R32

A-Gas (UK) Ltd

Version No: 9.1 Issue Date: 21/05/2024
Safety data sheet according to REACH Regulation (EC) No 1907/2006, as amended by UK REACH Regulations SI 2019/758 Print Date: 04/11/2024
L.REACH.GB.EN

SECTION 1 Identification of the substance / mixture and of the company / undertaking

1.1. Product Identifier

Product name R32

Synonyms Difluoromethane
Proper shipping name DIFLUOROMETHANE; REFRIGERANT GAS R 32
Chemical formula Not Applicable

Other means of identification Not Available

1.2. Relevant identified uses of the substance or mixture and uses advised against
Refrigerant.
Relevant identified uses The use of a quantity of material in an unventilated or confined space may result in increased exposure and an irritating atmosphere
developing. Before starting consider control of exposure by mechanical ventilation.

Uses advised against No specific uses advised against are identified.

1.3. Details of the manufacturer or supplier of the safety data sheet

Registered company name A-Gas (UK) Ltd
Address Banyard Road, Portbury West Bristol BS20 7XH United Kingdom
Telephone +44 (0) 1275 376600

Fax [+44] (0) 1275 376601

Website www.agas.com
Email info.uk@agas.com

1.4. Emergency telephone number

Association / Organisation A-Gas (UK) Ltd CHEMWATCH EMERGENCY RESPONSE (24/7)

Emergency telephone
+44 (0) 1275 376600 +44 20 3901 3542
number(s)

Other emergency telephone

Not Available +44 808 164 9592
number(s)

Once connected and if the message is not in your preferred language then please dial 01

SECTION 2 Hazards identification

2.1. Classification of the substance or mixture

Classified according to GB-CLP

Regulation, UK SI 2019/720 H220 - Flammable gases, Hazard Category 1A, H280 - Gases Under Pressure (Liquefied Gas)
and UK SI 2020/1567 [1]
Legend: 1. Classification by vendor; 2. Classification drawn from GB-CLP Regulation, UK SI 2019/720 and UK SI 2020/1567

2.2. Label elements

Hazard pictogram(s)

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Signal word Danger

Hazard statement(s)
H220 Extremely flammable gas.

H280 Contains gas under pressure; may explode if heated.

Supplementary statement(s)
EUH044 Risk of explosion if heated under confinement.

Precautionary statement(s) General

P101 If medical advice is needed, have product container or label at hand.
P102 Keep out of reach of children.

P103 Read carefully and follow all instructions.

Precautionary statement(s) Prevention

P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking.

Precautionary statement(s) Response

P377 Leaking gas fire: Do not extinguish, unless leak can be stopped safely.

P381 In case of leakage, eliminate all ignition sources.

Precautionary statement(s) Storage

P410+P403 Protect from sunlight. Store in a well-ventilated place.

Precautionary statement(s) Disposal

Not Applicable

Material does not contain any CLP Article 18 substances.

2.3. Other hazards

REACH - Art.57-59: The mixture does not contain Substances of Very High Concern (SVHC) at the SDS print date.

SECTION 3 Composition / information on ingredients

3.1.Substances
See 'Composition on ingredients' in Section 3.2

3.2.Mixtures
1. CAS No
2.EC No % Classified according to GB-CLP Regulation, UK SI Nanoform Particle
Name SCL / M-Factor
3.Index No [weight] 2019/720 and UK SI 2020/1567 Characteristics
4.REACH No

SCL: Not Available

1. 75-10-5
Flammable gases, Hazard Category 1A; H220, Acute M factor: Not
2.200-839-4
>60 difluoromethane Available Not Available
3.Not Available EUH044 [1]
4.01-2119471312-47-XXXX Chronic M factor:
Not Available

Legend: 1. Classification by vendor; 2. Classification drawn from GB-CLP Regulation, UK SI 2019/720 and UK SI 2020/1567; 3. Classification drawn
from C&L; * EU IOELVs available; [e] Substance identified as having endocrine disrupting properties

SECTION 4 First aid measures

4.1. Description of first aid measures

Eye Contact If product comes in contact with eyes remove the patient from gas source or contaminated area.
Take the patient to the nearest eye wash, shower or other source of clean water.
Open the eyelid(s) wide to allow the material to evaporate.
Gently rinse the affected eye(s) with clean, cool water for at least 15 minutes. Have the patient lie or sit down and tilt the head back.
Hold the eyelid(s) open and pour water slowly over the eyeball(s) at the inner corners, letting the water run out of the outer corners.

