
• To enhance the logical reasoning skills of the students and improve the problem-solving
abilities
• To strengthen the ability to solve quantitative aptitude problems
• To enrich the verbal ability of the students

Expected Course Outcome:


• Students will be introduced to basic concepts of Quantitative Aptitude, Logical reasoning,
and verbal ability
• Students will be able to read and demonstrate good comprehension of text in areas of the
student’s interest
• Students will be able to demonstrate the ability to resolve problems that occur in their
fields.

Student Learning Outcomes(SLO): 5, 9, 10, 12, 16


5. Having design thinking capability
9. Having problem-solving ability- solving social issues and engineering problems
10. Having a clear understanding of professional and ethical responsibility
11. Having interest in lifelong learning
12. Having adaptive thinking and adaptability
16. Having a good working knowledge of communicating in English

Module:1 Lessons on excellence 2 hours


Skill introspection, Skill acquisition, consistent practice

Module:2 Logical Reasoning 16 hours


Thinking Skill
• Problem Solving
• Critical Thinking
• Lateral Thinking
Taught through thought-provoking word and rebus puzzles, and word-link builder questions

Coding & decoding, Series, Analogy, Odd man out and Visual reasoning
• Coding and Decoding
• Series
• Analogy
• Odd Man Out
• Visual Reasoning

Sudoku puzzles

M.Sc Intg Biotechnology (5yr.) Page 65


Solving introductory to moderate level sudoku puzzles to boost logical thinking and comfort with
numbers

Attention to detail
Picture and word driven Qs to develop attention to detail as a skill

Module:3 Quantitative Aptitude 14 hours


Speed Maths
• Addition and Subtraction of bigger numbers
• Square and square roots
• Cubes and cube roots
• Vedic maths techniques
• Multiplication Shortcuts
• Multiplication of 3 and higher digit numbers
• Simplifications
• Comparing fractions
• Shortcuts to find HCF and LCM
• Divisibility tests shortcuts

Algebra and functions


Module:4 Recruitment Essentials 5 hours

Looking at an engineering career through the prism of an effective resume


• Importance of a resume - the footprint of a person's career achievements
• How a resume looks like?
• An effective resume vs. a poor resume: what skills you must build starting today and how?
Impression Management
Getting it right for the interview:
• Grooming, dressing
• Body Language and other non-verbal signs
• Displaying the right behaviour
Module:5 Verbal Ability 8 hours

Essential grammar for placements:


• Nouns and Pronouns
• Verbs
• Subject-Verb Agreement
• Pronoun-Antecedent Agreement
• Punctuations
Verbal Reasoning
Total Lecture hours: 45 hours

Mode of Evaluation: FAT, Assignments, 3 Assessments with Term End FAT (Computer Based
Test)
Text Book(s):

M.Sc Intg Biotechnology (5yr.) Page 66


1. FACE, Aptipedia Aptitude Encyclopedia, 2016, 1st Edition, Wiley Publications, Delhi.
2. ETHNUS, Aptimithra, 2013, 1st Edition, McGraw-Hill Education Pvt.Ltd.
3. SMART, PlaceMentor, 2018, 1st Edition, Oxford University Press.
4. R S Aggarwal, Quantitative Aptitude For Competitive Examinations, 2017, 3rd Edition, S.
Chand Publishing, Delhi.
Reference Book(s):
Arun Sharma, Quantitative Aptitude, 2016, 7th Edition, McGraw Hill Education Pvt. Ltd.

M.Sc Intg Biotechnology (5yr.) Page 67


Course code Course title L T P J C
STS 2022 Arithmetic problem solving 3 0 0 0 1
Pre-requisite None Syllabus version
1
Course Objectives:
• To enhance the logical reasoning skills of the students and improve the problem-solving
abilities
• To strengthen the ability to solve quantitative aptitude problems
• To enrich the verbal ability of the students for academic purpose

Expected course outcome:


• Students will be able to show more confidence in solving problems of Quantitative
Aptitude
• Students will be able to show more confidence in solving problems of Logical
Reasoning
• Students will be able to show more confidence in understanding the questions of Verbal
Ability

Student Learning Outcomes(SLO): 5, 9 and 16


5. Having design thinking capability
9. Having problem-solving ability- solving social issues and engineering problems
16. Having a good working knowledge of communicating in English

Module:1 Logical Reasoning 11 hours


Word group categorization questions
Puzzle type class involving students grouping words into right group orders of logical sense
Cryptarithmetic
Data arrangements and Blood relations
• Linear Arrangement
• Circular Arrangement
• Multi-dimensional Arrangement
• Blood Relations

Module:2 Quantitative Aptitude 18 hours


Ratio and Proportion
• Ratio
• Proportion
• Variation
• Simple equations
• Problems on Ages
• Mixtures and alligations
Percentages, Simple and Compound Interest
• Percentages as Fractions and Decimals
• Percentage Increase / Decrease
• Simple Interest
• Compound Interest
• Relation Between Simple and Compound Interest

M.Sc Intg Biotechnology (5yr.) Page 68


Number System
• Number system
• Power cycle
• Remainder cycle
• Factors, Multiples
• HCF and LCM

Module:3 Verbal Ability 16 hours


Essential grammar for placements
• Prepositions
• Adjectives and Adverbs
• Tenses
• Forms and Speech and Voice
• Idioms and Phrasal Verbs
• Collocations, Gerund, and Infinitives
Reading Comprehension for placements
• Types of questions
• Comprehension strategies
• Practice exercises
Articles, Prepositions, and Interrogatives
• Definite and Indefinite Articles
• Omission of Articles
• Prepositions
• Compound Prepositions and Prepositional Phrases
• Interrogatives
Vocabulary for placements
• Exposure to solving questions of
• Synonyms
• Antonyms
• Analogy
• Confusing words
• Spelling correctness

Total Lecture hours: 45 hours

Mode of Evaluation: FAT, Assignments, 3 Assessments with Term End FAT (Computer Based Test)
Text Book(s):
5. FACE, Aptipedia Aptitude Encyclopedia, 2016, 1st Edition, Wiley Publications, Delhi.
6. ETHNUS, Aptimithra, 2013, 1st Edition, McGraw-Hill Education Pvt.Ltd.
7. SMART, PlaceMentor, 2018, 1st Edition, Oxford University Press.
8. R S Aggarwal, Quantitative Aptitude For Competitive Examinations, 2017, 3rd Edition, S.
Chand Publishing, Delhi.

Reference Book(s):
Arun Sharma, Quantitative Aptitude, 2016, 7th Edition, McGraw Hill Education Pvt. Ltd.

M.Sc Intg Biotechnology (5yr.) Page 69


Course code Course title L T P J C
STS 3021 Getting started to skill enhancement 3 0 0 0 1
Pre-requisite None Syllabus version
1
Course Objectives:
• To develop the students’ logical thinking skills and apply them in the real-life scenarios
• To learn the strategies of solving quantitative ability problems
• To enrich the verbal ability of the students

Expected Course Outcome:


• Students will be able to demonstrate critical thinking skills, such as problem-solving
related to their subject matters
• Students will be able to demonstrate competency in verbal, quantitative and reasoning
aptitude
• Students will be able to perform good written communication skills

Student Learning Outcomes(SLO): 5, 9,16


5. Having design thinking capability
9. Having problem-solving ability- solving social issues and engineering problems
16. Having a good working knowledge of communicating in English

Module:1 Logical Reasoning 11 hours


Clocks, calendars, Direction sense and Cubes
• Clocks
• Calendars
• Direction Sense
• Cubes
Data interpretation and Data sufficiency
• Data Interpretation – Tables
• Data Interpretation - Pie Chart
• Data Interpretation - Bar Graph
• Data Sufficiency

Module:2 Quantitative Aptitude 18 hours


Time and work
• Work with different efficiencies
• Pipes and cisterns
• Work equivalence
• Division of wages
Time, Speed and Distance
• Basics of time, speed and distance
• Relative speed
• Problems based on trains
• Problems based on boats and streams
• Problems based on races
Profit and loss, Partnerships and averages

M.Sc Intg Biotechnology (5yr.) Page 70


• Basic terminologies in profit and loss
• Partnership
• Averages
• Weighted average

Module:3 Verbal Ability 13 hours


Sentence Correction
• Subject-Verb Agreement
• Modifiers
• Parallelism
• Pronoun-Antecedent Agreement
• Verb Time Sequences
• Comparisons
• Prepositions
• Determiners
Sentence Completion and Para-jumbles
• Pro-active thinking
• Reactive thinking (signpost words, root words, prefix suffix, sentence structure clues)
• Fixed jumbles
• Anchored jumbles

Module:4 Writing skills for placements 3 hours


Essay writing
• Idea generation for topics
• Best practices
• Practice and feedback

Total Lecture hours: 45 hours

Mode of Evaluation: FAT, Assignments, 3 Assessments with Term End FAT (Computer
Based Test)
Text Book(s):
9. FACE, Aptipedia Aptitude Encyclopedia, 2016, 1st Edition, Wiley Publications, Delhi.
10. ETHNUS, Aptimithra, 2013, 1st Edition, McGraw-Hill Education Pvt.Ltd.
11. SMART, PlaceMentor, 2018, 1st Edition, Oxford University Press.
12. R S Aggarwal, Quantitative Aptitude For Competitive Examinations, 2017, 3rd Edition,
S. Chand Publishing, Delhi.
Reference Book(s):
Arun Sharma, Quantitative Aptitude, 2016, 7th Edition, McGraw Hill Education Pvt. Ltd.

M.Sc Intg Biotechnology (5yr.) Page 71


Course code Course title L T P J C
STS 3022 Enhancing problem solving skills 3 0 0 0 1
Pre-requisite None Syllabus version
1
Course Objectives:
• To develop the students’ logical thinking skills and apply them in the real-life scenarios
• To learn the strategies of solving quantitative ability problems
• To enrich the verbal ability of the students
• To strengthen the basic programming skills for placements

Expected Course Outcome:
• The students will be able to interact confidently and use decision-making models
effectively
• The students will be able to deliver impactful presentations
• The students will be able to be proficient in solving quantitative aptitude and verbal
ability questions effortlessly

Student Learning Outcomes(SLO): 5, 7, 9, 12, 16


5. Having design thinking capability
7. Having computational thinking (Ability to translate vast data into abstract concepts and to
understand database reasoning)
9. Having problem-solving ability- solving social issues and engineering problems
12. Having adaptive thinking and adaptability
16. Having a good working knowledge of communicating in English

Module:1 Logical Reasoning 5 hours


Logical connectives, Syllogism and Venn diagrams
• Logical Connectives
• Syllogisms
• Venn Diagrams – Interpretation
Venn Diagrams - Solving

Module:2 Quantitative Aptitude 11 hours


Logarithms, Progressions, Geometry and Quadratic equations
• Logarithm
• Arithmetic Progression
• Geometric Progression
• Geometry
• Mensuration
• Coded inequalities
• Quadratic Equations
Permutation, Combination and Probability
• Fundamental Counting Principle
• Permutation and Combination
• Computation of Permutation
• Circular Permutations

M.Sc Intg Biotechnology (5yr.) Page 72


• Computation of Combination
Probability

Module:3 Verbal Ability 4 hours


Critical Reasoning
• Argument – Identifying the Different Parts (Premise, assumption, conclusion)
• Strengthening statement
• Weakening statement
• Mimic the pattern

Module:4 Recruitment Essentials 7 hours


Cracking interviews - demonstration through a few mocks
Sample mock interviews to demonstrate how to crack the:
• HR interview
• MR interview
• Technical interview
Cracking other kinds of interviews
• Skype/ Telephonic interviews
• Panel interviews
• Stress interviews
Resume building – workshop
A workshop to make students write an accurate resume

Module:5 Problem-solving and Algorithmic 18 hours


skills
• Logical methods to solve problem statements in Programming
• Basic algorithms introduced

Total Lecture hours: 45 hours

Mode of Evaluation: FAT, Assignments, Mock interviews, 3 Assessments with Term End FAT
(Computer Based Test)
Text Book(s):
13. FACE, Aptipedia Aptitude Encyclopedia, 2016, 1st Edition, Wiley Publications, Delhi.
14. ETHNUS, Aptimithra, 2013, 1st Edition, McGraw-Hill Education Pvt.Ltd.
15. SMART, PlaceMentor, 2018, 1st Edition, Oxford University Press.
16. R S Aggarwal, Quantitative Aptitude For Competitive Examinations, 2017, 3rd Edition,
S. Chand Publishing, Delhi.

Reference Book(s):
Arun Sharma, Quantitative Aptitude, 2016, 7th Edition, McGraw Hill Education Pvt. Ltd.

M.Sc Intg Biotechnology (5yr.) Page 73


Course code Course title L T P J C
STS 4022 Enhancing programming ability 3 0 0 0 1
Pre-requisite None Syllabus version
1
Course Objectives:
• Ability to translate vast data into abstract concepts and to understand JAVA concepts
• To have a clear understanding of subject-related concepts
• To develop computational ability in Java programming language

Expected Course Outcome:


• Clear Knowledge about problem-solving skills in JAVA concepts
• Students will be able to write codes in Java

Student Learning Outcomes(SLO): 7, 18
7. Having computational thinking (Ability to translate vast data into abstract concepts and to
understand database reasoning)
18. Having critical thinking and innovative skills

Module:1 Collections 12 hours


ArrayList, LinkedList, List Interface, HashSet, Map Interface, HashMap, Set
Programming questions based on collections
Real-world problems based on data structure

Module:2 Threads, Exceptions, LinkedList, Arrays 6 hours


Need of threads
Creating threads
Wait
Sleep
Thread execution

Need for exception handling


try, catch, throw, throws
Creating own exception (Java, Python)
Handling own exceptions

Solving programming questions based on linked list and arrays

Module:3 Stack and Queue, Trees 7 hours


Solving programming questions based on stacks and queues
How to implement a stack using queue?
How to implement a queue using stack?
Solving programming questions based on trees, binary trees, binary search trees

Module:4 JDBC Connectivity, JDBC Data 10 hours


JDBC Overview

M.Sc Intg Biotechnology (5yr.) Page 74


Database Setup
Install the MySQL Database
Create New Database User in MySQL WorkbenchSelecting data from tables
Inserting Data into the Database
Updating Data in the Database
Deleting Data from the Database
Creating Prepared Statements

Module:5 Networking with Java 10 hours


Working with URLs
Sending HTTP Requests
Processing JSON data using Java
Processing XML data using Java

Total Lecture hours: 45 hours

Reference Books
1. Java The Complete Reference, 2014, 9th Edition by By Herbert Schildt, McGraw-Hill
Education Pvt Ltd
2. Introduction to Programming with Java: A Problem-Solving Approach
by John Dean
Mode of Evaluation: FAT, Assignments, 3 Assessments with Term End FAT (Computer Based
Test)

M.Sc Intg Biotechnology (5yr.) Page 75


Course code Course title L T P J C
STS 4021 Introduction to programming skills 3 0 0 0 1
Pre-requisite None Syllabus version
1
Course Objectives:
• Ability to translate vast data into abstract concepts and to understand JAVA concepts
• To have a clear understanding of subject-related concepts
• To develop computational ability in Java programming language

Expected Course Outcome:


• Clear Knowledge about problem-solving skills in JAVA concepts
• Students will be able to write codes in Java

Student Learning Outcomes(SLO): 7, 18


7. Having computational thinking (Ability to translate vast data into abstract concepts and to
understand database reasoning)
18. Having critical thinking and innovative skills

Module:1 Object and Class, Data types 8 hours


Types of programming
Disadvantages of functional programming
Class & Objects
Attributes
Methods
Objects
Solving MCQs based on Objects and Classes
Solving tricky questions based on encapsulation
Solving frequently asked object-based questions
Data types
Data
Why data type
Variables
Available data types
Numeric – int, float, double
Character – char, string
Solving MCQs based on typecasting, data types
Solving debugging based MCQs

Module:2 Basic I / O, Decision Making, Loop Control 8 hours

Printing
Getting input from the user during run time
Command-line arguments
Solving programming questions based on CLA

M.Sc Intg Biotechnology (5yr.) Page 76


Solving MCQs questions based on CLA

Need for control statement


if..else
if..else if..else
Nested if..else
Switch case
Common mistakes with control statements (like using = instead of == )
Solving frequently asked questions on decision making

Types of looping statements


Entry Controlled
For
While
Exit Controlled
do-while
break and continue
Demo on looping
Common mistakes with looping statements (like using; at the end of the loop)
Solving pattern programming problems, series problems
Solving predict the output questions

Module:3 String, Date, Array 10 hours


String handling, data handling
Solving problems based on arrays like searching, sorting, rearranging, iteration)
Multi-dimensional arrays
Solving pattern problems using 2D arrays
Real-time application based on 2D arrays

Module:4 Inheritance, Aggregation & Associations 12 hours


Need
Is A – Inheritance
Types of inheritance supported
Diagrammatic representation
Demo on inheritance
Has A – Aggregation
Diagrammatic representation
Demo on aggregation
Uses A - Association
Diagrammatic representation
Demo on association
Assignment on relationships
Solving MCQs based on relationships between classes

Module:5 Modifiers, Interface & Abstract classes (Java 7 hours


specific), Packages

M.Sc Intg Biotechnology (5yr.) Page 77


Types of access specifiers
Demo on access specifiers
Assignment on access modifiers
Instance Members
Solving MCQs based on modifiers
Abstract Classes
Need
Abstract Classes
Abstract Methods
Interfaces
Assignment on abstract classes and interface
Need for packages
Access specifiers & packages
Import classes from other packages

Total Lecture hours: 45 hours

Reference Books
1. Java The Complete Reference, 2014, 9th Edition by By Herbert Schildt, McGraw-Hill
Education Pvt Ltd
2. Introduction to Programming with Java: A Problem-Solving Approach
by John Dean
Mode of Evaluation: FAT, Assignments, 3 Assessments with Term End FAT (Computer Based
Test)

M.Sc Intg Biotechnology (5yr.) Page 78


PROGRAMME CORES

M.Sc Intg Biotechnology (5yr.) Page 79


Course code Course title L T P J C
BIY1001 Biochemistry 3 0 2 0 4
Pre-requisite None Syllabus version
v. 1.1
Course Objectives:
1. Demonstrate the structure and function of biomolecules
2. Outline different pathways involved in cellular metabolism
3. Relate inhibitors and activators of key metabolic reactions

Expected Course Outcome:


1. Compare and contrast the structural basis of biological macromolecules.
2. Analyze the chemical bonds of importance in carbohydrates, lipids, proteins, and nucleic acids.
3. Illustrate the catabolism and anabolism of carbohydrates
4. Summarize the energetics and regulation of metabolic pathways
5. Interpret experiments and techniques based on the significance of biomolecules.

Student Learning Outcomes (SLO): 2, 11,18


2.Having a clear understanding of the subject related concepts and contemporary issues
11. Having interest in lifelong learning
18.Having critical thinking and innovative skills

Module:1 Chemistry of Life 5 hours


Elements of life, chemical bonding, covalent, ionic, and weak chemical bonds. Water and buffers.
Properties of water-solubility, ionization, and water as a reactant.

Module:2 Carbon the backbone of life 5 hours


Organic molecules and the origin of life. Properties of living system-review on cellular, chemical,
physical, the genetic, and evolutionary background to Biochemistry.

Module:3 Fuel and building material 7 hours


Proteins, Carbohydrates, and lipids. Classification, structure, and function. Energy by
oxidizing organic molecules: Catabolic pathway-glycolysis, TCA cycle

Module:4 Nucleotides structure and Biosynthesis of ATP 7 hours


Different nucleotide structures. ATP as cellular currency. Substrate level, oxidative, and
photophosphorylation. Amino acids from glycolysis, TCA intermediates by transamination.
Gluconeogenesis, Pentose phosphate pathway. Anaerobic respiration. ATP as important
currency in cells.

Module:5 Amino Acids and their polymer proteins 6 hours


Classification, structure, and biological importance of amino acids. Zwitter ion nature. Peptide
bond formation-polypeptide chain

Module:6 Proteins 6 hours


Structure, Classification and biological function, protein structure and function relationships
concerning fibrous proteins such as keratin, collagen, silk fibroin and globular proteins such as
hemoglobin and myoglobin, insulin, Protein denaturation

M.Sc Intg Biotechnology (5yr.) Page 80


Module:7 Lipids a diverse group of hydrophobic molecules. Fatty acids. 7 hours
Lipids
Classification, structure, properties, function, and metabolism of fatty acids. Classification,
structure, properties, and biological function of Simple lipids – triacylglycerol and waxes.
Compound lipids- phospholipids and glycolipids. Cholesterol- structure, properties, and
importance. Eicosanoids

Module:8 Contemporary issues: Lectures by experts 2 hours


Total Lecture hours: 45 hours

Text Book(s)
1. Nelson DL and Cox MM (2012) Lehninger’s Principles of Biochemistry, Sixth Edition, WH
Freeman, New York.

2. Rodwell VW, Bender D, Botham KM, Kennelly PJ (2015) Harpers Illustrated


Biochemistry, 30th Edition, McGraw-Hill Companies, Inc. USA
Reference Books
1. Mathews CK, van Holde KE, Appling DR, Anthony-Cahill SJ (2012) Biochemistry, 4th
Edition. Prentice-Hall
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
List of Challenging Experiments (Indicative)
1. Laboratory practices in biochemistry and reagent preparation -% solution, 2 hours
molar solution, and saturated solution.
2. Preparation of buffers and pH change 2 hours
3. Carbohydrates from biological sources fruits, sugarcane, corn, and milk. 4 hours
4. Quantitative analysis of reducing sugars. 4 hours
5. Use of Formal titration method to estimate glycine amino acid. 4 hours
6. Colorimetric analysis of amino acids arginine, cysteine, histidine, 4 hours
tryptophan, and tyrosine.
7. Acid-Base titration of amino acids 2 hours
8. Spectroscopic estimation of nucleic acids 2 hours
9. Fatty acids- chromatographic separation 4 hours
10. Revisions 2 hours
Total Laboratory Hours 30 hours
Mode of evaluation:
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 81


Course code Course title L T P J C
BIY1002 Cell Biology 3 0 2 0 4
Pre-requisite None Syllabus version
v. 1.1
Course Objectives:
1. Develop a basic understanding of the unit of life that is cell
2. Relate the organization and function of different cell organelles
3. Extend the knowledge earned from the course

Expected Course Outcome:


1. Recall critical concepts, facts, and theories relevant to biological sciences
2. Correlate the functions of different organelles of the cell
3. Examine contemporary issues in related fields
4. Interpret data presented in pictorial or numerical form
5. Perceive recent developments in the field
6. Able to apply scientific knowledge to address the nature problems.

Student Learning Outcomes (SLO): 2, 9, 18


2.Having a clear understanding of the subject related concepts and contemporary issues
9. Having an interest in lifelong learning
18.Having critical thinking and innovative skills

Module:1 The fundamental unit of life-Cell 5 hours

Cell theory, diversity, and commonalty of cells and evolutionary relations between organisms.
Structure of prokaryotic and eukaryotic cells; plant and animal cells.

Module:2 Cell structure and functions 9 hours

Biomembrane: lipid and protein constituents, cytoskeleton, cell wall, nucleus, mitochondria,
chloroplast, endoplasmic reticulum, Golgi apparatus, peroxisome, vacuole, lysosome, ribosome,
centrosome, and glyoxisome.

Module:3 The life cycle of cells 6 hours

Cell division in prokaryotes and eukaryotes, mitosis and meiosis, and regulation of cell cycle
by mitogens, cyclins, and Cdks. Apoptosis in multicellular organisms.

Module:4 Transport across cell membranes 7 hours

Osmosis, endocytosis, exocytosis, passive diffusion, uniporters, symporters, antiporters,


gated and non-gated ion channels, and ATP pumps.

Module:5 Cell signaling 5 hours


Primary and secondary signaling molecules. Autocrine, paracrine, and endocrine signal. Signal
amplification, each with one example.

M.Sc Intg Biotechnology (5yr.) Page 82


Module:6 Signal transduction pathways 6 hours
Introduction to major signaling pathways. G-protein coupled signal transduction pathway
involving cAMP, cGMP, IP3, DAG, and Ca2+ as second messengers.

Module:7 Cell motility and integration 5 hours


Module content
Role of motor proteins: kinesin, dynein, and myosin. Role of microtubules in the movement of
cilia and flagella. Formation of microfilaments in lamellipodia and filopodia. Muscle contraction.

Module:8 Contemporary issues: Lectures by experts 2 hours

Total Lecture hours: 45 hours

Text Book(s)
1. Lodish H, Berk A Kaiser CA Krieger M, Bretscher A, Ploegh H, Amon A, Martin KC
(2012) Molecular Cell Biology, 7th edition, W.H. Freeman. USA.
Reference Books
1. Lynne B. Jorde, John C. Carey, Michael, J. Bamshad, and Raymond, L. White (2010)
Medical genetics. 4th edition, Mosby. USA.

2. Cooper GM and Hausman RE (2013) The Cell: A Molecular Approach. 6th edition. Sinauer
Associates, Inc. USA.

3. Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, and Walter P (2014)


Molecular Biology of the Cell. 6th edition. Garland Science, USA.
Authors, book title, year of publication, edition number, press, place
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
List of Challenging Experiments (Indicative)
1. Principles and handling of microscopes. 2 hours
2. Studying the diversity of cells using permanent slides. 2 hours
3. Differentiating plant cells from animal cells using a basic, acidic, and a 4 hours
combination stain.
4. Subjecting cells to different pH, concentrations, and analyzing the structural 4 hours
changes occurring due to osmosis.
5. Imaging and visualization of sub-cellular organelles using a fluorescent 4 hours
microscope.
6. Fractionation of nucleus and mitochondria from cauliflower cells and 4 hours
visualization using methyl green pyronin under a bright-field microscope of
400x magnification.
7. Enumerating and finding out whether RBCs/WBCs are in the optimal range 2 hours

M.Sc Intg Biotechnology (5yr.) Page 83


in the sample and analyzing the results.
8. Growing root tips of different plants and comparing the chromosome 2 hours
number by fixing at the metaphase stage.
9. Comparison of various stages of Meiosis I and Meiosis II during 4 hours
microsporogenesis of Rheodiscolor.
10. Revisions 2 hours
Total Laboratory Hours 30 hours
Mode of evaluation: Continuous assessment and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 84


Course code Course title L T P J C
BIY1003 Biodiversity and Conservation Biology 2 0 0 4 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Demonstrate the concepts and values of biodiversity
2. Analyze the ways to protect the habitat
3. Formulate scientific intervention tools for conservation

Expected Course Outcome:


1. Illustrate the values of biodiversity
2. Summarize the genetic diversity and factors causing loss of genetic diversity
3. Demonstrate methods involved in species inventory and its richness.
4. Classify ecosystem types of the world and how to manage biodiversity.
5. Examine the process of evolution and various factors that govern a population.
6. Build possible measures to overcome species extension and loss of ecosystem.

