PLOS GLOBAL PUBLIC HEALTH

RESEARCH ARTICLE

Unrecognized hypertension among a general

adult Ghanaian population: An urban
community-based cross-sectional study of
prevalence and putative risk factors of
lifestyle and obesity indices
Enoch Odame Anto ID1,2,3☯*, Wina Ivy Ofori Boadu1☯, Emmanuel Ekow Korsah1,
Ezekiel Ansah ID1, Eric Adua4, Joseph Frimpong1, Patience Nyarkoa ID5, Valentine
Christian Kodzo Tsatsu Tamakloe ID1, Emmanuel Acheampong3, Evans Adu Asamoah6,
Stephen Opoku1, Ebenezer Afrifa-Yamoah7, Max Efui Annani-Akollor6,
a1111111111
Christian Obirikorang6
a1111111111
a1111111111 1 Faculty of Allied Health Sciences, Department of Medical Diagnostics, College of Health Sciences, Kwame
a1111111111 Nkrumah University of Science and Technology, Kumasi, Ghana, 2 School of Medical and Health Sciences,
a1111111111 Edith Cowan University, Joondalup Drive, Perth, Australia, 3 Centre for Precision Health, ECU Strategic
Research Centre, Edith Cowan University, Perth, Australia, 4 Rural Clinical School, Medicine and Health,
University of New South Wales, Sydney, NSW Australia, 5 Department of Physiology, School of Medicine
and Dentistry, College of Health Science, Kwame Nkrumah University of Science and Technology, Kumasi,
Ghana, 6 Department of Molecular Medicine, School of Medicine and Dentistry, College of Health Science,
Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, 7 School of Science, Edith Cowan
OPEN ACCESS University, Joondalup, Australia

Citation: Anto EO, Boadu WIO, Korsah EE, Ansah ☯ These authors contributed equally to this work.
E, Adua E, Frimpong J, et al. (2023) Unrecognized * odameenoch@yahoo.com
hypertension among a general adult Ghanaian
population: An urban community-based cross-
sectional study of prevalence and putative risk
factors of lifestyle and obesity indices. PLOS Glob Abstract
Public Health 3(5): e0001973. https://doi.org/
10.1371/journal.pgph.0001973 Hypertension (HTN) is the leading cause of cardiovascular diseases. Nevertheless, most
Editor: Zulkarnain Jaafar, Universiti Malaya, individuals in developing countries are unaware of their blood pressure status. We deter-
MALAYSIA mined the prevalence of unrecognized hypertension and its association with lifestyle factors
Received: February 24, 2023 and new obesity indices among the adult population. This community-based study was con-
ducted among 1288 apparently healthy adults aged 18–80 years in the Ablekuma North
Accepted: May 5, 2023
Municipality, Ghana. Sociodemographic, lifestyle characteristics, blood pressure and
Published: May 24, 2023
anthropometric indices were obtained. The prevalence of unrecognized HTN was 18.4%
Copyright: © 2023 Anto et al. This is an open (237 / 1288). The age groups 45–54 years [aOR = 2.29, 95% CI (1.33–3.95), p = 0.003] and
access article distributed under the terms of the
55–79 years [aOR = 3.25, 95% CI (1.61–6.54), p = 0.001], being divorced [aOR = 3.02 95%
Creative Commons Attribution License, which
permits unrestricted use, distribution, and CI (1.33–6.90), p = 0.008], weekly [aOR = 4.10, 95% CI (1.77–9.51), p = 0.001] and daily
reproduction in any medium, provided the original alcohol intake [aOR = 5.62, 95% CI (1.26–12.236), p = 0.028] and no exercise or at most
author and source are credited. once a week [aOR = 2.25, 95% CI (1.56–3.66), p = 0.001] were independently associated
Data Availability Statement: All relevant data are with HTN. Among males, the fourth quartile (Q4) of both body roundness index (BRI) and
within the manuscript. waist to height ratio (WHtR) [aOR = 5.19, 95% CI (1.05–25.50), p = 0.043] were independent
Funding: The authors received no specific funding determinants of unrecognized HTN. Among females, the third quartile (Q3) [aOR = 7.96,
for this work. 95% CI (1.51–42.52), p = 0.015] and Q4 [aOR = 9.87 95% CI (1.92–53.31), p = 0.007] of
Competing interests: The authors have declared abdominal volume index (AVI), the Q3 of both BRI and WHtR [aOR = 6.07, 95% CI (1.05–
that no competing interests exist.

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

34.94), p = 0.044] and Q4 of both BRI and WHtR [aOR = 9.76, 95% CI (1.74–54.96), p =
0.010] were independent risk factors of HTN. Overall, BRI (AUC = 0.724) and WHtR (AUC =
0.724) for males and AVI (AUC = 0.728), WHtR (AUC = 0.703) and BRI (AUC = 0.703) for
females yielded a better discriminatory power for predicting unrecognized HTN. Unrecog-
nized hypertension is common among the apparently healthy adults. Increased awareness
of its risk factors, screening, and promoting lifestyle modification is needed to prevent the
onset of hypertension.

Introduction
Chronic non-communicable diseases (CNCDs) are responsible for the majority of deaths
worldwide. CNCDs cause an estimated 41 million deaths annually and accounts for 71% of all
deaths globally [1,2]. This has placed a great burden on healthcare systems [3]. Hypertension
(HTN) is a common widespread non-communicable disease and a major global public health
concern [4]. Hypertension is a multifactorial clinical disorder depicted by high and sustained
levels of blood pressure [5] and the commonest risk factor for cardiovascular diseases such as
stroke and ischemic heart disease [6]. Despite HTN being a global health concern, many peo-
ple with hypertension remain unrecognized/undiagnosed thus increasing the risk of morbidity
and mortality [7].
HTN accounted for 10.8 million deaths in 2019 globally [4]. Findings from several studies
show an increasing prevalence of HTN in low- and middle-income countries [8,9]. Currently,
the economies of many developing nations are expanding at enormous rates. Unfortunately,
this growth usually comes with the adoption of unhealthy lifestyles that outpaces advance-
ments in healthcare [10]. Physical inactivity, alcohol intake and consumption of more western-
ized high-calorie diets impose a major burden on developing regions, where public awareness
and knowledge of the harm they pose to health is limited [11]. In Africa, the estimated number
of people with HTN has risen significantly from 54.6 million in 1990 to 130.2 million in 2010.
It is predicted to rise to 216.8 million by the year 2030 which is a 66% rise from the year 2010
[9]. Further studies have shown that of those with HTN, 73% were unrecognized; only 18%
received treatment and 7% had a controlled blood pressure measurement [12]. In Ghana, the
prevalence of hypertension in adults is reported to range from 19 to 48% across rural and
urban communities [13,14], making it the most predominant outpatient condition in the
country. More worrying is the fact that about two-thirds of Ghanaian adults with hypertension
are unrecognized/unaware of their status and so are unable to take appropriate measures to
manage it [15].
Increasing evidence from literature suggests that excess weight gain/obesity is significantly
associated with the development of hypertension [16,17]. The use of population-based studies
to investigate the link between obesity and hypertension have significant benefits because
these findings contribute to the knowledge on the burden of these potentially modifiable fac-
tors that can be addressed through public health intervention programs. These studies also
help assess the strength of this relationship especially recognizing the influence of regional,
ethnic, and geographic diversity [18].
Anthropometric indices have long been used in the characterization of adiposity and obe-
sity as it’s an easy, economical and effective method [19]. Dual-energy X-ray absorptiometry,
although considered the gold standard in accurately measuring body composition, may not be
available in practice in low-resource countries like Ghana due to its high cost, need for exper-
tise and long turnaround time [20,21]. Traditional anthropometric indices such as body mass

