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LABETALOL Drug Study

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Indication Mechanism of action Side effects Adverse effect Contradiction Nursing responsibilities

LABETALOL Labetalol exhibits CNS:  Monitor BP


Labetalol is both a nonselective Drowsiness, Anxiety, Asthma, and pulse
used to dizziness, cardiogenic frequently
B-adrenergic and confusion,
manage excessive shock, heart
hypertension selective A1 fatigue. depression, during dose
adrenergic dizziness, failure, adjustment
and severe Occasional
hypertension blocking (10% or less): drowsiness, hypersensitivity and
and treat properties. It Dyspnea, fatigue, to labetalol or its periodically
hypertensive lowers blood peripheral paresthesia, components, during
Generic Name: Trandate emergencies. pressure by edema, syncope, second-or third- therapy.
blocking peripheral depression, vertigo, degree heart  Check
anxiety, block, severe
arteriolar a- weakness, frequency of
Brand Name: Trandate constipation, bradycardia
adrenoceptors, diarrhea, nasal yawning. refill to
therby reducing congestion, determine
Dosage: peripheral CV: compliance.
weakness,
Tablets Adult: 100 mg, increased
ny 100 mg as needed.
resistance. It also diminished Bradycardia,  Patient
concurrently sexual function, chest pain, receiving IV
IV injection Adult- 20 mg;
inhibits B- transient scalp heart block, labetalol must
additional doses given in
andrenoceptors in tingling, heart failure,
increments of 40 to 80 mg. be supine
insomnia,
the heart from the hypotension, during and for
nausea,
reflex symphathetic vomiting, and orthostatic 3 hr after
Frequency: drive that may hypotension, administration.
abdominal
Tablets: 2-3 times a day. occur. It does not discomfort. ventricular  Monitor intake
significantly reduce Rare: Altered arrythmias. and output
IV injection: Given 2-5 mins. cardiac output at taste, dry eyes, ratios and
rest or after increased EENT: Nasal daily weight.
Route (Based on the doctors moderate exercise. urination, and congestion,
parethesia.
order): Oral, intramuscular, taste
or intravenous. perversion.

GI: Elevated
Drug classification: liver function
Pharmacotherapeutics: Alpha- test results,
beta-adrenergic blocker. hepatic
Clinical: Antihypertensive. necrosis,
hepatitis,
indigestion,
nausea,
vomiting.

GU:
Ejaculation
failure,
impotence.

RESP:
Dyspnea,
wheezing

SKIN:
Jaundice,
pruritus, rash,
scalp tingling
Nursing Consideration:

 During I.V. labetalol use, monitor blood pressure according to facility policy, usually every 5 minutes for 30 minutes, then
every 30 minutes for 2 hours, and then every hour for 6 hours.
 Keep patient in supine position for 3 hours after I.V. administration.
 Warning, be aware that labetalol masks common signs of shock.
 Monitor blood glucose level in diabetic patient because labetalol may conceal symptoms of hypoglycemia.
 Be aware that stopping labetalol tablets abruptly after long-term therapy could result in angina, MI, or ventricular
arrhythmias. Expect to taper dosage over 2 weeks while monitoring response.

Patient Teaching

 Advise patient to report confusion, difficulty breathing, rash, slow pulse, and swelling in arms or legs.
 Caution patient not to stop drug abruptly because doing so could cause angina and rebound hypertension.
 Suggest that patient minimize effects of orthostatic hypotension by rising slowly, avoiding sudden position changes, and
taking labetalol at bedtime, if approved by the physician.
 Instruct diabetic patient to check blood glucose level often and to be alert for signs and symptoms of hypoglycemia.
 Inform patient that scalp tingling may occur early in treatment but is transient.
 Urge patient to avoid alcohol during labetalol therapy.
 Advise patient to inform eye healthcare provider if he needs cataract surgery because intraoperative floppy iris syndrome
has occurred during cataract surgery in some patients treated with the class of drugs of which labetalol is a member.

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