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The patient may be in great pain and wish to keep the eyes closed. It is important that the material is rinsed from the eyes to prevent
further damage.
Ensure that the patient looks up, and side to side as the eye is rinsed in order to better reach all parts of the eye(s)
Transport to hospital or doctor.
Even when no pain persists and vision is good, a doctor should examine the eye as delayed damage may occur.
If the patient cannot tolerate light, protect the eyes with a clean, loosely tied bandage.
Ensure verbal communication and physical contact with the patient.
DO NOT allow the patient to rub the eyes
DO NOT allow the patient to tightly shut the eyes
DO NOT introduce oil or ointment into the eye(s) without medical advice
DO NOT use hot or tepid water.

If skin contact occurs:

Immediately remove all contaminated clothing, including footwear.
Flush skin and hair with running water (and soap if available).
Seek medical attention in event of irritation.
In case of cold burns (frost-bite):
Move casualty into warmth before thawing the affected part; if feet are affected carry if possible
Bathe the affected area immediately in luke-warm water (not more than 35 deg C) for 10 to 15 minutes, immersing if possible and
Skin Contact
without rubbing
DO NOT apply hot water or radiant heat.
Apply a clean, dry, light dressing of "fluffed-up" dry gauze bandage
If a limb is involved, raise and support this to reduce swelling
If an adult is involved and where intense pain occurs provide pain killers such as paracetomol
Transport to hospital, or doctor
Subsequent blackening of the exposed tissue indicates potential of necrosis, which may require amputation.
Following exposure to gas, remove the patient from the gas source or contaminated area.
NOTE: Personal Protective Equipment (PPE), including positive pressure self-contained breathing apparatus may be required to assure
the safety of the rescuer.
Prostheses such as false teeth, which may block the airway, should be removed, where possible, prior to initiating first aid procedures.
If the patient is not breathing spontaneously, administer rescue breathing.
If the patient does not have a pulse, administer CPR.
Inhalation If medical oxygen and appropriately trained personnel are available, administer 100% oxygen.
Summon an emergency ambulance. If an ambulance is not available, contact a physician, hospital, or Poison Control Centre for further
instruction.
Keep the patient warm, comfortable and at rest while awaiting medical care.
MONITOR THE BREATHING AND PULSE, CONTINUOUSLY.
Administer rescue breathing (preferably with a demand-valve resuscitator, bag-valve mask-device, or pocket mask as trained) or CPR if
necessary.
Not considered a normal route of entry.
For advice, contact a Poisons Information Centre or a doctor.
Ingestion
Avoid giving milk or oils.
Avoid giving alcohol.