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

index (BMI) waist to hip ratio (WHR), waist circumference (WC) hip circumference (HC),
waist to height ratio (WHtR) and conicity index (CI) are commonly used indicators of obesity,
as they are comparatively easy and cheap to measure despite their limitations [19,22]. Several
other relatively recent and useful anthropometric indices such as Abdominal volume index
(AVI), a body shape index (ABSI) and body roundness index (BRI) have been utilized as effec-
tive measures of obesity [23,24]. Few studies analyzing the validity and comparison of the old
and new indices in predicting HTN have been undertaken elsewhere [18,25,26]. Unsurpris-
ingly, there was variability in the choice of anthropometric indices which demonstrates out-
come specific to ethnic and geographic variability. Nonetheless, no study has comprehensively
assessed the performance of the relative newly added anthropometric indices and its’ compara-
bility with the traditional indices of obesity in predicting unrecognized hypertension in the
Ghanaian adult population. This affirms the need for such study in Ghana. Our study also
aimed at the estimation of cut-off points of anthropometric indices which will provide infor-
mation on population at risk of developing hypertension to undergo formal estimation of their
risk. The study will also contribute to knowledge in healthcare facilities and a new dimension
could be taken to include the new anthropometric indices in hypertension risk assessment.

Materials and methods

Ethics statement
The study was approved by the Committee for Human Research and Publication Ethics
(CHRPE), of the School of Medical Sciences (SMS), Kwame Nkrumah University of Science
and Technology, Kumasi (CHRPE/AP/474/22). Participation was fully voluntary and written
informed consent was obtained from each study participant.

Study design/study setting

This community based cross-sectional study was conducted between January to August 2022
in the Ablekuma North municipal district. Ablekuma North municipal district is one of the
twenty-nine districts in the Greater Accra region, Ghana, located in the Southwestern part of
Accra [27]. The Municipal is divided into seven (7) Electoral Areas namely, Odorkor, Darku-
man West, Darkuman East, Awoshie, Otaten, Sakaman and Kwashieman. The municipality is
advantageously placed, spanning the commercial, industrial, and residential regions of Accra.

Study population and participants selection

A total of 1,288 study participants were selected based on a multistage sampling approach
across the seven (7) electoral areas of Ablekuma North municipality. Adults aged 18–80 years
who had no complaint of any illness or known by any disease at the time of the study also
known as–apparently healthy adults were recruited into the study. Adults who were either
known hypertensive or had hypertensive related chronic illness, individuals with history of
hypertension or on anti-hypertension medication were not included in the study. The study
did not also include pregnant women, adults with history of chronic illness, diabetes, cardio-
vascular diseases and renal disease. In the first stage of sampling, four electoral areas were
selected using simple random sampling technique, and based on the proportion of size of the
electoral areas, we employed a systematic random sampling technique to select households
from the electoral areas in the second stage. Then we randomly selected one adult aged 18
years and above and meeting the inclusion criteria from each household using the lottery
method.

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

Sample size estimation. Using a single population formula by considering: the prevalence
of unrecognized hypertension in a previous study conducted in Ghana (P = 0.387) [28]. Mar-
gin of error (D = 0.05), level of significance (α = 0.05), Z α /2 at 95% CI = 1.96 and 10% contin-
gency rate using the Cochrane formula [29],
2
n = Z Pð1
D2
PÞ
, a sample size of 365 was obtained. To increase statistical power a total of 1,288
adults were included in the study.

Data collection
Study questionnaire. Each participant had a structured based interview which was con-
ducted privately and in person. The questionnaire was sectioned into four (4) parts. Section A
requested information on the socio-demographic characteristics such as age, gender, marital
status, occupation and level of education. Section B required information on lifestyle activities
which included alcohol intake, smoking and the level of physical activity. Section C requested
details on dietary patterns, mainly fruit and vegetables intake. Information on family history
and the current medical history of participants was requested in the last section, Section D.
The questionnaire was pre-tested for reliability in a pilot study which yielded a Cronbach
alpha value of 0.895.
Blood pressure measurement. A registered Nurse used an automatic validated device
(Omron HEM711DLX, UK) to measure the blood pressure of all participants. The measure-
ment was done on the upper left arm while the subject was seated with their legs uncrossed,
their arm supported at the height of the heart, and the arm wrapped in a cuff that was appro-
priate for their arm size. Blood pressure was measured after each participant had rested for at
least 10 mins. Measurements were repeated twice at 5 mins interval and the average systolic
blood pressure and diastolic blood pressure were recorded. Unrecognized hypertension was
defined as systolic pressure levels �140 mmHg and/or diastolic levels �90 mmHg according
to the 2018 European Society of Cardiology/European Society of Hypertension Guidelines
[30]. The diagnosis of BP was made by a medical practitioner.
Anthropometric assessment. Anthropometric measurements constituted height, weight,
hip and waist circumference. The subjects’ heights were measured by placing their heels
together, leaning their heads on a wall-mounted ruler, and standing up straight in bare feet.
Weight was measured using a digital scale (Etekcity EB930H), with participants barefooted
and wearing light indoor clothes. WC was measured using a Gulick II spring-loaded measur-
ing tape (Gay Mills, WI) placed horizontally, midway between the lowest costal margin and
the anterior superior iliac crest, with participants standing. The reading was obtained after
gentle expiration. HC was measured using a measuring tape at the level parallel to the floor, at
the largest circumference of the buttock with both hands open widely.
Anthropometric indices were calculated as follows [31], [32], [23], [24];

weight ðkgÞ
� BMI ¼ 2
height ðmÞ

WC ðcmÞ
� WHR ¼
HC ðcmÞ

WC ðcmÞ
� WHtR ¼
Height ðcmÞ

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

WC ðmÞ
� CI ¼ qffiffiffiffiffiffiffiffiffiffiffiffiffiffi :
0:109 � weight
height ðmÞ
ðkgÞ

