Trimethoprim is an antibacterial drug that inhibits nucleic acid and protein synthesis in bacteria. It is indicated to treat uncomplicated urinary tract infections caused by susceptible bacteria and acute otitis media in children from susceptible pneumococcal and H. influenzae strains. Common side effects include rash, nausea, vomiting and hematologic effects like thrombocytopenia. Nursing considerations include assessing for allergies, pregnancy, organ dysfunction and monitoring blood counts during treatment.
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Trimethoprim is an antibacterial drug that inhibits nucleic acid and protein synthesis in bacteria. It is indicated to treat uncomplicated urinary tract infections caused by susceptible bacteria and acute otitis media in children from susceptible pneumococcal and H. influenzae strains. Common side effects include rash, nausea, vomiting and hematologic effects like thrombocytopenia. Nursing considerations include assessing for allergies, pregnancy, organ dysfunction and monitoring blood counts during treatment.
Trimethoprim is an antibacterial drug that inhibits nucleic acid and protein synthesis in bacteria. It is indicated to treat uncomplicated urinary tract infections caused by susceptible bacteria and acute otitis media in children from susceptible pneumococcal and H. influenzae strains. Common side effects include rash, nausea, vomiting and hematologic effects like thrombocytopenia. Nursing considerations include assessing for allergies, pregnancy, organ dysfunction and monitoring blood counts during treatment.
Copyright:
Attribution Non-Commercial (BY-NC)
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Trimethoprim is an antibacterial drug that inhibits nucleic acid and protein synthesis in bacteria. It is indicated to treat uncomplicated urinary tract infections caused by susceptible bacteria and acute otitis media in children from susceptible pneumococcal and H. influenzae strains. Common side effects include rash, nausea, vomiting and hematologic effects like thrombocytopenia. Nursing considerations include assessing for allergies, pregnancy, organ dysfunction and monitoring blood counts during treatment.
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trimethoprim (TMP)
(trye meth' oh prim)
Primsol, Proloprim, Trimpex
Pregnancy Category C
Drug class Antibacterial
Therapeutic actions Inhibits the synthesis of nucleic acids and proteins in susceptible bacteria; the bacterial enzyme involved in this reaction is more readily inhibited than the mammalian enzyme.
Indications • Uncomplicated urinary tract infections caused by susceptible strains of E. coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species, and coagulase- negative Staphylococcus species, including Staphylococcus saprophyticus • Treatment of acute otitis media due to susceptible strains of S. pneumoniae and H. influenza in children
Contraindications and cautions
• Contraindicated with allergy to trimethoprim, pregnancy (teratogenic in preclinical studies), megaloblastic anemia due to folate deficiency. • Use cautiously with hepatic or renal dysfunction, lactation.
Available forms Tablets—100, 200 mg; solution—50 mg/5 mL
Dosages ADULTS 100 mg PO q 12 hr or 200 mg q 24 hr for 10 days. PEDIATRIC PATIENTS • Otitis media: 10 mg/kg/day in divided doses q 12 hr for 10 days. GERIATRIC PATIENTS OR PATIENTS WITH RENAL IMPAIRMENT For creatinine clearance of 15–30 mL/min, 50 mg PO q 12 hr; creatinine clearance of < 15 mL/min, not recommended.
Nursing considerations Assessment • History: Allergy to trimethoprim, megaloblastic anemia due to folate deficiency, renal or hepatic dysfunction, pregnancy, lactation • Physical: Skin color, lesions; T; status of mucous membranes; CBC; liver and renal function tests
Interventions • Perform culture and sensitivity tests before beginning drug therapy. • Protect the 200-mg tablets from exposure to light. • Arrange for regular, periodic blood counts during therapy. • Discontinue drug, consult with physician if any significant reduction in any formed blood element occurs.
Teaching points • Take the full course of the drug; take all the tablets prescribed. • Have periodic medical checkups, including blood tests. • These side effects may occur: Epigastric distress, nausea, vomiting (eat frequent small meals); rash (consult with your health care provider for appropriate skin care). • Report fever, sore throat, unusual bleeding or bruising, dizziness, headaches, rash.
Adverse effects in Italic are most common; those in Bold are life-threatening.
