C^O^N^T^E^N^T^S

CALENDAR OF EVENTS.................................................. 119

DABCI SCHEDULE/7WZZ.4, MISSOURI........................ 120

DABCI SCHEDULE/T(7ZA4, OKLAHOMA .....................121

FROM THE EDITOR'S DESK .........................................122

Virginia Kes singer

THE CLINICAL IMPORTANCE OF VITAMIN D

(CHOLECALCIFEROL)
A PARADIGM SHIFT WITH IMPLICATIONS FOR ALL
^K4ZT^C47?£TP2?OF72)^^^......................................................................124

Alex Vasquez, DC, ND

Gilbert Manso, MD
John Cannell, MD

RESOLUTION OF PROSTATE CANCER AFTER

NUTRITIONAL PROTOCOLS AND LIFESTYLE
MODIFICATIONS:
^C4^£'^T£72)y.............................................................................................l38

Jason Nardi, DC, DABCI, DACBN, FIAMA

THOUGHTS AT LARGE: Issue 18

CONTROVERSIES IN CLINICAL NUTRITION
AND FUNCTIONAL MEDICINE
A NUTRITIONAL SUPPORT FOR CANCER PATIENTS........................ 148
Jeffrey Moss, DDS, CNS, DACBN

DABCIs AND WHERE THEY ARE........................................................... 155

CLINTPUBLICA TIONS

VOL. 26, N0.4 • ISSN 1529-4722 • DECEMBER 2020

 tious prostatitis and prostate cancer has long been sus­
Resolution ofProstate pected. Systemic and localized applications of botani­
cal agents showed benefits, while PSA remained ele­
_
Cancer after Nutritional vated. The use of botanicals in prostate adenocarcmo­
mas warrants further investigation.

Protocols & Lifestyle Introduction:

Prostate cancer is the second leading cause of death in
Modifications: A Case Study American males and the most common cancer. Accord­
ing to recent figures, 1 in 9 men will be diagnosed with
prostate cancer during his lifetime with an estimated
164,690 new cases th.is year with an estimated 29,430 1
by: Jason Nardi, DC, DABCI,, DACBN, FIAMA. deaths. The most prevalent risk factors are age and
race·2 Other factors include diet, tobacco use, alcohol
consumption, low physical activity and exposure to
Keywo rds: Prostate Cancer; Remission Induction; environmental contaminants.3 Data also supports past
Clinical Nutrition; Food Habits; Lifestyle Factors prostatitis and infections have a strong link to future
prostate cancer.4·5
Abstract:
Introduction: The presented case focused on a 71 year-old Caucasian
This case study focused on the use of lifestyle, diet and male with prostate cancer confirmed with a needle bi­
nutritional supplementation to support the treatment of opsy, who presented for nutritional support before tra­
prostate adenocarcinoma. ditional treatment. Suppo1t included oral zinc, vitamin
C (VC), and vitamin K 1 and K2, as MK.7 (VK) supple­
Case Presentation: mentation and botanical agents.
The subject was a 72 year-old male recently diagnosed
with prostate cancer con. firmed with a 12-needle biopsy Clinical History:
by his urologist. History was positive for past prostati­ The patient a 71 year-old Caucasian retiree. His social
tis, benign prostatic hypertrophy and environmental and work history included tobacco use at the age of ten
exposure associated with prostate carcinoma. until 22 and exposme to petrochemicals as an auto me­
chanic. The subject worked at a family-owned nursery
Management & Outcome: and greenhouse but does not remember using chemical
Serological inflammatory and immunological markers fertilizers or pesticides. He also reported a history of
were high. Focus was on the use of botanicals with hematospermia eight years before the diagnosis of
high flavonoid and polyphenol content to help support prostate cancer; Hematospennia is associated with
the immune system to reduce inflammatory pathways. chronic prostatitis. 6
Dietary restrictions and lifestyle modifications were
implemented to also lower inflammation. Vitamin ther­ The patient had increasing PSA lab values from 3.8ng/
apy using oral vitamin C in combination with vitamin mL to 4.2ng/mL and was sent by his PCP to a urologist
K as an anti-cancer method. This combination has long in January 2018, who confirmed with a surgical biopsy
been thought to have benefits in preventing neoplastic of 12 specimens in March 2018. Biopsy results showed
activity. prostatic adenocarcinoma in the left apex with a Glea­
son Score of 6 (3+3) 7consisting of IO¾ of needle core
After six months of following protocols, blood markers tissue. Using the ISUPS grading, this amounts to a
were mostly improved and imaging showed no cancer prognostic grade group 1.8 After being told tr_eatm�nt
present in the prostate. would be determined with follow-up labs and unagmg
that would be scheduled in July and August, respec­
Di scussion: tively, the subject sought immediate alternative treat­
While the use of vitamin C and vitamin K is currently ment methods for the interim.
being used as an adjunct to traditional prostate cancer
treatment as Apatone®, oral supplementation in the Discussion:
same ratio may have equal benefit. This case also Alternative treatment began with simple dietary
showed there may be evidence that botanical support changes to cut down on and eliminate inflammatory
and vitamin therapy may be a viable vehicle in battling foods. Processed meats were removed due to the high
prostate carcinomas. The association between infec-
(Continued on page 140)
THE ORIGINA l lNTERNJST
M
DECEBER 2020 138
association in raising overall cancer risks, and red In one study, zinc levels were examined in several
meats were replaced with grass-fed versions to help groups of men with prostate issues: In prostate carci-
increase Omega 3 intake, especially conjugated linoleic noma, zinc levels were decreased by 83%, and in BPH
acid (CLA), due to its anticarcinogenic effect. there was a 61% decrease in tissue link levels com-
Other modifications were to increase activities to in- pared to normal tissues.
elude 20 minutes or more of walking, increase water
intake to 2-3 quarts daily, and replace coffee with green Additionally, Biocidin® capsules were used as a
tea.12 nightly rectal suppository to help with possible infec-
tious causes of prostatitis. Initial laboratory analysis
Initial Phase: showed increases in both lymphocytes and monocytes,
The initial 30-day phase of care included nutritional with normal white blood cell counts (Figure 1). Bio-
supplementation aimed at promoting clearance in the cidin® was chosen for its ingredient content (Figure 2),
body using botanicals that also contained anticarcino- especially bilberry; because it was in capsules that
genie properties. A product containing 50 mg each of could be delivered more locally as a suppository. The
Milk Thistle,13 turmeric,14 artichoke,15'16schisandra,17 most common infectious agents in the prostatitis are
rosemary,18'19 dandelion,20'2' yellow dock,22 gentian,23 Escherichia coli, Klebsiella, Proteus, Pseudomonas,
and barberry was used. Dosing was 50 mg of each, Enterobacter, Enterococcus, Serratia, and Staphylo-
combined in a capsule taken twice daily. Polyphenol coccus aiireus, all of which rely on efflux pumps to get
intake from these botanicals showed promise in fight- rid of toxic substances, including antibiotics. Inhibiting
ing cancerous cells; polyphenols' anti-carcinogenic efflux pump activity is shown to reduce biofilm forma-
properties include inhibitory effects on cancer cell pro- tion.3 Bilberry, or Vaccinium myrtilhis L., contains the