2 2
2WC ðcmÞ þ 0:7ðWC HCÞ ðcmÞ
� AVI ¼
1000

WC ðmÞ
� ABSI ¼ h 2 1
i
BMI � height ðmÞ2
3

WC
2p 0:5
� BRI ¼ 364:2 365:5 � f1 ½ 2 �g
ð0:5 � heightÞ

Statistical analysis
All data was documented in Microsoft Excel 2016, then entered electronically and analyzed
using IBM SPSS version 26.0 software and GraphPad Prism version 8.0. The data distribution
was tested for normality using the Kolmogorov–Smirnov test. Continuous variables were pre-
sented as mean ± standard deviation or median (interquartile range) where appropriate while
categorical variables were presented as frequencies and percentages. Comparisons across
socio-demographic characteristics such as age groups, sex, educational level, marital status and
between hypertensives and non-hypertensives participants were performed using chi-square
test. Student’s t-test or Mann–Whitney U test was used for comparing continuous variables
and hypertension status where applicable. All anthropometric indices were categorized by
quartiles except BMI which used the standard World Health Organization (WHO) categories.
Univariate logistic regression analysis followed by the multivariate logistic regression model
was performed to determine the association between these categories and HTN after adjusting
for age, marital status, alcohol intake and level of exercise. The performance of the anthropo-
metric measures as potential predictors of HTN was compared using the receiver operating
characteristic curve (ROC) analysis. The optimal cut-off points for WHR, WHtR, BMI, ABSI,
AVI, BRI and CI were determined by the best balance of sensitivity and specificity. Statistical
significance was set at p<0.05.

Results
Socio-demographic characteristics of study population
Table 1 shows the socio-demographic characteristics of the study population. A total of 1288
adult participants were recruited for the study. The majority of the participants were in the age
categories 18–34 (36.5%). Age categories was significantly associated with unrecognized
hypertension (HTN) status of participant (p < 0.001). Majority of the participants were
females (53.3%) with a male to female ratio of 1:1.1. Gender was significantly associated with
unrecognized HTN (p = 0.026). The highest proportion of the participants was married (55%)
and marital status of participants was found to be significantly associated with unrecognized
HTN (p <0.001). Also, level of education (p = 0.027), occupation (p = 0.004), alcohol intake
status (p < 0.001) and exercise level (p < 0.001) were all significantly associated with unrecog-
nized HTN.

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

Table 1. Socio-demographic characteristics of the study population.

Unrecognized HTN
Variable Total (n = 1288) No (n = 1051) Yes (n = 237) p-value
Age categories (years) <0.001
18–34 470(36.5) 423(40.2) 47(19.8)
35–44 333(25.9) 276(26.3) 57(24.1)
45–54 300(23.3) 219(20.8) 81(34.2)
55–79 185(14.4) 133(12.7) 52(21.9)
Gender 0.026
Male 601(46.7) 506(48.1) 95(40.1)
Female 687(53.3) 545(51.9) 142(59.9)
Marital status
Married 709(55.0) 567(53.9) 142(59.9) <0.001
Single 495(38.4) 436(41.5) 59(24.9)
Divorced 66(5.1) 38(3.6) 28(11.8)
Widowed 18(1.4) 10(1.0) 8(3.4)
Ethnicity 0.254
Akan 1060(82.3) 874(83.2) 186(78.5)
Ewe 51(4.0) 37(3.5) 14(5.9)
Ga 150(11.6) 119(11.3) 31(13.1)
Mole Dagbani 27(2.1) 21(2.0) 6(2.5)
Level of education 0.027
No education 30(2.3) 26(2.5) 4(1.7)
Basic 378(29.3) 297(28.3) 81(34.2)
Secondary 543(42.2) 436(41.5) 107(45.1)
Tertiary 337(26.2) 292(27.8) 45(19.0)
Occupation 0.004
Unemployed 233(18.1) 206(19.6) 27(11.4)
Formal 447(34.7) 367(35.0) 80(33.8)
Informal 608(47.2) 478(45.5) 130(54.9)
Alcohol intake <0.001
Occasionally 207(16.1) 172(16.4) 35(14.8)
Weekly 51(4.0) 30(2.9) 21(8.9)
Daily 18(1.4) 8(0.8) 10(4.2)
Never 1012(78.6) 841(80.0) 171(72.2)
Fruit intake 0.149
Two or more times a week 590(45.8) 471(44.8) 119(50.2)
Once a week/Never 698(54.2) 580(55.2) 118(49.8)
Vegetable intake 0.494
Two or more times a week 994(77.2) 815(77.5) 179(75.5)
Once a week/Never 294(22.8) 236(22.5) 58(24.5)
Regular physical exercise <0.001
Two or more times a week 417(32.4) 374(35.6) 43(18.1)
Once a week/Never 871(67.6) 677(64.4) 194(81.9)
Family medical history 0.577
Hypertension 31(2.4) 25(2.4) 6(2.5)
Stroke 60(4.7) 45(4.3) 15(6.3)
Diabetes 45(3.5) 36(3.4) 9(3.8)
(Continued )

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

Table 1. (Continued)

Unrecognized HTN
Variable Total (n = 1288) No (n = 1051) Yes (n = 237) p-value
None 1152(89.4) 945(89.9) 207(87.3)

Data is presented as Chi-square or Fisher’s test. P < 0.05 was considered significant.

https://doi.org/10.1371/journal.pgph.0001973.t001

Prevalence of unrecognized hypertension among the study population

The overall prevalence of unrecognized hypertension among the study population was 18.4%
(237/1288) as shown in Fig 1. Also, as shown in Fig 2, the prevalence of unrecognized hyper-
tension was high in females than male participants (20.7% vs 15.8%) Fig 2.

