Mono Globe-Artichoke English

NATURAL HEALTH PRODUCT
GLOBE ARTICHOKE – CYNARA CARDUNCULUS
This monograph is intended to serve as a guide to industry for the preparation of Product Licence
Applications (PLAs) and labels for natural health product market authorization. It is not intended
to be a comprehensive review of the medicinal ingredient.
Notes
Text in parentheses is additional optional information which can be included on the PLA and
product label at the applicant’s discretion.
The solidus (/) indicates that the terms and/or statements are synonymous. Either term or
statement may be selected by the applicant.
Date December 18, 2018
Proper name(s), Common name(s), Source material(s)
Table 1. Proper name(s), Common name(s), Source material(s)

Source material(s)
Proper name(s) Common name(s)
Proper name(s) Part(s) Preparation(s)
Cynara cardunculus Artichoke Cynara cardunculus Leaf Dried
Artichoke thistle
Cardoon
Cynara
Garden artichoke
Globe artichoke
Scotch thistle
References: Proper name: USDA 2018; Common names: McGuffin et al. 2000; Source material: Bradley
2006, ESCOP 2003, Blumenthal et al. 2000.
Route of administration
Oral
Dosage form(s)
This monograph excludes foods or food-like dosage forms as indicated in the Compendium of
Monographs Guidance Document.
Acceptable dosage forms for the age category listed in this monograph and specified route of
administration are indicated in the Compendium of Monographs Guidance Document.
Use(s) or Purpose(s)
Used in Herbal Medicine to help relieve digestive upset, such as indigestion (Bradley 2006;
ESCOP 2003; Blumenthal et al. 2000).
Used in Herbal Medicine to help increase bile flow (choleretic) (Bradley 2006; Mills and
Bone 2005; ESCOP 2003; Hoffmann 2003; Blumenthal et al. 2000).
The following combined use(s) or purpose(s) is/are also acceptable:
Used in Herbal Medicine to help relieve digestive upset, such as indigestion and help increase
bile flow (choleretic) (Bradley 2006; Mills and Bone 2005; ESCOP 2003; Hoffmann 2003;
Blumenthal et al. 2000).
Dose(s)
Subpopulation(s)
Adults 18 years and older
Quantity(ies)
Methods of preparation: Dry, Powder, Non-Standardised Extracts (Dry extract, Tincture, Fluid
extract, Decoction, Infusion)
1.5 - 10 grams of dried leaf, per day (Bradley 2006; Mills and Bone 2005; ESCOP 2003;
Direction(s) for use
No statement required.
Duration(s) of use
Globe Artichoke - Cynara cardunculus Page 2 of 4

Risk information
Caution(s) and warning(s)
Consult a health care practitioner/health care provider/health care professional/doctor/

physician if symptoms persist or worsen.
Consult a health care practitioner/health care provider/health care professional/doctor/
physician prior to use if you are pregnant or have gall stones (Brinker 2010; Barnes et al.
2007; Mills and Bone 2005; ESCOP 2003; Blumenthal et al. 2000).
Contraindication(s)
Do not use this product if you have a bile duct obstruction (Brinker 2010; Bradley 2006;
ESCOP 2003; Blumenthal et al. 2000).
Known adverse reaction(s)
Stop use if hypersensitivity/allergy occurs (Brinker 2010; Bradley 2006; ESCOP 2003;
Non-medicinal ingredients
Must be chosen from the current Natural Health Product Ingredient Database (NHPID) and must
meet the limitations outlined in the database.
Storage conditions
Specifications
The finished product specifications must be established in accordance with the requirements
described in the Natural and Non-prescription Health Products Directorate (NNHPD) Quality
of Natural Health Products Guide.
The medicinal ingredient must comply with the requirements outlined in the NHPID.
References cited
Barnes J, Anderson LA, Philipson JD. Herbal Medicines, 3rd edition. London (UK): The
Pharmaceutical Press; 2007.

Blumenthal M, Goldberg A, Brinkmann J, editors. Herbal Medicine: Expanded Commission E
Monographs. Boston (MA): Integrative Medicine Communications; 2000.
Bradley PR, editor. British Herbal Compendium: A Handbook of Scientific Information on

Widely Used Plant Drugs, Volume 2. Bournemouth (UK): British Herbal Medicine Association;
2006.
Brinker F. Herb Contraindications and Drug Interactions, 4th edition. Sandy (OR): Eclectic
Medical Publications; 2010.
ESCOP 2003: ESCOP Monographs: The Scientific Foundation for Herbal Medicinal Products,
2nd edition. Exeter (UK): European Scientific Cooperative on Phytotherapy and Thieme; 2003.
Hoffmann D. Medical Herbalism. Rochester (VT): Healing Arts Press; 2003.
McGuffin M, Kartesz JT, Leung AY, Tucker AO, editors. Herbs of Commerce, 2nd edition.
Silver Spring (MD): American Herbal Products Association; 2000.
Mills S, Bone K. The Essential Guide to Herbal Safety. St. Louis (MO): Elsevier Churchill
Livingstone; 2005.
USDA 2018: ARS, National Genetic Resources Program. Germplasm Resources Information
Network (GRIN). Cynara cardunculus L. National Germplasm Resources Laboratory, Beltsville
(MD). [Accessed 2018 September 27]. Available from: https://npgsweb.ars-
grin.gov/gringlobal/taxonomydetail.aspx?id=12839
References reviewed
Sinayoko L, Mennecier D, El Jahir Y, Corberand D, Harnois F, Thiolet C, Farret O. [Acute

hepatic injury secondary to ingestion of artichoke extracts (Hepanephrol).] Atteinte hépatique
aiguë secondaire à la prise d’extraits d’artichaut (Hépanéphrol®). Gastroentérologie clinique et
biologique 2007; 31(11):1039-1040 (in French).

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NATURAL HEALTH PRODUCT

GLOBE ARTICHOKE – CYNARA CARDUNCULUS

Date December 18, 2018

Proper name(s), Common name(s), Source material(s)

Table 1. Proper name(s), Common name(s), Source material(s)

The following combined use(s) or purpose(s) is/are also acceptable:

Adults 18 years and older

Direction(s) for use

Globe Artichoke - Cynara cardunculus Page 2 of 4

Caution(s) and warning(s)

Consult a health care practitioner/health care provider/health care professional/doctor/

Known adverse reaction(s)

Globe Artichoke - Cynara cardunculus Page 3 of 4

Bradley PR, editor. British Herbal Compendium: A Handbook of Scientific Information on

Hoffmann D. Medical Herbalism. Rochester (VT): Healing Arts Press; 2003.

Sinayoko L, Mennecier D, El Jahir Y, Corberand D, Harnois F, Thiolet C, Farret O. [Acute

Globe Artichoke - Cynara cardunculus Page 4 of 4

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