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    NELUPURE

    Uploaded by

    이호준

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    NELUPURE

    Uploaded by

    이호준
    39 views5 pages

    Copyright

    © © All Rights Reserved

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    PDF, TXT or read online from Scribd

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    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    39 views5 pages

    NELUPURE

    Uploaded by

    이호준

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 5

    Nelupure™ is a synergistic alliance of:

    Egyptian lotus
    (Nymphaea caerulea)
    Flower distinctive of the river
    Nile, appreciated by the pharaohs
    of ancient Egypt and represented
    in its architectural ornaments.

    Its blue color is associated with


    the victory of the spirit over
    wisdom.

    +
    Sacred lotus
    (Nelumbo nucifera)
    Flower cultivated in Asia for
    more than 7,000 years, used as
    food and in traditional medicine.

    Considered as the true lotus


    of Buddha.
    NELUPURE TM
    The sebum balancer inspired by lotus purity, with immediate effect

    IN VITRO EFFICACY
    Different in vitro studies were performed to test the effect of Nelupure™
    on sebum production in sebocytes.

    Modulation of gene expression

    Leptin, CIDEA, PLIN2 and PLIN3 are proteins involved in sebum synthesis and their
    gene expression was measured.
    In addition, to check the anti-inflammatory effect of Nelupure™, the gene
    expression of the cytokine IL-8 was measured too.

    0
    Ob-Rb CIDEA PLIN2 PLIN3 IL-8
    -50 (Leptin
    receptor)
    For the first time in cosmetics -100
    -102% -85% -90%
    we use the mechanism of -150
    Leptin-receptor blocking. -200

    -250

    -300 -269%
    -350
    -300%

    Reduction in sebum synthesis in sebocytes

    A sebocyte incubation with Nelupure™ was performed for 3 days to analyze lipid
    variation versus control.

    Decreased
    44% synthesis of
    lipids

    Decreased area
    47% of lipid droplets

    CONTROL NELUPURETM

    Fluorescence images of sebocytes: green color for lipid droplets and


    blue color for nucleus.

    NelupureTM reduces the activity of key factors


    in sebum overproduction
    IN VIVO EFFICACY
    3 different panels: 25 Asian women,
    27 Caucasian women and 26 Asian men.
    Twice daily application with a mist containing 2% of Nelupure™ on one
    side of the face and a placebo mist on the other side.
    Instrumental measurements were performed at D0, 8 hours, D14 and D28.

    GLOSSARY

    Blackheads
    Non-inflammatory
    Whiteheads
    Comedos
    Inflammatory Pustules / Papules

    Blemishes Any irregularity, spots.

    Values are D28 or D14 vs D0 of product with Nelupure™.

    TARGET 1: Asian women


    Shine is a great concern for asian women.

    IN ONLY 8 HOURS

    Active sebaceous
    14% Shine reduction 15% glands reduction

    Just one application is enough to see results of


    NelupureTM after only 8 hours
    NELUPURE TM
    The sebum balancer inspired by lotus purity, with immediate effect

    IN 28 DAYS

    D0 D28

    12% Shine reduction

    25% Sebum reduction

    In asian skins inflammatory lesions are prevalent.


    The less porphyrins, the less oxidation of squalene, which results in less inflammation and
    imperfections in the skin.

    D0 D28

    Porphyrins
    37% reduction

    Inflammatory
    65% lesions
    reduction

    Images of porphyrins (white dots) reduction.


    TARGET 2: Caucasian women (in 28 days)

    In caucasian skins non-inflammatory lesions are prevalent.

    D0 D28

    Non-inflammatory
    47% lesions reduction

    Blemishes
    41% reduction

    Imperfections reduction is very clear.

    TARGET 3: Asian men

    D0 D28

    Sebum reduction
    29% in only 2 weeks

    Active sebaceous
    17% glands reduction
    in 28 days

    The images show an obvious reduction of skin shine.

    NelupureTM is the active for getting oily skin


    under control

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