Student Learning Outcomes (SLO): 2, 10


2. Having a clear understanding of the subject related concepts and contemporary issues
10. Having interest in lifelong learning
Module:1 Introduction to Biodiversity 4 hours
Biodiversity Scope and its constraints, causes for diversity, quantifying biodiversity, Maintenance
of ecological biodiversity, Uses and Values of Biodiversity.

Module:2 Genetic diversity 4 hours


Importance of genetic diversity. Nature and origin of genetic variation, measurement of genetic
variation, loss of genetic diversity, factors causing loss of genetic diversity, Genetic drift.

Module:3 Species diversity 4 hours


Species inventory, problems in inventorying species, monitoring, the total number of species
of microbes, plants, and animals. Origin in species diversity, species richness, species
abundance, toxic diversity, future of species diversity studies

Module:4 Ecosystem diversity 4 hours


Classification of the ecosystem, measuring ecosystem diversity, major ecosystem types of the
world, agro ecosystem-, diversity of domesticated species-land races, advanced cultivars, wild
relatives of cultivated plants, wild plants, urban and peri-urban diversity, loss of ecosystem
diversity

Module:5 Evolutionary Genetics in a natural 4 hours


population
Factors controlling the evolution of population, selection, and adaptation, Migration and gene
flow, low genetic diversity in threatened species, mutation and selection balance

Module:6 Loss of Biodiversity 4 hours


Factors causing loss of biodiversity (Habitat degradation & loss, Overexploitation, Biological
invasions, Climate change) Loss of agro, ecosystem, and species. The fate of endangered species

M.Sc Intg Biotechnology (5yr.) Page 85


Module:7 Conservation Biodiversity 4 hours
Why conserve biodiversity? Ecological economics & nature conservation, Conservation of
genetic and methodologies, species and ecosystem

Module:8 Contemporary issues: Lectures by industrial 2 hours


experts

Total Lecture hours: 30 hours

Text Book(s)
1. Krishnamurthy KV (2017) An advanced textbook on Biodiversity, Principle and Practice,
Oxford and IBH publishing Co. Pvt.
Frankham (2010), Jonathan D. Ballou, David A. Briscoe. Introduction to Conservation
2.
Genetics, 2nd edition, Cambridge.
3.
Richard BP (2016) Principles of Conservation Biology, 4th edition, Sinauer Associates, Inc.
Reference Books
1. Reddy GV, Karanth KU, Samba Kumar N, Krishnaswamy J and Karanth KK (2016)
Recovering biodiversity in Indian forests, Springer
Talent JA (2012) Earth and Life, Springer

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar


Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 86


Course code Course title L T P J C
BIY1004 Genetics 2 0 0 4 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Recall basic concepts in molecular genetics
2. Dissect classical experiments to understand gene transfer
3. Choose the correct experimental model organism

Expected Course Outcome:


1. Explain genetic inheritance through historical experiments
2. Discuss chromosome organization and sex determination
3. Relate genetic makeup of different organisms
4. Distinguish factors that alter allele frequencies under exemptions
5. Relationship between mutation and evolution
6. Demonstrate the metabolic pathway and to utilize it for improvement of the human race.

Student Learning Outcomes (SLO): 2, 10, 11


2. Having a clear understanding of the subject related concepts and contemporary issues
10. Having a clear understanding of professional and ethical responsibility
11. Having an interest in lifelong learning
Module:1 Principles of Inheritance 4 hours

Mendelian laws, Post Mendelian inheritance – Codominance; Incomplete dominance; Epistasis;


Lethal Genes; Multiple alleles, Linkage, Crossing over and chromosomal mapping.
Module:2 Chromosomes structure and sex 4 hours
determination

Prokaryotic and eukaryotic chromosome structure, variations in structure and number. Giant
chromosomes - sex determination in plants and animals, dosage compensation. Sex chromosomes
and sex-linked inheritance, Extrachromosomal inheritance.
Module:3 Model systems to study genetics 4 hours

Bacteriophage, E. coli, Neurospora crassa, yeast, Arabidopsis, maize, Drosophila, C. elegans,


Zebra fish, Homo sapiens
Module:4 Forces that change allele Frequencies 4 hours

Hardy – Weinberg law and its applications, Factors affecting allele frequencies, selection,
mutation, migration and genetic drift, inbreeding and outbreeding, Quantitative Genetics, C-
value.
Module:5 Mutation 4 hours

Spontaneous and Induced mutations, and its role in evolution, Radiation injury and DNA repair
mechanisms, Relationship between Mutations and Phenotypes, genetic toxicity testing.
Module:6 Biochemical Genetics 4 hours

M.Sc Intg Biotechnology (5yr.) Page 87


Altered pathway of phenylalanine and tyrosine metabolism in humans, Eye pigmentation
pathways of Drosophila melanogaster
Module:7 Eugenics and euthenics 4 hours

Studies of twins, genetic disorders, Prenatal diagnosis with special emphasize on


amniocentesis and chorionic villus sampling, artificial insemination, genetic counseling
Module:8 Contemporary issues: Lectures by experts 2 hours

Total Lecture hours: 30 hours

Text Book(s)
1. Snustad DP, Simmons MJ (2011) Principles of Genetics (6th Edition) John Wiley
publications
Bhaskar (2012) Textbook of genetics, Campus book international.
Reference Books
1. T A Brown (2011) Introduction to Genetics: A Molecular Approach Garland Science.
‘J’ component: Experiments
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 88


Course code Course title L T P J C
BIY1005 General Microbiology 2 0 2 4 4
Pre-requisite None Syllabus version
v. 1.1
Course Objectives:
1. Recall necessary information related to all microorganisms in general
2. Elaborate on laboratory safety and specialized microbiological laboratory skills
3. Apply the knowledge gained towards research, diagnostic, and therapeutic purposes

Expected Course Outcome:


1. Demonstrates the structure, diversity, classification, and application of microorganisms
2. Compare the ubiquitous nature of microorganisms and their ecological niches
3. Outline the theoretical basis of the tools, technologies, and methods common to microbiology
4. Illustrate problem-solving skills and other concepts in microbiology
5. Relate the role of microbes in the fields of medicine and biotechnology
6. Utilize various research or internship activities in the field of microbiology

Student Learning Outcomes (SLO): 2, 10, 11


2. Having a clear understanding of the subject related concepts and of contemporary issues
10. Having a clear understanding of professional and ethical responsibility
11. Having an interest in lifelong learning
Module:1 Introduction 4 hours

Scope and branches of Microbiology, The Historical Foundations of Microbiology, General


Characteristics of Microorganisms, Taxonomy: Naming, Classifying, and Identifying
Microorganisms. Importance of Bergey’s classification
Module:2 Methods of studying Microorganism 4 hours

Microscopes (light microscope, phase contrast microscope, dark ground microscope, fluorescent
microscope, and electron microscope). Staining methods and identification of Bacteria. Different
culture methods, techniques of pure culture and preservation of cultures
Module:3 Microbial Nutrition, transport and 4 hours
Growth

Classification based on the nutritional requirements. Microbial growth, techniques of


Measurement of growth, and enumeration. Factors affecting growth, growth curve
Module:4 Microbial Metabolism 4 hours

Respiratory metabolism of microbes – aerobic and anaerobic paths of energy production.


Fermentative pathways – organisms, substrates, intermediates, and end-products. Excretory
metabolism.
Module:5 Antimicrobial therapy 4 hours

Principles of antimicrobial therapy, Antimicrobial agents, tests for antimicrobial agents.


Antimicrobial drug resistance and acquisitions
Module:6 Control of Microbial Growth 4 hours

M.Sc Intg Biotechnology (5yr.) Page 89


Controlling microorganism growth by Physical and Chemical agents.
Module:7 Microbes in infectious disease 4 hours

Normal Flora, Infection, and Methods of Transmission, Microbial Pathogenicity. Lab


diagnosis (Sample collection, processing, and reporting)
Module:8 Contemporary issues: Industrial expert lecture 2 hours

Total Lecture hours: 30 hours

Text Book(s)
1. Tortora GJ, Funke BR, Case CL (2015) Microbiology: An Introduction / 12th Edition

2. Willey JM, Sherwood LM, and Woolverton CJ (2016) Prescott's Microbiology 10thedition
McGraw Hill

3. Ananthanarayan R and Jayarama Panicker CK (2010) Text Book of Microbiology 8th


edition by Orient Longman Ltd.
Reference Books
1. Jorgensen JH and Pfaller MA (2015) Manual of Clinical Microbiology11th Edition ASM
Science

2. Tille PM (2016) Bailey & Scott's Diagnostic Microbiology, 14thEdition Mosby Elsevier
Project: ‘J’ component
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
List of Challenging Experiments (Indicative)
1. Different methods to sterilization 2 hours
2. Staining: Simple staining, differential staining, Capsule staining, Spore 4 hours
staining, acid-fast staining, and Lacto phenol cotton blue (LPCB).
3. Microbial specific media preparation: Solid and liquid media 2 hours
4. Techniques to culture microbes on solid media: Pour plate, Spread plate, 6 hours
Streak plate, and Dilution techniques.
5. Biochemical test for identification of bacteria: Catalase test, Oxidase test, 6 hours
Urease test, IMViC test, LAO test, Gelatin liquefaction test, Starch
degradation test, Carbohydrate fermentation.
6. Isolation of antibiotics producing microorganisms from soil 4 hours
7. Kirby-Bauer method of antibiotic susceptibility test 4 hours
8. Growth curve 2 hours
Total Laboratory Hours 30 hours
Mode of evaluation: CAT / Assignments / FAT / Quiz
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 90


Course code Course title L T P J C
BIY1006 Human Anatomy and Physiology 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Define all the anatomical and medical terminologies in the field
2. Relate the functions of different organ systems in the human body
3. Examine the physiological basis for human diseases and identify treatment

Expected Course Outcome:


1. Infer the various medical terminologies and discuss with health professionals
2. Outline the functions of different blood cell types
3. Evaluate the functions of the digestive and excretory systems
4. Compare the functions of the male and female reproductive systems
5. Discuss the mechanics of respiratory and cardiovascular systems
6. Explain the basics of the brain and the nervous system

Student Learning Outcomes (SLO): 2, 11


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having interest in lifelong learning
Module:1 Introduction 5 hours

Introduction to human anatomy and physiology. Anatomical and medical terminology. Osteology,
joints, and muscle cells. Body fluids and homeostasis
Module:2 Blood and its components 6 hours

Composition and functions of blood. Plasma proteins. Red blood cells, White blood cells, and
platelets. Blood groups and blood clotting.
Module:3 Digestive and excretory system 7 hours

Organs of the digestive system. Salivary secretion, gastric secretion, and pancreatic secretion.
Bile secretion and functions of bile. Absorption of food substances. Movements of the
digestive tract. Structure and function of excretory organs such as kidney, skin, and liver.
Module:4 Endocrine and reproductive systems 7 hours

Types of hormones and hormone receptors. Adenohypophysis and neurohypophysis. The


thyroid gland, parathyroid gland, and islets of Langerhans. Adrenal cortex and medulla. Male
reproductive organs and functions of androgens. Female reproductive organs and functions of
estrogen and progesterone.
Module:5 Respiratory system 6 hours

Organs of the respiratory system. Structure of the lungs. Mechanics of respiration. Lung volumes
and capacities. Transport of oxygen in the blood. Transport of carbon dioxide in the blood.
Regulation of respiration
Module:6 Cardiovascular system 6 hours

M.Sc Intg Biotechnology (5yr.) Page 91


Structure of heart and blood vessels. Conducting system of the heart and electrocardiogram.
Factors are maintaining arterial blood pressure. Regulation of arterial blood pressure.
Module:7 Nervous system 6 hours

Structure of neuron. Resting membrane potential and action potential. Brain and spinal cord,
reflex action. Functions of the cerebral cortex, Basal ganglia, Thalamus, hypothalamus, and
cerebellum.
Module:8 Contemporary issues: Lectures form 2 hours
industry/Hospital

Total Lecture hours: 45 hours

Text Book(s)
1. Ross JS, Wilson KJ, and Waugh A (2014) Ross and Wilson Anatomy and Physiology in
Health and Illness: Allison Grant: Books, 11th Edition, IRL press (Oxford University
Press, USA)
Reference Books
1. Richard S. Snell (2011) Clinical Anatomy 9th edition Lippincott Williams

2. Keele CA, Neil E, Joels N (2015) Samson Wright’s Applied Physiology, 13th edn Oxford
University Press, Hong Kong

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar


Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 92


Course code Course title L T P J C
BIY1007 Molecular Biology 3 0 2 0 4
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Illustrate the molecular concepts of life.
2. Explain the organization and functions of DNA, RNA, and proteins
3. Demonstrate the regulation of various biological processes

Expected Course Outcome:


1. Recall key concepts, facts, and theories relevant to biological macromolecules
2. Outline the contemporary issues in related fields
3. Correlate the different steps in the translation of genetic information.
4. Apply the knowledge gained to address various problems
5. Perceive recent developments in the field
6. Interpret biological data presented in pictorial or numerical forms

Student Learning Outcomes (SLO): 2, 11, 18


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having interest in lifelong learning
18. Having critical thinking and innovative skills
Module:1 Genome organization 6 hours

Molecular Biology – An Overview – Structure of DNA - denaturation, and renaturation of DNA -


Genome organization in prokaryotes and eukaryotes - DNA packaging in nucleosome - chromatin
and chromosome.
Module:2 Genetic Material / Replication enzymes 6 hours

DNA as genetic material. Central dogma concept. Semi-conservative replication. Enzymes in


DNA replication -prokaryotic and eukaryotic DNA polymerases, fidelity, and processivity of
polymerases. Genetic code: commaless, non-ambiguous, degenerate, triplet code and its feature,
wobble hypothesis, universality of genetic code.
Module:3 DNA Replication 6 hours

Replication in prokaryotes-origin of replication, replication fork, leading and lagging strand


replication. Okazaki fragments. Elongation, termination of replication. Eukaryotic DNA
replication. Inhibitors of replication.
Module:4 RNA and Transcription 6 hours

RNA structure, types of RNA, RNA polymerases, transcription in prokaryotes-initiation and


elongation, promoters, termination of transcription. Eukaryotic promoters.
Module:5 Post Transcriptional process 6 hours

Distinction between pro and eukaryotic transcription. Post¬transcriptional processing and


modifications of RNA -mRNA, t-RNA, and r-RNA, reverse transcription.
Module:6 Translation 6 hours

M.Sc Intg Biotechnology (5yr.) Page 93


Translation initiation, elongation, and termination in prokaryotes. Translation in eukaryotes. Post-
translational modifications. Antibiotics-inhibitors of protein synthesis.
Module:7 Post Translational Modification 7 hours
Protein structure-folding of the polypeptide chain, alpha-helix and secondary beta structures.
Principles of regulation - Cis-acting sites, and transacting molecules - feedback inhibition and
allosteric regulation - The lac operon - trp operon, regulation of mRNA stability - Eukaryotic
regulation.

Module:8 Contemporary issues: Lecture by industrial 2 hours


experts

Total Lecture hours: 45 hours

Text Book(s)
1. Alberts B, Johnson A, Lewis J, Morgan D, Raff M, Roberts K, and Walter P (2014)
Molecular Biology of the Cell. 6th edition. Garland Science, USA.

Bender D, Botham KM, Kennelly PJ (2015) Harper’s Illustrated Biochemistry, 29th


2. Edition, McGraw-Hill Companies, Inc. The USA.
Reference Books
1. Mathews C K, van Holde K E, Appling D R, Anthony-Cahill S J (2012) Biochemistry, 4th
Edition. Prentice-Hall Bench Marked with 1.

2. Cooper G M and Hausman R E (2013) The Cell: A Molecular Approach. 6th edition. Sinauer
Associates, Inc. The USA.

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar


List of Challenging Experiments (Indicative)
1. Learning Molarity, normality, and molality by preparing various buffers 4 hrs
used in the molecular biology lab
2. Understanding differences in the absorption of light by DNA, RNA, and 6 hrs
protein by using a spectrophotometer
3. Measuring absorption of DNA at different temperatures and understanding 2 hrs
the theory behind the melting curve
4. Learning how to separate DNA and RNA molecules by using agarose gel 4 hrs
electrophoresis
5. Understanding the role played by different reagents in isolating genomic 2 hrs
DNA from plants
6. Isolation and classification of RNA by separating on agarose gel 4 hrs
electrophoresis

M.Sc Intg Biotechnology (5yr.) Page 94


7. Learning Beer Lambert’s law by performing protein estimation by Lowry’s 2 hrs
method
8. Separation of given proteins based on molecular weight by SDS-PAGE 4 hrs
9. Western blotting (Demonstration) 2 hrs
Total Laboratory Hours 30 hours
Mode of evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 95


L T P J C
Course code Course title
BIY1008 Research Methodology 3 0 2 0 4
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Identify the essential components of research
2. Design the various strategies involved in experimental research
3. Recommend the importance of statistical analysis in research

Expected Course Outcome:


1. List the various modalities that are to be followed while conducting research
2. Compare the various methodologies that are available in higher education
3. Develop an understanding of ethical as well as safety aspects for good quality research
4. Analyze systematic methods for data collection, data processing, and data analysis
5. Evaluate statistical methods to assess the outcome of the research
6. Build various steps involved in the conduct of proper research

Student Learning Outcomes (SLO): 2, 3


2. Having a clear understanding of the subject related concepts and contemporary issues
3. Having an ability to be socially intelligent with good SIQ (Social Intelligence Quotient) and EQ
(Emotional Quotient)

Module:1 What is Research Methodology 6 hours


Module content
Research Methodology: Research – Qualities of Researcher – Components of Research Problem
– Various Steps In Scientific Research – Types of Research, Research approaches, purpose, and
significance Hypotheses poses. Research Design – Survey Research & Case Study Research.
Module:2 Research Methods Vs. Methodology 5 hours
Module content
Library research, Field research, and laboratory research
Module:3 Testing of Hypothesis and Lab design 6 hours
Module content
Formulation of hypothesis, the concept of Null hypothesis. Testing the significance of the
Null hypothesis. Lad design- Basic, containment.
Module:4 Biosafety Guidelines 6 hours
Module content
Microbiological risk assessment, Biosafety levels, laboratory animal facilities, guidelines for
lab facility commissioning, certification, biosecurity, safety cabinets, Good microbial
practices, biosafety and recombinant DNA technology, chemical, fire, and electrical safety,
safety organization and training, safety for support staff, safety checklist
Module:5 Data Collection 6 hours
Module content
Sources of Data – Primary Data – Secondary Data - Procedure Questionnaire – Sampling
Methods – Merits and Demerits – Experiments – Observation Method – Sampling Errors - Type-I
Error & Type-II Error.
Module:6 Statistical Analysis 6 hours

M.Sc Intg Biotechnology (5yr.) Page 96


Module content
Introduction To Statistics – Probability Theories – Conditional Probability, Poisson Distribution,
Binomial Distribution and Properties of Normal Distributions – Hypothesis Tests – One-Sample
Test – Two-Sample Tests / Chi-Square Test, Association of Attributes - Standard Deviation – Co-
Efficient of Variations
Module:7 Research Reports 6 hours
Module content
Structure and Components of Research Report – Types of Report, Characteristics of Good
Research Report, Pictures and Graphs, writing a field report. Role of computer in research.
Introduction To SPSS.
Module:8 Research Methodology of the present and 4 hours
future: problems and perspectives

Total Lecture hours: 45 hours

Text Book(s)
1. Kothari C.R. (2013) Research Methodology – Methods and Techniques – 3rd edition.
New age international publishers. New Delhi

2. Kothari C.R. and Gaurav Garg (2019) Research Methodology: Methods and Techniques
Reference Books
1. Trochim W, Donnelly JP, Arora K 2015. Research Methods: the essential knowledge base.
Cengage Learning. USA

2. Statistical Methods by SP Gupta (2012)


Blaxter L, Hughes C and Tight M (2010), How to Research – 4th edition. McGraw Hill UK
3.
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
List of Challenging Experiments (Indicative)
1. Using and calibration of instruments generally used in the laboratory 2 hours
2. Understanding the purpose of using different biosafety cabinets 2 hours
3. Methods to dispose of microbial plates 2 hours
4. Methods and place to store different chemicals 2 hours
5. Understanding the differences between qualitative and quantitative research 2 hours
6. Purpose of using animals on research and ethics involved 2 hours
7. Disposal methods for laboratory waste disposal 2 hours
8. Disposal methods for cell culture waste / sharp materials 2 hours
9. Methods to dispose of the sharp waste 2 hours
10. Different sterilization technique 2 hours
11. Laboratory safety from chemical, fire, and electricity 2 hours
12. Animal house rules and regulations 2 hours
13. Importance of labeling and methods of labeling laboratory animals 2 hours
14. Different chemicals used as disinfectants in Microbial spill and containment 2 hours
15. Designing a laboratory ( Microbiology lab / Cell culture / Animal dissection 2 hours
/ Plant culture lab / Biosafety lab III and IV )

M.Sc Intg Biotechnology (5yr.) Page 97


Total Laboratory Hours 30 hours
Mode of evaluation: CAT / Assignments /Quiz / FAT
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 98


Course code Course title L T P J C
BIY1009 Analytical Techniques 3 0 2 0 4
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Demonstrate the principle and applications of various techniques in biotechnology
2. Analyze various samples using appropriate techniques
3. Utilize analytical instruments for biomolecular estimation

Expected Course Outcome:


1. List the various Good Laboratory Practices (GLPS)
2. Recall concepts related to solution preparation
3. Outline the principles of various analytical instruments
4. Summarize the role of instrumentation
5. Infer the applications of various analytical instruments
6. Demonstrate advanced analytical instruments to carry out an estimation
of various biomolecules

Student Learning Outcomes (SLO): 2, 11, 13


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning
13. Having cross-cultural competency exhibited by working in teams
Module:1 GoodLab Practices 7 hours

Analytical Lab – record maintenance. Documentation - Standard Operating Procedures-


Analytical Methods and Validations- Laboratory Notebooks - Specifications and Report Sheets -
Calibration and Maintenance Logs.
Module:2 Biological Solutions 6 hours

Types of the solution- molarity, percent solutions, buffers- Henderson hasselbach equation, types
of buffers. Preparation of buffers, pH meter.
Module:3 Advanced microscopy 6 hours

Principle, construction, and working of Bright-field, SEM, and TEM – image formation,
resolving power and magnification.
Module:4 Chromatography 6 hours

The principle, column, and planar chromatography. Classification based on separation


mechanism. Applications.
Module:5 Electrophoretic Techniques 5 hours

Principle and working of Gel Electrophoresis, Pulse field, Zone, Isoelectric focussing, Capillary,
Gel filtration, and Affinity.
Module:6 Spectrophotometry 6 hours

M.Sc Intg Biotechnology (5yr.) Page 99


Fluorometry, colorimetry, polarimetry, nephelometry, and turbidimetry- principle and
applications. The absorption laws of spectrophotometry. Methods used in single-beam and double
- beam spectrophotometry.
Module:7 Radioisotope Techniques 6 hours

Basics, GM and Scintillation counter, Medical, Agricultural and Industrial application


Module:8 Contemporary issues: Lecture by industry 2 hours
experts

Total Lecture hours: 45 hours

Text Book(s)
1. Rajan Katoch (2011) Analytical Techniques in Biochemistry and Molecular Biology
Springer Science & Business Media
2.
Wilson K and Walker J (2016) Principles and Techniques of Biochemistry and Molecular
Biology 8th Ed. Cambridge University Press.
Reference Books
1. Boyer RF (2012) Biochemistry Laboratory: Modern Theory and Techniques, Prentice-
Hall.

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar


List of Challenging Experiments (Indicative)
1. Maintenance of Lab Notes and Records 1 hour

2. Collection, storing and transport of different types of samples 2 hour


3. Buffer preparation 3 hour
4. pH measurement 1 hour
5. Calorimetry 3 hour
6. Estimation of BSA sodium using UV Spectrophotometer 2 hour
7. Estimation of BSA sodium using VIS Spectrophotometer 2 hour
8. Conductivity Meter 3 hour
9. Estimation of sodium by Flame photometer 3 hour
10. Analysis of samples by HPLC 3 hour
11. Demonstration of IR Spectrophotometer 2 hour
12. Demonstration of SEM 2 hour
13. Demonstration of TEM 2 hour

M.Sc Intg Biotechnology (5yr.) Page 100


Total Laboratory Hours 30 hours
Mode of evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 101


Course code Course title L T P J C
BIY1010 Immunology 3 0 2 0 4
Pre-requisite BIY 1002 Syllabus version
v. 1.1
Course Objectives:
1. Recall the basics of immunology and facilitate the understanding of core immunology
2. Develop skills necessary for the critical analysis of contemporary literature on topics related to
health and diseases.
3. Outline the molecular and cellular basis of the development and function of the immune system
in states of health and disease.

Expected Course Outcome:


1. Describe the role of the immune cells in both maintaining health and contributing to disease.
2. Identifying the cellular and molecular basis of antigen processing and immune responses.
3. Distinguish and define the molecular basis of complex cellular processes involved in immune
disorders.
4. Translate theoretical immunology into clinical decision-making and cancer diagnosis.
5. Effectively interpret underlying mechanisms of disease and therapeutic implications of
vaccines.
6. Build a strong foundation for more advanced courses in immunology.