4.2 Most important symptoms and effects, both acute and delayed
See Section 11

4.3. Indication of any immediate medical attention and special treatment needed
for intoxication due to Freons/ Halons;
A: Emergency and Supportive Measures
Maintain an open airway and assist ventilation if necessary
Treat coma and arrhythmias if they occur. Avoid (adrenaline) epinephrine or other sympathomimetic amines that may precipitate ventricular arrhythmias. Tachyarrhythmias
caused by increased myocardial sensitisation may be treated with propranolol, 1-2 mg IV or esmolol 25-100 microgm/kg/min IV.
Monitor the ECG for 4-6 hours
B: Specific drugs and antidotes:
There is no specific antidote
C: Decontamination
Inhalation; remove victim from exposure, and give supplemental oxygen if available.
Ingestion; (a) Prehospital: Administer activated charcoal, if available. DO NOT induce vomiting because of rapid absorption and the risk of abrupt onset CNS depression. (b)
Hospital: Administer activated charcoal, although the efficacy of charcoal is unknown. Perform gastric lavage only if the ingestion was very large and recent (less than 30
minutes)
D: Enhanced elimination:
There is no documented efficacy for diuresis, haemodialysis, haemoperfusion, or repeat-dose charcoal.
POISONING and DRUG OVERDOSE, Californian Poison Control System Ed. Kent R Olson; 3rd Edition
Do not administer sympathomimetic drugs unless absolutely necessary as material may increase myocardial irritability.
No specific antidote.
Because rapid absorption may occur through lungs if aspirated and cause systematic effects, the decision of whether to induce vomiting or not should be made by an
attending physician.
If lavage is performed, suggest endotracheal and/or esophageal control.
Danger from lung aspiration must be weighed against toxicity when considering emptying the stomach.
Treatment based on judgment of the physician in response to reactions of the patient
For frost-bite caused by liquefied petroleum gas:
If part has not thawed, place in warm water bath (41-46 C) for 15-20 minutes, until the skin turns pink or red.
Analgesia may be necessary while thawing.
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If there has been a massive exposure, the general body temperature must be depressed, and the patient must be immediately rewarmed by whole-body immersion, in a
bath at the above temperature.
Shock may occur during rewarming.
Administer tetanus toxoid booster after hospitalization.
Prophylactic antibiotics may be useful.
The patient may require anticoagulants and oxygen.
[Shell Australia 22/12/87]
For gas exposures:
--------------------------------------------------------------
BASIC TREATMENT
--------------------------------------------------------------
Establish a patent airway with suction where necessary.
Watch for signs of respiratory insufficiency and assist ventilation as necessary.
Administer oxygen by non-rebreather mask at 10 to 15 l/min.
Monitor and treat, where necessary, for pulmonary oedema .
Monitor and treat, where necessary, for shock.
Anticipate seizures.
--------------------------------------------------------------
ADVANCED TREATMENT
--------------------------------------------------------------
Consider orotracheal or nasotracheal intubation for airway control in unconscious patient or where respiratory arrest has occurred.
Positive-pressure ventilation using a bag-valve mask might be of use.
Monitor and treat, where necessary, for arrhythmias.
Start an IV D5W TKO. If signs of hypovolaemia are present use lactated Ringers solution. Fluid overload might create complications.
Drug therapy should be considered for pulmonary oedema.
Hypotension with signs of hypovolaemia requires the cautious administration of fluids. Fluid overload might create complications.
Treat seizures with diazepam.
Proparacaine hydrochloride should be used to assist eye irrigation.
BRONSTEIN, A.C. and CURRANCE, P.L.
EMERGENCY CARE FOR HAZARDOUS MATERIALS EXPOSURE: 2nd Ed. 1994

SECTION 5 Firefighting measures

5.1. Extinguishing media

DO NOT EXTINGUISH BURNING GAS UNLESS LEAK CAN BE STOPPED SAFELY:
OTHERWISE: LEAVE GAS TO BURN.
FOR SMALL FIRE:
Dry chemical, CO2 or water spray to extinguish gas (only if absolutely necessary and safe to do so).
DO NOT use water jets.
FOR LARGE FIRE:
Cool cylinder by direct flooding quantities of water onto upper surface until well after fire is out.

5.2. Special hazards arising from the substrate or mixture

Fire Incompatibility Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine bleaches, pool chlorine etc. as ignition may result

5.3. Advice for firefighters

FOR FIRES INVOLVING MANY GAS CYLINDERS:
To stop the flow of gas, specifically trained personnel may inert the atmosphere to reduce oxygen levels thus allowing the capping of
leaking container(s).
Reduce the rate of flow and inject an inert gas, if possible, before completely stopping the flow to prevent flashback.
DO NOT extinguish the fire until the supply is shut off otherwise an explosive re-ignition may occur.
If the fire is extinguished and the flow of gas continues, used increased ventilation to prevent build-up, of explosive atmosphere.
--------------------------------------------------------------
Fire Fighting
GENERAL
--------------------------------------------------------------
Alert Fire Brigade and tell them location and nature of hazard.
May be violently or explosively reactive.
Wear breathing apparatus plus protective gloves.
Consider evacuation
Fight fire from a safe distance, with adequate cover.

