Mr. Vishak
Mr. Vishak
Mr. Vishak
Biochemistry
Investigation Observed Value Unit Biological Ref. Interval Specimen
Comments:
c-Reactive Protein, an acute phase reactant, is a pentameric protein found in blood and whose circulating concentrations increase following an
inflammatory reaction. It binds to lysophosphatidylcholine expressed on the surface of dead or dying cells and some strains of bacteria. This
binding then activates the complement system and promotes phagocytosis by macrophages to clear the dead cells/bacteria.
CRP plays a role in innate immunity as an early defense system against infections.
CRP level is an independent risk factor for atherosclerotic disease, although not a very specific prognostic indicator. Patients with elevated basal
levels of CRP are more likely to develop stroke, myocardial infarction and peripheral vascular disease. hsCRP or high sensitivity CRP test is
more sensitive in detecting low levels of CRP, hence used as a risk factor for cardiovascular disease.
Elevated levels are also seen in IBD, colon cancer, obstructive sleep apnoea, avian influenza etc.
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