Student Learning Outcomes (SLO): 2, 11, 18


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having interest in lifelong learning
18. Having critical thinking and innovative skills
Module:1 Introduction 5 hours

Overview of the immune system, innate immunity, acquired immunity, cells, and organs of the
immune system, antigens, structure of antigen, and its different types.
Module:2 Immune cells 6 hours

Biology of T and B lymphocytes, functions of T cells, and B cells. Antibodies, structure, types,
and their functions. TCR structure. Antibody structure and types. Molecular basis of TCR and
antibody diversity.
Module:3 Defense strategies in immune system 6 hours

Complement Pathways, biological consequences and deficiencies. Immune response:humoral


immune response and cell mediated immune response.
Module:4 MHC and immune system 6 hours

Major Histocompatibility Complex, Class-I, II, and III, Antigen processing and presentation.
Transplantation immunology
Module:5 Immune related disorders 6 hours

Immune tolerance, auto-immunity, autoimmune disorders, immunotherapy for autoimmune


disorders, hypersensitivity reactions, types and treatment. AIDS.
Module:6 Cancer and Immunology 6 hours

M.Sc Intg Biotechnology (5yr.) Page 102


Tumor immunology, Immunotherapy to tumors. Role of immune cells in preventing cancer and
metastasis.
Module:7 Molecular basis of vaccination and 8 hours
techniques used in immunology

Immunodeficiency diseases, Immunization: active and passive immunization. Different types


of vaccines with examples. Antigen-antibody reactions, Immunoelectrophoresis, ELISA,
Immunoblotting, Immunohistochemistry, Radioimmunoassay, Monoclonal antibodies, and its
production and uses.
Module:8 Contemporary issues in Immunology 2 hours
Lecture by Industrial experts

Total Lecture hours: 45 hours

Text Book(s)
1. Janis Kuby (2013), Immunology, 7th edition. W.H Freeman and company.

2. Abbas AK, Lichtman AH, and Pillai S (2012) Basic immunology: functions and disorders
of the immune system. 4th edition Elsevier health sciences.
Reference Books
1. Chapel H, Haeney M, Misbah S and Snowden N,(2014) Essentials of Clinical Immunology
6th Edition, Wiley Blackwell.

2. Murphy K and Weaver C (2017) Janeway’s Immunobiology, 9thedition, Garland Science


Publishing.
3.
Abbas AK, Lichtman AH, Pillai S (2011) Cellular and molecular immunology, 8th edition,
Elsevier Health Sciences.

Authors, book title, year of publication, edition number, press, place


Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
List of Challenging Experiments (Indicative)
1. Detection of antibody against pathogen from patient’s serum by slide 3 hours
agglutination
2. Detection of blood group by Rh typing 2 hours
3. Antigen quantitation by Single Radial Immuno Diffusion (SRID) method 4 hours
4. Antibody Titration by Ouchterlony Double Diffusion 4 hours
5. Determination of IgM, IgG, and IgA in the given serum by 4 hours
Immunoelectrophoresis
6. Detection of interaction between antigen and antibody by ELISA 4 hours
7. Visual differentiation of Blood cells with Wright’s stain 2 hours
8. Lymphatic system and organs of the immune system (demo only) 3 hours
9. Methods to raise antibodies in animals (Demo only) 4 hours
Total Laboratory Hours 30 hours
Mode of evaluation: Assignments, Continuous assessment tests and Final assessment test.

M.Sc Intg Biotechnology (5yr.) Page 103


Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 104


Course code Course title L T P J C
BIY1011 Fundamentals of Chemical Engineering 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Relate basic laws of chemical engineering about the calculation for processes
2. Demonstrate knowledge on solving heat transfer, material and energy balances for chemical
process systems
3. Interpret fluid mechanics to analyze the complexities involved in solving fluid flow problems
and ideal reactors

Expected Course Outcome:


1. Choose problems related to units and conversions and fit given data using methodologies
2.Solve problems related to material and energy balance concepts and design reactors for
biochemical processes
3. Illustrate the types and design of a heat exchanger
4. Utilize the knowledge gained on different types of flow and losses of flow in pipes
5. Select the right choice of pipes, valves, and pumps
6. Design ideal batch, mixed flow, and plug flow reactors

Student Learning Outcomes (SLO): 2, 9, 18


2. Having a clear understanding of the subject related concepts and contemporary issues
9. Having problem-solving ability- solving social issues and engineering problems
18. Having critical thinking and innovative skills
Module:1 Dimensions and system of units 7 hours
Module content
Fundamental quantities, derived quantities and conversions- Basic chemical engineering
calculations, Atomic, molecular and equivalent weights, molar concepts, concentration units for
pure components, vapour pressures, moles, mixtures and solution, Molarity, normality and partial
pressures, composition of mixtures and solutions, weight fraction, mole fraction, volumetric
composition, partial pressures, density and specific gravity.
Module:2 Gases 6 hours
Module content
Properties of gases, Ideal gas law, ideal mixtures and solution, Dalton’s Law of Additive
pressures, Amagot’s Law of Additive volumes.
Module:3 Material Balance 6 hours
Module content
Law of conservation of mass, meaning of material balance and its applications, process flow
sheet, drawing material balance on non reacting steady system, recycling, bypassing, material
balance on steady-state reacting systems with recycling and bypassing.
Module:4 Energy Balance 6 hours
Module content
Law conservation of Energy, the meaning of Energy balance and its importance inputs of
energy balance, specific heat and sensible heat, Latent heat and heats of transition,
sublimation, enthalpy of solutions, chemical reactions, conversion, yield, standard heats of
reaction, Hess Law, Kirchoff’s Law

M.Sc Intg Biotechnology (5yr.) Page 105


Module:5 Heat transfer 5 hours
Module content
Introduction, classification, performance, and application of types of the heat exchanger, Different
methods of heat exchange, Design of Heat Exchanger, Estimation of heat exchange area
Module:6 Fluid Mechanics 6 hours
Module content
Concept of fluid, the behavior of Newtonian and non-Newtonian fluids, types of fluid flow,
nature of the flow, Fluid head and manometry, the basic equation of fluid flow, continuity and
Bernoulli’s equation, application Bernoulli’s equation, the concept of friction factor piping system
and its components
Module:7 Pipes, Valves and Pumps and Ideal reactors 7 hours
Module content
Factors and selection of pipe size, good piping system, types of valves, and fitting.
Transportation devices, pumps, and their working. Design for homogeneous systems, Design
equation for the Batch reactor, Stirred tank reactor, and tubular flow reactor.
Module:8 Contemporary issues: Lecture by Industrial 2 hours
expert

Total Lecture hours: 45 hours

Text Book(s)
1. Bhatt B. I and Thakore S B. (2017) Stoichiometry, 5th edition, Tata McGraw Hill.

2. McCabe W, Smith J, and Harriott P, (2017) Unit operations of Chemical Engineering, 7th
Edn, McGraw Hill International Editions.
Reference Books
1. Himmelblau D.M. and Riggs JB (2015) Basic Principles and Calculations in Chemical
Engineering, 8th Edn, Pearson education India

2. White F.M. Fluid Mechanics in S I units, 2017, 8th Edition, McGraw Hill Inc.

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar


Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 106


Course code Course title L T P J C
BIY1012 Bioinformatics 2 0 2 4 4
Pre-requisite None Syllabus version
v. 1.1
Course Objectives:
1. Recall the basic practical techniques of bioinformatics
2. Extend the knowledge of bioinformatics and biological databases to solving real research
problems
3. Formulate the use of a wide variety of tools, servers, biological databases and apply them in
appropriate fields

Expected Course Outcome:


1. Choose knowledge of the basic principles of biology, computer science, and mathematics
2. Evaluate biological databases using bioinformatics algorithms
3. Build existing software effectively to extract information from large databases and apply the
information in computer modeling
4. Assess problem-solving skills, including the ability to develop new algorithms and analysis
methods
5. Perceive knowledge about analyzing big datasets statistically and bioinformatically
6. Improve skills in a professional environment via an industrial or academic internship in
bioinformatics

Student Learning Outcomes (SLO): 2, 11


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having interest in lifelong learning

Module:1 Important contributions 4 hours


Aims and tasks of Bioinformatics - applications of Bioinformatics - challengees, and opportunities

Module:2 Knowledge of various databases 5 hours


Literature databases: PubMed, Nucleic acid sequence databases: GenBank, EMBL. Protein
sequence databases: UniProt, PDB. Sequence submission databases – BankIt

Module:3 Sequence analysis 4 hours


Various file formats for bio-molecular sequences: genbank, FASTA, GCG, nbrf-piretc-Basic
concepts of sequence similarity, identity and homology- Sequence-based Database Searches-
BLAST and FASTA algorithms

Module:4 Sequence Alignment 4 hours


Dot plot and Dynamic Programming - Local alignment smith waterman algorithm - and Global
alignment - Needleman-Wunsch - (algorithm and example) –sequence formats

Module:5 Multiple sequence alignment 3 hours


Multiple sequence alignment for analysis of Nucleic acid and protein sequences and interpretation
of results– Clustal W algorithm - Feng Doolittle algorithm. Definition and description of
phylogenetic trees and various types of trees

M.Sc Intg Biotechnology (5yr.) Page 107


Module:6 Structural Bioinformatics 4 hours
3D structure prediction – Homology modeling – folds recognition &Ab-initio methods.
Visualization of structures using SPDBViewer or PyMol

Module:7 Pharma-informatics 4 hours


Bioinformatics in the Pharmaceutical Industry- Drug discovery

Module:8 Contemporary issues: Lecture by industrial 2 hours


experts

Total Lecture hours: 30 hours

Text Book(s)
1. Pevsner J (2015) Bioinformatics and functional genomics 3rd edition John Wiley, UK

2. Lesk A (2013) Introduction to Bioinformatics 4th edition Oxford University Press UK


Reference Books
1. Mount D (2014) Bioinformatics: Sequence and Genome Analysis, Cold Spring Harbor
Laboratory Press, New York.

2. Higgs PG and Attwood TK (2013) Bioinformatics and molecular evolution. John Wiley UK

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar


List of Challenging Experiments (Indicative)
1. Nucleotide sequence from primary nucleotide database
2 Hrs
2. Protein sequence from protein database
2 Hrs
3. Protein structure from a structure database
2 Hrs
4. Access of secondary biological data from various Biological database
2 Hrs
5. Pairwise alignment using a dot plot
2 Hrs
6. Pairwise alignment using dynamic programming
2 Hrs
7. Heuristic Sequence Alignment using BLAST/ FASTA
4 Hrs
8. Multiple sequence alignment
2 Hrs
9. Construction of Phylogenetic tree
2 Hrs
10. Gene prediction analysis
2 Hrs
11. Prediction of the secondary structure of the protein.
4 Hrs
12. Visualization of Protein Structure 4 Hrs
Total Laboratory Hours 30 hours

M.Sc Intg Biotechnology (5yr.) Page 108


Mode of evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 109


Course code Course title L T P J C
BIY1013 Bio Resource Management 2 0 0 4 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Explain the significance of biological wealth in day-to-day life
2. Illustrate the various approaches used for the management of biological resources
3. Justify the socio-economic issues involved with bio-resource management

Expected Course Outcome:


1. Recall knowledge on bio-resource management of various ecosystems
2. Develop theoretical expertise in socio-economy of biodiversity and biotechnology
3. Integrate the knowledge of various disciplines of sciences
4. Assess the economic values of flora and fauna in the environment
5. Create knowledge on the loss and cause of biodiversity
6. Formulate the management of various socio-economic dimensions in the environment

Student Learning Outcomes (SLO): 2, 10, 11,18


2. Having a clear understanding of the subject related concepts and contemporary issues
10. Having a clear understanding of professional and ethical responsibility
11. Having interest in lifelong learning
18. Having critical thinking and innovative skills

Module:1 Natural resources and human population 4 hours

Bioresource – Plant and Animal: Aquatic and terrestrial, Natural resources and human populations
Genetics resources, human resources – biosystematics, productivity, and working practices.
Module:2 Ecological Values, Economic value 4 hours

Species, habitats, and ecosystem, poverty, cultural values, ethics, and equity. Living plant
(produce) collections, botanical gardens, zoo and aquaria, marine stations.
Module:3 Biodiversity loss, causes of Biodiversity loss 4 hours

Biological Resources – rules, property rights, and intellectual resource rights; Fair and
Equitable benefits sharing. Legal measures – traditional, national, and international laws.
Biodiversity Act, 2002, and Biodiversity Rules 2004.
Module:4 Sustainable use of biodiversity 4 hours

Biodiversity information management -data collection, tools and techniques, Protected Area
Network (PAN), Measures for conservation and sustainable use of biodiversity in natural
resource management; Biodiversity and Biotechnology – sustainable use of bioresources.
Module:5 Socio-economic Dimensions of Environmental 4 hours
Management

Population explosion and social factors are affecting development. Impact of development on the
environment - changing patterns of land use, land reclamation, deforestation, resource depletion,
pollution, and environmental degradation.

M.Sc Intg Biotechnology (5yr.) Page 110


Module:6 Socio-economic Dimensions of Environmental 5 hours
Management

Managing biodiversity, protecting and restoring ecosystems, ecofeminism, socio-economic


strategies – ecotourism, community management, Eco-technology –industry, reuse, and recycle.
Module:7 Biotechnological approaches in bio-resource 5 hours
Management

Afforestation, Biotechnological methods of bioresource management building capacity for


management.

Module:8 Contemporary issues: lecture by industrial 2 hours


expert

Project: ‘J’ Component

Total Lecture hours: 30 hours

Text Book(s)
1. umar D, Rajendran KV and Jahageerdar S (2011) Bioresource Management and Climate
Change Studium Press (India) Pvt. Ltd.

2. Raju NJ, Gossel W, Ramanathan AL, and Sudhakar M (2014) Management of water,
energy, and Bioresources in the era of climate change: emerging issues and challenges.
Springer.
Reference Books
1. Thangadurai D and Sangeetha J (2017) Industrial Biotechnology: Sustainable production and
Bioresource utilization, Apple Academic Press.

2. Etingoff K (2014) Agricultural resource use and management Apple academic press NJ.

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar


Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 111


Course code Course title L T P J C
BIY1014 Bio Business & IPR 2 0 0 4 3
Pre-requisite None Syllabus version
v..1
Course Objectives:
1. Interpret the various terminologies involved in bio business
2. Develop cGMP, cGLP skills and become aware of the importance of business models
3. Estimate the possibilities of IP rights and the various ways of securing national and
international protection

Expected Course Outcome:


1. Identify the origin of bio business and the current scenario
2. Evaluate the various sectors of bio business
3. Determine different types of business models viz. product, subscription and integrated
4. Adopt international standards and certifications for cGMP and cGLP
5. Perceive the role of IPR in bio business
6. Utilize IP rights in business effectively
7. Decide on patenting procedures, types and filing

Student Learning Outcomes (SLO):2,10,18


2. Having a clear understanding of the subject related concepts and contemporary issues
10. Having a clear understanding of professional and ethical responsibility
18. Having critical thinking and innovative skills

Module:1 Fundamentals of Bio business: Hours 6


History of evolution of Bio Business, Importance of Finance for Bio business –Sectorial support
by Government of India - policies, and frameworks.

Module 2 Overview of Bio business in various sectors Hours 5

Healthcare, Industrial life-Sciences, Agriculture and Agri-biotechnology, Environment and


Environmental Biotechnology.

Module:3 Business Models in Bio business- Hours 6


Product Based-Service Based-Subscription Based-Integrated Models.

Module:4 BestPractices Hours 6


Current Good Manufacturing Practices (cGMP), Current Good Laboratory Practices (cGLP).

Module:5 IPR Hours 8

Determining "patentability"; Industry-wise implications; use of patents – relevant case studies


highlighting its importance. Importance of IPR in the Pharmaceutical Industry- Drug
development-Product/Process Patenting- Marketing.

M.Sc Intg Biotechnology (5yr.) Page 112


Module:6 IPR Rights Hours 6
Rights conferred by different types of intellectual property; interpreting the rights conferred by a
patent; the patent-granting system, Patent trends.

Module:7 Applications forms and procedures Hours 6


Patent costs and values; and the post-grant processes for enforcing, Safeguarding IPR.

Module:8 Recent updates Hours 2

Group Project Presentation: Case studies of different business models and IPR, eg. Biocon is
protecting cancer medicine.

Total Lecture hours Hours 45

Text Book(s)
1. Principles of gene manipulation and Genomics - Primrose S.B. and Twyman R.M.
Blackwell
Scientific Publications, 2008.
2. Genes IX - Benjamin Lewis. Oxford University & Cell Press, 2008.
3. Shahi, G. BioBusiness in Asia: How Asian Countries Can Capitalize on the
Life Science Revolution. Pearson Prentice Hall. 2004.
4. Hirsch RD & Peters MP, “Entrepreneurship,” Tata McGraw Hill Publishers, New Delhi,
2002.
5. Holt DH, “Entrepreneurship – New Venture Creation,” Prentice Hall of India, 1999.

Reference Books

Project : ‘J’ component


Mode: Use of technology in teaching, lecture by industry
Mode of Evaluation: Written Examination, Projects, and assignments
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 113


Course code Course title L T P J C
BIY2001 Microbial Genetics 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Outline the regulation of gene expression
2. Explain the importance of mutations
3. Illustrate chromosome inheritance pattern

Expected Course Outcome:


1. Recall key concepts about the organization of genes and the process of replication
2. Compare different methods of gene transfer and their related mechanisms
3. Discuss the basis of mutations and gene arrangements
4. Summarize DNA repair mechanisms
5. Elaborate on gene recombination processes

Student Learning Outcomes (SLO): 2, 11


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having interest in lifelong learning

Module:1 Organization of Genes and Replication 8 hours


Module content
Introduction to genetics. Eukaryotic, Prokaryotic, and Viral Genome and their replication.
Pathogenicity island
Module:2 Gene Transfer and Mechanism 8 hours
Module content
Lateral and Horizontal gene transfer. Conjugation, Transformation, and Transduction
(Generalized transduction and specialized transduction) Transformation and & its mechanism.
Griffith experiment.
Module:3 Mutation and Gene arrangement 3 hours
Module content
Classes of mutations, spontaneous and induced mutation, mutagens, Reversion and
suppression mutations, Ames test. Genetic characterization of mutants.
Module:4 DNA repair 4 hours
Module content
DNA damage and causative agents. The mechanism that reverse, excise, or tolerate DNA repair.
Module:5 Genetic Recombination 6 hours

Module content
Homologous Recombination, enzymes, and models (Double-stranded invasion model and
Meselson and Radding model). Site-specific recombination (Bacteriophage lambda). Short
sequence recombination
Module:6 Transposition 4 hours
Module content
Transposons, structure ,types and mechanism
Module:7 Bacteriophage and Natural Plasmids 6 hours
Module content

M.Sc Intg Biotechnology (5yr.) Page 114


Bacteriophage structure, lifecycle (lytic and non-lytic cycle), superinfection, Restriction, and
modification of DNA. Plasmid types, replication, copy number, incompatibility, and
amplification. Genes carried by plasmids.
Module:8 Contemporary issues: 6 hours

Total Lecture hours: 45 hours

Text Book(s)
1. Chaudhuri K (2012) Microbial Genetics The Energy and Resources Institute, TERI

2. Snyder L, Peters JE, Henkin TM, Champness W (2013) Molecular Genetics of Bacteria,
4thEdition ASM press
Reference Books
1. Krebs JE Lewin B, Goldstein ES and Kilpatrick ST (2014) Lewin's GENES XI Jones &
Bartlett Publishers

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar


Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 115


Course code Course title L T P J C
BIY2002 Genetic Engineering 0 2 0 4
Pre-requisite BIY1007 Syllabus version
v. 1
Course Objectives:
1. Recall different DNA modifying enzymes used in recombinant DNA technology
2. Compare different vectors and their applications in recombinant DNA technology
3. Illustrate different techniques used in genetic engineering

Expected Course Outcome:


1. Choose from different DNA modifying enzymes to modify given DNA as per requirement
2. Design different vectors for cloning and expression of genes in various expression systems
3. Apply appropriate techniques to research in various fields of biotechnology
4. Evaluate different strategies for cloning of gene from various cDNA libraries
5. List the risks associated with genetic engineering experiments
6. Modify genes for higher yield of biotechnology-derived products

Student Learning Outcomes (SLO): 2,11,18


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having interest in lifelong learning
18. Having critical thinking and innovative skills

Module:1 Enzymes used in genetic engineering 6 hours


Polymerases, ligases, E. coli, alkaline phosphatase, polynucleotide kinases, terminal transferases.
Endonucleases with special reference to restriction enzymes; properties, creation of sticky and
blunt ends, restriction digestion, double digestion, restriction mapping, star activity,
Isoschizomers, neoschizomers. Linkers and adapters.

Module:2 Vectors for gene cloning 6 hours


Plasmids, Bacteriophage; λ phage and M13 phage, hybrid vectors; cosmids and phagemids.
Vectors for eukaryotic cell; yeast vector, chromosomal vector; BAC, YAC, Ti and Ri vectors,
Bacculovirus vectors. Advantages and disadvantages of these vectors one over the other, with
examples.

Module:3 Methods to locate gene in the genome 7 hours


and modifying cloned genes
Transposon tagging, chromosome walking, and chromosome jumping. Site-directed mutagenesis,
deletion mutants, and fusion proteins.

Module:4 Nucleic acid hybridization 5 hours


Southern and Northern blotting; procedure and application.

Module:5 Methods for gene cloning from the 6 hours


genome of prokaryotes and eukaryotes
Genomic DNA library screening, cDNA library screening. PCR and RT-PCR.

Module:6 Introduction of a foreign gene into 6 hours

M.Sc Intg Biotechnology (5yr.) Page 116


organisms
Methods for gene transfer in bacteria, yeast, plant, and animal cells — selection markers used
for the selection of recombinants from non-recombinants.

Module:7 Gene expression and regulation 6 hours


Features of expression vectors, constitutive, inducible, and tissue-specific promoters. Regulation
of gene expression with the example of lac and trp promoters.

Module:8 Contemporary issues: Lecture by industrial 3 hours


experts

Total Lecture hours: 45 hours

Text Book(s)
1. Old RW and Primrose SB (2014) Principles of gene manipulation, 7th edn Wiley
Blackwell Scientific Publications.
2. Jogdand SN (2016) GENE biotechnology 4th Edn Himalaya publishing group
Reference Books
1. Somnath De (2016) Basic Concept of Recombinant DNA Technology Createspace
Independent Publications India
2. Sambrook and Russel. Molecular cloning Vol. 1-3, CSH Press (from 2001 till date updated
protocols)
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
List of Challenging Experiments (Indicative)
1. Preparation of competent cells (BL -21). 4 hours
2. Transformation of BL-21 competent cells with pGEX 4T-1 vector. 4 hours
3. IPTG induction of BL-21 cells containing pGEX 4T – 1 and isolation of 4 hours
proteins from control and induced cells.
4. Analysis of the protein profile of 3rd experiment on SDS-PAGE 4 hours
5. Purification of GST protein from whole cell lysate obtained from 3rd 4 hours
experiment
6. Cloning of the PCR product in TA cloning vector – transformation in DH5 a 4 hours
bacteria.
7. Screening for recombinant plasmid for experiment 6 by i) colony PCR ii) 4 hours
Restriction digestion.
Total Laboratory Hours 30 hours
Mode of evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 117


Course code Course title L T P J C
BIY2003 Bioprocess Principles 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1.1
Course Objectives:
1. Summarize the basics of different types of fermentors
2. Recall the basics of sterilization procedures and metabolic stoichiometry
3. Demonstrate the growth kinetics, production kinetics, and inhibition models.

Expected Course Outcome:


1. Design appropriate bioreactor configurations and operation modes based upon the nature
of bioproducts
2. Evaluate model required for the microbial growth and can design own batch thermal
sterilization
3. Formulate medium using various kinetics for maximum production of metabolites and
biocatalyst for commercial applications
4. Model the kinetics of living cells and to develop a strategy to solve the issues emerging
during fermentation processes
5. Choose better yield using gene manipulation of microorganisms and integrate research lab and
industry
6. Identify problems and seek practical solutions for large scale implementation of biotechnology

Student Learning Outcomes (SLO): 2, 9


2. Having a clear understanding of the subject related concepts and contemporary issues
9. Having problem-solving ability- solving social issues and engineering problems

Module:1 Overview of Fermentation Processes 6 hours


The fermentation process and its development, general requirements of fermentation processes.
Factors affecting fermentation

Module:2 Fermentor and its types 6 hours


The basic configuration of fermentor and ancillaries, main parameters to be monitored and
controlled in fermentation processes. Different types of fermentor with example

Module:3 Medium and Sterilization 5 hours


Thermal death kinetics of microorganisms, batch and continuous heat, sterilization of liquid
media, filter sterilization of liquid media, Air, Design of sterilization equipment

Module:4 Metabolic Stoichiometry 6 hours


Stoichiometry of Cell growth and product formation, elemental balances, degrees of reduction of
substrate and biomass, available electron balances, yield coefficients of biomass and product
formation

Module:5 Energetics 7 hours


Maintenance coefficients energetic analysis of microbial growth and product formation, oxygen
consumption, and heat evolution in aerobic cultures, the thermodynamic efficiency of growth.

M.Sc Intg Biotechnology (5yr.) Page 118


Module:6 Kinetics of microbial growth and 7 hours
product formation
Phases of cell growth in batch cultures, Monod model, Growth associated (primary) and non-
growth associated (secondary) product formation kinetics, Leudeking-Piret models

Module:7 title 6 hours


Substrate and product inhibition on cell growth and product formation. Gene manipulation of
microorganisms for better yield with examples.

