CELLMOL Final Exam PDF

5/7/22, 2:14 PM FINAL EXAM Cell Biology: [1212_CELLMOL_N01] - CELL BIOLOGY AND MOLECULAR BIOLOGY
FINAL EXAM Cell Biology

Due No due date Points 50 Questions 50 Time Limit 100 Minutes
Instructions
Best of luck!
Attempt History
Attempt Time Score
LATEST Attempt 1 42 minutes 45 out of 50
Score for this quiz: 45 out of 50

Submitted May 7 at 2:14pm
This attempt took 42 minutes.
Question 1 1 / 1 pts
The endoplasmic reticulum is a site for
potassium storage in muscle cells.
Correct!
N-linked glycosylation of polypeptides.
addition of lipid residues.
drug detoxification by catalase.
Course Chat 
https://dlsu.instructure.com/courses/90425/quizzes/213438 1/26
Which of the following molecules stabilizes the cell membrane during

coated pit formation?
botulinum toxin
stabilin
Correct!
mannose-6-phosphate
clathrin
KDEL signals
Send
The release of mucus by the epithelial cells lining the respiratory tract is
an example of
the mucus response.
regulated secretion.
phagocytosis.
the formation of clathrin-coated pits.
Correct!
constitutive secretion.
Course Chat 
In a longitudinal section of a nerve cell, at the presynaptic site you note a

variety of vesicles that are anchored to the plasma membrane. The
vesicles must be specialized for
zymogen secretion.
Correct! Send
polarized secretion.
None of the choice
In a lysosomal storage disease, the hydrolases of lysosomes are

released from the cells, rather than being isolated into vesicles. What is
one possible mechanism for this result?
Lysosomal enzymes were not phosphorylated in the rER.
There is a mutation in all hydrolase genes that results in loss of the signal
peptide.
Course Chat 
A proton gradient within vesicles was not generated.
Correct!
There is a lack of mannose-6-phosphatase activity.
The ER was unable to produce lysosomal vesicles.
Which of the following organelles is associated with the ability to

catabolize alkanes found in oil and petroleum products?
Send
lysosomes
smooth endoplasmic reticulum
mitochondria
All the choices are correct
Correct!
peroxisomes
Bacterial proteins were radioactively labeled and fed to phagocytic cells.

The proteins within the phagocytic cell became increasingly more
radioactive over time. This observation is the result of the activity of
Course Chat 
peroxisomes.
Correct!
lysosomes.
chloroplasts.
the Golgi apparatus.
mitochondria.
All of the following are true about botulinum toxin/Botox except Send
It has been used to remove wrinkles caused by muscle contractions.
It has potential use as a migraine headache treatment.
It can be used therapeutically to stop muscle spasms.
The toxin is one of the most potent toxins known.
Correct!
Botox is a SNARE protein.
You are working with cells and observe the transport of your target protein
within a cell. You suspect that sorting conforms to the SNARE hypothesis.
You, therefore, expect
Course Chat 
All the choices are correct
the protein molecules were internalized by phagocytosis.
Correct!
to eventually identify vesicle-SNAP receptors.
to eventually identify transport-SNAP receptors.
an association with clatherin-coated pits.
Send
Regulatory secretion of hormones would be associated with ________ at

the transface of the Golgi.
lysosomes
endosomes
Correct!
clathrin-coated vesicles
microsomes
non-clathrin vesicles
Course Chat 
Of the following cell types, the greatest concentration of high-density

lipoprotein (HDLs) would be associated with ________ cells.
blood
muscle
Correct!
Liver
skin
connective tissue
Send
All of the following statements about cellular trafficking are true except
movement may be mediated by microtubules.
COPII-coated vesicles move materials from ER to Golgi.
Correct!
COPI-coated vesicles move materials from Golgi to the secretory vesicle.
tethering proteins mediate docking between target and vesicle.
v-SNAREs occur in vesicles; t-SNAREs occur on target sites.
Course Chat 
Which of the following cellular processes has/have been linked to

cancer/tumor formation?
autophagy
caveolae uptake
EGF desensitization
NMDA receptors
Send
Correct! Autophagy + EGF desensitisation
.................................. act as proton pumps and keep the internal proton

concentration of lysosomes high.
ou Answered
ATPases
orrect Answers ATP ases
Course Chat 
................................. are proteins associated with clathrin-coated vesicles

that are involved in the binding of vesicles to specific receptors.
Correct!
Adaptins
orrect Answers Adaptins
Send
Cavolae are involved in the exocytosis of lipid rafts from the plasma
membrane.
orrect Answer True
ou Answered False
Correct Answer
The basic unit of clathrin lattices is known as ………………..
Correct!
triskelion
Course Chat 
orrect Answers Triskelion
The proteins localized to the ER containing the sequence RXR and also
found in some proteins destined for the plasma membrane are examples
of …………… Tag.
ou Answered
retention
orrect Answers Retention Tag
Send
When the indigestible material is all that remains in a lysosome then the
lysosomes become a ……………….
Correct!
residual body
orrect Answers Residual body
Cells of the pancreas produce and release enzymes to the digestive

