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    Exercises Chapter 3

    Uploaded by

    Atifah Rozlan
    The document contains 3 exercises related to estimating lifetime distribution functions using Kaplan-Meier and Nelson-Aalen estimates. The first exercise provides data on times until failure or replacement of a kitchen appliance and asks questions about calculating the survival function and variance estimates. The second exercise provides clinical trial data on patient deaths and withdrawals and asks for survival function and confidence interval calculations. The third exercise provides data on the number of processed foods affected each day over 10 days and asks for Kaplan-Meier and Nelson-Aalen survival function estimates and a comparison of the graphs.

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    Exercises Chapter 3

    Uploaded by

    Atifah Rozlan
    25 views2 pages
    The document contains 3 exercises related to estimating lifetime distribution functions using Kaplan-Meier and Nelson-Aalen estimates. The first exercise provides data on times until failure or replacement of a kitchen appliance and asks questions about calculating the survival function and variance estimates. The second exercise provides clinical trial data on patient deaths and withdrawals and asks for survival function and confidence interval calculations. The third exercise provides data on the number of processed foods affected each day over 10 days and asks for Kaplan-Meier and Nelson-Aalen survival function estimates and a comparison of the graphs.

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    The document contains 3 exercises related to estimating lifetime distribution functions using Kaplan-Meier and Nelson-Aalen estimates. The first exercise provides data on times until failure or replacement of a kitchen appliance and asks questions about calculating the survival function and variance estimates. The second exercise provides clinical trial data on patient deaths and withdrawals and asks for survival function and confidence interval calculations. The third exercise provides data on the number of processed foods affected each day over 10 days and asks for Kaplan-Meier and Nelson-Aalen survival function estimates and a comparison of the graphs.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    25 views2 pages

    Exercises Chapter 3

    Uploaded by

    Atifah Rozlan
    The document contains 3 exercises related to estimating lifetime distribution functions using Kaplan-Meier and Nelson-Aalen estimates. The first exercise provides data on times until failure or replacement of a kitchen appliance and asks questions about calculating the survival function and variance estimates. The second exercise provides clinical trial data on patient deaths and withdrawals and asks for survival function and confidence interval calculations. The third exercise provides data on the number of processed foods affected each day over 10 days and asks for Kaplan-Meier and Nelson-Aalen survival function estimates and a comparison of the graphs.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    Exercise Chapter 3:- Estimating the Lifetime Distribution Function

    1. A chef specialising in the manufacture of fluffy meringues uses a Whiskmatic


    disposable electric kitchen implement. The Whiskmatic is rather unreliable and often
    breaks down, so the chef is in the habit of replacing the implement in use at a given
    time, shortly before an important social function or after making the 1,000th fluffy
    meringue with that implement.

    The following times until mechanical failure (no asterisk) or replacement whilst working
    in order (asterisk) were observed (measured in days of use): 17, 13, 15*,7*,21, 18*,
    5, 18, 6*, 22, 19*, 15, 4, 11, 14*, 18, 10, 10, 8*, 17.

    (i) State the values of n,m,k, tj, dj, and nj for these data, assuming the censoring
    occurs just after the failures were observed.
    (ii) Calculate the Kaplan-Meier estimate of the Whiskmatic survival function
    ~
    (iii) Using Greenwood’s formula, estimate var[ 𝑆 (16)].
    (iv) Calculate the Nelson-Aalen estimate of the cumulative hazard function using
    the given data values.
    ~
    (v) Use the given data values to estimate Var[ Λ 16].

    2. A clinical trial is being carried out to test the effectiveness of a new drug. Sixty patients
    were involved in the trial, which followed them for 2 years from the start of their
    treatment. The following data show the period in complete months from the start of
    treatment to the end of observation for those patients who died or withdrew from the
    trial before the end of the 2-year period.

    Deaths : 8,10,10,16,20
    Withdrawals : 2,6,9,16,18,22,22

    (i) Calculate the Kaplen-Meier estimate of the survival function.


    (ii) Construct an approximate 95% confidence interval for the probability that a
    patient survives for at least 18 months after the start of the drug treatment.
    3. Arif worked as a risk manager in a food processing company. One of his main tasks is
    to look at the lifetime of processed food produced. He decided to observe the
    production of 15 processed foods for 10 days to find the survival function. The results
    are as follows:

    Day Number of Affected Food


    1 No food affected
    2 1 affected
    3 No food affected
    4 3 affected
    5 No food affected
    6 2 affected
    7 1 affected
    8 No food affected
    9 2 affected
    10 No food affected

    (i) Calculate the Kaplen-Meier and Nelson Aalen estimates of the survival function
    of the processed food for 10 days.
    (ii) Compare the graph for each survival function and give your comment.

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