Module:8 Contemporary issues: Inhibition Models 2 hours

Total Lecture hours: 45 hours

Text Book(s)
1. Stanbury P.F., Whitaker A, Hall S.J (2016) Principles of Fermentation Technology,
Butterworth Heinemann, 3rd edition. UK
2. Shuler M.L and Kargi F (2017) Bioprocess Engineering: Basic concepts Prentice Hall, 2nd
edition.
Reference Books
1. Doran PM (2013) Bioprocess Engineering Principles Elsevier, 2nd edition.
2. Cornish-Bowden A, (2012) Fundamentals of Enzyme Kinetics, Butterworth group, 4th
edition.
3. Okafor N (2016) Modern Industrial Microbiology and Biotechnology, SP publishers.
Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No.46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 119


Course code Course title L T P J C
BIY 2009 Genomics 3 0 0 0 3
Pre-requisite BIY1012 Syllabus version
v. 1.1
Course Objectives:
1. Build a foundation in the fundamental principles of genomics
2. Compare different methods available to study DNA and RNA sequence analyses
3. Apply genomic data to provide new insights in the fields of biology and medicines

Expected Course Outcome:


1. Improve the knowledge and skills to differentiate recent advances in genome complexities
between eukaryotic and prokaryotic genomes and their database.
2. Summarize current updates on genome sequencing technologies to appreciate the differences
between these technologies and illustrate the pros and cons of each method
3. Analyze information relating to Human Genome Project towards ELSI, with GWAS, SNP and
miRNA techniques using specific databases and bioinformatics tools
4. Design and evaluate expression profiling using different methods such as microarray acquisition
and analysis and tag-based profile analysis
5.Extend the concept of pharmacogenomics and toxicogenomics towards personalized medicine
6. Formulate the concept, methods, and application of metagenomics in phylogeny and novel gene
identification

Student Learning Outcomes (SLO): 2,8,10


2. Having a clear understanding of the subject related concepts and contemporary issues
8. Having Virtual Collaborating ability
10.Having a clear understanding of professional and ethical responsibility

Module:1 Genome structure and organization 6 hours


Genomes-Prokaryotes, Eukaryotes, Organelles (Mitochondria, Chloroplast), Overview of Genome
organization. Various genome databases and their uses.

Module:2 NGS Sequencing platforms and principles 7 hours


SOLiD™- Applied Biosystems, GS-FLX-Roche, Ion-Torrent- Thermo Fisher, and Illumina
Solexa

Module:3 The story of the Human Genome 7 hours


Genome Mapping, Goals and Benefits of HGP, Drawback and ELSI issues, HapMap, GWAS,
Micro RNA sequences

Module:4 Techniques in Comparative Genomics 7 hours


Traditional and global analysis of RNA expression: spotted DNA arrays, printed oligonucleotide
chips – data acquisition and analysis – SAGE, MPSS, DDRTPCR, expression profiling in human
diseases

Module:5 Pharmacogenomics 6 hours


Concepts and Tools in Pharmacogenomics, Pharmacogenetics Vs. Pharmacogenomics;
Understanding drug responses, Gene-disease association; the concept of Personalized Medicine.

M.Sc Intg Biotechnology (5yr.) Page 120


The bridge between pharmacogenomics and toxicogenomics

Module:6 Metagenomics 6 hours


Concept, Methods, and Techniques, Metagenome projects and applications

Module:7 Ethical issues in the classification of the 4 hours


human genome
Ethical issues and Genetic Discrimination: Genetic Information Non discrimination Act 2007

Module:8 Contemporary issues: Lecture by industrial 2 hours


experts

Total Lecture hours: 45 hours

Text Book(s)
1. S. C. Rastogi N. Mendiratta P. Rastogi (2013) Bioinformatics: Methods And Applications:
(Genomics, Proteomics And Drug Discovery), Edition 4, PHI Learning Pvt. Ltd
Reference Books
1. Schmidt D (2014) Using the Biological Literature: A Practical Guide, Fourth Edition by CRC
Press
Primrose SB, Twyman R (2013) Principles of Gene Manipulation and Genomics, 7th Edition:
2.
2013, Wiley-Blackwell
Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 121


Course code Course title L T P J C
BIY2011 Proteomics 3 0 0 0 3
Pre-requisite None Syllabus version
v. 2.1
Course Objectives:
1.. Describe the basics in the field of proteomics
2. Classify various techniques that are used in the study of proteomics
3. Illustrate the biological importance of protein-protein interaction, modeling
and protein database, and their clinical relevance

Expected Course Outcome:


1. Recall the basics of proteomics
2. Utilize various techniques in protein separations
3. Choose different methods to identify proteins
4. Explain the importance of protein-protein interactions

Student Learning Outcomes (SLO): 2,20


2. Having a clear understanding of the subject related concepts and contemporary issues
20. Having a good digital footprint

Module:1 Overview of Proteomics 4 hours


Proteomics – Introduction, Applications in scientific research, Proteomics in post-genomic era,
Human proteome draft

Module:2 Protein Separation Techniques 8 hours


Proteomics experimental workflow, Basics of protein separation-Centrifugation, Ultrafiltration,
Chromatography - GC-MS, LCMS, Electrophoresis – 1-D, 2-D, and DIGE

Module:3 Protein Identification Techniques 8 hours


Introduction to Mass spectrometry, Experimental design, Sample preparation, Quantitative and
qualitative proteomics by mass spectrometry - Basics, ionization techniques and mass analyzers,
electrospray ionization (ESI) and matrix adsorption laser dissociation ionization (MALDI) and
triple quadrupole (QQQ), SELDI, Peptide mass fingerprinting, Protein Microarray, protein
sequencing, FRET analysis, NMR, X-ray crystallography. Analysis of post-translational
modifications - Phosphorylation, ubiquitination, acetylation nitration, glycosylation, Sumoylation
etc.

Module:4 Protein-protein/Protein-DNA 6 hours


Interaction Studies
Mapping of protein interactions using mass spectrometry-based approaches (ICAT, ITRAQ,
SILAC approaches) Yeast Two-Hybrid, Phase Display. Protein-DNA interactions- Identification
of ligand-receptor pairing and transcriptional regulators.

Module:5 Protein Modeling 6 hours


Steps in homology modeling, tools, databases, side-chain modeling, loop modeling. Predicting
Protein Structures by Threading using related soft wares

M.Sc Intg Biotechnology (5yr.) Page 122


Module:6 Clinical Proteomics 5 hours
Proteomics in the study of diseases, Storage transportation and processing of clinical samples,
Proteomic analysis of body fluids, IHC, Western Blotting

Module:7 title 6 hours


Uniprot-KB: SWISS-PROT, TrEMBL, UniParc; Structure Databases: PDB, NDB, PubChem,
ChemBank

Module:8 Contemporary issues: Lecture by industrial 2 hours


experts

Total Lecture hours: 45 hours

Text Book(s)
1. Lesk AM (2014) Introduction to Bioinformatics, 4th Edition, Oxford University Press UK
2. R.M. Twyman (2013) Principles of Proteomics, Taylor and Francis, Garland Science, UK
Reference Books
1. Mirzaei H and Carrasco M (2016) Modern Proteomics – sample preparation, analysis and
practical applications. Springer publications
Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No.46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 123


Course code Course title L T P J C
BIY3001 Downstream Processing 3 0 2 0 4
Pre-requisite Bioprocess Principles Syllabus version
v. 1
Course Objectives:
1. Utilize the unique properties of proteins to separate them from each other
2. Demonstrate the importance of protein purification techniques
3. Assess different stages and techniques involved in protein purification and polishing

Expected Course Outcome:


1. Summarize the basic concepts of protein structure
2. Examine the methods to track a protein of interest during different stages of purification
3. Decide upon the type of technique to break the cell and purify the required analyte
4. Apply different enrichment techniques for protein concentration
5. Compare different chromatography technique used for protein purification
6. Develop methods for product polishing and assess different types of vectors available for
expression and purification of recombinant proteins

Student Learning Outcomes (SLO): 2,18


2. Having a clear understanding of the subject related concepts and contemporary issues
18. Having critical thinking and innovative skills

Module:1 Role of Downstream Processing in 5 hours


Biotechnology
Role and importance of downstream processing in biotechnological processes. Economics of
downstream processing in Biotechnology. Importance of obtaining pure biological products.
Advantages of obtaining biologically relevant compounds through biological method over
chemical method.

Module:2 Overview of purification of Bio-molecules 6 hours


Basics related to protein structure and purification strategies. Characteristics of biological
mixtures. Qualitative and Quantitative assays for protein detection and quantification through
different stages of protein purification.

Module:3 Terminologies used in biological 6 hours


samples purification
Enzyme activity, specific activity, enzyme unit, chiral carbon, plane-polarized light, Absorption,
Absorption maximum, enantiomers, optical activity, and viscosity.

Module:4 Cell lysis methods, separation of solids 6 hours


and liquids
Mechanical and Chemical methods of cell lysis. Solid-liquid separation techniques: Flocculation
and Sedimentation, centrifugation, and filtration methods. Centrifuge models used in industries

Module:5 Enrichment operations 7 hours


Precipitation methods (with salts, organic solvents and polymers). Extractive separations:
Solvent extraction, Aqueous two phase extraction, Riverse micelle extraction, supercriticial

M.Sc Intg Biotechnology (5yr.) Page 124


extraction. Membrane-based separations: Porous and dense membrane separations, Dialysis,
Reverse osmosis, Ultrafiltration, Electrodialysis, Pervaporation, Gas permeation, Liquid
membranes.

Module:6 Product Resolution 7 hours


Chromatographic principles: distribution coefficients, retention parameters, qualitative and
quantitative aspects of chromatography, column efficiency, selectivity and resolution, Gel
permeation chromatography, Ion exchange chromatography, Reverse Phase Chromatography,
Affinity chromatography. Adsorption chromatography, HPLC

Module:7 Product polishing and advanced 6 hours


methods for protein purification
Crystallization, Drying, and product formulation, Lyophilization. Vectors designed for protein
purification.

Module:8 Contemporary issues: Lecture by industrial 2 hours


experts

Total Lecture hours: 45 hours

Text Book(s)
1. Wilson K and Walker J (2010) Principles and Techniques of Biochemistry and Molecular
Biology 7th Edn Cambridge University Press

2. Roe S (2010) Protein Purification Techniques: A Practical Approach 2nd edition Oxford
University Press
Reference Books
1. Belter PA, Cussler EL, and Hu WS (2011) Bioseparations: Downstream Processing for
Biotechnology Paperback Wiley
Mode of Evaluation: Written examinations, assignments, and quizzes.
List of Challenging Experiments (Indicative)
1. Protein estimation 2 Hours
2. Cell lysis followed by protein estimation 2 Hours
3. Precipitation of proteins (ammonium sulfate) 2 Hours
4. Precipitation of proteins (Acetone) 2 Hours
5. Aqueous two-phase extraction 2 Hours
6. Reverse micelle extraction 2 Hours
7. Size Exclusion Chromatography 2 Hours
8. Affinity chromatography 2 Hours
9. Dialysis 2 Hours
10 Crystallization 2 Hours
11 HPLC (Demonstration) 2 Hours
12 Fraction collector used in chromatography (Demonstration) 2 Hours
13 Lyophilization (Demonstration) 2 Hours
Total Laboratory Hours 30 hours

M.Sc Intg Biotechnology (5yr.) Page 125


Mode of evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 126


PROGRAMME ELECTIVES

M.Sc Intg Biotechnology (5yr.) Page 127


Course code Course title L T P J C
BIY1015 Environmental Health 2 0 0 4 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Describe genetic, physiologic and psychosocial factors that affect susceptibility to adverse
health outcomes following exposure to environmental hazards
2. Identify current environmental health issues and environmental contaminants
3. Evaluate methods of collection, treatment, disposal, and recycling of solid waste and describe
the health hazards associated with improper management of these wastes

Expected Course Outcome:


1. Outline the physical, chemical, and biological hazards associated with water pollution, as well
as the importance of water quality related to contamination, protection, and monitoring of water
supplies
2. Distinguish between health risks associated with indoor and outdoor air pollutions and methods
of hazard control
3. Explain the significant sources and types of environmental agents
4. List the transport and fate of these agents in the environment
5. Classify the carriers or vectors that promote the transfer of these agents from the environment
to the human
6. Analyze the interaction of agents with biological systems and the mechanisms by which they
exert adverse health effects.

Student Learning Outcomes (SLO): 2,9,10,18


2. Having a clear understanding of the subject related concepts and contemporary issues
9. Having problem-solving ability- solving social issues and engineering problems
10. Having a clear understanding of professional and ethical responsibility
18. Having critical thinking and innovative skills

Module:1 Emerging global environmental health Issues 4 hours


Municipal waste - Industrial waste - Hazardous waste - Air and water pollution.

Module:2 Environmental issues in Human 4 hours


Biomarkers and risk analysis - Mutagenesis and carcinogenesis - Chromosomal analysis -
Congenital anomalies - Congenital disabilities and infertility.

Module:3 Environmental Toxicology 4 hours


Classification of toxicants in the environment - Factors affecting toxicity – Mutagenesis –
Teratogenesis - Carcinogens – Hallucinogens - Phytotoxins and animal toxins.

Module:4 Toxicity transformation 4 hours


Absorption and distribution of toxicants in animal body; Biotransformation of toxicants; Antidotes
treatment and detoxification of toxicants; Bio-accumulation.

Module:5 Environmental Quality Assessment and 4 hours


Monitoring

M.Sc Intg Biotechnology (5yr.) Page 128


Definition for environmental quality – Deterioration and assessment of environmental quality -
Matrix method and system diagram technique.

Module:6 Environmental Impact Assessment 4 hours


Environmental Impact Assessment techniques - Adhoc method - Checklist method - Overlay
mapping method - Network method - Simulation and modeling technique - Merits and Demerits
of EIA studies.

Module:7 Survey studies 4 hours


Short term studies/surveys - Rapid assessment - Continuous short and long term monitoring.

Module:8 Contemporary issues- Lecture by industry 2 hours


experts

Total Lecture hours: 30 hours


Text Book(s)
1. Zimeri AM (2012) Introduction to environmental health: A Global Perspective, Revised
Edition, Cogenella Academic Publishing.
2. Moeller DW (2011) Environmental Health, Fourth Edition, Cambridge: Harvard University
Press.
Reference Books
1. Nadakavukaren, A (2011) Our global environment: A health perspective. Seventh Edition.
Prospect Heights: Waveland Press, Inc.
Project: ‘ J’ component
Mode of Evaluation: CAT / Assignments / FAT
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 129


Course code Course title L T P J C
BIY1016 Behavioral Science 2 0 0 4 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Interpret the behavior of individuals with society
2. Deduce how communication changes behavioral patterns
3. Relate interrelationship with society

Expected Course Outcome:


1. Choose from different methods available to study human behavior
2. Explain how modern communication network is changing human behavior
3. Summarize various body activities controlled by the human brain such as processing,
integrating, and coordinating the information it receives from the sense organs and making
decisions as to the instructions sent to the rest of the body
4. Demonstrate that the outcome of repeated conscious effort becomes a habit and how it needs
enough practice to become a habit
5. Infer behavioral activities explored by various applied disciplines that are practiced in the
context of everyday life for counseling
6. Perceive communication as a fundamental life process that is necessary as individuals and to
our relationships, groups, organizations, cultures, and societies

Student Learning Outcomes (SLO): 2,10,18


2. Having a clear understanding of the subject related concepts and contemporary issues
10. Having a clear understanding of professional and ethical responsibility
18. Having critical thinking and innovative skills

Module:1 Behavior Sciences study methods and societal 3 hours


role
Introduction, Methods of studying Behavior Science, Scope, Experimental and non-experimental
approaches of research

Module:2 Evolution of Human Behavior 3 hours


Chronobiological, Comparison of traditional lifestyle and modern lifestyle. Electronic Gadgets,
Social networks affecting behaviors, Netoholic, Whatsapp…..etc

Module:3 Brain, Sensory organs and Intelligence 4 hours


Brain- parts of the brain, the role of each part. The conscious and subconscious mind. Role of the
nervous system and endocrine system in behavior. Sensory process (Vision, auditory, touch, taste,
vestibular and kinesthesis); Perception; Cognition (Concepts, language and thought, problem-
solving and decision – making); Intelligence ( Characteristics, assessment, the role of creativity)

Module:4 Habit-forming & Personality Development 5 hours


Learning and memory (Principles, types and effective methods); Individual development across
the life span; Psychological disorders (Types – moods, anxiety, depression, suicide); Overview of
therapies

M.Sc Intg Biotechnology (5yr.) Page 130


Module:5 Application of Behavioral Sciences 3 hours
Counseling, Conflict Resolution, Crisis Intervention, Eugenics, Dealing with Special Kids

Module:6 Communication and Human Behavior 4 hours


Behavioural Emotional and Social Difficulties (BESD), SLCN, Language, Culture, and Cognition,
Linguistic Relativity of Thought, A Post-Whorfian Approach, Body movement, and
interpersonal communication, Gesture and posture

Module:7 Social concepts 4 hours


Social perceptions; social influences; social relationships; the dynamic interplay of culture and
society.

Module:8 Contemporary issues: 4 hours


Lecture by industrial expert

Total Lecture hours: 30 hours


Text Book(s)
1. Weiten W, Dunn D S, Hammer E Y (2014) Psychology Applied to Modern Life:
Adjustment to the Turn of the Century, Cengage Learning.
Reference Books
1. Becker G S (2013) The Economic Approach to Human Behaviour. Chicago: University of
2. Chicago Press
West R and Turner LH (2010) Understanding Interpersonal Communication: Making Choices
in Changing Times, Cengage Learning
Project: ‘J’ Component
Mode of Evaluation: CAT / Assignments / FAT
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 131


Course code Course title L T P J C
BIY1017 Pharmaceutical Biotechnology 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Outline the importance of fundamental and conceptual aspects of pharmacological sciences
2. Illustrate the mechanistic aspects of specific categories of drugs including manufacturing and
quality control issues
3. Elaborate upon the mechanistic aspects of other drug categories and extend knowledge in
Biopharmaceuticals

Expected Course Outcome:


1. Recall the essential aspects of pharmacokinetics/pharmacodynamics and solve
pharmacokinetics and pharmacodynamics-related problems
2. Classify different drugs based on the mechanism of action and improve fundamental
comprehension
3. Discuss manufacturing and quality control issues and develop competencies relevant to the
Pharmaceutical Industry
4. Outline the importance of developing biopharmaceuticals in the future
5. Build on the necessary knowledge and be able to demonstrate the ability to recall the salient
aspects of clinical trials and regulatory issues

Student Learning Outcomes (SLO): 2,11


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning

Module:1 Overview 6 hours


Development of drugs, Pharmacodynamics - Antagonists, and Agonists

Module:2 Pharmacokinetics 6 hours


Pharmacokinetics – Absorption, Distribution, Metabolism, and Excretion. Routes of drug
administration, Prodrugs

Module:3 General Pharmacology 6 hours


Antacids, Antiseptics, NSAIDs, Local Anesthetics, Pharmacotherapy of cough, and peptic ulcer.

Module:4 Oral Dosage Forms 6 hours


Manufacturing, quality control and packaging requirements of tablets, capsules, and solutions

Module:5 Parenteral and Topical Dosage Forms 7 hours


Manufacturing, quality control and packaging requirements of parenteral, ointments, aerosols,
and modified dosage forms

Module:6 Biologics 6 hours


Monoclonal antibodies, rDNA drugs, Therapeutic proteins, Hormones, Immunobiologicals,

M.Sc Intg Biotechnology (5yr.) Page 132


Vaccines.

Module:7 Clinical Trials and Regulatory affairs 6 hours


Phases, Design, ICH GCP, FDA Regulations, Indian Drug Regulations. Regulatory aspects of
pharmaceutical and bulk drug manufacturers

Module:8 Contemporary topics 2 hours


Lecture by industrial experts

Total Lecture hours: 45 hours


Text Book(s)
1. Loyd, V., Jr. Howard C A and Ansel (2013) Ansel's Pharmaceutical Dosage Forms and Drug
Delivery Systems, Publisher: Wolters Kluwer Health

2. Satoskar RS, Rege N, Bhandarkar SD (2015) Pharmacology and Pharmacotherapeutics,


24thedn Elsevier India.
Reference Books
1. Brunton L, Chabner BA and Knollman B (2011) Goodman and Gilman's The
Pharmacological Basis of Therapeutics, McGraw Hill Education; 12th edition.

2. Khar RK and Vyas SP ( 2013) Lachman/Liebermans: The Theory and Practice of Industrial
Pharmacy, Publisher: CBS; 4th edition.

3. Milligan GN and Barrett A (2015) Vaccinology: An Essential Guide Publisher: Wiley-


Blackwell; 1st edition.
Mode of Evaluation: CAT / Assignment / FAT
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 133


Course code Course title L T P J C
BIY1018 Industrial Biotechnology 2 0 0 4 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Recall knowledge on medium formulation and strain improvement for enhanced production of
bioproducts
2. Develop fundamental knowledge to explore microbes for the production of industrially relevant
primary and secondary metabolites
3. Extend knowledge on the industrial method of fermentation processes for the production of
bioproducts

Expected Course Outcome:


1. Outline process-flow sheeting for the industrial fermentation processes
2. Demonstrate the methods of cell culture under various conditions, formulate and optimize
media and apply strain improvement to enhance the production
3. Apply the knowledge of kinetics for microbial growth and product formation
4. Choose from the production processes for primary and secondary metabolite
5. Explain the production of commercially critical recombinant proteins

Student Learning Outcomes (SLO): 2,14,18


2. Having a clear understanding of the subject related concepts and contemporary issues
14. Having an ability to design and conduct experiments, as well as to analyze and interpret data
18. Having critical thinking and innovative skills

Module:1 Introduction to industrial bioprocess 4 hours


A historical overview of industrial fermentation processes and products. Outline of the various
unit operation involved in an integrated bioprocesses; process flow-sheeting; a brief survey of
organisms, processes, products and market economics relating to modern industrial biotechnology

Module:2 Fermentation process 4 hours


Isolation, preservation, and improvement of industrial micro-organisms for overproduction of
primary and secondary metabolites: medium requirements for fermentation process-carbon,
nitrogen, minerals, vitamins, and other nutrients-examples of complex media.

Module:3 Kinetics of Microbial growth and Product 4 hours


formation
Batch cultivation and continuous cultivation. Simple unstructured models for microbial growth,
Monod model, growth of filamentous organisms, product formation kinetics - Leudeking- Piret
models, substrate and product inhibition on cell growth and product formation. Biomass
estimation – Direct and Indirect methods

Module:4 Production of primary metabolites 4 hours


Commercially essential organic acids (e.g. Citric acid, itancoic acid, acetic acid, glucanoic acid,
etc). Aminoacids (glutamic acid, lysine, aspartic acid, phenylalnineetc). Alcohols (ethanol, 2, 3,
butanediol

M.Sc Intg Biotechnology (5yr.) Page 134


Module:5 Production of secondary metabolites 4 hours
The concept of biocatalysis- Importance of microbial products over chemically synthesized
products – ill effects of chemicals - Bacterial pigments – prodigiosin – violacein and
deoxyviolacein -fungal monascin - bacterial and algal carotenoids – astaxanthin –production and
application

Module:6 Production of commercially important 4 hours


enzymes
Proteases, amylases, lipases, cellulases, pectinases, isomerases, and other commercially
essential enzymes for the4 food and pharmaceutical industries.

Module:7 Production of commercially important 4 hours


recombinant proteins
Production of recombinant proteins having therapeutic and diagnostic applications: production of
vaccines. Specially bio-products for agricultural, food and pharmaceutical industries-bio-
pesticides, biofertilizers and plant growth factors: natural bio-preservatives (nisin), biopolymers
(xanthan gum and PHB): single-cell protein

Module:8 Contemporary topics 2 hours


Lecture by Industrial experts

Total Lecture hours: 30 hours

Text Book(s)
1. Peter F Stanbury, Allan Whitaker, Stephen J Hall, “Principles of Fermentation Technology”
Butterworth Heinemann, Third Edition,2016.
2. WulfCrueger, AnnelieseCrueger, K.R.Aneja, “ Biotechnology -A textbook of Industrial
Biotechnology” Medtech,2017
Reference Books
1. Colin Ratledge, Bjorn Kristiansen, “Basic Biotechnology” Cambridge University Press, Third
Edition,2006
2. Thangadurai D and Sangeetha J (2017) Industrial Biotechnology: Sustainable production and
Bioresource Utilization. CRC press
3. Michael L Shuler, FikretKargi, Mathew DeLisa (2017) Bioprocess Engineering, Third
Edition, Prentice-Hall International Series
Authors, book title, year of publication, edition number, press, place
Mode of Evaluation: CAT / Assignments / FAT
Project: ‘J’ component
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 135


Course code Course title L T P J C
BIY1019 Nanobiotechnology 2 0 0 4 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Recall the basics of nanotechnology
2. Explain potential applications of nanobiotechnology
3. Compare existing and new concepts, methodologies and research results and apply them in an
academic or industrial research environment

Expected Course Outcome:


1. Appraise students about basic concepts and theories of the subject
2. Demonstrate the applications of analytical techniques in examining nanostructures/ particles
3. illustrate the scope of biomacromolecules in nanotechnology
4. Explain the potential of nanobiotechnology in consumer applications and diagnostics
5. Create a necessary foundation for training in research
6. Infer the importance of risk assessment in the usage of nanostructures/particles in various
applications

Student Learning Outcomes (SLO): 2,10,14


2. Having a clear understanding of the subject related concepts and contemporary issues
10. Having a clear understanding of professional and ethical responsibility
14. Having an ability to design and conduct experiments, as well as to analyze and interpret data

Module:1 The science of nano-bio interface 3 hours


History and development of nanobiotechnology; Structure-property relationships.

Module 2 Types of biologically relevant nanomaterials 4 hours

Self-assembly as in proteins, lipids, and nucleic acids; Polymeric nanoparticles; Inorganic


nanoparticles- quantum dots, silica-based nanostructures; metallic nanoparticles like silver and
gold; nanotubes, nanowires, and nanofibers.

Module:3 Synthesis and production 4 hours


Physical, Chemical, and Biological means of synthesis; Biomimetic approaches of production:
case studies- ferritins, silica in diatoms, FeNPs in magnetosomes; Merits and demerits of bio-
based approaches.

Module:4 Characterization of nanomaterial 4 hours

Optical techniques like UV-Vis and fluorescence spectroscopy; FTIR spectroscopy; electron
microscopy (TEM and SEM); Atomic Force Microscopy, dynamic light scattering, zeta potential
measurement, XRD (with emphasis on how these techniques to aid in characterizing
nanoparticles).

Module:5 Functional nanomaterials for biological 5 hours


applications

M.Sc Intg Biotechnology (5yr.) Page 136


Strategies for chemical and biological functionalization; Applications in tissue engineering &
regenerative medicine.

Module:6 Nanoparticles in biological labelling and 4 hours


cellular imaging
Nanoparticles as a reporter: metallic nanoparticles and quantum dots in rapid diagnostics tools;
FRET and Molecular Beacons; SPR and SERS-based imaging.