liferation, tumor growth, angiogenesis, metastasis, and polyphenol proanthocyanidin that has been shown to
inflammation, and help induce apoptosis.25'2 Polyphe- prevent bacterial adhesion.
nols have shown promise in targeting signal transduc-
tion pathways involved in carcinogenesis and reduces Vitamin K (VK) has been well known to have antioxi-
NF-kB mediated pathways, reducing inflammation as- dant effects on cancer, however recent studies are
sociated with tumor cells; Up-regulation of NF-kB in showing that VK and its analogs have additional effects
tumors cells inhibits apoptosis, increases angiogenesis on cancer, including apoptosis, cell cycle arrest, auto-
and metastatic capacity of tumor cells.27'28 Enzymatic phagy and modulation of various transcription fac-
and antioxidative properties of flavonoids add to their tors.34 It has long been suspected that VK combined
effectiveness; Antioxidative effects of flavonoids in- with vitamin C (VC) would be effective in treating can-
duce enzyme deactivation of free radicals and reactive cer. Tareen, et. al. showed that VC and VK as Apa-
oxygen species (ROS) and prevent them from becom- tone® were effective in delaying the progression of
mg mutagens/ advanced prostate cancer in 17 patients who did not
respond to standard therapy. While VC has been shown
Second Phase: to be an effective anti-oxidant and is shown to reduce
Compliance with suggestions was good after the initial chromosomal damage, thus reducing neoplasm activity.
30 days. While dietary restrictions and lifestyle modifi- Taper et al. demonstrated that VC inhibited the growth
cations did not change after the initial 30 days, new of both androgen-dependent and androgen-independent
nutritional support was implemented. This phase of human prostate carcinoma cells in mouse models. Dos-
care was focused on concepts that would arrest and ing for this phase was Apatone® of 100:1 VC to VK;
lower inflammation in the prostate and help support 6,000 mg ofVC was used with 620 mcg ofVK.
anticancer pathways.
Results:
With ample indicators of prostatitis, a large focus was The subject remained compliant with care after four
on reducing inflammation. It is well known that copper months of the above dietary and lifestyle modifications,
has a proclivity for prostate tissue. Copper is readily and nutritional supplementation. A new PSA lab was
leached from pipes used for plumbing in the US and taken in July; though still elevated at 5.2 ng/mL, this
can at times exceed safe levels, depending on the tem- would be within normal for a patient of this age.38 One
perature of the water, mineral content, the age of the month after the PSA lab multiplanar magnetic reso-
plumbing and how long water has been standing in the nance images of the pelvis were obtained using Gadav-
plumbing. To remove suspected copper from the pa- ist IV contrast. Clinical findings were: post obstmctive
tient, 60 mg of zinc picolinate was given daily. Some hypertrophy of the bladder wall, most likely due to
data shows that zinc is essential to good prostate health. BPH. The prostate measured 4.3 x 4.8 x 4.8 cm, with
(Continued on next page)
THE ORIGINAL INTERNIST DECEMBER 2020 140
 an overall volume of 48 ec. This is considered specific functions in treatment; the use of polyphe-
enlarged39 and was elevated at the bladder base; there nols and flavonoids to reduce inflammatory signal-
was mild heterogeneity of peripheral zone without sig- ing pathways and cell proliferation, while inducing
nificant foci of diffusion restriction, or unusual vascu- apoptosis appears to be a good reason for their in-
larity on computer-aided postcontrast evaluation; The clusion.
prostate capsule was intact; The neurovascular bundle
appeared normal bilaterally. The overall impression While there is evidence that associates infection
was an enlarged prostate with BPH centrally. There with prostatitis and evidence that links prostatitis to
was no evidence of any suspicious lesion in the gland prostate carcinoma, the connection between infec-
and no evidence of extracapsular spread of a tumor. tious prostatitis and the prevalence of prostate can-
The treating medical doctor agreed and stated their im- cer has never been shidied in-depth. Localized appli-
pression overall was an enlarged prostate gland with cation of botanicals may prevent bacterial adhesion
benign prostatic hypertrophy. No suspicious lesions in and the reduction of biofilms which may be an ef-
the gland were noted and no evidence of any tumor. fective, low-cost solution to treat several prostate-
related disorders, most especially benign prostatic
Post-treatment suggestions were to continue with die- hypertrophy and prostatitis.
tary and lifestyle modifications and follow through
with the urologist's recommendations of annual PSA The use of VC and VK has long been thought to
and DRE. have antineoplastic effects. While the drug Apa-
tone® has been shown safe and is moving into ad-
Conclusion: vanced clinical studies, the use of oral VC and VK
There has been ample study in the use of nutrition, sup- supplementation is limited to case and small cohort
plementation, lifestyle and dietary changes being used studies, which warrant further investigation.
to help hinder neoplastic activity. There appears to be
Acknowledgments:
much overlap in the lifestyle changes having a benefit
This case would not have been a success without the
in different forms of cancer; from the removal of sugars
guidance of Dr. Delilah Renegar.
and high inflammatory foods to the addition of foods
Conflicts of Interest:
that support the body as a whole. Nutritional protocols,
The author declares that they do not have conflicts
on the other hand, should be aimed at supporting
of interest.
Figures & Charts
Figure 1: Initial and follow-up lab values