system. The type of secretory mechanism associated with the pancreatic
Course Chat 
cells is
intracellular secretion.
transport secretion.
Correct!
consistent secretion.
Send
All of the following are ways cancer cells avoid growth and invasion
restriction imposed by the immune system except
Correct!
cancer cells often respond to density-dependent growth factors.
some cancers often "hide" in dense supporting tissue.
some cancers produce low levels of surface antigens.
they are heterogeneous groups of cells.
some cancer cells produce leukotoxins.
Course Chat 
PAHs (polycyclic aromatic hydrocarbons) found in tobacco smoke

preferentially bind to regions within the ________ and trigger base
substitutions.
viral gene
GAL-4 gene
DMBA gene
homeogenes
Correct! p53 gene

Send
The group of proteins associated with the binding of cells to the

extracellular matrix are the
Correct! integrins.
MHC.
matrix metalloproteins.
monolins.
RAS proteins.
Course Chat 
Aneuploidy (the gain or loss of chromosomes) is associated with which

protein molecule in cancer cells?
None of the choices are correct.
Correct! p53
Blc-2
Send
Myc
pRB
Which of the following with regard to cancer cells is false ?
The cell cycle is disrupted.
Growth is not regulated by growth factors.
Correct! Most cancer cells die in G1
Growth is not stopped by high levels of DNA damage.
Course Chat 
The apoptosis pathway is blocked.
A tumor is actively producing both VEGF and FGF, factors associated

with angiogenesis. However, no network of blood vessels to the tumor has
been established in spite of the fact that blood vessels are nearby. This
observation most likely suggests that
the tumor is metastatic.

Send
only one of the molecules is active, not both.
angiostatin is not produced by the cancer cells.
Correct! angiogenesis inhibitors are in greater concentration.
the VEGF and FGF are not functional.
The correct order of events in metastasis of a cancer is
transport → invasion → angiogenesis → new site
Course Chat 
Correct! angiogenesis → invasion → transport → new site
invasion → angiogenesis → transport → new site
transport → angiogenesis → invasion → new site
angiogenesis → transport → invasion → new site
The promotion phase of carcinogenesis refers to
Send
metabolic oxidation by a P450 cytochrome
enhanced levels or exposures to a carcinogen
normal cell progression to a precancerous cell
Correct! precancerous cell progression to a cancerous cell
the amount of DNA damage in a cell
The first documentation of a viral infection causing oncogenesis was

established with
Course Chat 
Epstein-Barr virus in Burkitt's lymphoma.
Correct!
Rous sarcoma virus in chickens.
HIV in humans.
hepatitis B in liver cancer.
human papilloma virus in cervical cancer.
In some forms of breast cancer, estrogen is a(n) Send
Correct!
promoter.
inhibitor.
mutagen.
initiator.
progressor.
Hereditary retinoblastoma is the result of a(n) ________ in the RB gene of

chromosome 13 in both homologues. Course Chat 
Correct! deletion
insertion
duplication
point mutation
inversion
Send
Familial adenomatous polyposis coli (APC) is characterized by a small

deletion in chromosome 5. In which cells is this deletion present in
affected individuals?
Correct! all cells
germline cells
somatic cells
colon polyps
colon epithelial cells
Course Chat 
The normal RB gene functions as
an activator of translation.
a proto-oncogene.
a cell surface receptor.
Correct! an inhibitor of transcription.
an activator of transcription.
Send
Angiostatin, Endostatin, and Thrombospon are examples of
Promoters of Metastasis
Promotors of Angiogenesis
Inhibitors of Metastasis
Correct! Inhibitors of angiogenesis
Course Chat 
Highly invasive cancer cells usually have………….. level of E-cadherin

than do normal cells.
Correct! Less
More
Same level
Irrelevant information to answer the question
Send
………………………. hypothesis attempts to explain that the circulating

cancer cells have an affinity for the environment provided by particular
organs
SNARE Hypothesis
Two hit Hypothesis
Correct! Seed and soil Hypothesis
Multi hit hypothesis
Course Chat 
…………… allow cancer cells to penetrate the basal lamina and facilitate
migration by degrading the ECM of underlying tissues
TGFβ
Correct! proteases
None of the choices are correct
Chemoattractants
Send
pRB actively inhibit cell cycle progression when it is
Activated
Correct! Dephosphorylated
Denatured
Phosphorylated
Course Chat 
Sarcoma is the cancer of brain glial cells.
orrect Answer True
ou Answered False
correct answer
Send
Any dominant mutation in the Oncogenes will be expressed as “loss of
function” mutation. True or False
orrect Answer True
ou Answered False
correct answer
Cancer cells express telomerase, an enzyme that continuously shortens