Module:7 Biosafety and Potential risks of nanomaterials 4 hours

Routes of exposure; Fate of nanoparticles- short and long term; Cellular interaction;
environmental safety; Risk assessment and regulatory mechanisms.

Module:8 Contemporary topics discussion: Lecture by 2 hours


industrial experts
Project: “ J” COMPONENT
Total Lecture hours: 30 hours

Text Book(s)
1. Bhushan B (2010) Handbook of Nanotechnology, Springer-Verlag, Berlin,
Heidelberg,Germany
Reference Books
1. Xie Y (2012) The Nanobiotechnology Handbook CRC Press
2. Eddy G and Poinern J (2014) A Laboratory Course in Nanoscience and Nanotechnology by
CRC Press
Authors, book title, year of publication, edition number, press, place
Mode of Evaluation: CAT / Assignments / FAT
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 137


Course code Course title L T P J C
BIY1020 Vaccinology 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Demonstrate the concepts of vaccines and their mechanisms
2. Outline the up-to-date knowledge, skills and expertise on new and current vaccines and
immunization programs
3. Examine the current and emerging challenges to immunization

Expected Course Outcome:


1. Recall the historical background of the most critical vaccines
2. Illustrate the immunological and epidemiological mechanisms of vaccine action
3. Summarize the infectious diseases and their vaccines
4. Distinguish the advantages and disadvantages of current vaccines
5. Examine the challenges in the development of new vaccines
6. Justify the use of current vaccines and reflect upon the challenges and opportunities of new
vaccine strategies

Student Learning Outcomes (SLO): 2,5,11


2. Having a clear understanding of the subject related concepts and contemporary issues
5. Having design thinking capability
11. Having an interest in lifelong learning

Module:1 Overview of Vaccination 5 hours


Concept of vaccines, vaccination against infectious disease, Immunization and eradicating
infectious diseases; Effectiveness of vaccines: efficacy and safety

Module:2 Vaccines and their types 6 hours


Classification of vaccines: conventional vaccines-inactivated or killed vaccines and live attenuated
vaccines, recombinant vaccines against viral diseases; Viral and recombinant vaccine production,
adjuvant in vaccine and their development

Module:3 DNA Vaccines 6 hours


DNA Vaccines and induction of immunity, factors influencing the immune response after genetic
vaccination-method of plasmid delivery, a dose of injected DNA

Module:4 Chimeric DNA Vaccines 6 hours


Antigenic form of the expressed protein, cocktail DNA vaccines and co-stimulatory molecules,
immuno-stimulating sequences

Module:5 Novel Genetic vaccines 6 hours


Multigene vaccines, Suicidal DNA Vaccine, DISC virus vaccines, Expression library
immunization

Module:6 Marker vaccines and edible vaccines 6 hours


Pseudorabies virus DIVA vaccines, classical swine fever virus DIVA vaccines, bovine viral

M.Sc Intg Biotechnology (5yr.) Page 138


diarrhea virus (BVDV) DIIA vaccines, DIVA vaccines in disease eradication and prospects for
human DIVA vaccines. Edible vaccines vis-à-vis mucosal and systematic immunity, working
principles of edible vaccines, current status of edible vaccines for infectious diseases, issues of
concern in developing a feasible edible vaccine

Module:7 IAP – Immunization 5 hours


Immunization, Indian Academy of Pediatrics – Recommendations, Guidelines, Immunization
schedule

Module:8 Contemporary issues: 5 hours


Hospital/Industry expert lectures

Total Lecture hours: 45 hours

Text Book(s)
1. John W, Morrow W, Sheikh NA, Schmidt CS and Davies DH (2012) Vaccinology: principles
and practice Wiley Blackwell
2. Karstak E (2010) Modern Vaccinology Springer US
Reference Books
1. Barrett A (2015) Vaccinology: an essential guide Wiley Blackwell
Mode of Evaluation: CAT / Assignments / FAT
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No.46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 139


Course code Course title L T P J C
BIY1021 Epidemiology 2 0 0 4 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Relate epidemiology and biostatistics in disease control and the improvement of human health
2. Demonstrate a basic understanding of epidemiologic methods and study design
3. Combine appropriate epidemiological concepts and statistical methods

Expected Course Outcome:


1. Summarize the use of epidemiology in the evaluation of screening process
2. Analyze the impact of epidemiology on national and local policies
3. Describe the influence of epidemiology on ethical and professional issues
4. Outline the epidemiology of infectious and non-infectious diseases, problem-solving skills and
other concepts
5. Evaluate study design, bias, errors and causal inference in epidemiologic studies
6. Choose disciplines in research or internship activities in the field of epidemiology

Student Learning Outcomes (SLO): 2,10,18


2. Having a clear understanding of the subject related concepts and contemporary issues
10. Having a clear understanding of professional and ethical responsibility
18. Having critical thinking and innovative skills

Module:1 What is epidemiology? 5 hours


Pioneers in epidemiology. The nature and scope of biological, social, and ecological science and
of epidemiological variables and outcomes. Epidemiology is a science and practice. Concepts of
Disease and health problem: interdependence of clinical medicine and epidemiology

Module:2 Study Design 5 hours


Incidence studies (Incidence studies / Incidence case-control studies ) Prevalence studies
(Prevalence studies / Prevalence case-control studies ) complex study designs ( Other axes of
classification/ Continuous outcome measures / Ecologic and multilevel studies )

Module:3 Study Design Issues 5 hours


Precision (Basic statistics / Sample size calculation and power) Validity (Confounding/ Selection
bias /information bias)Effect modification(Concepts of interaction/ Additive and multiplicative
models /Joint effects )

Module:4 Conducting a Study 5 hours


Measurement of exposure and health status ( Exposure/Health status ) Cohort studies (Defining
the source / population and risk period/Measuring exposure/Follow-up) Case-control studies
(Defining the source population and risk period/Selection of cases/Selection of controls/Measuring
exposure) Prevalence studies (Defining the source / population/ Measuring health status/
Measuring exposure)

M.Sc Intg Biotechnology (5yr.) Page 140


Module:5 Analysis and interpretation of studies 5 hours
Data analysis (Basic principles/Basic analyses/Controlling for Confounding) Interpretation
(Appraisal of a single study/ Appraisal of all of the available evidence) Meta-analysis.

Module:6 Epidemiology of communicable disease and 2 hours


prevention
Influenza, Tuberculosis, Ebola. Vaccines and therapeutics.

Module:7 Epidemiology of non-communicable disease 2 hours


and prevention
Coronary heart disease, diabetes and lung cancer. Vaccines and therapeutics.

Module:8 Contemporary topics 1 hours

Total Lecture hours: 30 hours


Text Book(s)
1. Rothman KJ, Lash TL, Greenland S (2012) Modern Epidemiology, Wolters Kluwer Health-
Lippincott Williams and Wilkins Publishers.
Reference Books
1. Szklo M, Nieto J (2014) Epidemiology: Beyond the Basics, 3rd Edition Burlington,
Massachusetts: Jones & Bartlett Learning
2. Gordis L (2014) Epidemiology: with STUDENT CONSULT, 5th Edition Elsevier Saunders.
3. Park, K. (2015). Textbook of Preventive and Social Medicine, 23rd Edition, Banarsidas
Bhanot Publishers.
Authors, book title, year of publication, edition number, press, place
Project : “J” component
Mode of Evaluation: CAT / Assignments / FAT
Mode of evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 24-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 141


Course code Course title L T P J C
BIY1022 Nutraceuticals 3 0 0 0 3
Pre-requisite None Syllabus version
v..1
Course Objectives:
1. Explain the nutraceutical constituents in different foods and their role in human health
2. Demonstrate the health benefits of functional foods
3. Illustrate the technologies and processing procedures used to extract functional ingredients from
a natural source

Expected Course Outcome:


1. Outline the basis of various phytochemical compounds in maintaining normal physiological
function
2. Build awareness about the latest investigations on nutraceutical and functional food
components
3. Identify the different sources of nutraceuticals, their extraction methods, and their metabolism
4. Discover various food products that are used as nutraceuticals in making functional foods
5. Relate the role of various nutraceuticals in combating major health problems such as diabetes,
obesity, cardiovascular diseases, cancer, and osteoporosis
6. Extend the safety and efficacy of functional foods and regulatory issues

Student Learning Outcomes (SLO): 2, 11, 14


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning
14. Having an ability to design and conduct experiments, as well as to analyze and interpret data

Module:1 Introduction to nutraceuticals and functional 4 hours


foods
Definition, the concept of nutraceuticals, classification of nutraceuticals, dietary supplements,
fortified foods, functional foods, scope involved in the industry- Indian and global scenario.

Module:2 Importance of nutraceuticals 6 hours


The food pyramid, nutritional assessment, recommended dietary intake, glycemic index, basal
metabolic rate, nutraceuticals in fruits, vegetables and grains with health benefits, nutraceuticals
about sports and exercise.

Module:3 Extraction, analysis, physiology, processing of 6 hours


nutraceuticals
Nutraceutical extraction and isolation; nutraceutical analysis; absorption, disposition, metabolism,
and elimination of nutraceuticals.

Module:4 Nutraceuticals of plant and animal origin 7 hours


Phytochemicals as nutraceuticals- sources and applications in preventive medicine; animal
metabolites- sources and applications in preventive medicine; protein and peptide-based
nutraceuticals, lipid‐based nutraceuticals.

M.Sc Intg Biotechnology (5yr.) Page 142


Module:5 Microbial and marine nutraceuticals 7 hours

Concept, applications of prebiotics and probiotics as nutraceutical agents, microbial


nutraceuticals and their applications, marine nutraceuticals and their applications.

Module:6 Nutraceuticals in disease prevention 8 hours

Nutraceuticals for- cardiovascular health, HIV and cancer risk reduction, bone and joint health,
diabetes, hypertension, hypercholesterolemia, immune system, oxidative stress, cognitive
function, anti-aging, maternal and infant health, gut health, reproductive health.

Module:7 Marketing, regulation, health claims, clinical 4 hours


trials
Assessment of safety and efficacy of functional foods and ingredients, regulatory issues and health
claims, use of animal models, and pre-clinical and clinical trials involved.

Module:8 Contemporary topics: Lecture by experts 3 hours

Total Lecture hours: 45 hours


Text Book(s)
1. Bagchi D, Preuss HG, Swaroop A (2015) Nutraceuticals and Functional Foods in Human
Health and Disease Prevention, CRC Press.
Reference Books
1. Mine Y, Li-Chan E, and Jiang B (2010) Bioactive Proteins and Peptides as Functional Foods
and Nutraceuticals, Blackwell Publishing Ltd.
2 Hurst WF (2010) Methods of analysis for functional foods and nutraceuticals. Taylor &
Francis Group, CRC Press.
Mode of Evaluation: CAT / Assignments / FAT
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 143


Course code Course title L T P J C
BIY1023 Nutrition and Health 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Outline an overview on general aspects of nutrition, health, and food intake
2. Identify different types of foods, nutritive values, and nutritional disorders
3. Relate the assessment of nutrition status based on different criteria/indices

Expected Course Outcome:


1. Recall the influence of food on human health
2. Identify different types of functional foods
3. Summarize the metabolism of various food types
4. Formulate healthy diets to prevent lifestyle diseases
5. Construct a balanced diet based on the knowledge gained from the course

Student Learning Outcomes (SLO): 2,11,12


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning
12. Having adaptive thinking and adaptability

Module:1 Introduction to health 4 hours


Importance and value of health; Dimensions involved- physical, cognitive, cultural, and
environmental.

Module:2 Food Choices 4 hours


Food sources- cereals, pulses, vegetables, fruits, confectionery, meat, egg, seafood, dairy,
and
beverages. Case Study- Evaluating information from various sources- media, supermarkets,
internet

Module:3 Nutrients Vs. Health 4 hours


Categories of nutrients- carbohydrates, proteins, lipids, vitamins, minerals, and bioactive
components; Process of digestion and absorption; factors influencing the process. Case
Study- Effect of processing on the nutrients

Module:4 Food to fuel 4 hours


Extraction of energy from nutrients; biosynthesis, and storage of nutrients. Case Study- energy
turn over during fasting and feasting

Module:5 Fluids and health 4 hours


Importance of electrolyte balance; sources of electrolytes. Case study- Delicate balance between
water and electrolytes.

Module:6 Complementary nutrition 4 hours

M.Sc Intg Biotechnology (5yr.) Page 144


Dietary supplements; functional foods; alternative medicines and health. Case study- Symbiotic
role in health.

Module:7 Assessment of nutritional status 4 hours


Anthropometric measurements, biochemical tests, molecular markers, clinical observations,
dietary assessment, others- personal family history, socio-economic, occupational conditions.
Case study-facts and fallacies involved in obesity assessment

Module:8 Contemporary issues: 2 hours


Lecture by industrial experts

Total Lecture hours: 30 hours

Text Book(s)
1. Paul Insel , Don Ross, Kimberley McMahon, Melissa Bernstein 4rth edition. 2012.
Discovering Nutrition. Jones and Bartlett Publishers, Inc;
Reference Books
1. Catherine Sanderson and Mark Zelman. 2015. E s s e n t I a l H e a l t h, 1 s t E d I t I o n .G - W
publIshers
Mode of Evaluation: CAT / AssignmentS / FAT /
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 145


Course code Course title L T P J C
BIY1024 Computational Biochemistry and Biomedicine 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Outline the modern computational methods for handling bio-molecules
2. Demonstrate the principle of Biomolecular interactions and their respective mechanism
3. Solve some biochemical problems using computer-assisted methods

Expected Course Outcome:


1. Outline significant biotransformation reactions and the applications of computer technology in
biochemistry
2. Explain the underlying mechanism of biomolecular interactions, as well as protein-carbohydrate
interactions
3. Demonstrate the mechanism of protein-protein interactions and protein-nucleic acid interactions
4. Solve problems using analytical thinking skills in performing molecular modeling towards the
prediction of protein function
5. Relate the terminology of biochemistry and pathogenesis with various genetic disorders
6. Formulate the concept of in silico mutational and drug discovery studies

Student Learning Outcomes (SLO): 2,17,18


2. Having a clear understanding of the subject related concepts and contemporary issues
17.Having an ability to use techniques, skills and modern engineering tools necessary for
engineering practice
18. Having critical thinking and innovative skills

Module:1 The computing of Physical principles 6 hours


Significant biotransformation reactions in a biological system, Energy contribution and distance of
non-covalent interactions in biomolecules, computation of intra-molecular and inter-molecular
interactions

Module 2 Biomolecular Interaction I 6 hours


Binding of Oxygen to heme, Mechanism of Allosteric change, Protein-Carbohydrate Interaction-
Mechanism of Lysozyme action, Mechanism, and Regulation of Multienzyme complex.

Module:3 Biomolecular Interaction II 6 hours


Protein-Protein and Protein- Nucleic Acid Interaction: Mechanism of chymotrypsin action, DNA
Ligase action, Intron-Splicing mechanism.

Module:4 Discovering Biomolecular Mechanisms 6 hours


Deriving Biological Function of Genome Information with sequence and structure Analysis-
Reliable and Specific Protein Function Prediction by Combining Homology with Genomic(s)
context - Clues from Three-Dimensional Structure Analysis and Molecular Modeling - Prediction
of Protein Function, Obtaining, viewing and analyzing structural data.

Module:5 Biochemistry and Medicine 6 hours


The major cause of the diseases, Metabolic basis of disease –An aberration of lipid metabolism -

M.Sc Intg Biotechnology (5yr.) Page 146


Inborn errors of metabolism - Mechanism - Neonatal Aminoacidopathies - Phenylketonuria -
Online Mendelian Inheritance in Man (OMIM).

Module:6 Pathogenesis 6 hours


Genetic basis of disease- - 3 significant classes of Genetic Disorders -Chromosomal, Monogenic,
Multifactorial - Genetic Variation - Types of mutation - Molecular Consequences of Mutation -
Hemoglobin Disorders - Molecular basis of Diabetes & Cystic Fibrosis.

Module:7 In silico mutational studies and Drug design 6 hours


Sequence-based approach, structure-based approach, diverse models, Drug resistance mechanism
– SBDD – active site-directed drug design -pharmacogenomics.

Module:8 Contemporary issues 3 hours


Industry-related / Invited talk

Total Lecture hours: 45 hours


Text Book(s)
1. Moran LA, Horton RA, Scrimgeour G, and Perry M (2011) Principles of Biochemistry, 5th
Edition. ISBN-10: 0321707338, Publisher: Prentice-Hall.
Reference Books
1. Muppalaneni NB and Gunjan VK (2015) Computational Intelligence Techniques for
Comparative Genomics, Springer Singapore
Mode of Evaluation: CAT / Digital-Assignment / FAT
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 147


Course code Course title L T P J C
BIY 1025 Plant Biology 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Recall the concepts central to the study of plant science
2. Apply a comprehensive exposure to the subject of plant physiology
3. Summarize cutting edge technologies employed in contemporary plant biology

Expected Course Outcome:


1. Demonstrate the basics of plant biology and the organization of plants
2. Relate physiological mechanisms of plant growth, function, and development
3. Translate the fundamental concepts of plant physiology
4. Outline the plant metabolism
5. Illustrate mineral nutrition in plants
6. Extend a broad overview of the geographical distribution of plants

Student Learning Outcomes (SLO): 2,11


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning

Module:1 Water and transpiration 6 hours


Water relations - diffusion, permeability, osmosis, water potential, and its components. Absorption
of water - apoplast, and symplast. Mechanism - passive and active. Transpiration - types and
significance. Stomatal mechanisms.

Module:2 Plant Growth hormones 6 hours


Plant growth regulators (auxins, gibberellins, cytokinins, ethylene, and abscisic acid) - mechanism
of action and Practical application. Mineral nutrition - macro and micronutrients and deficiency
symptoms.

Module:3 Plant Physiology 6 hours


Photomorphogenesis - photoperiodism, vernalization, phytochromes. Dormancy (seed and bud),
seed viability, and germination.

Module:4 Photosynthesis 6 hours


Plant pigment system: Absorption and action spectrum – Phosphorescence and fluorescence. Light
reaction - Pathways of carbon fixation C3, C4 subtypes, and CAM.

Module:5 Respiration 5 hours


Aerobic - Glycolysis, Krebs Cycle, electron transport system, oxidative phosphorylation,
respiratory quotient.

Module:6 Nitrogen assimilation 6 hours


Role of Nitrogen and sources, Conversion of nitrate to ammonia - assimilation of ammonia.

M.Sc Intg Biotechnology (5yr.) Page 148


Molecular nitrogen, mechanism of biological nitrogen fixation.

Module:7 Phytogeography 6 hours


Principles of Phytogeography, Phytogeographical regions of India. Vegetational types in Tamil
Nadu. A detailed study of the vegetation types - Evergreen, deciduous, scrub jungle, and
mangrove forest.

Module:8 Contemporary issues 4 hours

Total Lecture hours: 45 hours


Text Book(s)
1. Jain VK (2014) Fundamentals of Plant Physiology 19 edition, S Chand publishing
Reference Books
1 Kochhar SL and Gujral SK (2011) Comprehensive Practical Plant Physiology Lakshmi
publications
Mode of Evaluation: CAT / Assignments/ FAT
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 149


Course code Course title L T P J C
BIY1026 Forensic Science 3 0 0 0 3
Pre-requisite + 2 Biology Syllabus version
v .1
Course Objectives:
1. Demonstrate the methods, principles, and applications of forensic science in
criminal investigations
2. Improve basic scientific principles of forensic science applied in solving criminal cases
3. Outline the concepts of forensic sciences such as crime scene investigation, forensic
photography, digital forensics, ballistics, fingerprinting, court and police organizational structures,
and forensic DNA analysis.

Expected Course Outcome:


1. Explain the basics of forensic science
2. Assess the organizational structure and procedures within forensic science
3. Illustrate the concepts, principles, and significance of impression evidence.
4. Summarize the practices behind collection, analysis, and interpretation of evidence.
5. Demonstrate the capabilities, in theory, laboratory techniques in analyzing body fluids, and
other evidence analysis.

Student Learning Outcomes (SLO): 2, 7


2. Having a clear understanding of the subject related concepts and contemporary issues
7. Having computational thinking (Ability to translate vast data into abstract concepts and to
understand database reasoning)
Module:1 Historical Background of Forensic Science 6 hours
Past and present scenarios. Forensic Science Laboratories, Experts and Divisions, Organizational
set up of Forensic Science Laboratories at central and state level. Body Farm.

Module:2 Crime Scene Profiling 6 hours


Crime Scene: Role of Investigator in evaluation, evidence collection, protection, and
documentation of crime scene. Sketching technique, types of Sketches, Searching Methods.

Module:3 Evidence and Documentation 7 hours


Impression based evidence analysis: Fingerprint Types and techniques, Modus Operandi Sheet
preparation. Fingerprint use in Biometric system .Tool markings, Tire, Footwear markings. Bite-
mark analysis, Fibers, and polymers. Handwriting analysis, Question documents.

Module:4 Ballistics: 6 hours


Types, application, forensic ballistic procedures (internal, external, and terminal ballistics) and
identification of firearms, Available ballistic databases.

Module:5 Blood, Toxicology, Pathology Profiling in 6 hours


Forensic Evaluation
Serological analysis (blood, saliva, semen, etc.), Blood Splatter- Origin of impact study Abusive
Drug types, Poisons, and analysis. DNA fingerprinting in Forensics: Forensic Medicine DNA

M.Sc Intg Biotechnology (5yr.) Page 150


fingerprinting: RFLP and PCR. Forensic pathology: Time of death analysis; Entomology and
pathology in death analysis.

Module:6 Forensic Photography and Digital Criminalistics 6 hours


The principle application of SLR-camera, Digital camera, CCTV in forensic analysis, Forensic
Facial Reconstruction. Cyber Forensics: Computer, Mobile phone data analysis, Ethical
hacking, drones. Deception detection tests (DDT): polygraph, narco-analysis, and brain-
mapping

Module:7 Forensic and Legal proceedings 6 hours


Forensic and Legal proceedings in India: Legal proceedings in forensics, CSI in India: problems
and perspectives.

Module:8 Case studies & Expert Guest lectures 2 hours

Total Lecture hours: 45 hours

Text Book(s)
1. Criminalistics: An Introduction to Forensic Science, 11/E, Richard Saferstein, ISBN-
10:0133458822 • ISBN-13: 9780133458824, 2015 • Prentice Hall.
Reference Books
1. Forensic DNA Typing, 2nd Edition, Biology, Technology, and Genetics of STR Markers, J
Butler, 2005, Imprint: Academic Press, eBook ISBN: 9780080470610, Print Book ISBN:
9780121479527, Pages: 688

2. Introduction to Criminalistics: The Foundation of Forensic Science, 2009, by Barry A.J.


Fisher, William J. Tilstone, Catherine Woytowicz, Elsevier Academic Press USA, 2009.

3. Hendry Lee’s Crime Scene Handbook, H.C. Lee, T. Palmbach, M.T. Miller (Academic
Press), Published: June 2001, ISBN: 978-0-12-440830-2
Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.

Recommended by Board of Studies 03-08-2017


Approved by Academic Council No. 46 Date 24.08-2017

M.Sc Intg Biotechnology (5yr.) Page 151


Course code Course title L T P J C
BIY2004 Biophysics 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Analyze physics concepts applied in biology
2. Deduce importance of molecular machines, membrane logistics, and macromolecular transition
3. Utilize various biophysical techniques and their applications

Expected Course Outcome:


1. Recall the molecular forces and their interactions and various physical laws
2. Identify the various types of kinetics and models involved in cell dynamics
3. Determine the applied aspects of biophysics through membrane logistics, and networks
4. Recognize macromolecular transition
5. Evaluate the function of molecular machines.
6. Apply the principles and applications of various biophysical methods/techniques

Student Learning Outcomes (SLO):2,5,18


2. Having a clear understanding of the subject related concepts and contemporary issues
5. Having design thinking capability
18. Having critical thinking and innovative skills

Module:1 Chemical and Physical setup of the cell 6 hours


Intra and intermolecular forces, chemical bonds, bond length, bond angle, dipole moment,
electrostatic interactions and Hydrogen bonding interactions, small molecules, and
macromolecules.

Module 2 Mathematical Biophysics 6 hours


Boltzmann Distribution, Fick's law, Graham's law, Gibbs free energy, Reynolds number, Fokker–
Planck equation, Gibbs–Donnan effect, Nernst equation

Module:3 Cell functioning models 6 hours


Michaelis-Menten kinetics, Goldbeter-Koshland kinetics, Hodgkin–Huxley model, Vector field
models, Bifurcation theory, Deterministic and Stochastic models

Module:4 Methods in Structural Biology 6 hours


Mass Spectrometer, NMR, Circular dichroism, XRD, FTIR, SEM and TEM

Module:5 Macromolecular transition 6 hours


Polymer elasticity and stretching, Effects of physical factors on Polymers, Allostery

Module:6 Molecular machines and enzymes 6 hours


Enzyme saturation kinetics, Catalytic transition, Energy landscape, Cytoskeletal-rotary
polymerization -rotary motors

M.Sc Intg Biotechnology (5yr.) Page 152


Module:7 Membrane logistics and Bioelectrical 7 hours
networks
Osmotic effects, Membrane potential, Ion pumping, Chemiosmotic mechanism in mitochondria.
Action potential, Ohmic conductance, Voltage gating, Neuromuscular junction

Module:8 Contemporary Issues: 2 hours


Industry expert lectures on contemporary issues

Total Lecture hours: 45 hours

Text Book(s)
1. Nelson P (2013) Biological Physics with New Art. First edition, MacMillan Higher
Education.
Reference Books
1. Buxbaum E (2011) Biophysical Chemistry of Proteins: An Introduction to Laboratory
Methods, Springer

Mode of Evaluation: CAT / Assignment / Quiz / FAT


Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 153


Course code Course title L T P J C
BIY2005 Advanced Biochemistry 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Recall the structure, composition, and functions of various biomolecules.
2. Demonstrate the properties of biomolecules involved in various metabolic pathways
3. Extend the significance of these biomolecules to solve biotechnological problems

Expected Course Outcome:


1. Discuss the structure of glycans, membrane lipids, and proteoglycans
2. Summarize the structure of glycosaminoglycans and bacterial polysaccharides
3. Compare the biological functions of macromolecules, amino acids, and protein
4. Elaborate the higher-order organization of proteins and function
5. Relate the organization and functions of biomembranes
6. Illustrate the transport of vital molecules across the membrane
7. Assess the significance of redox reactions in cellular metabolism and the importance of
bioenergetics

Student Learning Outcomes (SLO): 2, 11


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning

Module:1 Carbohydrates 6 hours


Classification, Stereochemistry, N-Glycans, O-Glycans, Glycosphingolipids, Glycophospholipid
Anchors, Proteoglycans

Module:2 Glycobiology 6 hours


Glycosaminoglycans, Classes of Golgi-derived glycans, Sialic acids, Bacterial polysaccharides

Module:3 Amino acids 6 hours


Types of amino acids. Metabolism of phenylalanine, tyrosine, tryptophan, and sulfur-containing
amino acids, inborn errors of amino acids metabolism.

