Closed Loop UV Analysis 4 - RS TDT

Solutions and Applications No.
1010
Closed Loop Tablet Dissolution Testing
Using UV detection
Dissolution profiles generated automatically in real time
Unprecedented automation for Tablet Dissolution testing for formulation,

development or QC according to USP/EP/JP
ALS provides the widest range of automated systems for
Pharmaceutical Analysis in Dissolution testing. Our Closed Features
Loop Dissolution systems consist of a Bath, Pump and
Spectrophotometer controlled by our IDIS software. At the § Controls all instrument Parameters
sampling time, IDIS controls the spectrophotometer and § Can connect up to 2 Baths to 1 UV (depends on UV)
reads the Absor bance values for all Vessels. § Acquires UV data, plots and displays profiles in real
time.
Systems are configured using instruments from different § Controls tablet dissolution baths from ALS, Agilent,
manufacturers thus allowing customers to choose the best Distek, Copley, Erweka, Hanson, Pharmatest, Sotax.
instrument for each task, Dissolution Tester, Pump (which can § Uses spectrophotometers from ALS SP700, Agilent
be Peristaltic or Metering ) and spectrophotometers from 8453, Agilent Cary 50/60, Jena Specord, Perkin
different suppliers. Elmer Lambda 25/35/45, Shimadzu UV1600/1700,
Our systems offer the most flexible methodology, providing 1800, 2401/2501, Thermo E300.
grouping of Vessels for Method Development or Product § Cell Grouping , for Method Development using a
Comparison, Multi-component analysis, acquisition of Bath different wavelength for each Group and for
data Temperature or Speed, stand- alone systems or Product Comparison
networking with Fault Tolerant Database in case of network § Calibration Curve, Multi-Component Analysis with
break. Savitzky–Golay Derivative smoothing
§ Professional report presentation of results
Our systems offer the most flexible methodology, providing personalised to each customer requirements
grouping of Vessels for Method Development or Product
Comparison, Multi-component analysis, acquisition of Bath
data Temperature or Speed, stand- alone systems or
networking with Fault Tolerant Database in case of network
break.
ALS systems are very flexible and can be applied to pharmaceutical analysis in R&D, Formulation and most importantly for
Quality Control providing high sample throughput, reduction in manpower allowing quick return on investment.
The Pharmaceutical industry requires quality systems.
ALS ASP2000 analysis systems provide features compliant with quality standards… Standard Checks, Standard Bracketing,
Quantification using Calibration Curve, full compliance with 21 cfr Part 11.
All ALS systems are provided with IQ, OQ and optional PQ fully in line with pharmaceutical testing requirements.
IDIS professional report

showing a dissolution test
performed in two medias.
Note the different statistics
for each group, making IDIS
very important for your
method development.
Automation from a company who knows

At ALS, we offer much more than just innovative dissolution systems. We provide a complete solution including
qualification, training, SOP guidance and support options.
Our dedicated technical support lines are always open to help with method development, further automation and any
other issues.
§ We were the first company to introduce a database to manage dissolution records

§ We were the first company to network data stations to reduce administrative tasks and provide remote access to
results in real time
§ We were the first company to introduce Cell Grouping for Method Development and Product Comparison
§ We are the first company to measure pH in each Vessel and titrate to a set pH
Overall Advantages
§ Allows you to select from most popular makes of instruments, Baths, Pumps and Spectrophotometers so you can
choose the instruments you prefer
§ Reliable, automated, flexible methodology allows faster method development
§ Networked solutions deliver your results immediately remotely and internationally
§ Professional presentation results negates the need to use Excel or other packages
Automated Lab Systems

Unit 2 Pinecopse, Nine Mile Ride
Wokingham, Berkshire
RG40 3ND, UK
LAB SYSTEMS
Tel: +44 1344 780141; Fax: +44 1344 563039
www.auto-labsystems.co.uk

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Solutions and Applications No.

Dissolution profiles generated automatically in real time

Unprecedented automation for Tablet Dissolution testing for formulation,

IDIS professional report

Automation from a company who knows

§ We were the first company to introduce a database to manage dissolution records

Automated Lab Systems

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