Neurology Work Book
Neurology Work Book
Neurology Work Book
WORKBOOK
By
Dr. Priyansh Jain
MEDICINE
NEUROLOGY
BY
CHAPTER 2: MENINGITIS
CHAPTER 3: DEMENTIA
CHAPTER 4: HEADACHE
CHAPTER 5: APHASIA
CHAPTER 6: EPILEPSY
CHAPTER 8: DYSTROPHINOPATHIES
CHAPTER 1
STROKE/CEREBRO-VASCULAR ACCIDENT
EDH —
— CT -
— Lucid Interval
SDH —
— CT -
— Lucid Interval
ICP — Sign -
— MC CN involved -
— Complication -
— Rx — Most effective —
— Other -
— PCA
— Gaganhalton
??.
— Temporal Lobe
— Occipital Lobe
Dominant Non-Dominant
Patient A Patient B
CEREBELLAR LESION
• Neo-cerebellum —
• Archi-Cerebellum —
TREMOR
Contraction of agonist and antagonist muscle
• Intentional tremor
Goal
Starting
Point
• Resting tremor
Goal
Starting
Point
• ESS: Tremor — MC
— Rx -
Goal
Starting
Point
Lesion of Basal Ganglia — Caudate Nucleus
— Putamen
— Subthalamic Nucleus
Types of CVA
a-
b-
c-
Hemorrhagic
MANAGEMENT OF TREMOR AND STROKE
55 year / male / uncontrolled HTN
C/F-
Inv- 1st-
Rx-
C/I -
8 DR. PRIYANSH JAIN MEDICINE
NEUROLOGY:STROKE/CVA
C/f -
Inv - 1st-
- radiological investigation -
— Time
— Age
Contra-indication — BP
SUMMARY
CHAPTER 2
MENINGITIS
ETIOLOGY
a) Bacterial meningitis
MCC-
Other -
b) Viral meningitis
MCC -
Other - HSV- 1
HSV -2
10 DR. PRIYANSH JAIN MEDICINE
NEUROLOGY:MENINGITIS
c) Fungal Meningitis
Seen in -
MC-
C/F OF MENINGITIS
O/E —
Investigation
CSF - production by -
- absorbtion by -
- color -
- cell -
- protein -
- glucose -
CSF ANALYSIS
• Seen in -
• Fundus -
• Rx -
SUMMARY
A....B.....C.....D
CHAPTER 3
DEMENTIA
Definition
Decrease in .......................
Causes of Dementia
ALZHEIMER’S DISEASE
Patho-physiology
Intracellular accumulation of -
Extracellular accumulation of -
Alz. Disease
Sporadic Familial
Chromosome - ... - ..................... ........... gene
Chromosome - ... - ...................... .............. gene
Chromosome - ... - ............... ........... gene
Chromosome - ... - ............ .. ..........
C/F
Unable to recall name of objects -
Investigation:
Treatment:
MULTI-INFARCT DEMENTIA
C/F
Time
FRONTO-TEMPORAL DEMENTIA
____________ is spared
So
__________________
Due_______________
to accumulation of tau _______
LEWY BODY DEMENTIA
D/t accumulation of _________ Protein
|
LEWY ____
|
Damage to ___________
|
DR. PRIYANSH JAIN MEDICINE 3
NEUROLOGY:DEMENTIA
C/F
— | Severity of disease in
successive generations
Rx - Mc
Rx
Parkinson’s related dementia —
CRETZFELD-JAKOB DISEASE
Patho-physiology
CH
Prp (prion related Protien)
Found in cytoplasm
Types Of CJD 1. Mc —
2.
3. Contaminated meats —
4.
C/F
• EEG -
• CSF -
• MRI -
(Brain)
Rx
Summary of demantia
- extra neuronal -
C/a -
Severity of alz. Disease depends on -
MC lobe involved in alz disease -
PARKINSONISM
1 2
C/f C/f
Eg - Multi-system atrophy(MSA)
Eg - Parkinson d/s Progressive supra-nuclear palsy(PSP)
Cortico-basal degeneration (CBD)
PARKINSON DISEASE
Patho-physiology
Bodies
Protien Substantia
Nigra
Degenerate
n PD
Limbs>axis
C/F
____ hypothesis is related to Parkinson’s d/s
C/f - Motor — T —
R—
A—
P—
Treatment
Non motor
Treatment:
Last Rx —
Electrode is placed in
— Rx —
S/E of — L-DOPA
— ROPINIROLE
ATYPICAL PARKINSONISM
a) Multisystem Atrophy (MSA)
|
Atypical Parkinsonism
|
Bradykinesia & Rigidity (neck&spine) +
In axis
Q) MRI brain
C/f —
MRI —
c) Cortico-Basal Degeneration
Atypical Parkinsonism +
Protein Accumulation
DEMENTIA PUGLISTICA
— seen in
— C/F —
— a/c/a — Syndrome
SUMMARY
- Gait -
CHAPTER 4
HEADACHE
TYPES OF HEADACHE
1 (idiopathic) 2
MIGRAINE • F M
• B/w. YR
• Last for Hr
• Type headache
• Disabling in character
• Mostly
• Hint MCQ — asso. c
Patho-physiology
Vasodilation
Vascular theory Meninges Stretch in Rx Vasoconstriction
meninges
Cortical wave
Of depolarisation
Types of Migraine
— _________ migraine — migraine c
— _________ migraine
• Variant Migraine
TREATMENT OF MIGRAINE
a) For acute attack 1st line
DOC
Other Dx
b) For Prevention of migraine
Verapamil —
SSRI — DR. PRIYANSH JAIN MEDICINE 3
NEUROLOGY:HEADACHE
c) Other Modalities
STATUS MIGRANOSUS
Rx —
— cluster headache
-
— SUNCT/SUNA
C/F • M F
• Trigger —
• Pain (___________ in nature)
+
+
Last for 30 mins to 2 hour
— Ist Line —
Rx — For acute attack
— DOC
— For Prevention
b) Paroxysmal c) SUNCT/SUNA
-
-
S-
Hemicranial Headache
- U-
N-
C-
T-
M F M F
10-20 20-100
Indomethaline
Indomethacin Indomethacin
Rx Rx
— PO2 —
— S. Na —
— Character —
— Lasting —
— Rx —
No autonomic symptoms
SUMMARY
A….B……C……D…….E……..F………G….