the telomere length.
Course Chat 
True
Correct! False
You want to engineer a yeast cell to manufacture and secrete a bacterial

protein product. To do this properly, you need to make certain that
all of the choices are correct
mannose-6-phosphate is added to the protein. Send
Correct! the appropriate signal sequence is present.
the yeast cell is capable of phagocytosis.
plenty of clathrin-coated pits may be formed.
Which of the following statements is true regarding factors associated with

the immortalization of cancer cells?
Course Chat 
inhibition of growth
Correct!
telomerase activity
stimulation of apoptosis
tumor-suppressor activation
all choices are correct
The continuous release of mucus by the epithelial cells lining the Send
respiratory tract is an example of
Correct!
the mucus response.
the formation of clathrin-coated pits.
phagocytosis.
Course Chat 
Peroxisomes
possess amylase activity.
are bounded by double membranes.
Correct! are not derived from the endoplasmic reticulum.
all choices are correct
possess acid phosphatase activity.
Send
If you were looking within a cell for organized clathrin structures, you
would find them associated with which of the following structures?
Correct!
trans Golgi complex
extracellular matrix
inner membrane of mitochondria
endoplasmic reticulum
lysosomes
Course Chat 
Microsomes are
organelles through which electrons cannot pass.
Correct! artifacts generated during homogenization of cells.
too small to be seen with an electron microscope.
organelles of eukaryotic cells.

Send
structures observed in cyanobacteria.
Compared with the trans-Golgi proteins, the cis-Golgi proteins would
Correct!
be glycosylated only.
be shorter in length.
be glycosylated and contain amino acid modifications.
be identical.
contain sialic acid.
Course Chat 
Exocytosis is stimulated by regional increases in ________

concentration.
Correct!
calcium
orrect Answers calcium
1 / 1 pts Send
Question 50
________ are proteins associated with clathrin-coated vesicles that are

involved in the binding of vesicles to specific receptors.
Correct!
adaptins
orrect Answers Adaptins
Quiz Score: 45 out of 50
Course Chat 

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5/7/22, 2:14 PM FINAL EXAM Cell Biology: [1212_CELLMOL_N01] - CELL BIOLOGY AND MOLECULAR BIOLOGY

FINAL EXAM Cell Biology

Score for this quiz: 45 out of 50

The endoplasmic reticulum is a site for

potassium storage in muscle cells.

addition of lipid residues.

drug detoxification by catalase.

Which of the following molecules stabilizes the cell membrane during

the mucus response.

the formation of clathrin-coated pits.

In a longitudinal section of a nerve cell, at the presynaptic site you note a

None of the choice

In a lysosomal storage disease, the hydrolases of lysosomes are

Lysosomal enzymes were not phosphorylated in the rER.

A proton gradient within vesicles was not generated.

The ER was unable to produce lysosomal vesicles.

Which of the following organelles is associated with the ability to

smooth endoplasmic reticulum

All the choices are correct

Bacterial proteins were radioactively labeled and fed to phagocytic cells.

the Golgi apparatus.

It has been used to remove wrinkles caused by muscle contractions.

It has potential use as a migraine headache treatment.

It can be used therapeutically to stop muscle spasms.

The toxin is one of the most potent toxins known.

All the choices are correct

the protein molecules were internalized by phagocytosis.

to eventually identify transport-SNAP receptors.

an association with clatherin-coated pits.

Regulatory secretion of hormones would be associated with ________ at

Of the following cell types, the greatest concentration of high-density

movement may be mediated by microtubules.

COPII-coated vesicles move materials from ER to Golgi.

COPI-coated vesicles move materials from Golgi to the secretory vesicle.

tethering proteins mediate docking between target and vesicle.

v-SNAREs occur in vesicles; t-SNAREs occur on target sites.

Which of the following cellular processes has/have been linked to

.................................. act as proton pumps and keep the internal proton

orrect Answers ATP ases

................................. are proteins associated with clathrin-coated vesicles

orrect Answers Adaptins

orrect Answer True

The basic unit of clathrin lattices is known as ………………..

orrect Answers Triskelion

orrect Answers Retention Tag

orrect Answers Residual body

Cells of the pancreas produce and release enzymes to the digestive

some cancers often "hide" in dense supporting tissue.

some cancers produce low levels of surface antigens.

they are heterogeneous groups of cells.

some cancer cells produce leukotoxins.

PAHs (polycyclic aromatic hydrocarbons) found in tobacco smoke

Correct! p53 gene

The group of proteins associated with the binding of cells to the

Aneuploidy (the gain or loss of chromosomes) is associated with which

None of the choices are correct.

Which of the following with regard to cancer cells is false ?

The cell cycle is disrupted.

Growth is not regulated by growth factors.