Module:4 Protein Science 6 hours


Primary, secondary, tertiary, and quaternary structures of protein, protein folding and dynamics,
molecular chaperones. Proteins architecture and functions.

Module:5 Bio-membranes & cellular transport 7 hours


Tri-glycerols, phospholipids, steroids, membrane lipids, artificial membranes (vesicles and
black). Structural receptors, signal transduction, channels, and transporters. Physicochemical
properties of nucleic acids and their polymers.

Module:6 Metabolic diversity 6 hours


Energy from the oxidation of inorganic electron donors, Iron oxidation, Methanotrophy and

M.Sc Intg Biotechnology (5yr.) Page 154


methylotrophy, Nitrate and sulfate reduction, Acetogenesis, Methanogenesis, Fermentation-
energetics, and redox constraints, Examples: Calvin cycle, Reverse citric cycle.

Module:7 Bioenergetics 6 hours


Principles of thermodynamics, Bioenergetics, and oxidative phosphorylation, Mitochondrial
bioenergetics, Electron transport complexes: Complex I (NADH-Q reductase), Complex II
(Succinate-Q reductase), Complex III (ubiquinol-cytochrome C reductase), Complex IV
(cytochrome c Oxidase).

Module:8 Contemporary Issues 2 hours


Lecture by industrial expert

Total Lecture hours: 45 hours

Text Book(s)
1. Singh SP (2015) Textbook of Biochemistry, Sixth Edition, CBS Publishers.

2. Lapsley M W, Day A and Ayling R (2014) Clinical Biochemistry: Metabolic and Clinical
Aspects. Churchill Livingstone, UK
Reference Books
1. Berg JM, Tymoczko JL, Gatto GJ, Jr Stryer L (2015) Biochemistry, Eighth Edition,
Macmillan learning.

2. Nelson, DL and Cox M M (2012)


Lehninger’s Principles of Biochemistry, Sixth Edition, WH Freeman, New York.
Mode of Evaluation: CAT / Assignments / FAT
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 155


Course code Course title L T P J C
BIY2006 Clinical Biochemistry 2 0 0 4 3
Pre-requisite None Syllabus version
v.1
Course Objectives:
1. The purpose of this course is to relate the safety, quality assurance and quality control in
Clinical Biochemistry
2. Compare the changes in the levels of biochemical analytes under normal and abnormal
conditions and to correlate test results with patient conditions
3. Analyze the pathophysiological processes and their manifestations that determine the health and
disease states of the human body

Expected Course Outcome:


1. Perceive factors that affect the analytical results of a specimen from its collection to processing
stage
2. Deduce the functioning and dynamics of a clinical laboratory
3. Outline fundamental scientific principles underpinning laboratory medicine and core cellular
and molecular processes underlying health and disease
4. Apply logical, systemic thinking and high-level critical analysis to solve problems using
diagnostic techniques and methodologies in the chosen areas of clinical laboratory specialization
5. Build advanced knowledge of core clinical specialty disciplines such as laboratory medicine
and advanced management skills
6. Relate pathophysiology of disease in the study of body functions
7. Summarize recent updates on laboratory diagnostic methods

Student Learning Outcomes (SLO): 2,11,18


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning
18.Having critical thinking and innovative skills

Module:1 Basic Concepts of Clinical Biochemistry 4 hours


Methods for collection, handling, and analysis of clinical samples. Quality control in biochemical
analysis: commonly measured analytes and normal values.

Module:2 Diseases Related to Carbohydrate 4 hours


Metabolism
Blood Glucose regulation; hypo and hyperglycemia, Diabetes mellitus-types, clinical features,
GTT.

Module:3 Inborn errors of amino acid metabolism 4 hours


Aminoacids-Cystinuria, phenylketonuria, alkaptonuria, albinism, and tyrosinemia.

Module:4 Lipids and Lipoproteins 4 hours


Cholesterol, plasma lipoproteins-structure, types, and functions, hyper and hyperlipoproteinemia,
risk factors for atherosclerosis and fatty liver.

M.Sc Intg Biotechnology (5yr.) Page 156


Module:5 Liver function tests 4 hours
Metabolism of bilirubin, jaundice-types, clinical features, and test for bile pigments in blood and
urine.

Module:6 Kidney function tests 4 hours


Clearance principle, Clearance tests- urea, creatinine, and insulin.

Module:7 Gastric function tests 4 hours


The stimulus for the secretion of gastric juice, gastric juice – constituents and composition. Gastric
sampling, gastric function tests using a test meal, tubeless gastric analysis, and analysis of gastric
contents.

Module:8 Recent topics in clinical biochemistry 2 hours


Lectures by doctors

Total Lecture hours: 30 hours


Text Book(s)
1. Chatterjee and Shinde (2012) Textbook of Medical Biochemistry. Published by Jaypee
Medical Publishers, New Delhi
Reference Books
1. Devlin T M (2010) Text Book of Biochemistry with clinical correlations. 7th edition, Wiley
Liss, New York.
2. BaynesJ W and Dominiczak M (2014) Medical Biochemistry. Fourth Edition, Saunders
Elsevier.
Project: ‘J’ Component
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2018

M.Sc Intg Biotechnology (5yr.) Page 157


Course code Course title L T P J C
BIY2007 Developmental Biology 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Outline the basic principles and different model systems used in developmental biology.
2. Infer the establishment of the body plan invertebrates and their corresponding cellular and
genetic mechanisms
3. Assess modern implications of developmental biology by imparting knowledge regarding gene
knockout animals, microarray and teratogens

Expected Course Outcome:


1. Explain the contributions of sperm and egg to the zygote and structure informing function
2. Apply critical thinking and logical analysis in the assessment of embryonic developmental
events including germ layer development, extra-embryonic membranes, embryo implantation, and
significance of placental formation.
3. Determine when cells become specified, fate determined, and initiate organ development.
4. Utilize the principles and techniques of molecular biology to identify the genes involved in
embryo development
5. Translate the knowledge on cellular mechanisms of development to identify the genetic and
molecular elements involved in the development of an embryo
6. Outline principles of sex determination occur during embryo development

Student Learning Outcomes (SLO): 2, 18


2. Having a clear understanding of the subject related concepts and contemporary issues
18.Having critical thinking and innovative skills

Module:1 Gametes structure and fertilization 6 hours


Structure of sperm and egg. Egg contents and membrane structure concerning fertilization and
embryogenesis. Gametes binding and recognition in mammals, gamete fusion, and the prevention
of polyspermy. Events that occur in external and internal fertilization with one example up to
embryo formation.

Module:2 Differential gene expression and 6 hours


embryogenesis
Different methods of differential gene expression that occur during embryo development.
Mechanism of cellular differentiation. Different types of cell to cell communication in
embryogenesis

Module:3 Techniques to study embryo development 7 hours


I am using mutants, microarray, Transgenic, and knockout mice to study the role played by a gene
in embryo development.

Module:4 Cleavage & Gastrulation 6 hours


Cleavage: Characteristics of cleavage, the role played by Cyclins and CDKs. Patterns of
embryonic cleavage in Frog, drosophila, and mammals. Gastrulation: Events that occur in the
embryo during the transition from cleavage to gastrulation. Mid gastrula phase, cell movement,

M.Sc Intg Biotechnology (5yr.) Page 158


asymmetry in egg, cell differentiation, and gastrula formation. Ectoderm, Mesoderm, and
Endoderm.

Module:5 Cellular differentiation and organogenesis 6 hours


Mechanism of differentiation and organogenesis, With the example of Neurulation, limb, and Eye
development.

Module:6 Axis specification 6 hours


Genetics of axis specification with the mechanism. Establishment of left-right body axis with
one example.

Module:7 Sex determination and role of environment on 6 hours


embryogenesis
Genetic and environmental sex determination. Role of sex chromosomes and genes involved in
sex determination in mammals. Ethics in the pre-natal sex determination of humans. Regulation of
normal development by the environment, disruption of normal development by teratogens.

Module:8 Contemporary Topics: Lectures by experts 2 hours

Total Lecture hours: 45 hours

Text Book(s)
1. Gilbert S F (2016) Developmental Biology, Illustrated edition, Sinauer Associates.
Reference Books
1. Hillis S and Berenbaum H (2014) LIFE: The Science of Biology, Tenth Edition. Sinauer
Associates Inc

Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.

Recommended by Board of Studies 03-08-2017


Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 159


Course code Course title L T P J C
BIY2008 Biological Databases 2 0 2 4 4
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Appraise different formats and data-types of molecular sequence and structures
2. Demonstrate the significance of resources before starting the research
3. Interpret biological data in a meaningful way complimentary to biological research

Expected Course Outcome:


1. Identify data resources and fetch the right content from open-source biology databases
2. Utilize the appropriate database and allied tools to solve the puzzles in biological research
3. Analyze nucleotide and protein data from various databases
4. Build adequate skills to challenge the upcoming big-data content analysis and interpretation
5. Examine the data from biology and perform a pattern search
6. Design database to slice and dice the biological data from different biological data resources
and bridge the ontological information in research.

Student Learning Outcomes (SLO): 2,20


2. Having a clear understanding of the subject related concepts and contemporary issues
20. Having a good digital footprint

Module:1 Important contributions 4 hours


Submission of sequences to the database, sequence formats, conversion of one sequence into
another.

Module:2 Regulatory databases 4 hours


Regulatory sequence databases-TRANSFAC, the exon-intron database (EID).

Module:3 Secondary protein databases 4 hours

Pfam-protein Family, PRINTS & Blocks, ProDom.

Module:4 Macromolecular databases 4 hours


MMDB- Molecular Modeling Database, Protein Databank in Europe (PDBe), Mod Base,
PDBsum.

Module:5 Genome Browser 4 hours


Types of genome browsers, ENSEMBL, UCSC.

Module:6 Mutation databases 4 hours


HGMD, Pathway Database-Kyoto Encyclopedia of Genes and Genomes(KEGG Database).

Module:7 Protein-protein and other molecular 4 hours


interactions

M.Sc Intg Biotechnology (5yr.) Page 160


STRING, Drug Bank, Therapeutic Target Database.

Module:8 Contemporary issues: Lecture by experts 2 hours

Total Lecture hours: 30 hours

Text Book(s)
1. Attwood TK and Parry-Smith DJ (2014) Introduction to bioinformatics, Pearson
Education.
Reference Books
1. Mount D (2014) Bioinformatics: Sequence and Genome Analysis, Cold Spring Harbor
Laboratory Press, New York.
2. Most of the topics will be covered using online resources
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
List of Challenging Experiments (Indicative)
1. Conversion of sequence from one database format to another using file 3 hours
format converter
2. Extraction of real matrices and identification of promoter motifs by 3 hours
TRANSFAC
3. Identification of protein domains using Pfam 3 hours
4. MMDB- Molecular Modeling Database 3 hours
5. Evaluation of comparative protein structure models by Mod Base 2 hours
6. Comparing genes and genomes with Ensembl 2 hours
7. Variation data in Ensembl 2 hours
8. Finding features that regulate genes – the Ensembl Regulatory Build 2 hours
9. Determining Protein Physico-Chemical Properties using PDBsum 2 hours
10 Analysis of inherited and complex disease using HGMD 2 hours
11 Understanding high-level functions and utilities of the biological 2 hours
systemKyotoEncyclopedia of Genes and Genomes
12 Reactions took from KEGG ENZYME and additional reactions taken from 2 hours
the metabolic pathway maps in KEGG PATHWAY using KEGG
REACTION
13 Visualization of protein-protein interaction using STRING 2 hours
Total Laboratory Hours 30 hours

Projects: ‘J’ Component

Mode of evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 161


Course code Course title L T P J C
BIY2010 Plant Biotechnology 2 0 2 4 4
Pre-requisite None Syllabus version
v. .1
Course Objectives:
1. Explain the developmental processes operating in plants
2. Demonstrate plant tissue culture methods
3. Analyze biotechnological tools for engineering plants in agriculture and industry

Expected Course Outcome:


1. Outline the importance and fundamentals of plant tissue culture
2. Summarize the applications of tissue culture
3. Design vectors for plant transformation
4. Create clean and green transformation protocols
5. Measure the suitability of transgenics to consumers, industrialists, and environment
6. Apply tissue culture techniques and get employed in a plant biotechnology-based industry

Student Learning Outcomes (SLO): 2, 14


2. Having a clear understanding of the subject related concepts and contemporary issues
14. Having an ability to design and conduct experiments, as well as to analyze and interpret data
Module:1 Plant Tissue Culture I 4 hours
Plant cell culture – history and importance; Explant, sterilization techniques, culture media, their
constituents, and culture types; Role of plant growth regulators in tissue culture

Module:2 Plant Tissue culture II 4 hours


Organogenesis; Somatic embryogenesis; Hardening; Somaclonal variation; Applications of tissue
culture

Module:3 Vector components for plant 4 hours


transformation
Selectable markers, reporter genes, promoters, terminators and expression cassettes;
Optimization of vector components; Gene silencing

Module:4 Indirect Plant transformation 4 hours


Agrobacterium-mediated gene transfer - Ti plasmid, the molecular mechanism of T-DNA
transfer and integration, binary, RNAi and Gateway vectors, advantages and disadvantages of
Agrobacterium-mediated gene transfer

Module:5 Direct Plant Transformation Methods 4 hours


Particle bombardment, protoplast fusion, electroporation, advantages and disadvantages of direct
gene transfer; Clean gene technology and plastid transformation

Module:6 Transgenic Plant Technology I 5 hours


Case studies on the production of genetically modified plants for herbicide tolerance, biotic and
biotic stress tolerance and improvement of quality traits

M.Sc Intg Biotechnology (5yr.) Page 162


Module:7 Transgenic Plant Technology II 3 hours
Molecular pharming; importance and risks of transgenes in the ecosystems; technology protection
systems

Module:8 Contemporary issues: 2 hours


Lecture by an Industrial Expert

Total Lecture hours: 30 hours

Text Book(s)
1. Adrian Slater, N W Scott, M Fowler, Plant Biotechnology: The Genetic Manipulation of
Plants, Second Edition, 2014, Oxford University Press.
2. M.K. Razdan. 2014. Introduction to Plant Tissue Culture. 2nd Edition, Oxford and IBH
Publishing Company, India.
Reference Books
1. Wang, Aiming, and Ma, Shengwu. 2014. Molecular Farming in Plants: Recent Advances and
Future Prospects. Springer, New York, USA.
2. Gamborg OL and Phillips GC. 2013. Plant Cell, Tissue, and Organ Culture: Fundamental
Methods. Springer-Verlag.
Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar
List of Challenging Experiments (Indicative)
1. Media preparation for plant cell culture 4 Hours
2. Preparation of media for bacterial culture 4 Hours
3. Sterilization techniques 2 Hours
4. Instruments required for plant cell culture 2 Hours
5. Explant isolation methods 2 Hours
6. Different methods of sterilization for explants 2 Hours
7. Callus induction 2 Hours
8. Co-culturing of Agrobacterium containing an engineered plasmid 2 Hours
9. Agrobacterium-mediated transformation 2 Hours
10 Screening of transformed plant cells with the help of a marker assay 2 Hours
11 Protoplast isolation and fusion techniques 2 Hours
12 Shoot induction 2 Hours
13 Root induction and Hardening 2 Hours
Total Laboratory Hours 30 hours
Project ‘J’ Component
Mode of evaluation: Assignments, Quiz, Continuous assessment tests and Final assessment test
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 163


Course code Course title L T P J C
BIY2012 Enzymology 2 0 2 4 4
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Relate basic knowledge of enzymology with its useful applications in health care,
Environment and industries
2. Illustrate enzyme kinetics and parameters of enzymatic reactions through a practical approach
3. Apply knowledge on mechanistic enzymology.

Expected Course Outcome:


1. Summarize structure, function, and properties of enzymes
2. Define rate equations for enzyme-catalyzed reaction and how key factors affect enzyme
reactions rates
3. Classify the types of enzyme inhibitions and their mechanisms
4. Evaluate enzyme activity and its regulation in maintaining cellular structure and function
5. Analyze enzyme mutations and their role in protein engineering
6. Solve industrial problems using enzymes

Student Learning Outcomes (SLO): 2,5,18


2. Having a clear understanding of the subject related concepts and contemporary issues
5. Having design thinking capability
18. Having critical thinking and innovative skills
Module:1 Introduction 4 hours
Importance of enzymes, the nature of the enzyme, functional organization of enzyme- domains,
(multi-enzyme complex); active site of enzyme- standard features.

Module:2 Enzyme classification and nomenclature 4 hours


IUBMB, Kinases, phosphatases, Oxido-reductases, transferases, hydrolases, lyases, isomerases
and ligases

Module:3 Kinetics 4 hours


Free energy, activation energy, enzyme-substrate complex, transition state, binding energy,
enzyme reaction coordinate diagram. Kinetics-. Michaelis – Menten kinetics; kinetic parameters-
Km, Vmax, Kcat; Lineweaver Burk plot, Factors affecting enzyme activity; Enzyme inhibition –
types of inhibition

Module:4 General mechanism of action 4 hours


Catalytic strategies- covalent, general acid-base, approximation, metal ions, protease, restriction
endonuclease, kinase, and phosphatase

Module:5 Regulation of enzyme activity 4 hours


Mechanisms of enzyme regulation in metabolism- - reversible covalent modification, allosteric
regulation, proteolytic cleavage, isozymes, compartmentalization

Module:6 Methods to obtain mutant enzymes with 4 hours

M.Sc Intg Biotechnology (5yr.) Page 164


desired features
Methods to induce mutations and screening in microorganisms, Site-directed mutagenesis.

Module:7 Application of enzymes 4 hours


Industrial processes, molecular biology, diagnostics and therapeutics

Module:8 Contemporary issues: 2 hours


Lecture by industrial expert
Total Hours 34 hours
Text Book(s)
1. Gray N, Calvin M, and Bhatia SC (2010) Enzymes Biotechnology CBS Publishers and
Distributors Pvt Limited Edition

2. Nelson, D.L., and Cox MM. (2012) Lehninger’s Principles of Biochemistry, Sixth Edition,
WH Freeman, New York.
Reference Books
1. Shanmugam S, Sathishkumar T, and Shanmugaprakash M (2012) Enzyme technology 2nd
edition IK international publishing House Pvt. Ltd

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar


List of Challenging Experiments (Indicative)
1. Determination of the activity of Enzymes: Protease, amylase, lipase 4 hours
2. Determination of the specific activity of alkaline phosphatase. 4 hours
3. Glucose estimation using glucose oxidase. 4 hours
4. Determination of Vmax and Km for a given enzyme 4 hours
5. Effect of pH on Enzyme activity - pH 2- 10 6. Effect of temperature on 4 hours
Enzyme activity (10- 800C)
6. Effect of Inhibitors (PMSF, EDTA, Iodoacetate) on enzyme activity 4 hours
7. Effect of Substrate concentration on enzyme 4 hours
Total Laboratory Hours 28 hours
Project: J component
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No.46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 165


Course code Molecular Endocrinology L T P J C
BIY 2013 3 0 0 0 3
Pre-requisite Molecular Biology Syllabus version
v. 1
Course Objectives:
1. Discuss different endocrine organs and hormones secreted by them
2. Illustrate the molecular mechanism of modulation of gene expression by steroid and non -
steroid hormones
3. Asses hormonal dysfunction leading to endocrine disorders and techniques used in molecular
endocrinology

Expected Course Outcome:


1. Compare the physiological role of hormones and the mechanism of regulation of hormone
levels in humans
2. Outline how steroid hormones along with its receptors interact with other proteins to regulate
gene expression
3. Summarize different signal transduction pathways regulated by non-steroid hormones leading to
differential gene expression
4. Determine the molecular reason behind endocrine disorders
5. Evaluate how environmental pollutants disturb the endocrine system
6. Apply the knowledge gained in this subject for researching the field of molecular biology and
molecular endocrinology

Student Learning Outcomes (SLO): 2,11


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning

Module:1 Basic principles 5 hours


Endocrine organs. Pituitary and hypothalamus as master glands. Characteristics of hormones and
types of hormones and their receptors.

Module:2 Mechanisms of hormone action and 6 hours


regulation
Negative and positive feedback effect with example. Hormone receptor down-regulation,
Desensitization of hormone receptor. Mechanism of hormone elimination from the system

Module:3 Extra cellular receptors 6 hours


Types of membrane receptors, its structure, and function: Extracellular domain, Transmembrane
domain, Intracellular domain; Role in signal transduction; G-protein linked receptors; Ion channel
linked receptor; Enzyme-linked receptor. Role of second messengers in signal transduction

Module:4 Steroid receptor 6 hours


Examples of Nuclear Receptors (NR). NR superfamily – structural organization of NR; domains
(N-terminal regulatory domain, DNA binding Domain, Hinge region, Ligand binding Domain, C-
terminal domain), hormone response elements, homodimers, and heterodimers. Transactivation
and Trans repressor Nuclear receptor co-activators, Nuclear receptor co-repressor and its role in
the regulation of gene expression

M.Sc Intg Biotechnology (5yr.) Page 166


Module:5 Hormones involved in Reproduction 6 hours
Role of estrogen in females and males. Lessons from ERKO mice. Androgen functions in males.
Lessons from ARKO mice.

Module:6 Endocrine disorders 6 hours


Molecular mechanism of hormone role in causing a) Cancer b) Diabetes c) reproductive system
malfunction and d) Obesity. Hormone, receptor mutations, and related diseases. Environment
pollutants as hormone analogues and their effect on human health

Module:7 Techniques used in Endocrinology 8 hours


Orphan receptors and methods to identify ligand for the orphan receptors. CHIP assay, ELISA,
RIA, Real-Time PCR, and Microarray.

Module:8 Contemporary issues: Lecture by industrial 2 hours


experts

Total Lecture hours: 45 hours

Text Book(s)
1. Bolander FF (2010) Molecular Endocrinology, 3rd edn Elsevier Academic Press

2. Kramer IM, (2015) Signal Transduction Third Edition, Academic press

Reference Books
1. Park-Sarge OK and Curry Jr TE (2010) Molecular Endocrinology: Methods and protocols
springer protocols
2. .Leonard F (2010) Molecular Biology of steroid and nuclear hormone receptors Birkhauser
Mode of Evaluation: Written examinations, Projects, and assignments
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No.46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 167


Course code Course title L T P J C
BIY2014 Aquatic Biotechnology 2 0 0 4 3
Pre-requisite None Syllabus version
v. .1
Course Objectives:
1. Explaining the evolution of marine biology.
2. Summarize aquatic habitats to acquire knowledge
3. Translate the significance of biotechnological implementations in marine and
aquatic sector

Expected Course Outcome:


1. Elaborate on the importance of marine and aquatic sector in day to day life
2. Outline how steroid hormones along with its receptors interact with other proteins to regulate
gene expression
3. Summarize different signal transduction pathways regulated by non-steroid hormones leading to
differential gene expression
4. Determine the molecular reason behind endocrine disorders
5. Evaluate how environmental pollutants disturb the endocrine system.
6. Outline various bioactive compounds isolated to aquatic systems

Student Learning Outcomes (SLO): 2,11,18


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning
18. Having critical thinking and innovative skills

Module:1 Introduction to marine and freshwater 4 hours


environments
History of Biotechnology, Importance of Fresh and Sea Waters - Abiotic and biotic factors of
aquatic environment - Food chain – Biological characters of aquatic habitats

Module:2 Aquatic resources 4 hours


Culturing of various aquatic living organisms - Fisheries potential of freshwater and salt waters.
Capture and culture fisheries

Module:3 Diseases in aquaculture 4 hours


World organization of Aquatic animal health listed diseases in aquaculture - pathogens, signs, and
epidemiology.

Module:4 Diagnosis of Diseases 4 hours


Conventional diagnostic methods, Antibody, and nucleic acids based diagnostic methods with
examples.

Module:5 Aquatic animal health management 4 hours


Antimicrobials and chemotherapeutics in aquaculture. Probiotics, Case studies, Vaccination and
disease control.

Module:6 Aquaculture food processing 4 hours

M.Sc Intg Biotechnology (5yr.) Page 168


Processing, chilling, freezing, and drying. Quality control in seafood processing:
Microbiological analysis — quality standards of seafood.

Module:7 Marine conservation 4 hours


Marine conservation – Threats to marine biodiversity, physical alternations of coastal habitats,
marine pollution action plan to conserve marine bio-resources, biofouling, bio-corrosion

Module:8 Contemporary issues: Expert lecture from 2 hours


Aquaculture Industry

Total Lecture hours: 30 hours

Text Book(s)
1. Lucas JS, and Paul C. (2012) Aquaculture: Farming aquatic animals and plants.
Southgate, eds. John Wiley & Sons.
Reference Books
1. Dunham, RA (2011) Aquaculture and fisheries biotechnology: genetic approaches. CABI,
Manual of Diagnostic Tests for Aquatic Animals, 7th edition 2015 Renouf Publishing
2.
Company Limited

Project: ‘J’ component

Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No.46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 169


Course code Course title L T P J C
BIY2015 Biological Spectroscopy 3 0 0 0 3
Pre-requisite BIY1001 Biochemistry Syllabus version
v. 1
Course Objectives:
1. Discuss spectroscopic techniques such as visible (VIS), fluorescence, near-infrared (NIR),
infrared (IR), Raman and nuclear magnetic resonance (NMR) spectroscopy
2. Infer various spectroscopic tools for biomolecular quantitation and characterization
3. Formulate interdisciplinary methods to solve biological problems using physical and chemical
engineering techniques

Expected Course Outcome:


1. Outline the physics involved in most abundant non-destructive spectroscopic techniques
2. Apply spectroscopy for on- or at-line process monitoring and quality control in the modern
food, pharma or biotech industry
3. Discuss the practical use of spectroscopy, problems involved and tricks of the trade-in relation
to the quantitative use of spectroscopy such as spectroscopic calibration and optimal sample
presentation to the spectrometer
4. Summarize advantages and disadvantages of spectroscopic measurements

Student Learning Outcomes (SLO): 9,18


2. Having a clear understanding of the subject related concepts and contemporary issues
18.Having critical thinking and innovative skills
Module:1 Basics of quantum mechanics 5 hours
Schrodinger wave equation; atomic and molecular structures; transition energy states.