Fire/Explosion Hazard HIGHLY FLAMMABLE: will be easily ignited by heat, sparks or flames.
Will form explosive mixtures with air
Fire exposed containers may vent contents through pressure relief valves thereby increasing fire intensity and/ or vapour concentration.
Vapours may travel to source of ignition and flash back.
Containers may explode when heated - Ruptured cylinders may rocket
Fire may produce irritating, poisonous or corrosive gases.
Combustion products include:
carbon monoxide (CO)
carbon dioxide (CO2)
hydrogen fluoride
other pyrolysis products typical of burning organic material.
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Contains low boiling substance: Closed containers may rupture due to pressure buildup under fire conditions.
Vented gas is more dense than air and may collect in pits, basements.

SECTION 6 Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures

See section 8

6.2. Environmental precautions

See section 12

6.3. Methods and material for containment and cleaning up

Avoid breathing vapour and any contact with liquid or gas. Protective equipment including respirator should be used.
Minor Spills DO NOT enter confined spaces where gas may have accumulated.
Shut off all sources of possible ignition and increase ventilation.
Clear area of all unprotected personnel and move upwind.
Alert Emergency Authority and advise them of the location and nature of hazard.
May be violently or explosively reactive.
Wear full body clothing with breathing apparatus.
Major Spills
Remove leaking cylinders to a safe place.
Fit vent pipes. Release pressure under safe, controlled conditions
Burn issuing gas at vent pipes.
DO NOT exert excessive pressure on valve; DO NOTattempt to operate damaged valve.

6.4. Reference to other sections

Personal Protective Equipment advice is contained in Section 8 of the SDS.

SECTION 7 Handling and storage

7.1. Precautions for safe handling

· Consider use in closed pressurised systems, fitted with temperature, pressure and safety relief valves which are vented for safe dispersal.
Use only properly specified equipment which is suitable for this product, its supply pressure and temperature
· The tubing network design connecting gas cylinders to the delivery system should include appropriate pressure indicators and vacuum or
suction lines.
Safe handling
· Fully-welded types of pressure gauges, where the bourdon tube sensing element is welded to the gauge body, are recommended.
· Before connecting gas cylinders, ensure manifold is mechanically secure and does not containing another gas.
Avoid generation of static electricity. Earth all lines and equipment.
DO NOT transfer gas from one cylinder to another.

Fire and explosion protection See section 5

Cylinders should be stored in a purpose-built compound with good ventilation, preferably in the open.
Such compounds should be sited and built in accordance with statutory requirements.
Other information The storage compound should be kept clear and access restricted to authorised personnel only.
Cylinders stored in the open should be protected against rust and extremes of weather.
Store below 45 deg. C.

7.2. Conditions for safe storage, including any incompatibilities

Cylinder:
Ensure the use of equipment rated for cylinder pressure.
Suitable container Ensure the use of compatible materials of construction.
Valve protection cap to be in place until cylinder is secured, connected.
Cylinder must be properly secured either in use or in storage.
Compressed gases may contain a large amount of kinetic energy over and above that potentially available from the energy of reaction
produced by the gas in chemical reaction with other substances
Storage incompatibility
Presence of heat source and direct sunlight
Avoid magnesium, aluminium and their alloys, brass and steel.

Hazard categories in
accordance with Regulation
Not Available
(EC) No 2012/18/EU (Seveso
III)
Qualifying quantity (tonnes) of
dangerous substances as
Not Available
referred to in Article 3(10) for
the application of

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+ x + x + + +

X — Must not be stored together

0 — May be stored together with specific preventions
+ — May be stored together

Note: Depending on other risk factors, compatibility assessment based on the table above may not be relevant to storage situations, particularly where large volumes of dangerous
goods are stored and handled. Reference should be made to the Safety Data Sheets for each substance or article and risks assessed accordingly.