migraine treatment -
acute attack -
Prophylaxis -
CHAPTER 5
APHASIA
Unable to
SPEECH-CIRCUIT Or
Aphasia Unable to
Area Area
Cortex Cortex
TYPES OF APHASIA
CONDUCTION
TRANSCORTICAL
SENSORY
TRANSCORTICAL
MOTOR
ISOLATION
(Echolalia)
GLOBAL
MC Aphasia —
• Comp —
• Rep —
• Fluency —
• Naming —
SUMMARY
CHAPTER 6
EPILEPSY
SEIZURE
CLASSIFICATION OF SEIZURE
Generalised Focal
Both Hemispheres involved One Hemisphere involved
GENERALIZED
a) GTCS (Gen. Tonic clonic seizures)
A) Stages — Ist
IInd
IIIrd
IVth
DOC —
— Occurs — Yr
— Pt. in morning —
— EEG —
Rx — DOC —
JME — Trigger —
MC presentation of JME
Myoclonic epilepsy + Lafita body in —
sweat gland Bx
JME associated with —
DR. PRIYANSH JAIN MEDICINE 3
NEUROLOGY:APHASIA
c) Tonic Seizure
d) Atonic Seizure
e) Absence Seizure
_____ yr
EEG —
Rx —
FOCAL SEIZURE
a) Focal aware
(Marching/progression)
Of C/F d/t involvement
Rx -
of nearby neuron
C/F —
Rx —
EPILEPSY SYNDROME
a) LENNOX-GESTAUT Syndrome
H/o
EEG —
Rx —
S/E of Vigabatrin —
EEG — Triphasic
— Hypsarrythmia
— 4-6Hz
SPECIAL POINTS
— Rx of GTCS if NO I/V access —
— old case -
— Photosensitive seizure — Rx —
— C/F -
— EEG -
— Rx -
SUMMARY
- DOC -
juvenile myoclonic epilepsy - myoclonic …………. F/b …………../……………
CHAPTER 7
NEURO-MUSCULAR JUNCTION DISORDER
NEURO-MUSCULAR JUNCTION
A) MYASTHENIA GRAVIS
Patho-physiology
C/F —
Types of M.G.
— Ocular M.G.
— Generalised M.G.
— M. Crisis
— Most specific
Treatment
1) Only ocular M.G. —
2) Generalise M.G. —
3) M. Crisis —
B) LAMBORT-EATON SYNDROME
Patho-Physiology
C/F —
Investigation —
Treatment —
SUMMARY
CHAPTER 8
DYSTROPHINOPATHIES
Dystrophin
Patho-Physiology
| Quality | Quantity
TYPES OF DYSTROPHINOPATHY
DUCHENE’S BACKER’S
Inheritance -
Pathogenesis -
C/F -
GOWER sign -
Age group -
Cardiomyopathy -
IQ -
Rx -
Cause of Death -
• C/F
— MC —
— optic neuritis —
— cerebellum involvement —
— spinal cord —
— involvement of MLF —
(medial longitudinal fasiculus)
• Types of MS
Time
• Lhermitte sign
• Investigation - CSF —
IOC —
• Rx — Acute —
Rx —
— Antibody -
Rx -
Steroid
SUMMARY
CHAPTER 9
MOTOR NEURON DISEASE
CORTICO-SPINAL TRACT
Motor cortex
Corona radiata
Internal capsule
TYPES OF MND
a) UMN type
b) LMN type
c) Mixed type
Tounge —
C/F — UL —
HMF —
— LL —
Eye Ball —
Investigation —
Rx —
TABESDORSALIS
Patho-Physiology
Joint sense
Gait - Position sense
Vibration sense
Pupil -
ROMBERG TEST
• Hint — CBC —
SYRINGOMYELIA
Patho-physiology
C/F —
Investigation — IOC —
Rx —
Ankle reflex
[S1/S2]
Knee reflex
[L2/L3/L4]
Saddle sensation
[S2/S3/S4]
Symmetry
BRAIN STEM
Mid Brain — 3 CN
— 4CN
PONS — 5 CN
— 6 CN
— 7 CN
— 8 CN
Medulla — 9 CN — Brain
10 CN
11 CN SUPPLY
Supply —
12 CN
Midline
Tracts in B-stem
— cortico-spinal tract
— spinothalamic tract
C/F
12 CN
M.L.
CST CST
8 CN
Sympathetic tract
Spinothalamic tract
Sensory nuclei of CN 5
N. ambiguous
– CN 9 —
– CN 10 —
– CN 11 —
PONTINE SYNDROME
Millard Gubler Syndrome Foville Syndrome
• Locked in Syndrome
Mid Brain
• Weber Syndrome
— Artery involved
• Nothnagel syndrome —
— taste sensation
— S. cord —
— Planter Reflex -
— GAG Reflex
— Pupil
— EEG
SUMMARY