Module:2 UV-Visible spectroscopy 5 hours


Selection rules; biological chromophores including charge transfer complexes; surface plasmon
resonance

Module:3 Fluorescence spectroscopy 6 hours


Biological fluorophores – intrinsic and extrinsic; quenching mechanisms; fluorescence probes;
Fluorescence resonance energy transfer

Module:4 Infrared spectroscopy 6 hours


Selection rule; fundamental and harmonic transitions; normal mode analysis; amide bands I and II
– characterization and their application; ATR

Module:5 Raman spectroscopy 6 hours


Instrumentation; Strokes and anti stokes – Rayleigh scattering; selection rules; Amide bands I
and II; Coherent Anti Stokes Raman Scattering

Module:6 XPS 5 hours


Instrumentation; XPS patterns; Spin orbital Splitting; Quantitative analysis; Chemical effect;
Chemical shift

Module:7 1D NMR 6 hours

M.Sc Intg Biotechnology (5yr.) Page 170


Boltzmann distribution; coupling constants; dipolar coupling; nuclear overhauled effect; NMR
spectra of selected nuclei (H, C, P, F, N). Multidimensional NMR and other advanced Techniques:
Multidimensional NMR; application to larger biomolecules; electron paramagnetic resonance,
Auger electron spectroscopy

Module:8 Contemporary issues: 2 hours

Total Lecture hours: 45 hours

Text Book(s)
1. Atkins P and de Paula J Atkins' Physical Chemistry, 10th edition, (2014).Oxford University
Press, UK.
Reference Books
1. Marques M.P., de Carvalho B, L.A.E., Haris, P.I (2013) Spectroscopy of Biological
Molecules IOS Press, Netherlands.

2. Principles of Fluorescence Spectroscopy, 3rd edition by Joseph R. Lakowicz, Springer (2007)


Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 171


Course code Course title L T P J C
BIY2016 Stem Cell Technology 3 0 0 0 3
Pre-requisite None Syllabus version
v. .1
Course Objectives:
1. Recall the fundamental concepts of stem cells
2. Dissect mechanistic details about stem cells and regeneration (horizontal and vertical
integration)
3. Extend these concepts in the industrial and academic sectors

Expected Course Outcome:


1. Relate the fundamental aspects of stem cell technology
2. Illustrate the principles and methodologies about the mechanistic aspects
3. Determine the commonalities and distinguish between embryonic and adult stem cells
4. Apply the knowledge gained in regenerative aspects and therapeutic potential
5. Formulate solutions in a socially and ethically responsible manner concerning the use of stem
cells and state-of-the-art technologies

Student Learning Outcomes (SLO): 2,10 ,18


2. Having a clear understanding of the subject related concepts and contemporary issues
10. Having a clear understanding of professional and ethical responsibility
18. Having critical thinking and innovative skills

Module:1 Introduction 6 hours


Embryonic stem cells, Blastula, Inner cell mass, Totipotent, pluripotent, multipotent and Induced
pluripotent stem cells characterization, potency, self-renewal, cell division, and differentiation

Module:2 Pathways involved in stem cell proliferation, 6 hours


differentiation, and dedifferentiation
Signal transduction pathways and signaling molecules involved cellular proliferation,
differentiation, and dedifferentiation. Relationship between cellular proliferation and
differentiation concerning stem cells

Module:3 Embryonic stem cells 7 hours


How embryonic stem cells are obtained, in vitro multiplication: embryonic stem cells gene
manipulation and nuclear transfer technology.

Module:4 Adult stem cells 6 hours


Methods to obtain stem cells from adults (Amniotic fluid, cord blood cells, Mesenchymal stem
cells, etc). Induced pluripotent technology (IPS), genes, and their mode of action in inducing
stemness in adult cells. Advantages and disadvantages of IPS technology

Module:5 Organ regeneration using Stem cells 6 hours


Heart regeneration, angiogenesis, kidney regeneration, a neurodegenerative disorder, spinal cord
injury, tissue engineering

Module:6 Application of stem Cells 6 hours

M.Sc Intg Biotechnology (5yr.) Page 172


Overview of embryonic and adult stem cells for therapy in Neurodegenerative diseases;
Parkinson’s, Alzheimer's, Spinal Code Injuries and other brain Syndromes; Tissue system
Failures; Diabetes; Cardiomyopathy; Kidney failure; Liver failure; Cancer; Hemophilia, etc.

Module:7 Ethics in using Embryonic stem cells 5 hours


Human stem cell research: Ethical consideration; Stem cell religion consideration; Stem cell-based
theories: Preclinical regulatory consideration, and Patient advocacy.

Module:8 Contemporary issues: Lectures by experts 3 hours

Total Lecture hours: 45 hours

Text Book(s)
1. Cherian E (2011) Stem cells JP brothers medical publishers
Reference Books
1. Atala A (2012) Progenitor and Stem Cell Technologies and Therapies Woodhead publishing

2. Phinney DG (2011) Adult stem cells: Biology and methods of analysis Humana press
Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 173


Course code Course title L T P J C
BIY2017 Neurobiology 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Develop a basic understanding of neuroanatomy
2. Build a basic understanding of neurophysiology
3. Elaborate on the biological basis of behavior

Expected Course Outcome:


1.Relate basic brain structure and function from the molecular to the systemic level
2. Illustrate the properties of cells that make up the nervous system including the propagation of
electrical signals used for cellular communication
3. Discuss the various aspects of the pathogenesis of the nervous system
4. Interpret the contribution of the nervous system to sensory experiences, thoughts, emotions, and
behavior
5. Criticise primary literature at the cognitive, behavioral, and cellular level
6. Formulate a research question based on adequate insights into the current knowledge

Student Learning Outcomes (SLO): 2,10,18


2. Having a clear understanding of the subject related concepts and contemporary issues
10. Having a clear understanding of professional and ethical responsibility
18. Having critical thinking and innovative skills

Module:1 What is Neurobiology? 6 hours


History of Neurosciences, Perspectives in studying the brain, Structure, and function of neurons,
glial cells, molecular and cellular organization of neuronal differentiation, characterization of
neuronal cells, the blood-brain barrier.

Module:2 Neural Signaling 6 hours


Electrical Signals of Nerve Cells, Voltage-Dependent Membrane Permeability, Channels and
Transporters, Synaptic Transmission, Neurotransmitters, Receptors, and Their Effects, Molecular
Signaling within Neurons.

Module:3 Neuro-anatomy 6 hours


Organization of Central Nervous System, the autonomous nervous system, Peripheral Nervous
System, Meninges, and cerebrospinal fluids.

Module:4 Sensation and Sensory Processing 6 hours


The Somatic Sensory System, Pain, Vision: The Eye, Central Visual Pathways, The Auditory
System, The Vestibular System, The Chemical Senses.

Module:5 Complex Brain Functions 6 hours


The Association of Cortices, Language and Speech, Sleep and Wakefulness, Emotions, Sex,
Sexuality, and the Brain, Memory.

M.Sc Intg Biotechnology (5yr.) Page 174


Module:6 Neurological disorders 6 hours
Neurodegenerative conditions. Stroke. Epilepsy. Syndromes and sensory impairments,
Amnesias, Parkinson disease, Alzheimer's disease, Schizophrenia, Mood disorders: depression,
mania, and anxiety. Alien-hand syndrome.

Module:7 Current techniques in Neurobiology 6 hours


Optogenetics, Electrophysiology, behavioral analyses, measuring neurochemistry in vivo by
microdialysis and amperometry, crayfish sensory or motor neurons.

Module:8 Contemporary issues: Lecture by industrial 3 hours


experts

Total Lecture hours: 45 hours

Text Book(s)
1. Purves D, Augustine GJ, Fitzpatrick D, Hall WC, LaMantia AS, and White LE
(2012)Neuroscience.Sinauerpublications Fifth Edition.
2. Zupanc, G. K. H. (2010) Behavioral Neurobiology: An Integrative Approach, Oxford
University Press. 2nd edition
Reference Books
1. Ropper AH, Samuels MA, and Klein JP (2014) Adams and Victor’s principle of neurology
McGraw Hill Education 10 Edn
Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 175


Course code Course title L T P J C
BIY2018 Bioremediation 2 0 0 4 3
Pre-requisite None Syllabus version
v. .1
Course Objectives:
1. Create awareness on environmental issues
2. Relate the role of microbes and plants in environmental remediation.
3. Identify appropriate biological approaches for remediation of environmental contaminants.

Expected Course Outcome:


1. Outline the concept of pollution and bioremediation methods to control it
2. Evaluate the use of different microbes for remediation of pollutants
3. Outline the metabolism of microbes and the genes and enzymes involved in the process
4. Make use of different types of microbes and plants to clean pollutants present in the atmosphere
5. Analyze the conventional wastewater treatment strategies
6. Experiment with biotechnological techniques to remediate the environment

Student Learning Outcomes (SLO): 2,11,18


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning
18. Having critical thinking and innovative skills

Module:1 Introduction to bioremediation 4 hours


Basics and terminologies in bioremediation, sources of pollution, Nature and Toxic effects of the
pollutants on various trophic levels, Permissible limits and its agencies – APHA, EPA and Indian
standards

Module:2 Microbes and bioremediation 4 hours


Microbes and its degradative capabilities, Screening for useful microbe for the bio-removal of
toxic compounds, Bioremediation of specific pollutants - pesticides, Dye, petroleum
hydrocarbons and other xenobiotic compounds

Module:3 Metabolism of Microbes 6 hours


Metabolism of Microbial degradation, Bacterial resistance mechanism - towards toxic compounds,
Detection of candidate genes and enzymes involved in the process of degradation – Application of
KEGG pathway in bioremediation

Module:4 Fungal Biodegradation 3 hours


Fungal Biodegradation and Phycoremediation, Biodegradation in biofuel production,
Co2Sequestration

Module:5 Types of phytoremediation 4 hours


Phytoremediation and its types, rhizoremediation strategy and processes, a case study in the
removal of heavy metals and other toxic compounds (Chernobyl accident) onsite

Module:6 Wastewater treatment 4 hours


Conventional wastewater treatment strategies, Bioreactors - slurry, batch and continuous

M.Sc Intg Biotechnology (5yr.) Page 176


processes, Application of GMO’s in Bioremediation, natural gene transfer in the environment

Module:7 Application of Proteomics and 3 hours


Metabolomics in bioremediation
Superbugs as super savers, engineered enzymes, products involved in biodegradation, Application
of Proteomics and Metabolomics in bioremediation

Module:8 Contemporary issues: Lecture by industrial 2 hours


expert

Total Lecture hours: 30 hours

Text Book(s)
1. Thankur IS (2011) Environmental biotechnology: Basic concepts and applications. Second
Edition (revised), I.K. International.
Reference Books
1. Maier RM, Pepper IL, Gerba CP (2011) Environmental Microbiology, Second Edition,
Academic Press.

2. Alexander M (2014) Biodegradation and Bioremediation, Second Edition, Academic Press.


Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.
Project: ‘J’ Component CO: 6
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 177


Course code Course title L T P J C
BIY2019 Molecular Evolution and Phylogeny 3 0 2 0 4
Pre-requisite None Syllabus version
v..1
Course Objectives:
1. To understand the evolutionary relationship between the various kingdom of life.
2. To gain knowledge on existing algorithmic approaches make the evolutionary and
phylogenic prediction more interesting
3. To develop new methods on evolutionary analysis using biological sequences.

Expected Course Outcome:


1. To understand the evolutionary relationship between the various kingdom of life.
2. Apply apt algorithmic approaches for specific sequence datasets.
3. Build phylogeny and analyze evolutionary relationships based on different algorithms.
4. Compare different algorithms and optimize them to give a better relationships than the existing
ones.
5. Students will compare and contrast different molecular evolution techniques
6. Gain significant new knowledge about the function of biological molecules and structures.

Student Learning Outcomes (SLO): 2, 20


2. Having a clear understanding of the subject related concepts and contemporary issues
20. Having a good digital footprint

Module:1 Molecular Archeology 7 hours


Introduction to molecular evolution, driving forces in evolution, evolutionary changes in
nucleotide sequences.

Module:2 Phylogenetic Trees 7 hours

Molecular phylogenetics, phylogenetic trees, trees, and distances.

Module:3 Phylogeny Algorithms 7 hours


Measuring genetic change, Genetic distance-Measuring evolutionary change on the tree- kinds of
data.

Module:4 Methods of reconstruction 6 hours


Distance matrix methods, Maximum parsimony methods, Maximum likelihood methods

Module:5 Evolutionary Analysis 4 hours


Models of Molecular evolution, Functional constraints, and the rate of substitution patterns of
codon usage and base composition.

Module:6 Molecular Evolution theory 5 hours

M.Sc Intg Biotechnology (5yr.) Page 178


Evolutionary clocks, Neutral Theory, Genetic variation within species, Natural selection.

Module:7 Applications of molecular phylogenetics 5 hours


Organismal phylogeny, what does evolutionary medicine to offer, host-parasite co-speciation?

Module:8 Contemporary issues: 4 hours


Lecture by industrial expert

Total Lecture hours: 45 hours

Text Book(s)
1. Bromham L (2016) An Introduction to Molecular Evolution and Phylogenetics 2nd Edn
oxford
University press
Graur D and Li WH (2010) Fundamentals of Molecular Evolution,., three eds. Sinauer
2. Associates,
Reference Books
1. Pevsner J (2015) Bioinformatics and Functional Genomics, 3rd Edition Wiley-Blackwell.
Page R, and Holmes EC (2010) Molecular evolution, A phylogenetic approach, Blackwell
2. Science Inc;

Mode of Evaluation: Written examinations, assignments, and quizzes.


List of Challenging Experiments (Indicative)
1. Exploration and retrieval of DNA and Protein Sequence database 2 hours
2. Retrieval of published sequence datasets for evolutionary reports 3 hours
3. Evolutionary tools for molecular data: File format conversion 2 hours
4. Aligning multiple sequences with CLUSTAL-W 3 hours
5. Selecting Evolution and Phylogenetic models 3 hours
6. Phylogenetic analyses of DNA or protein sequences using maximum 3 hours
likelihood.
7. A simple user interfaces for creating input files to run BEAST. 2 hours
8. LogCombiner program to combine log and tree files from multiple runs of 2 hours
BEAST
9. TreeAnnotator program for summarizing the information in a sample of trees 3 hours
produced by BEAST
10. Bayesian Evolutionary Analysis Sampling Trees. 2 hours

M.Sc Intg Biotechnology (5yr.) Page 179


11. Virus Pathogen Database and Analysis Resource (ViPR) Bacterial dataset 2 hours
analysis.
12. ML program for estimating mutation rates using cancer mutation databases. 3 hours
Total Laboratory Hours 30 hours
Mode of Evolution: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 180


Course code Course title L T P J C
BIY 3002 Environmental Genetics 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1.1
Course Objectives:
1. Relate environmental factors affecting life through interaction with genes/DNA
2. Explain the factors involved in mutagenesis
3. Discuss antimutagens with suitable examples

Expected Course Outcome:


1. Perceive the influence of various environmental factors on biological systems through the
introduction of changes in DNA sequences
2. Illustrate the roles of chromosomes and genes in heredity
3. Summarize the roles of genes and the environment in the determination of phenotype.
4. Categorize the sources of irradiation (e.g., UV x-rays) in the environment and describe their
genetic significance.
5. Describe sources of mutagenic, carcinogenic, and teratogenic chemicals in the environment and
identify their known effects
6. Analyze the human genome and identify common chromosome and gene disorders

Student Learning Outcomes (SLO): 2, 11


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning

Module:1 MUTATION 6 hours


Mutagenesis - Spontaneous and induced mutation – Somatic and germ cell Mutations; Gene
mutations and chromosomal mutations. Physical, chemical and biological agents, Interaction of
chemical mutagens and radiation with genetic material- electromagnetic spectrum- biological
effects of ionizing radiation and ultraviolet rays

Module:2 ANTIMUTAGENS 5 hours


Modification of mutagenic damage- anti-mutagenesis and de-mutagenesis in yeast, Neurospora,
Drosophila- and C. elegans life cycle

Module:3 Molecular techniques to induce mutation 6 hours


Mutagenicity assessment- Salmonella (Ames test), Methods to induce genetic variation in single
genes: Insertional mutagenesis - transposon and TDNA mutagenesis; In vitro mutagenesis;
Oligonucleotide and PCR mediated site-specific mutagenesis; TILLING; RNAi mutagenesis.

Module:4 Techniques to detect mutations 6 hours


Mouse-cytogenetic procedures and techniques to assess gene mutations. In vitro mammalian
systems for mutagenicity evaluation- human lymphocytes, fibroblasts, and Chinese hamster cells
in culture- Unscheduled DNA synthesis, Chromosomal aberrations, Sister chromatid exchanges,
gene mutation- HGPRT and TK.

M.Sc Intg Biotechnology (5yr.) Page 181


Module:5 Mutation induced cancer and congenital 7 hours
disabilities
The interrelationship between mutagenesis and Carcinogenesis, Tests for evaluation.
Teratogenesis- Mouse as test system congenital anomalies-teratogens in comparison with
mutagens and carcinogens- congenital disabilities in man radiosensitizers.

Module:6 Environmental factors affecting reproduction 6 hours


DNA repair defects in man. Biomonitoring of human population - chromosomal analysis,
Environmental factors affecting human reproduction

Module:7 Mechanisms involved in the protection of 7 hours


genome from environmental mutagens
Various DNA repair mechanisms involved in the protection of genome from mutagens.

Module:8 Contemporary topics: 2 hours


Lectures by industrial expert

Total Lecture hours: 45 hours

Text Book(s)
1. Hayes AW, Kruger CL(2014) Haye’sPrinciples and Methods of Toxicology, Sixth Edition,
CRC Press.
Reference Books
1. Kilbey BJ, Legator M, Nichols W, and Ramel C (2012) Handbook of Mutagenicity test
procedures, Elsevier, Amsterdam.

2. Scott Hawley.R, Michelle Walker 2003 Advanced Genetic Analysis Finding Meaning in a
Genome, Wiley-Blackwell Publishing.
3.
Philip Meneely 2009 Advanced Genetic Analysis: Genes, Genomes, and Networks in
Eukaryotes 1st Edition, Oxford University Press.

Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.

Recommended by Board of Studies 03-08-2017


Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 182


Course code Course title L T P J C
BIY 3003 Protein Engineering 2 0 0 4 3
Pre-requisite Syllabus version
v. 1
Course Objectives:
1. Recall the basics concepts of protein engineering
2. Summarize the necessary elements of protein overexpression systems in bacteria.
3. Illustrate the importance of engineering the proteins and their novel applications

Expected Course Outcome:


1. Explain about different techniques for protein analysis
2. Formulate and purify proteins
3. Discuss advanced biophysical techniques for protein analysis, their relative merits and interpret
data from those techniques
4. Evaluate the steps required to produce an expression system for a new protein
5.Outline the techniques for modifying proteins
6. Utilize various software for protein visualization and modeling

Student Learning Outcomes (SLO): 2 ,11,18


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning
18. Having critical thinking and innovative skills

Module:1 Overview of Protein Structure and Function 4 hours


Properties of proteins; Levels in protein structure – folding pattern, 3D structures; Covalent
chemical modification of proteins – covalent and non-covalent forces are determining protein
structure; Overview of protein synthesis & degradation.

Module:2 Techniques for the study of proteins 4 hours


structures
UV spectroscopy, Circular dichroism, Fluorescence, Mass spectrometry, Nuclear magnetic,
Resonance spectroscopy, X-ray diffraction technique.

Module:3 Protein stability and dynamics 4 hours


Factors determining the intrinsic and extrinsic stability of proteins, thermodynamic stability
versus kinetic stability of proteins, unfolding and folding of proteins, induced molecular
conformational changes in proteins, molecular dynamics of proteins.

Module:4 Design of Recombinant Proteins 4 hours


Types of mutagenesis, Recombinant protein production – Differences in the host cells, Over-
expression of proteins, Directed Evolution Strategy, High throughput production, and analysis of
recombinants, proteins, inclusion bodies, co-expression of proteins with specific properties,
stabilization of proteins.

M.Sc Intg Biotechnology (5yr.) Page 183


Module:5 Techniques in Protein Engineering 4 hours
Expressing and analyzing protein in Prokaryotic and eukaryotic systems, Identification and
analysis of sequence-specific DNA- binding proteins. Enhanced recovery and folding of
recombinant proteins using fusion protein strategies; protein engineering for affinity purification;
stabilization of enzymes by protein engineering, engineering specificity of enzymes.

Module:6 Covalent Modifications and Protein 4 hours


Engineering by Semi Synthesis
Susceptibility of amino acid side chains for chemical modification, residue-specific
modifications, reagents for modifications; cross-linkers in protein modifications; insulin and
cytochrome c semi-synthesis; press-stud conjugations; Application of protein conjugates.

Module:7 Peptidomics and Peptidomimetics 4 hours


Engineering antibodies and vaccines; hormones & receptors; Combinatorial Enzyme Engineering,
Engineering Proteins for degradation of recalcitrant compounds, Peptidomimetics in Medicinal
chemistry, and drug design.

Module:8 Contemporary issues: Lecture by invited 2 hours


experts.

Total Lecture hours: 30 hours

Text Book(s)
1. Cleland JL and Craik CS (2010) Protein Engineering: Principles and Practice, Wiley
publishers
2. Ramya M and Ponmurugan P (2015) Protein Engineering Narosa publishing house
Reference Books
1. Park S and Cochran J (2010) Protein Engineering and Design CRC Press
.
2. Creighton TE (2010) Protein Function – A Practical Approach (2nd ed.,), Oxford University
Press, Oxford, UK
Authors, book title, year of publication, edition number, press, place
Projects: ‘J’ Components
Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 184


Course code Molecular Modelling and Drug Designing L T P J C
BIY3004 3 0 2 0 4
Pre-requisite None Syllabus version
v. 1.1
Course Objectives:
1. Outline preliminary concepts in molecular modeling using molecular dynamics
2. Utilize basic modeling techniques to explore biological phenomena at the molecular level
3. Perceive knowledge in protein-ligand interaction study by docking and visualization tools for
molecular dynamics.

Expected Course Outcome:


1. Illustrate the concepts of Molecular modeling using Molecular Dynamics
2. Utilize basic modeling techniques to explore biological phenomena at the molecular level
3. Experiment with protein-ligand interaction study by docking.
4. Translate the understanding of visualization tools for molecular dynamics
5. Apply the information gained in various chemistry and biochemistry courses toward solving
problems pertinent to drug designing
6. Demonstrate the relative importance of molecular modeling and drug designing

Student Learning Outcomes (SLO): 2, 18


2. Having a clear understanding of the subject related concepts and contemporary issues
18. Having critical thinking and innovative skills

Module:1 Quantum mechanics & concepts in molecular 7 hours


modeling
Coordinate systems, potential energy surfaces. Introduction to quantum mechanics.

Module 2 Force Fields 7 hours


Bond stretching; angle bending. torsional terms; non-bonded interactions; electrostatic
interactions; Vander Waals interactions

Module:3 Molecular Dynamics and Monte Carlo 7 hours


simulation
Design constraints, Potentials in MD simulation, Molecular dynamics algorithms.

Module:4 Analysis and Properties 6 hours


Geometry optimization, Vibrational frequencies: potential energy surface, harmonic vs.
fundamental frequencies, zero-point vibrational energies.

Module:5 Modeling 5 hours


Homology modeling, Ab initio, Protein Threading.

Module:6 Drug design 6 hours


Structure-based methods to identify lead compounds: finding lead compounds by searching 3D
databases; de novo ligand design.

M.Sc Intg Biotechnology (5yr.) Page 185


Module:7 Molecular Docking 5 hours
Docking - molecular modeling in drug design – structure-based drug design – pharmacophores -
QSAR.

Module:8 Contemporary issues: 2 hours


Lectures by industrial expert

Total Lecture hours: 45 hours

Text Book(s)
1. Leach AR (2010) Molecular Modeling, Principles & Applications, (Dorling Kindersley(India)
(P)Ltd with Pearson education Ltd, UK.

2. Arjun S (2103) Drug Discovery, Design & Development Lambert Academic publishing.
Reference Books
1. Clark T, Thurston DE, and Banting L (2012) Drug Design Strategies: Computational
Techniques& Applications Royal society of chemistry
Authors, book title, year of publication, edition number, press, place
Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.
List of Challenging Experiments (Indicative)
1. Exploration of small molecule and macromolecule database 3 hours
2. Small molecule drawing and optimization using Chem Sketch 2 hours
3. Macromolecular visualization using PyMOL 3 hours
4. Macromolecular visualization using SPDBV 2 hours
5. Homology modeling of the drug target protein 2 hours
6. Protein structure exploration with active site prediction 2 hours
7. Protein-Protein interaction using HADDOCK 2 hours
8. Protein-Ligand interaction using Autodock 3 hours
9. Quantitative structure-activity relationships modeling tools 3 hours
10. Molecular Mechanics for small molecules 2 hours
11. Avogadro for molecular mechanics 2 hours
12. Pharmacophore screening of small molecules 2 hours
13. Quantitative structure-activity relationship 2 hours
Total Laboratory Hours 30 hours
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017
M.Sc Intg Biotechnology (5yr.) Page 186
Course code Course title L T P J C
BIY4001 Cancer Biology 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Illustrate the cellular and molecular mechanisms that are dysregulated in cancerous cells.
2. Summarize the genomic technologies and develop critical thinking skills in cancer research
3. Analyze traditional chemotherapy and novel targeted therapeutic approaches

Expected Course Outcome:


1. Infer cancer causing mutations and specific therapeutic targets.
2. Compare the biological treatment processes and development of suitable technologies
3. Determine the challenging sides of using cancer models in cancer research
4. Interpret the data published in scientific articles
5. Relate the molecular biology of cancer with clinical aspects of the disease

Student Learning Outcomes (SLO): 2,18


2. Having a clear understanding of the subject related concepts and contemporary issues
18. Having critical thinking and innovative skills

Module:1 Cell cycle and molecular mechanism of 7 hours


carcinogenesis

Cell cycle and molecular players involved in the cell cycle. Deregulation of cell cycle and causes
for deregulation of cell cycle. Role of an oncogene, proto-oncogene, tumor suppressor proteins,
and oncoviruses in cancer. Cancer and its types. Molecular mechanisms of mutagens such as
Chemical carcinogen and radiation. Types of carcinogen and their mode of action with an example.
Module 2 Evading apoptosis in cancer 6 hours
The apoptotic mechanism, altered pathways in cancer cells that can evade apoptosis. Pathways are
regulating tumor initiation and/or its progression.