Anthropometric variables of the study population

Table 2 shows the baseline characteristics and anthropometric variables of the general study
population. The median age of the total participants was 39 years. Participants with hyperten-
sion had significantly higher age median levels compared to normotensives (49 years versus 37
years, p <0.001).
Except for the median height which was significantly high amongst normotensives partici-
pants than hypertensives subjects (166.40 cm versus 165.50 cm, p = 0.032), all other anthropo-
metric indices including weight, BMI, ABSI, AVI, BRI, CI, WHR and WHtR had significantly
higher median or mean levels amongst hypertensives compared to normotensives (p < 0.05).

Fig 1. Prevalence of unrecognized hypertension among the general adult population.

https://doi.org/10.1371/journal.pgph.0001973.g001

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

Fig 2. Prevalence of unrecognized hypertension among male and female populations.

https://doi.org/10.1371/journal.pgph.0001973.g002

Overall, the median systolic blood pressure (SBP) (145.00 vs 112.50) and diastolic blood pres-
sure (DBP) (91.50 vs 67.50) was significantly higher among participants with hypertension
compared to normotensives (p < 0.001).

Table 2. Anthropometric variables of the study population.

Unrecognized HTN
Variable Total (n = 1288) No (n = 1051) Yes (n = 237) P value
Age 39.00 (28.00–49.00) 37.00 (26.00–46.00) 49.00 (44.00–56.00) <0.001
SBP (mmHg) 117.00 (106.50–129.00) 112.50 (104.50–121.00) 145.00 (141.50–151.00) <0.001
DBP (mmHg) 70.00 (64.50–83.00) 67.50 (62.00–75.50) 91.50 (87.50–97.00) <0.001
Height (cm) 166.00 (160.00–170.00) 166.40 (160.00–171.00) 165.50 (158.80–168.00) 0.032
Weight (kg) 70.30 (63.10–79.00) 69.90 (62.38–78.08) 72.30 (68.90–83.00) <0.001
WC (cm) 85.70 ± 10.70 84.16 ± 9.92 92.52 ± 8.77 <0.001
HC (cm) 98.30 (92.25–106.40) 97.70 (91.65–104.80) 102.50 (97.60–109.10) <0.001
BMI (kg/m2) 25.03 (23.24–29.09) 24.75 (22.97–28.51) 28.21 (24.72–30.97) <0.001
WHR 0.86 (0.82–0.90) 0.85 (0.81–0.90) 0.88 (0.84–0.93) <0.001
WHtR 0.52 ± 0.07 0.51 ± 0.07 0.57 ± 0.06 <0.001
BRI 3.75 (2.72–4.74) 3.59 (2.52–4.54) 4.68 (3.78–5.44) <0.001
ABSI (m11/6kg-2/3) 0.076 ± 0.006 0.076 ± 0.006 0.078 ± 0.006 0.020
AVI (cm2) 15.08 ± 3.51 14.55 ± 3.34 17.41 ± 3.30 <0.001
CI (m3/2/kg1/2) 1.21 (1.14–1.27) 1.19 (1.12–1.25) 1.26 (1.20–1.31) <0.001

Non-parametric data are presented as median (interquartile range); compared using Mann-Whitney test. P < 0.05 was considered statistically significant. Parametric
data are presented as mean ± SD; compared using independent sample t-test. P <0.05 was considered statistically significant. N: Number. IQR: Interquartile range. SD:
Standard deviation. SBP: Systolic blood pressure. DBP: Diastolic blood pressure. BMI: Body mass index. CI: Conicity index. ABSI: A body shape index. BRI: Body
roundness index. AVI: Abdominal volume index. WC: Waist circumference. HC: Hip circumference. WHR: Waist-to-hip ratio. WHtR: Waist-to-height ratio.

https://doi.org/10.1371/journal.pgph.0001973.t002

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

Table 3. Gender-specific anthropometric variables of the study population.

Unrecognized HTN
Variable Total (n = 1288) No (n = 1051) Yes (n = 237) P value
Males
Age 38.00 (26.00–48.00) 36.00 (24.00–46.75) 47.50 (39.25–55.75) <0.001
SBP (mmHg) 117.00 (107.63–126.50) 113.00 (106.63–122.88) 149.50 (142.63–152.38) <0.001
DBP (mmHg) 70.00 (65.13–79.00) 68.00 (64.00–75.50) 92.25 (89.00–98.75) <0.001
Height (m) 169.85 (169.63–173.60) 170.00 (167.00–175.13) 168.00 (164.25–170.75) 0.018
Weight (kg) 71.13 (66.05–79.20) 70.75 (65.43–78.85) 72.55 (68.78–83.75) 0.063
WC (cm) 83.52 ± 9.33 82.42 ± 8.85 89.28 ± 11.55 0.001
HC (cm) 94.70 (90.00–99.00) 94.00 (89.50–98.85) 98.30 (94.25–102.60) 0.004
BMI (kg/m2) 24.42 (22.69–27.03) 24.30 (22.39–26.55) 25.81 (24.09–29.92) 0.004
WHR 0.87 (0.83–0.92) 0.87(0.83–0.91) 0.89 (0.86–0.94) 0.014
WHtR 0.49 ± 0.06 0.48 ± 0.05 0.54 ± 0.07 <0.001
BRI 3.13 (2.36–3.88) 2.95 (2.31–3.73) 3.78 (3.27–4.97) <0.001
ABSI (m11/6kg-2/3) 0.075 ± 0.006 0.075 ± 0.006 0.077 ± 0.007 0.067
AVI (cm2) 14.25 ± 3.18 13.85 ± 2.77 16.68 ± 4.37 0.001
CI (m3/2/kg1/2) 1.16 (1.11–1.24) 1.16 (1.11–1.23) 1.23 (1.15–1.30) 0.008
Females
Age 41.00 (32.00–49.00) 37.00 (28.00–46.00) 49.00 (44.00–56.00) <0.001
SBP (mmHg) 117.00 (104.75–134.50) 111.25 (102.50–120.13) 142.50 (141.00–149.50) <0.001
DBP (mmHg) 70.00 (64.00–81.00) 67.00 (61.38–75.13) 90.75 (86.50–96.00) <0.001
Height (m) 161.00 (156.20–166.10) 160.95 (156.88–165.70) 161.50 (155.00–167.00) 0.859
Weight (kg) 70.00 (61.90–78.63) 68.43 (60.09–78.00) 73.00 (68.90–82.25) <0.001
WC (cm) 87.60 ± 10.63 85.85 ± 10.92 93.73 ± 6.62 <0.001
HC (cm) 103.50 (96.00–109.00) 102.50 (95.00–109.63) 107.00 (99.50–111.50) 0.011
BMI (kg/m2) 26.45 (24.03–30.06) 25.96 (23.68–29.49) 28.91 (24.86–32.90) <0.001
WHR 0.85 (0.81–0.89) 0.84 (0.80–0.88) 0.87 (0.83–0.93) <0.001
WHtR 0.55 ± 0.07 0.53 ± 0.07 0.58 ± 0.05 <0.001
BRI 4.35 (3.52–5.23) 4.10 (3.12–5.02) 4.99 (4.19–6.10) <0.001
ABSI (m11/6kg-2/3) 0.077 ± 0.006 0.077 ± 0.006 0.078 ± 0.005 0.023
AVI (cm2) 15.80 ± 3.62 15.22 ± 3.69 17.82 ± 2.50 <0.001
CI (m3/2/kg1/2) 1.24 (1.16–1.28) 1.23 (1.15–1.27) 1.27 (1.22–1.31) <0.001