7.3. Specific end use(s)

See section 1.2

SECTION 8 Exposure controls / personal protection

8.1. Control parameters

DNELs PNECs
Ingredient
Exposure Pattern Worker Compartment

0.142 mg/L (Water (Fresh))

Inhalation 7035 mg/m³ (Systemic, Chronic)
difluoromethane 1.42 mg/L (Water - Intermittent release)
Inhalation 0.75 mg/m³ (Systemic, Chronic) *
0.534 mg/kg sediment dw (Sediment (Fresh Water))

* Values for General Population

Occupational Exposure Limits (OEL)

INGREDIENT DATA

Source Ingredient Material name TWA STEL Peak Notes

Not Available Not Available Not Available Not Available Not Available Not Available Not Available

Not Applicable
Ingredient Original IDLH Revised IDLH

difluoromethane Not Available Not Available

MATERIAL DATA

8.2. Exposure controls

Engineering controls are used to remove a hazard or place a barrier between the worker and the hazard. Well-designed engineering controls
can be highly effective in protecting workers and will typically be independent of worker interactions to provide this high level of protection.
8.2.1. Appropriate engineering The basic types of engineering controls are:
controls Process controls which involve changing the way a job activity or process is done to reduce the risk.
Enclosure and/or isolation of emission source which keeps a selected hazard "physically" away from the worker and ventilation that
strategically "adds" and "removes" air in the work environment.

8.2.2. Individual protection

measures, such as personal
protective equipment

Safety glasses with side shields.

Chemical goggles. [AS/NZS 1337.1, EN166 or national equivalent]
Eye and face protection
Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. A written policy document,
describing the wearing of lenses or restrictions on use, should be created for each workplace or task.
Skin protection See Hand protection below
When handling sealed and suitably insulated cylinders wear cloth or leather gloves.
Insulated gloves:
Hands/feet protection
NOTE: Insulated gloves should be loose fitting so that may be removed quickly if liquid is spilled upon them. Insulated gloves are not
made to permit hands to be placed in the liquid; they provide only short-term protection from accidental contact with the liquid.
Body protection See Other protection below
Other protection The clothing worn by process operators insulated from earth may develop static charges far higher (up to 100 times) than the minimum
ignition energies for various flammable gas-air mixtures. This holds true for a wide range of clothing materials including cotton.
Avoid dangerous levels of charge by ensuring a low resistivity of the surface material worn outermost.
BRETHERICK: Handbook of Reactive Chemical Hazards.
Protective overalls, closely fitted at neck and wrist.
Eye-wash unit.
IN CONFINED SPACES:
Non-sparking protective boots

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Static-free clothing.
Ensure availability of lifeline.
Some plastic personal protective equipment (PPE) (e.g. gloves, aprons, overshoes) are not recommended as they may produce static
electricity.
For large scale or continuous use wear tight-weave non-static clothing (no metallic fasteners, cuffs or pockets).
Non sparking safety or conductive footwear should be considered. Conductive footwear describes a boot or shoe with a sole made from
a conductive compound chemically bound to the bottom components, for permanent control to electrically ground the foot an shall
dissipate static electricity from the body to reduce the possibility of ignition of volatile compounds.

Respiratory protection
Type AX Filter of sufficient capacity. (AS/NZS 1716 & 1715, EN 143:2000 & 149:2001, ANSI Z88 or national equivalent)

8.2.3. Environmental exposure controls

See section 12

SECTION 9 Physical and chemical properties

9.1. Information on basic physical and chemical properties

Appearance Clear colourless compressed liquefied gas with a slight ethereal odour; insoluble in water.

Physical state Liquified Gas Relative density (Water = 1) 1.1

Partition coefficient n-octanol
Odour Not Available Not Available
/ water
Odour threshold Not Available Auto-ignition temperature (°C) Not Available
Decomposition
pH (as supplied) Not Available Not Available
temperature (°C)
Melting point / freezing point
-136 (freezing point) Viscosity (cSt) Not Available
(°C)

Initial boiling point and boiling

-51.7 Molecular weight (g/mol) 52
range (°C)
Flash point (°C) Not Available Taste Not Available
Evaporation rate Not Available Explosive properties Not Available
Flammability Not Available Oxidising properties Not Available
Surface Tension (dyn/cm or
Upper Explosive Limit (%) 31 Not Available
mN/m)
Lower Explosive Limit (%) 14 Volatile Component (%vol) 100
Vapour pressure (kPa) 1700 @ 25 deg C Gas group Not Available
Solubility in water Immiscible pH as a solution (1%) Not Available
Vapour density (Air = 1) 1.86 VOC g/L Not Available
Heat of Combustion (kJ/g) Not Available Ignition Distance (cm) Not Available
Flame Height (cm) Not Available Flame Duration (s) Not Available

