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    Meclizine Hydro Chloride

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    Meclizine hydrochloride is an oral antihistamine and anticholinergic drug used to prevent and treat nausea, vomiting, and vertigo associated with motion sickness. It works by blocking cholinergic receptors in the vomiting center of the brain and has peripheral anticholinergic effects. Common side effects include drowsiness, dry mouth, and dizziness. It should be used cautiously in elderly patients, those with narrow-angle glaucoma or cardiac conditions, and is contraindicated in pregnancy.

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    Meclizine Hydro Chloride

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    api-3797941
    1K views3 pages
    Meclizine hydrochloride is an oral antihistamine and anticholinergic drug used to prevent and treat nausea, vomiting, and vertigo associated with motion sickness. It works by blocking cholinergic receptors in the vomiting center of the brain and has peripheral anticholinergic effects. Common side effects include drowsiness, dry mouth, and dizziness. It should be used cautiously in elderly patients, those with narrow-angle glaucoma or cardiac conditions, and is contraindicated in pregnancy.

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    Meclizine hydrochloride is an oral antihistamine and anticholinergic drug used to prevent and treat nausea, vomiting, and vertigo associated with motion sickness. It works by blocking cholinergic receptors in the vomiting center of the brain and has peripheral anticholinergic effects. Common side effects include drowsiness, dry mouth, and dizziness. It should be used cautiously in elderly patients, those with narrow-angle glaucoma or cardiac conditions, and is contraindicated in pregnancy.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    1K views3 pages

    Meclizine Hydro Chloride

    Uploaded by

    api-3797941
    Meclizine hydrochloride is an oral antihistamine and anticholinergic drug used to prevent and treat nausea, vomiting, and vertigo associated with motion sickness. It works by blocking cholinergic receptors in the vomiting center of the brain and has peripheral anticholinergic effects. Common side effects include drowsiness, dry mouth, and dizziness. It should be used cautiously in elderly patients, those with narrow-angle glaucoma or cardiac conditions, and is contraindicated in pregnancy.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Download as doc, pdf, or txt
    of 3

    meclizine hydrochloride

    (mek' li zeen)
    Bonamine (CAN), Bonine
    Oral prescription tablets:
    Antivert, Antrizine, Dramamine Less Drowsy Formula, Meni-D

    Pregnancy Category B

    Drug classes
    Antiemetic
    Anti-motion sickness drug
    Antihistamine
    Anticholinergic

    Therapeutic actions
    Reduces sensitivity of the labyrinthine apparatus; probably acts at least partly by blocking
    cholinergic synapses in the vomiting center, which receives input from the chemoreceptor
    trigger zone and from peripheral nerve pathways; peripheral anticholinergic effects may
    contribute to efficacy.

    Indications
    • Prevention and treatment of nausea, vomiting, motion sickness
    • Possibly effective for the management of vertigo associated with diseases
    affecting the vestibular system

    Contraindications and cautions


    • Contraindicated with allergy to meclizine or cyclizine, pregnancy.
    • Use cautiously with lactation, narrow-angle glaucoma, stenosing peptic ulcer,
    symptomatic prostatic hypertrophy, bronchial asthma, bladder neck obstruction,
    pyloroduodenal obstruction, cardiac arrhythmias, postoperative state (hypotensive
    effects may be confusing and dangerous).

    Available forms
    Tablets—12.5, 25, 50 mg; chewable tablets—25 mg; capsules—25, 30 mg

    Dosages
    ADULTS
    • Motion sickness: 25–50 mg PO 1 hr prior to travel. May repeat dose every 24 hr
    for the duration of the journey.
    • Vertigo: 25–100 mg PO daily in divided doses.
    PEDIATRIC PATIENTS
    Not recommended for use in children < 12 yr.
    GERIATRIC PATIENTS
    More likely to cause dizziness, sedation, syncope, toxic confusional states, and
    hypotension in elderly patients; use with caution.

    Pharmacokinetics
    Route Onset Peak Duration
    Oral 1 hr 1–2 hr 12–24 hr

    Metabolism: T1/2: 6 hr
    Distribution: Crosses placenta; may enter breast milk
    Excretion: Feces

    Adverse effects
    • CNS: Drowsiness, confusion, euphoria, nervousness, restlessness, insomnia and
    excitement, seizures, vertigo, tinnitus, blurred vision, diplopia, auditory and visual
    hallucinations
    • CV: Hypotension, palpitations, tachycardia
    • Dermatologic: Urticaria, rash
    • GI: Dry mouth, anorexia, nausea, vomiting, diarrhea or constipation
    • GU: Urinary frequency, difficult urination, urinary retention
    • Respiratory: Respiratory depression, death (due to overdose, especially in
    young children), dry nose and throat

    Interactions
    Drug-drug
    • Increased sedation with alcohol or other CNS depressants

    Nursing considerations
    Assessment
    • History: Allergy to meclizine or cyclizine, pregnancy, narrow-angle glaucoma,
    stenosing peptic ulcer, symptomatic prostatic hypertrophy, bronchial asthma,
    bladder neck obstruction, pyloroduodenal obstruction, cardiac arrhythmias,
    postoperative patients, lactation, pregnancy
    • Physical: Skin color, lesions, texture; orientation, reflexes, affect; ophthalmic
    exam; P, BP; R, adventitious sounds; bowel sounds, normal output, status of
    mucous membranes; prostate palpation, urinary output

    Interventions
    • Monitor I & O, and take appropriate measures with urinary retention.

    Teaching points
    • Take as prescribed. Avoid excessive dosage. Chew the chewable tablets carefully
    before swallowing.
    • Anti-motion sickness drugs work best if used ahead of time for prevention.
    • Avoid alcohol; serious sedation could occur.
    • These side effects may occur: Dizziness, sedation, drowsiness (use caution
    driving or performing tasks that require alertness); epigastric distress, diarrhea, or
    constipation (take with food); dry mouth (practice frequent mouth care, suck
    sugarless lozenges); dryness of nasal mucosa (try another motion sickness,
    antivertigo remedy).
    • Report difficulty breathing, hallucinations, tremors, loss of coordination, visual
    disturbances, irregular heartbeat.

    Adverse effects in Italic are most common; those in Bold are life-threatening.

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