Non-parametric data is presented as median (interquartile range); compared using Mann-Whitney test. P < 0.05 was considered statistically significant. Parametric data
is presented as mean ± SD; compared using independent sample t-test. P <0.05 was considered statistically significant. N: Number. IQR: Interquartile range. SD:
Standard deviation. SBP: Systolic blood pressure. DBP: Diastolic blood pressure. BMI: Body mass index. CI: Conicity index. ABSI: A body shape index. BRI: Body
roundness index. AVI: Abdominal volume index. WC: Waist circumference. HC: Hip circumference. WHR: Waist-to-hip ratio. WHtR: Waist-to-height ratio.

https://doi.org/10.1371/journal.pgph.0001973.t003

Gender-specific anthropometric variables of the study population

Table 3 shows the gender specific anthropometric variables of the general study population.
The median age of hypertension was significantly higher in hypertensives than normotensives
in male participants (47.5 years versus 36 years, p < 0.001). A similar trend was seen among
female participants (49 years versus 37 years, p < 0.001). Among the male participants, the
median height was significantly high in normotensives compared to hypertensives. Except for
ABSI (p = 0.067) and weight (p = 0.063) all other anthropometric indices had significantly
higher levels amongst hypertensives compared to normotensives (p < 0.05). Among the female
participants, all anthropometric indices were significantly high in hypertensives (p <0.05)
except for height (p = 0.859) compared to normotensive females. For both male and female,

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

Table 4. Sociodemographic characteristics associated with unrecognized hypertension.

Variable cOR (95% CI) p-value aOR (95% CI) p-value
Age group(years)
18–34 (ref) 1.000 1.000
35–44 1.859 (1.228–2.814) 0.003 1.190(0.955–1.483) 0.121
45–54 3.329 (2.490–4.940) < 0.001 2.288(1.325–3.952) 0.003
55–79 3.519 (2.266–5.463) <0.001 3.245(1.610–6.542) 0.001
Gender
Male (ref) 1.000 1.000
Female 1.388(1.042–1.848) 0.025 1.269(0.670–1.809) 0.188
Marital status
Married (ref) 1.000 1.000
Single 0.540(0.389–0.750) <0.001 0.724(0.450–1.165) 0.183
Divorced 2.942(1.746–4.957) <0.001 3.019(1.334–6.900) 0.008
Widowed 3.194(1.238–8.241) 0.023 2.211(0.663–7.400) 0.198
Level of education
No formal education 0.998(0.333–2.994) 0.986 0.223(0.019–2.612) 0.232
Basic 1.770(1.188–2.636) 0.005 1.117(0.769–1.622) 0.561
Secondary 1.592(1.091–2.325) 0.016 1.015(0.948–1.086) 0.667
Tertiary (ref) 1.000 1.000
Occupation
Unemployed (ref) 1.000 1.000
Formal 1.663(1.041–2.657) 0.029 1.256(0.948–1.742) 0.172
Informal 2.075(1.329–3.240) 0.002 0.935(0.790–1.107) 0.433
Alcohol intake
Occasional 1.001(0.672–1.491) 0.997 1.500(0.623–3.611) 0.366
Weekly 3.443(1.925–6.157) <0.001 4.101(1.769–9.505) 0.001
Daily 6.148(2.392–15.803) <0.001 5.619(1.262–12.326) 0.028
Never (ref) 1.000
Exercise
Two or more times a week (ref) 1.000 1.000
Once a week/Never 2.492(1.750–3.550) <0.001 2.253(1.556–3.655) 0.001

cOR, Crude Odd ratio; CI, Confidence interval; aOR Adjusted Odd ratio; Compared using univariate and multivariate logistic regression analysis. P-value of < 0.05 was
considered statistically significant. 1.000 indicates reference category.

https://doi.org/10.1371/journal.pgph.0001973.t004

the median systolic blood pressure (SBP) and diastolic blood pressure (DBP) was significantly
higher among participants with hypertension compared to normotensives (p < 0.001).

Sociodemographic characteristics associated with unrecognized

hypertension
Table 4 shows the univariate and multivariate-adjusted odds of socio-demographic character-
istics in association with unrecognized HTN among the study population. In the multivariate
analysis being in age groups 45–54, 55–79, divorced, weekly and daily intake of alcohol and
exercising at most once a week were independently associated with unrecognized
hypertension.
Anthropometric indices associated with unrecognized hypertension among male and
female participants. The odds of association of the various anthropometric indices with
unrecognized HTN in male participants were analyzed using logistic regression as shown in

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

Table 5. Anthropometric indices associated with unrecognized hypertension in males.