Element 3/31/2018 12/28/2018 Units Optimal Range Standard Range

Glucose 117.00 113.00 mg/dL 72.00-90.00 65.00-99.00

AlkPhos 51.00 59.00 IU/L 70-100 35-115

AST 36.00 26.00 IU/L 10.00-26.00 10.00-25.00

ALT 61.00 34.00 IU/L 10.00-26.00 6.00-29.00

Femtin 753.00 604.00 ng/mL 50.0-150.0 10.0-232.0

Hs CRP, Male 4.10 1.19 mg/L 0.00-0.99 0.00-2.90

WBC 5.40 5.20 k/cumm 5.30-7.50 3.80-10.80

RBC 4.86 4.56 m/cumm 4.20-4.90 4.20-5.80

Neutrophils 45.00 49.80 % 40.00-60.00 40.00-60.00

Lymphocytes 41.60
M;onocytes 11.00 11.00 % 0.00-7.00 0.00-7.00

Eosinophils 2.00 2.10 % 0.00-3.00 0.00-3.00

Basophils 0.40 0.40 % 0.00-1.00 0.00-1.00

(Continued on next page)

141 THE ORIGINAL INTERNIST DECEMBER 2020

 Fignre2: Biocidin ingredients & actions

Ingredient Medicinal Action Reference

40.41.42
Bilberry Vaccinhim myrtillns Anti-inflammatory, antimicrobial, antioxidant, urinary antiseptic
41
Noni Morinda citrifolia Anti-inflammatory, antimicrobial, antioxidant
Antimicrobial, antioxidant, choleretic, hepatic trophorestorative, hepa-
40,42
Milk Thistle Silybiim marianum toprotective.
Echinacea pnrpnrea

Echinacea Anti-inflammatory, antifungal, antiviral, depurative,

41.42
Echinacea angiistifolia immune-enhancing, immune-modulating, lymphatic

Hydrastis Antibacterial, antihistamine, anti-inflammatory, antimicrobial, mucous

40.42
Golden Seal canadensis membrane, trophorestorative.

Shitake Lentimila
42
mushroom edodes Antibacterial, antifungal, antioxidant, iiTimune-modulating.
White willow
40
bark Salix alba Analgesic, anti-inflammatory.
40
Garlic Allium sativum Anthehnintic, anti-inflammatory, antimicrobial, antioxidant.
42
Grape Seed Vitis vinifera Antheknintic, anti-inflammatory, antioxidant.
40
Black Walnut Juglans nigra Anthelmintic, antimicrobial, depurative.
40.42
Raspberry Rubus idaens Anti-inflammatory, antimicrobial, antioxidant.
Fnmaria
40,42
Fumitory officinalis Antimicrobial, antioxidant
Gentian Genriana lntea Anti-inflammatory, antimicrobial, antioxidant.
Melalenca
44. 45,46
Tea Tree oil allernifolia Antifangal, antimicrobial.
Ferula
47
Galbanum oil galbaniflua Anti-inflammatory, antimicrobial, antiseptic.
Lavandiila
48
Lavender oil officinalis Antifungal, anti-mflammatory, antimicrobial.

Origanum
49
Oregano oil vulgare Antibacterial, antifungal, anti-inflanimatory

About the Author S.Pacheco SOS, Pacheco FJ, Zapata GMJ, et al. Food Hab-
Dr. Jason Nardi is a Board-Certifled Chiropractic Intermst
its, Lifestyle Factors, and Risk of Prostate Cancer in Central
and clinical nntritiomst and he holds a fellow in medical acu- Argentina: A Case Control Study Involving Self-Motivated
puncture. Dr. Nardi maintains a private practice in Jimean, Health Behavior Modifications after Diagnosis. Nutrients.
Alaska that focuses on neuro-strnctnral issues, pain condi- 2016;8(7):419.doi:10.3390/nu8070419.
tions, and digestive and hormonal health using a whole- 4Jiang J, Li J, Yunxia Z, Zhu H, Liu J, Pumill C. The Role
person, holistic approach. Dr. Nardi has a passion for ediica- of Prostatitis in Prostate Cancer: Meta-Analysis. Galds G,
tion and research and has worked with several magazines in ed. PLoS ONE. 2013;8(12):e85179. doi:10.1371/
the including HealthLine, LifeZette, Organic Authority, and joumal.pone.0085179.

CafeMom as an expert source for authors. He is the past Di- 5.Dennis LK, Lynch CF, Tomer JC. Epidemiologic associa-

rector of Research and current Director of Education for the tion between prostatitis and prostate cancer. Urology. July

American Chiropractic Association's Council on Nutrition.

2002;60(1):78-83.
6.Lee G. Chronic Prostatitis: A Possible Cause ofHemato-
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