Topic 18
Topic 18
Topic 18
(1 mark)
ii Give two possible causes of this variation that result from meiosis during
gamete formation.
(2 marks)
(2 marks)
2 Brown rats are classed as pests. Warfarin has been used as a rodenticide since
the 1950s. Warfarin interferes with the way in which vitamin K is used in blood
clotting. Rats which eat warfarin are killed due to internal bleeding.
Warfarin-resistant rats have been identified in various parts of Britain.
Resistance to warfarin is determined by a gene with two codominant alleles, WR
and WS.
Some rats are resistant to warfarin as they have the allele WR. Rats have three
possible genotypes:
1. WRWR resistant to warfarin but with a very high requirement for vitamin K
2. WRWS resistant to warfarin with slightly increased vitamin K requirement
3. WSWS susceptible (not resistant) to warfarin with normal low requirement for
vitamin K.
In addition, rats with the genotype WRWR require very large amounts of vitamin K
in their diets. If they do not receive this they will die within a few days due to
internal bleeding.
(1 mark)
b A population of 480 rats was reared in a laboratory. They were all fed on a
diet containing an adequate amount of vitamin K. In this population, 16 rats
had the genotype WSWS, 352 had the genotype WRWS, and 112 had the
genotype WRWR.
i Use these figures to calculate the actual frequency of the allele WR in this
population. Show your working.
(2 marks)
ii The diet of the rats was then changed to include only a small amount of
vitamin K. The rats were also given warfarin. How many rats out of the
population of 480 would be likely to die within a few days?
(1 mark)
iii If the surviving rats were allowed to breed, more susceptible rats would
appear in the next generation. Draw a genetic diagram to explain how.
(2 marks)
c The graph shows the change in the frequency of the WS allele in an area
where warfarin was used regularly.
(4 marks)
3 The Old Order Amish of Lancaster County, Pennsylvania, are an isolated human
population. Marriages occur almost exclusively within the population. Nearly all
can trace their ancestry back to a small group of people who settled in the area
in the 18th century.
Microcephaly is a condition which occurs in this population with a frequency of
1 in every 480 births. It is caused by a recessive allele of a single gene.
Sufferers usually die within six months of birth.
a The incidence of microcephaly in this population is very high compared to
non-isolated populations. Suggest two reasons for this high incidence.
(2 marks)
(3 marks)
(1 mark)
4 In recent years studies have been carried out into the bird song of great tits in
cities and rural environments. The noise in the city can cover up bird song.
Great tits have responded by increasing the pitch and speed of their songs so
they can be heard over the low pitch noise of their environment.
a In a city environment, great tits with shorter, more high-pitched songs may
attract mates more successfully than those with lower pitched, longer songs.
Suggest why.
(1 mark)
b Natural selection may be acting on the great tits in cities. Explain how.
(2 marks)
(1 mark)
d Scientists could investigate whether the alteration in great tit song in city
populations is the result of changes in allele frequency. Describe how they
could carry out the investigation.
(3 marks)
(3 marks)
(1 mark)
i Although ten beaches were visited there are only eight results on the
diagram.
Suggest why.
(1 mark)
One student decided that there was a positive correlation between wave
exposure and the number of bladders found on the seaweeds. He
decided to find out if the correlation was significant.
ii Suggest a suitable null hypothesis.
(1 mark)
iii Suggest a suitable statistical test. Give a reason for your choice.
(2 marks)
(2 marks)
The rat snake has six distinct populations in the USA. The distribution of
these populations is shown in the diagram.
(2 marks)
(3 marks)