Variable cOR (95% CI) p-value aOR (95%) CL p-value
ABSI quartiles
Q1 Ref (1)
Q2 0.458 (0.108–1.944) 0.290 -
Q3 1.194 (0.371–3.841) 0.766 -
Q4 2.278 (00.813–2.378) 0.114 -
AVI quartiles
Q1 Ref (1)
Q2 2.089 (0.492–8.860) 0.318 1.481 (0.332–6.609) 0.607
Q3 3.439 (0.872–13.563) 0.078 2.363 (0.559–10.001) 0.243
Q4 4.017 (1.033–15.624) 0.045 2.373 (0.584–9.642) 0.227
BRI quartiles
Q1 Ref (1)
Q2 1.565 (0.250–9.800) 0.409 1.628 (0.252–10.533) 0.609
Q3 6.286 (1.318–29.988) 0.021 4.830 (0.980–23.814) 0.053
Q4 8.000(1.684–37.997) 0.009 5.186 (1.054–25.504) 0.043
CI quartiles
Q1 Ref (1)
Q2 1.335 (0.337–5.295) 0.465 1.135 (0.274–4.705) 0.862
Q3 1.913 (0.523–6.992) 0.487 1.054 (0.414–6.071) 0.502
Q4 3.711 (1.107–12.439) 0.034 2.497 (0.712–8.817) 0.152
WHR quartiles
Q1 Ref (1)
Q2 2.182 (0.514–9.225) 0.659 2.403 (0.451–12.793) 0.914
Q3 3.512 (0.891–13.843) 0.129 3.566 (0.695–18.304 0.619
Q4 4.103 (1.055–15.947) 0.042 3.308 (0.649–16.865) 0.982
WHtR quartiles
Q1 Ref (1)
Q2 1.565 (0.250–9.800) 0.409 1.628 (0.252–10.533) 0.609
Q3 6.286 (1.318–29.988) 0.021 4.830 (0.980–23.814) 0.053
Q4 8.000(1.684–37.997) 0.009 5.186 (1.054–25.504) 0.043
BMI categories
Normal Ref (1)
Overweight 1.1872 (0.746–4.694) 0.181 1.203 (0.459–3.151) 0.707
Obese 4.773 (1.589–14.331) 0.005 3.019 (0.948–9.609) 0.061

cOR: Crude odds ratio. aOR: Adjusted odds ratio. Inf: Infinity. Ref: Reference. Compared using univariate and multivariate logistic regression. p < 0.05 was considered
significant. Adjusted for age, marital status, alcohol intake and exercise level of participants. Q1: First quartile. Q2: Second quartile. Q3: Third quartile. Q4: Fourth
quartile. ABSI: A body shape index. BRI: Body roundness index. BMI: Body mass index. CI: Conicity index. WHtR: Waist-to-height ratio. WHR: Waist-to-hip ratio.

https://doi.org/10.1371/journal.pgph.0001973.t005

Table 5. Multivariate regression showed that the fourth quartile (Q4) of BRI [aOR = 5.19, 95%
CI (1.05–25.50), p = 0.043] and WHtR [aOR = 5.19, 95% CI (1.05–25.50), p = 0.043] were
shown to be independent determinant of HTN.
Among female participants, Q3 and Q4 of AVI, BRI and WHtR were independent predic-
tors of unrecognized HTN in multivariate logistic regression as shown in Table 6 {AVI quar-
tiles; Q3 [aOR = 7.96, 95% CI (1.51–42.52), p = 0.015] and Q4 [aOR = 9.87 95% CI (1.92–
53.31), p = 0.007], BRI and WHtR quartiles; Q3 [aOR = 6.07, 95% CI (1.05–34.94), p = 0.044]
and Q4 [aOR = 9.76, 95% CI (1.74–54.96), p = 0.010]}.

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

Table 6. Anthropometric indices associated with unrecognized hypertension in females.

Variable cOR (95% CI) p-value aOR (95%) CL p-value
Females
ABSI quartiles
Q1 Ref (1)
Q2 1.026 (0.384–2.739) 0.960 0.898 (0.299–2.693) 0.848
Q3 1.736 (0.683–4.414) 0.246 0.954 (0.326–2.799) 0.932
Q4 2.743 (1.103–6.821) 0.030 1.286 (0.434–3.814) 0.650
AVI quartiles
Q1 Ref (1)
Q2 5.729 (1.196–27.449) 0.029 3.944 (0.690–22.553) 0.113
Q3 11.687 (2.554–53.476) 0.002 7.957 (1.510–42.515) 0.015
Q4 17.286 (3.825–78.114) <0.001 9.874 (1.921–53.310) 0.007
BRI quartiles
Q1 Ref (1)
Q2 8.750 (1.888–40.559 0.006 5.179 (0.946–30.768) 0.070
Q3 9.821 (2.129–45.316) 0.003 6.065 (1.053–34.936) 0.044
Q4 14.865 (3.277–67.431) <0.001 9.764 (1.735–54.962) 0.010
CI quartiles
Q1 Ref (1)
Q2 2.713 (0.889–8.283) 0.122 3.137 (0.906–10.857) 0.071
Q3 3.714 (1.248–11.056) 0.018 1.854 (0.527–6.616) 0.336
Q4 5.200 (1.783–15.164) 0.003 1.984 (0.290–1.984) 0.290
WHR quartiles
Q1 Ref (1)
Q2 2.655 (0.089–8.283) 0.086 1.471 (0.420–5.158) 0.546
Q3 3.805 (1.277–11.337) 0.016 2.809 (0.835–9.450) 0.095
Q4 5.200 (1.783–15.164) 0.003 2.032 (0.609–6.777) 0.249
WHtR quartiles
Q1 Ref (1)
Q2 8.750 (1.888–40.559 0.006 5.179 (0.946–30.768) 0.067
Q3 9.821 (2.129 (45.316) 0.003 6.065 (1.053–34.936) 0.044
Q4 14.865 (3.277–67.431) <0.001 9.764 (1.735–54.962) 0.010
BMI categories
Normal Ref (1)
Overweight 1.605 (0.733–3.516) 0.237 1.356 (0.539–3.414) 0.517
Obese 3.012 (1.371–6.617) 0.006 2.477 (0.976–6.284) 0.056

cOR: Crude odds ratio. aOR: Adjusted odds ratio. Inf: Infinity. Ref: Reference. Compared using univariate and multivariate logistic regression. p < 0.05 was considered
significant. Adjusted for age, marital status, alcohol intake status and exercise level of participants. Q1: First quartile. Q2: Second quartile. Q3: Third quartile. Q4: Fourth
quartile. ABSI: A body shape index. BRI: Body roundness index. BMI: Body mass index. CI: Conicity index. WHtR: Waist-to-height ratio. WHR: Waist-to-hip ratio.

https://doi.org/10.1371/journal.pgph.0001973.t006

Predictive potential of the various anthropometric indices for unrecognized hyperten-

sion in male and female participants. Table 7 demonstrates the predictive performance of
the various anthropometric indicators based on ROC curve analysis. Among male participants,
the highest AUC was recorded for BRI and WHtR (0.724; 95% CI: 0.623–0.824) and AVI
(0.688; 95% CI: 0.585–0.791). BMI recorded an AUC of 0.672 (95% CI: 0.567–0.777). The opti-
mal WHtR, BRI and BMI cut-offs for identifying males with HTN were 0.480 (sensitivity 0.89
and specificity 0.51), 2.982 (sensitivity 0.89 and specificity 0.51), and 24.633 (sensitivity 0.71
and specificity 0.58). respectively. AVI (0.728; 95% CI: 0.658–0.799), WHtR (0.703; 95% CI:

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

Table 7. Anthropometric indices for predicting unrecognized hypertension.