Module:3 Genomic instability 6 hours


Types of genomic instability: instability due to micro and mini satellite sequence, Loss of DNA
repair mechanisms, Dysfunction of telomerase. Chromosomal aberrations that cause cancer. Single
nucleotide polymorphisms and cancer.

Module:4 Angiogenesis and Metastasis 6 hours


Tumor angiogenesis, Clinical significance in invasion, Three-step theory of invasion, Proteinases,
and tumor cell invasion.

Module:5 Cancer stem cells 6 hours


The stem cell theory of cancer, tumor heterogeneity, Origin of cancer stem cells, and controlling
cancer by targeting cancer stem cells.

M.Sc Intg Biotechnology (5yr.) Page 187


Module:6 Cancer Therapeutics and Diagnosis 7 hours
Detection of Cancers, Prediction of aggressiveness of cancer, Advances in cancer detection.
Different forms of therapy, Chemotherapy, Radiation Therapy, Targeted therapy: Monoclonal
antibody, and kinase blockers.

Module:7 In vitro and In vivo models to study cancer 5 hours


Cell culture techniques: MTT assay, colony-forming assay, and matrigel assay. Animal models
used to study cancer: Nude mice, Transgenic and knockout mice, Cre mice, and patient-derived
xenografts (PDXs).

Module:8 Contemporary Topics: Lecture by experts 2 hours

Total Lecture hours: 45 hours

Text Book(s)
1. . The Biology of Cancer – Robert Weinberg. Edition – 2nd ISBN:9780815342205 - 2013
Reference Books
1. Textbook readings; primary literature; in-class discussion. The Molecular Biology of
Cancer: A Bridge from Bench to Bedside. Stella Pelengaris, Mike Khan -2nd Edition - 2013

2. Molecular Biology of Cancer. Lauren Pecorina, 4th edition. Oxford University Press – 2016.

3. Introduction to cancer biology, Robin Hesketh, Cambridge University Press – 2013.

Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No.46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 188


Course code Course title L T P J C
BIY4002 Food Science 2 0 2 4 4
Pre-requisite Syllabus version
v. 1
Course Objectives:
1. Demonstrate the basic principles involved in food science
2. Illustrate the chemical and physical properties of food
3. Explain the role of microbes in food.

Expected Course Outcome:


1. Relate the basic concepts of food science and the different components of food.
2. Appraise the physical and chemical characteristics of food for application in various food
industries.
3. Demonstrate the association of microbes with foods.
4. Relate the principles of processing in food preservation.
5. Appraise the sensory attributes of food and its evaluation.
6. Evaluate the role of regulatory agencies governing food production and processing.

Student Learning Outcomes (SLO): 2, 18


2. Having a clear understanding of the subject related concepts and contemporary issues
18. Having critical thinking and innovative skills

Module:1 Product 4 hours


Characteristics of raw materials-cereals, legumes, fruits, vegetable nut, meat, dairy, egg, and
seafood.

Module:2 Physical characteristics of food 4 hours


Salient physical properties in foods- viscosity, specific gravity, surface tension. Colloids-sols, gels,
emulsions, foams.

Module:3 Chemical characteristics of food 4 hours


Chemical constituents (macromolecules and bioactive compounds) of food; major chemical
changes during food processing.

Module:4 Microbiology of food 4 hours


Overview of microbes in food; Underlying principles in food spoilage.

Module:5 Principles of food processing 4 hours


Basic principles of food preservation and processing; emerging techniques in processing and
packaging

Module:6 Sensory properties of food 4 hours


Significance of sensory characteristics in food; Overview of methods of sensory evaluation.

Module:7 Food quality and analysis 4 hours


General principles; critical regulatory bodies, quality assurance programs Comparison of methods
for proximate analysis; significant minerals, vitamins, and bioactive compounds in food. Case
Study- Anti-oxidant analysis in food.

M.Sc Intg Biotechnology (5yr.) Page 189


Module:8 Contemporary issues: Lecture by industrial 2 hours
experts
Total Lecture hours: 30 hours

Text Book(s)
1. Ward JD(2013) Principles of food science, 3rd edition. G-W Publishers

2. Jay JM, Loessner MJ, and Golden DA (2012) Modern food microbiology. Fifth Edition, An
Aspen Publication.
Reference Books

1. Jeantet R, Croguennec T, Schuck P, and Brule G (2016) Handbook of Food Science and
Technology 3: Food Biochemistry and Technology. Wiley and Sons Publishers.

Authors, book title, year of publication, edition number, press, place


Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.
List of Challenging Experiments (Indicative) CO: 07
1. Determination of Quality of Milk sample by Methylene Blue Dye
2 Hours
Reduction (MBRT) Test
2. Qualitative Testing of Adulterated food samples 2 Hours
3. Examination of spoiled food products 2 Hours
4. Fermented foods 2 Hours
5. Examination of wheat flour for gluten 2 Hours
6. Determination of Acid Value of Fat sample 2 Hours
7. Study of chemical properties of food 2 Hours
8. Experiment title Bioreactor – demonstration 2 Hours
9. Isolation of lactic acid bacteria from foods 2 Hours
10. Examination of yeast from foods 2 Hours
11. Stages of sugar cookery 2 Hours
12. Malting, puffing, and popping of grains 2 Hours
13. Visit food processing unit 2 Hours
Total Laboratory Hours 30 Hours

Project: ‘J’ Component CO: 07

M.Sc Intg Biotechnology (5yr.) Page 190


Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 191


Course code Course title L T P J C
BIY5001 Animal Biotechnology 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives :
1. Explain the methods of gene manipulations in animal cells and embryonic stem cells
2. Develop breeding and conservation approaches in animals
3. Appraise the legal and ethical issues related to animal maintenance.

Expected Course Outcome:


1. Extend the best practices followed during maintenance of cell lines
2. Apply different techniques to manipulate the genome of animal cells.
3. Formulate ideas for the production of genetically modified organisms.
4. Organize different approaches in reproduction technology
5. Utilize the concept of molecular techniques involved in animal conservation

Student Learning Outcomes (SLO): 2,10 and 18


2. Having a clear understanding of the subject related concepts and contemporary issues
10. Having a clear understanding of professional and ethical responsibility
18. Having critical thinking and innovative skills

Module:1 Animal cell culture and applications 6 hours


Primary cells and cell lines. Methods to transform primary cells. Choice of animal cells for protein
production, Viral vaccine production. Scale-up of animal cell culture. Applications of animal cell
culture with examples.

Module:2 Gene transfer methods in animal cells 6 hours


Transformation, Transfection, and Electroporation. Selection of cells for stable transfection and
continuous production of protein from the transgene. Methods to knockdown the expression of
endogenous genes.

Module:3 Gene manipulations in Animals 6 hours


Embryonic stem cells, gene manipulations in embryonic stem cells, transgenic, knockout, and
Cre/LOXP mice. Cloning of animals.

Module:4 Animal breeding methods for better traits 6 hours


Artificial insemination-estrous synchronization; superovulation; embryo transfer, pregnancy, and
parturition control; monitoring reproductive status in animals, in-vitro fertilization, sperm and
embryo sexing; pre-implantation genetic diagnosis.

Module:5 Conservation of Animals 6 hours


Animal and human Genome projects genetic linkage maps; polymorphic DNA markers; Physical
map; integrating genetic linkage and physical map; DNA sequencing; Molecular techniques in
genetic conservation of Farm Animals, and detection of Animal Diseases.

Module:6 Genetically modified animals and their 7 hours


applications

M.Sc Intg Biotechnology (5yr.) Page 192


Genetically modified animal models used in biomedical research such as Cancer, Diabetes,
Immunology, and Toxicology

Module:7 Ethics and social problems: 6 hours


a) Classification based on genome, b) genetically modified organism, c) Cloning, d) Stem cell
technology

Module:8 Contemporary topics: Lecture by industrial 2 hours


experts

Total Lecture hours: 45 hours

Text Book(s)
1. Singh B, Gautam SK, and Chauhan M S (2015) Textbook of Animal Biotechnology, TERI.
New Delhi
2. Panno J(2014) Animal Cloning: The Science of Nuclear Transfer.
Reference Books
1. Freshney RI (2010) Culture of Animal Cells: A Manual of Basic Technique and Specialized
applications John Wiley & Sons, Inc.

2. Evans J (2012) Genetic Engineering of Animals: An Agricultural Perspective Springer


Science & Business Media
Authors, book title, year of publication, edition number, press, place
Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test

Recommended by Board of Studies 03-08-2018


Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 193


Course code Course title L T P J C
BIY5002 Gene Therapy 3 0 0 0 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Recall various forms of therapeutic nucleic acids, and compare their significance with those of
chemical, protein and cell-based therapies
2. Dissect different methods that are currently available to deliver therapeutic genes into target
cells, and distinguish challenges of each method
3. Evaluate various regulatory considerations for a clinical trial, and infer from previously
conducted gene therapy clinical trials for specific human diseases

Expected Course Outcomes:


1. Relate the principle of gene therapy with its potential use a future drug
2. Adapt different gene delivery methods based on the nature of the disease, therapeutic threshold,
and type of target tissue involved
3. Choose different genetic elements (both viral and non-viral) based on their roles in viral
titration, gene expression, and gene silencing
4. Design novel viral vectors by pseudotyping (retrovirus) or serotyping (adenovirus) to broaden
their tropism for multiple different tissues
5. Identify potential disease models (both in vitro and in vivo) to test a candidate vector carrying a
specific therapeutic gene
6. Criticize severe adverse events of a gene therapy clinical trial due to vector-related genotoxicity
and immunotoxicity

Student Learning Outcomes (SLOs): 2,11,12


2. Having a clear understanding of the subject related concepts and contemporary issues
11. Having an interest in lifelong learning
12. Having adaptive thinking and adaptability

Module:1 Introduction to Gene Therapy 5 hours


Genes as drugs; Therapeutic nucleic acids: antisense oligonucleotides, ribozymes, aptamers,
siRNAs and miRNAs

Module:2 Physical and Chemical Methods of gene 5 hours


Delivery
Cellular barriers to gene delivery; Direct inoculation of DNAs and RNAs; Physical methods:
electroporation, hydroboration, sonoporation, gene gun, and jet injection; Chemical methods:
liposomes and cationic lipids, cationic polymers and proteins

Module:3 Viral Vectors for Gene Therapy 8 hours


Viral genome organization, vector construction, production and properties of gamma retroviral,
lent viral, adenoviral and adeno‐associated virus vectors; Overview of foamy and herpes simplex
virus vectors for gene therapy applications

Module:4 Overview of Preclinical and Clinical Testing 6 hours

M.Sc Intg Biotechnology (5yr.) Page 194


Therapeutic gene expression in cell lines; Comparison of small and large animal models; Phases of
clinical trials; Types of transplant therapies; Gene transfer into stem cells; Regulatory
considerations for gene therapy

Module:5 Clinical Applications of Gene Therapy I 7 hours

Gene therapy for severe combined immune deficiencies, X-SCID and ADA-SCID; Gene therapy
for cystic fibrosis; Gene therapy for muscular dystrophies; Gene therapy for hemophilia A and B

Module:6 Clinical Applications of Gene Therapy II 7 hours

Gene therapy for cancer; Gene therapy for neurodegenerative disorders, Alzheimer’s and
Parkinson’s diseases; Gene therapy for eye diseases, retinitis pigmentosa, and Leber’s
congenital amaurosis; Gene therapy for HIV infection

Module:7 Ethical and Social Problems of Gene Therapy 5 hours


Safety of clinical experimentation; Germline gene therapy; In utero gene therapy; Gene therapy of
the embryo; Gene transfer for the cosmetic appearance and gene doping

Module:8 Contemporary issues 2 hours


Gene editing using CRISPR/Cas9 technology; Status of gene therapy in India and abroad

Total Lecture hours: 45 hours

Text Book(s)
1. Giacca M (2010) Gene Therapy First Edition, Springer Press, USA
2. Elsersawel A (2016) Gene Editing, Epigenetic, Cloning, and Therapy. Author house
publishing
Reference Books
1. Herzog RW and Zolotukhin S (2010) A Guide to Human Gene Therapy (First Edition)
World Scientific Publishing Co, UK
2. Daniel S (2013) Advanced Textbook On Gene Transfer, Gene Therapy And Genetic
Pharmacology: Principles, Delivery And Pharmacological And Biomedical Applications Of
Nucleotide-based Therapies(Volume 1 of Icp Textbooks In Biomolecular Sciences) World
Scientific publishers, Singapore
3. Jayandharan GR (2018)Gene and Cell Therapy: Biology and Applications (First Edition)
Springer Nature, Singapore
Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.

Recommended by Board of Studies 03-08-2017


Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 195


Course code Course title L T P J C
BIY 5003 Enzyme Technology 2 0 0 4 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Discuss the concepts of food biotechnology
2. Relate the role of biotechnology in the food industry
3. Explain the consumer perception of food biotechnology

Expected Course Outcome:


1. Select suitable purification techniques
2. Evaluate the optimization of enzyme activity
3.Infer recent types and advantages of immobilization techniques
4. Outline the modern techniques used in enzyme engineering
5. Categorize applications of enzymes
6. Design new processes with the use of enzymes

Student Learning Outcomes (SLO): 2, 5, 9


2. Having a clear understanding of the subject related concepts and contemporary issues
5. Having design thinking capability
9. Having problem-solving ability- solving social issues and engineering problems

Module:1 Enzymes purification 4 hours


Introduction of Enzymes, Isolation of Enzymes, Objectives, and strategy in enzyme purification,
Choice of source, Methods of homogenization, Methods of separation, Success of purification,
Examples of purification procedures

Module:2 Large scale production and purification of 4 hours


enzymes
Methods involved in Large scale production of enzymes and large scale purification of Enzymes,
recombinant enzymes.

Module:3 Optimization of enzyme activity 4 hours


Enzymatic reactions in biphasic liquid systems, The stabilization of enzymes in biphasic aqueous-
organic systems, Equilibria in biphasic aqueous-organic systems, Use of aqueous 2-phase systems,
Practical examples of the use of enzymes ‘in reverse’.

Module:4 Immobilization techniques 4 hours


Immobilization of enzymes and cells, Effect of immobilization on enzyme properties, Application
of immobilized enzymes and cells, Syrup production from corn starch, L-aminoacids from
racemic mixtures, Acrylamide synthesis, Therapeutic applications of immobilized enzymes

Module:5 Enzymes in the clinical industry 4 hours


Enzymes for clinical diagnosis, Role of biosensors in diagnosis, Use of enzymes to determine the
concentration of metabolites of clinical importance. Enzyme inhibitors and drug design, Enzyme
therapy: Treatment of genetic deficiency disease, Cancer therapy

M.Sc Intg Biotechnology (5yr.) Page 196


Module:6 Microbial enzymes in industry 4 hours
Application of microorganisms in brewing, cheese making, organic chemicals, Isolated enzymes
in industrial processes

Module:7 Modification of enzymes for industrial use 4 hours


Methods to modify enzymes for improvement of enzyme activity as per the industrial requirement
with examples.

Module:8 Contemporary issues: Lecture by industrial 2 hours


experts

Total Lecture hours: 30 hours

Text Book(s)
1. Khan MY and Khan F (2015) Principles of Enzyme `Technology PHI learning India

2. Bhatt SM (2011) Enzymology and Enzyme Technology, S Chand publishing India


Reference Books
1. books published after 2010 (preferably after 2015) to be given (please give complete
bibliography)

Recommended by Board of Studies 03-08-2017


Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 197


Course code Course title L T P J C
BIY5004 Food Biotechnology 2 0 0 4 3
Pre-requisite None Syllabus version
v. 1
Course Objectives:
1. Discuss the concepts of food biotechnology
2. Relate the role of biotechnology in the food industry
3. Explain the consumer perception of food biotechnology

Expected Course Outcome:


1. Recall critical concepts in food production and contemporary issues in the field
2. Extend the principles of fermentation and its application in the processing of food
3. Demonstrate the role of enzymes in the food industry
4. Appraise the role of biotechnology in designing novel food products
5. Build quality assurance and control systems for specific food industries
6. Justify the management of food waste, global food trade, and related national and international
laws

Student Learning Outcomes (SLO): 2,18


2. Having a clear understanding of the subject related concepts and contemporary issues
18. Having critical thinking and innovative skills

Module:1 Introduction to Food Biotechnology 3 hours


Definition; scope in the food industry; Interdisciplines involved; overview of biotechnological
methods in the food sector.

Module:2 Microbial biotechnology 5 hours


Fermentation- principles, types, starter cultures, advantages, disadvantages. Chemicals used in
processing, Case study-fermented milk products;

Module:3 Biotechnology for improved food process 4 hours


rDNA chymosin; overview of enzymes in the food industry. Case study-HFCS production through
biotechnology.

Module:4 Novel products through biotechnology 3 hours


GM foods-regulatory systems, Functional foods; designer foods; nano foods.

Module:5 Molecular food diagnostics 4 hours


Molecular methods- overview, types, comparison with conventional techniques. Case study-
molecular detection of Salmonella in food matrices.

Module:6 Utilization of food waste 4 hours


Characteristics and types of food wastes; value-added products from food wastes.

Module:7 Food biotechnology and Consumerism 4 hours


Consumer perception-national and international scenario; factors influencing the consumers,
impact on global food trade, import, and export laws.

M.Sc Intg Biotechnology (5yr.) Page 198


Module:8 Contemporary issues: Lectures by experts 3 hours

Total Lecture hours: 30 hours

Text Book(s)
1. Joshi VK, Singh RS (2013) Food Biotechnology: Principles and Practices.
I K International Publishing House Pvt. Ltd; First Edition.
Reference Books
1. Lee BH (2014) Fundamentals of Food Biotechnology, 2nd Edition.John Wiley & Sons.

2. Pometto A, Shetty K, Paliyath G, and Levin RE (2005) Food Biotechnology. Second edition.
CRC Press.
Authors, book title, year of publication, edition number, press, place
Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.
Project: ‘J’ Component

Recommended by Board of Studies 03-08-2017


Approved by Academic Council No.46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 199


Course code Environmental Biotechnology L T P J C
BIY5005 2 0 0 4 3
Pre-requisite Syllabus version
v.1.2
Course Objectives:
1. Elaborate on the various types of pollutants and ways to control them
2. Illustrate microbial-mediated bioremediation and their types
3. Choose suitable methods to protect the environment

Expected Course Outcome:


1. Assess the different types of pollution and the role of biogeochemical cycles in the environment
2. Utilize the knowledge in the field of bioremediation to remediate the environment
3. Demonstrate the types of solid waste and their management
4. Build bioremediation and phytoremediation-mediated environmental cleanup technologies.
5. Formulate GMOs for degradation and bioremediation through extremophiles
6.Examine environmental pollution and develop models to resolve it

Student Learning Outcomes (SLO): 2,10


2. Having a clear understanding of the subject related concepts and contemporary issues
10. Having a clear understanding of professional and ethical responsibility
Module:1 Pollutants and its type 4 hours
Sources of pollution, Physico-chemical parameters of the pollutants, molecular detection of the
microbial community (Metagenomics), Role of living organisms in primary biogeochemical
cycles C, N, S, and P - disruption of biogeochemical cycles -Causes and effects.Eutrophication,
Environmental Qualitative and Quantitative detection of the toxic compounds from the polluted
site.

Module:2 Microbial mediated Bioremediation 4 hours


Microbial degradative pathways (Aromatic and aliphatic compounds), metal microbe interactions,
Biohydrometallurgy and Biomining, biomagnification, Biosorption, Bioaccumulation and
Biodegradation, Bioremoval of xenobiotic compounds

Module:3 Types of Bioremediation 4 hours


Bioremediation - In-situ – Bioaugmentation, Bioventing, and other technologies, Ex-situ – solid
waste management (Landfarming, composting, and Biopiles).

Module:4 Bioremediation Techniques 4 hours


Technologies in bioremediation – Biofilms based removal (Quorum sensing)-. activated sludge
(suspended growth), N and P removal - lagoons, trickling filter (attached growth) - Rotating
Biological contactors (RBC)

Module:5 Phytoremediation 4 hours


Phytoremediation and its types, rhizome remediation strategy and processes, a case study in the
removal of heavy metals and other toxic pollutants

Module:6 Bioreactors for Bioremediation 4 hours

M.Sc Intg Biotechnology (5yr.) Page 200


Aerobic and anoxic type bioreactor for biodegradation- solid, liquid and air (slurry, batch, and
continuous processes), Application of GMO’s in Bioremediation

Module:7 Extremophiles in bioremediation 4 hours


Microbial habitat in various ecological niches, Extremophiles, and its types, Hydrothermal vent
ecosystem and its biotechnological potentials, Ecofriendly Bioproducts

Module:8 Contemporary issues: Lecture by industrial 2 hours


experts

Total Lecture hours: 30 hours

Text Book(s)
1. Ansari AA, Gill SS, Gill R, Lanza G, Newman L (2017) Phytoremediation Management of
Environmental Contaminants. Springer international publication

2 Jördening HJ and Winter J(2010)Environmental biotechnology: concepts and applications.


John Wiley & Sons.
Reference Books
1. Rathoure AK and Dhatwalia VK (2015) Toxicity and Waste Management Using
Bioremediation, IGI global publishers

Authors, book title, year of publication, edition number, press, place


Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test
Project: J component
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No.46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 201


Course code Medical Biotechnology L T P J C
BIY5006 3 0 0 0 3
Pre-requisite Syllabus version
v. 1
Course Objectives:
1. Outline the biology and diagnostics for various diseases
2. Appraise host-microbe interactions in causing infectious diseases and different methods of their
relative diagnosis and prophylaxis
3. Utilize medical engineering to take up research in challenging areas of therapy and diagnosis

Expected Course Outcome:


1. Evaluate the biology of various diseases
2. Discover various diagnostic methods and imaging techniques
3. Assess disease etiology, respective diagnosis, and molecular therapeutic approaches
4. Relate histocompatibility, transplantation and stem cell culture
5. Appraise the principles of teratogenesis
6. Formulate the use of automated systems in therapeutics

Student Learning Outcomes (SLO): 2 and 10


2. Having a clear understanding of the subject related concepts and contemporary issues
10. Having a clear understanding of professional and ethical responsibility
Module:1 An Introduction to Human Diseases 5 hours
Human health and Disease, Characteristics of Disease, Classification of Disease (Congenital /
Hereditary / Inflammatory/ Degenerative / Metabolic / Neoplastic Disease).

Module:2 Principles of Diagnosis 7 hours


History, Physical Examination, Treatment, Differential Diagnosis, Tests and procedure (Clinical
laboratory test, Tests using Radioisotopes, Endoscopy, Ultrasound, X-Ray, MRI, CT scan, PET
scans, cytologic and Histologic examination of cells and tissue from patients).

Module:3 Host – Microorganism Interaction 6 hours


Microorganism entry, colonization, invasion, outcome, and Prevention of Disease. Microbial
Virulence factors and pathogenicity Island. Epidemiology and investigation of recent pandemics
(SARS). Antimicrobial resistance and Detection (MRSA/MDRTB ).

Module:4 Transplantation 6 hours


Blood screening, cross matching, and transfusion. Histocompatibility Testing Methods – HLA
typing (serology and Molecular method/ Cytotoxic (Cell-Based) Antibody Screening) stem cell
culture – organ culture – artificial blood.

Module:5 Teratogenesis 5 hours


Teratology, Causes of congenital anomalies, surveillance, Cytogenetics Versus Teratology,
Teratology Correlated with Chromosome Alteration, Carcinogen-Induced Point Mutations,
Mutation, and Abnormal Development.

Module:6 Diagnostics 7 hours


Microbiological semi-automated and automated identification systems (Vitek system / The

M.Sc Intg Biotechnology (5yr.) Page 202


phoenix system / BACTEC Blood culture system, BACTEC 460TB) Biosensors – as
diagnostics. Detection and quantitation of antigen, Immuno-detection of antigen in cells and
tissues. Molecular virology (PCR for diagnosis / Quantitative Realtime PCR for therapeutic
protocols/detection of mutation and drug resistance).

Module:7 Medical Engineering and Therapeutics 7 hours


Antibody (polyclonal & monoclonal) Engineering. Therapeutics such as vitamins, laxatives,
analgesics, non – steroidal contraceptives, and biological hormones. Therapeutic proteins &
enzymes– Vaccine development – gene therapy.

Module:8 Contemporary issues: Lecture by experts 2 hours

Total Lecture hours: 45 hours

Text Book(s)
1. Amanullah M (2012) Medical Biochemistry and Biotechnology LAP Lambert Academic
Publishing
Orlicki R, Cieńciala C, Krylova LP, Pielichowski J, and Zaikov GE (2013) Pharmaceutical
2.
and Medical Biotechnology: New Perspectives Nova publishers UK Ed.

Reference Books
1. Wilson BA, Salyers AA (2011) Bacterial Pathogenesis: A molecular approach ASM Press,
3rd edition.
Delves PJ, Martin SJ, Burton DR, Roitt IM (2011) Roitt's Essential Immunology Wiley-
2.
Blackwell 12th Edition
Authors, book title, year of publication, edition number, press, place
Mode of Evaluation: Assignments, Continuous assessment tests and Final assessment test.

Recommended by Board of Studies 03-08-2017


Approved by Academic Council No. 46 Date 24-08-2017

M.Sc Intg Biotechnology (5yr.) Page 203

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