Variable AUC (95% CI) Cut off Sensitivity Specificity PPV NPV
Males BMI 0.672 (0.567–0.777) 24.633 0.714 0.576 0.215 0.925
WHR 0.645 (0.540–0.750) 0.882 0.679 0.610 0.221 0.921
WHtR 0.724 (0.623–0.824) 0.480 0.893 0.512 0.229 0.967
BRI 0.724 (0.623–0.824) 2.982 0.893 0.512 0.229 0.967
ABSI 0.610 (0.483–0.738) 0.077 0.607 0.674 0.223 0.913
AVI 0.688 (0.585–0.791) 13.610 0.893 0.512 0.229 0.967
CI 0.657 (0.559–0.789) 1.216 0.571 0.733 0.258 0.913
Females BMI 0.667 (0.588–0.744) 27.214 0.647 0.601 0.317 0.856
WHR 0.668 (0.587–0.749) 0.862 0.608 0.652 0.333 0.853
WHtR 0.703 (0.628–0.777) 0.566 0.627 0.669 0.352 0.862
BRI 0.703 (0.628–0.777) 4.679 0.627 0.669 0.352 0.862
ABSI 0.605 (0.517–0.693) 0.081 0.401 0.803 0.364 0.822
AVI 0.728 (0.658–0.799) 16.360 0.725 0.635 0.363 0.890
CI 0.674 (0.593–0.755) 1.269 0.569 0.747 0.392 0.858

ROC determined cut-off, sensitivity and specificity of each anthropometric index for predicting unrecognized hypertension, ROC receiver operating curve, AUC area
under the curve, PPV positive predictive value, NPV negative predictive value.

https://doi.org/10.1371/journal.pgph.0001973.t007

0.628–0.777) and BRI (0.703; 95% CI: 0.628–0.777) recorded the highest AUC values among
female subjects. However, ABSI recorded the lowest AUCs for both male and female partici-
pants (0.610 and 0.605 respectively). Fig 3 compares the ROC curves of the various anthropo-
metric indices for males and females respective.

Discussion
Evidence for the association between hypertension and obesity abounds and for the first time,
this study evaluated the prevalence of unrecognized hypertension and its association with

Fig 3. ROC curves of anthropometric indices for males and females.

https://doi.org/10.1371/journal.pgph.0001973.g003

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

lifestyle factors and obesity indices among the adult population in the Ablekuma North
Municipality.
The prevalence of unrecognized HTN in the current study was 18.4% which was compara-
ble to a study in the Urban communities of Southwest Ethiopia [33] but higher compared to a
study done in Addis Ababa, Ethiopia [34]. It was however, lower compared to studies among
Bus Drivers [28], traders at regional markets in Nigeria [35] and a systematic review in sub-
Saharan Africa [12]. Different sociodemographic traits of research participants could be to
blame for the observed reduced risk in the current study. For instance, the studies in Ghana
among bus drivers, Nigeria among traders at regional markets, and the systematic review in
sub-Sahara were conducted on populations with greater risk to HTN, in contrast to the current
study, which was conducted on the general adult population. In our study, the prevalence of
unrecognized hypertension was high in females (22.3%) as compared to males (14%). This
finding is consistent with studies conducted in the Kumasi metropolis in Ghana [36] but
unusual as compared to most studies [12,33]. This higher risk of HTN in females may be due
to the advanced median ages of the female study participants. Majority of the hypertensive
females in this study were in the age region of menopausal transition (44–55years). This period
is usually associated with a physiological reduction in ovarian hormones and leads to progres-
sive increase in blood pressure [37,38]. The low physical activity and high overweight/obesity
rate in our female participants also play a role.
Our study reported that being in the age groups of 45–54 and � 55 were associated with
unrecognized HTN. This can be explained by the loss in vascular compliance as a result of
artery hardening and stiffness with increasing age, which contributes to high prevalence of
HTN in older groups [39].
In this study, marital status of participants was significantly associated with unrecognized
HTN status. Being divorced was associated with a significant 4-folds increase of having HTN
compared to being married even after adjustment for possible confounders. Getachew and col-
leagues reported a similar finding in a cross-sectional study conducted among Ethiopian adults
in Addis Ababa [34]. The driving factor is, however, not well understood. These findings may
be possibly due to psychological constructs of divorce-related emotional intrusion-hyper-
arousal as well as lack of social support [40].
Furthermore, weekly and daily intake of alcohol were associated with HTN. Owiredu et al.
reported a similar finding [41]. The exact mechanism that alcohol affects blood pressure is still
unknown. Several mechanisms have been put forth, including imbalances in the central ner-
vous system, baroreceptor dysfunction, stimulation of the renin-angiotensin-aldosterone sys-
tem, and elevated vascular reactivity as a result of higher intracellular calcium levels [42].
Also, this study found a significant association between the exercise level of participants
and unrecognized HTN. Never exercising or exercising once a week was associated with
increased odds of having HTN. This finding is consistent with several cross-sectional studies
[41,43] who reported that not exercising routinely was associated with increasing blood pres-
sure Low physical activity is a driving factor for obesity related health complications.
Controversies still exist as to which anthropometric index of obesity is highly associated
and can best predict the occurrence of hypertension among the general adult population.
Advanced research has led to the development of new and affordable indices. BMI is the most
commonly used obesity measure and has been associated with HTN. However, in this present
study, BMI showed a poor predictability performance for unrecognized HTN compared to the
best performing indices of central obesity (WHtR, BRI, AVI). In the logistic regression model,
BMI failed to independently predict unrecognized hypertension. Consequently, BMI showed
lower AUC values of 0.672 for the males versus 0.667 for females in the ROC analysis com-
pared to WHtR, BRI, and AVI, which yielded better discriminatory power (AUC �7.0) in

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

predicting HTN. This is in keeping with several previous studies that have reported BMI as an
inferior predictor of HTN compared to central adiposities indices [18,44,45]. A plausible rea-
son for this observation is that BMI is limited in its ability to differentiate between fat and mus-
cle mass, as well as between various fat compartments such as visceral adipose tissue and
subcutaneous tissue [46]. However, other studies have reported that BMI has a similar predict-
ability performance as other measures of central adiposity [47,48]. This disparity may be due
to variations in the sample size, differences in the median age group of participants and geo-
graphical location.
ABSI was proposed to predict the risk of pathologies that cannot be readily identified by
BMI [23]. Nevertheless, in our study, ABSI showed the poorest association with hypertension
across gender as evidenced by an AUC of 0.610 in males and 0.605 in females. Previous studies
have also indicated similar findings; ABSI is a very weak predictor of hypertension [18,26]. A
probable reason for ABSI’s failure to predict hypertension is that it was originally designed as a
mortality risk predictor in a cohort study. In contrast, we determined it predictive potential
for hypertension in a cross-sectional study and this may be the primary reason ABSI showed
poor association with hypertension.
The association of AVI with unrecognized hypertension was also examined in our study.
AVI stood out as an independent predictor of unrecognized HTN after possible confounders
were controlled in the multivariate logistic model in females but not males. An increase in HC
causes an increase in AVI when WC < HC in the AVI formula. Since females have a larger
HC than males do, an increase in HC values typically results in an increase in AVI values,
which explains the differences in the two genders’ predictive skills [49].
WHtR and BRI showed similar predictability performance for unrecognized HTN in our
study. WHtR and BRI were associated with HTN across genders. It consequently showed bet-
ter discrimination for HTN than BMI for both male (0.724 versus 0.672) and female partici-
pants (0.703 versus 0.667). Our findings concur with several other studies [18,26,36]. One
major factor for WHtR and BRI to strongly predict HTN is their ability to rightfully measure
visceral/central fat deposits which is a proposed contributor to the incidence of HTN. The
exact pathogenesis of hypertension associated with central obesity remains unclear. However,
the systematic activity of visceral fat deposits provides a plausible cause for the strong associa-
tion between central obesity and HTN. Visceral fat deposits are noted to be metabolic active
and its accumulation stimulate the production of a variety of pro-inflammatory cytokines such
as imterlukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-a), as well as adipokines such as
leptin. These molecules initiate a series of events characterized by inflammation, arterial stiff-
ness and impaired vascular function. In addition, these molecules enhance insulin resistance
which can lead to the concurrent stimulation of the sympathetic nervous system, all of which
contribute to the onset of hypertension [50,51].
Also, this present study determined cut-off values that may be used to gauge normalcy and
evaluate the risk of HTN in the Ghanaian setting. The WHtR cut-off levels in this study for
males (0.48) and females (0.57) were slightly lower and slightly higher respectively, when com-
pared to the generic cut-off values proposed by WHO (0.5 for adults). The cut-off value we
determined for BMI in females (27.2) was higher than the established standard cut-off values
by WHO (24.9) but similar cut-off for males (24.63). This differences between the observed
values from the standard and recommended values by WHO is not surprising because geo-
graphical and ethnic factors can influence the optimal cut-off values of these obesity measures
that predict the risk for HTN [18,48]. Moreover, our females generally had higher cut-off val-
ues for these obesity indices than males which is different to the WHO established values.
However, this finding is consistent with earlier studies among Ghanaian, Nigerian and Iranian
adults [18,36,52]. Ghanaian and other African women typically view higher weights as

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

desirable due to the traditional associations between such features and beauty and wealth [36].
Lower physical activity in females is also a factor.
This study had some notable significance as it employed various obesity indices, which
made it possible to investigate and ascertain the most effective indices for predicting HTN and
their potential usefulness in screening programs and individual assessment of one’s health.
Also, this study employed reliable statistical techniques which enabled us indicate the irregu-
larities in pre-established optimal thresholds from our determined values. Despite these find-
ings, it is important to recognize some of the limitation of this study. First, because the study
was cross-sectional and the disease’s origin was not identified, conclusions concerning a
cause-and-effect relationship cannot be drawn. Hence, a longitudinal investigation is neces-
sary. Also, this study did not consider prehypertension which is also known to increase the
risk of cardiovascular disease. Future comparative studies should take this category of blood
pressure into consideration. Lastly, there is a possibility of discrepancies or errors between dif-
ferent observers when measuring waist circumference and hip circumference. However,
anthropometric indices were measured using a defined methodology by well-trained data per-
sonnel, so errors were probably at a minimum.

Conclusion
There is a high prevalence of unrecognized hypertension among perceived healthy Ghanaian
adults. The prevalence of unrecognized hypertension is associated with older age, divorce,
alcoholic beverage intake, physical inactivity, and obesity. We emphasize that BMI may not be
the most effective method for predicting the risk of hypertension and its associated pathologies
regardless of its common use in clinical practice. However, we propose that central obesity
indices (WHtR, BRI and AVI) are best associated with the risk of HTN and we recommend
their frequent inclusion in screening programs (both self and mass) and clinical settings. For
simplicity and cost-effective measures WHtR may be preferred and in the near future, assess-
ment of BRI and AVI (especially in females) may be available in a user-friendly software plat-
form that could provide information on individual risk to HTN. Health professionals are
needed to create awareness of these risk factors through educational and screening programs
along with individual self-check for blood pressure, lifestyle modifications and weight manage-
ment to prevent the onset of HTN.

Acknowledgments
The authors are grateful to the Assembly member of the Ablekuma North municipal district,
research assistants and volunteers who contributed in diverse ways for the successful comple-
tion of the study.

Author Contributions
Conceptualization: Wina Ivy Ofori Boadu, Emmanuel Ekow Korsah.
Formal analysis: Enoch Odame Anto, Joseph Frimpong, Stephen Opoku.
Investigation: Emmanuel Ekow Korsah, Ezekiel Ansah, Valentine Christian Kodzo Tsatsu
Tamakloe.
Methodology: Emmanuel Ekow Korsah.
Supervision: Enoch Odame Anto, Wina Ivy Ofori Boadu.
Writing – original draft: Enoch Odame Anto, Joseph Frimpong.

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PLOS GLOBAL PUBLIC HEALTH Unrecognized hypertension and putative risk factors

Writing – review & editing: Enoch Odame Anto, Wina Ivy Ofori Boadu, Emmanuel Ekow
Korsah, Eric Adua, Joseph Frimpong, Patience Nyarkoa, Valentine Christian Kodzo Tsatsu
Tamakloe, Emmanuel Acheampong, Evans Adu Asamoah, Stephen Opoku, Ebenezer
Afrifa-Yamoah, Max Efui Annani-Akollor, Christian Obirikorang.

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