Enclosed Space Ignition Time Enclosed Space Ignition

Not Available Not Available
Equivalent (s/m3) Deflagration Density (g/m3)
Nanoform Particle
Nanoform Solubility Not Available Not Available
Characteristics
Particle Size Not Available

9.2. Other information

Not Available

SECTION 10 Stability and reactivity

10.1.Reactivity See section 7.2

Unstable in the presence of incompatible materials.
10.2. Chemical stability Product is considered stable.
Hazardous polymerisation will not occur.
10.3. Possibility of hazardous
See section 7.2
reactions
10.4. Conditions to avoid See section 7.2
10.5. Incompatible materials See section 7.2

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10.6. Hazardous
See section 5.3
decomposition products

SECTION 11 Toxicological information

11.1. Information on toxicological effects

Inhalation of vapours or aerosols (mists, fumes), generated by the material during the course of normal handling, may be damaging to the
health of the individual.
Limited evidence or practical experience suggests that the material may produce irritation of the respiratory system, in a significant number
of individuals, following inhalation. In contrast to most organs, the lung is able to respond to a chemical insult by first removing or
neutralising the irritant and then repairing the damage. The repair process, which initially evolved to protect mammalian lungs from foreign
matter and antigens, may however, produce further lung damage resulting in the impairment of gas exchange, the primary function of the
lungs. Respiratory tract irritation often results in an inflammatory response involving the recruitment and activation of many cell types,
mainly derived from the vascular system.
Depression of the central nervous system is the most outstanding effect of most halogenated aliphatic hydrocarbons. Inebriation and
excitation, passing into narcosis, is a typical reaction. In severe acute exposures there is always a danger of death from respiratory failure or
cardiac arrest due to a tendency to make the heart more susceptible to catecholamines (adrenalin)
Material is highly volatile and may quickly form a concentrated atmosphere in confined or unventilated areas. The vapour may displace and
Inhaled replace air in breathing zone, acting as a simple asphyxiant. This may happen with little warning of overexposure.
Symptoms of asphyxia (suffocation) may include headache, dizziness, shortness of breath, muscular weakness, drowsiness and ringing in the
ears. If the asphyxia is allowed to progress, there may be nausea and vomiting, further physical weakness and unconsciousness and, finally,
convulsions, coma and death. Significant concentrations of the non-toxic gas reduce the oxygen level in the air. As the amount of oxygen is
reduced from 21 to 14 volume %, the pulse rate accelerates and the rate and volume of breathing increase.
The use of a quantity of material in an unventilated or confined space may result in increased exposure and an irritating atmosphere
developing. Before starting consider control of exposure by mechanical ventilation.
Exposure to high concentrations of fluorocarbons may produce cardiac arrhythmias or cardiac arrest due sensitisation of the heart to
adrenalin or noradrenalin. Deaths associated with exposures to fluorocarbons (specifically halogenated aliphatics) have occurred in
occupational settings and in inhalation of bronchodilator drugs.
Bronchospasm consistently occurs in human subjects inhaling fluorocarbons. At a measured concentration of 1700 ppm of one of the
commercially available aerosols there is a biphasic change in ventilatory capacity, the first reduction occurring within a few minutes and the
second delayed up to 30 minutes.
Not normally a hazard due to physical form of product.
Ingestion
Considered an unlikely route of entry in commercial/industrial environments
Repeated exposure may cause skin cracking, flaking or drying following normal handling and use.

Limited evidence exists, or practical experience predicts, that the material either produces inflammation of the skin in a substantial number
of individuals following direct contact, and/or produces significant inflammation when applied to the healthy intact skin of animals, for up to
four hours, such inflammation being present twenty-four hours or more after the end of the exposure period. Skin irritation may also be
present after prolonged or repeated exposure; this may result in a form of contact dermatitis (nonallergic). The dermatitis is often
characterised by skin redness (erythema) and swelling (oedema) which may progress to blistering (vesiculation), scaling and thickening of
the epidermis. At the microscopic level there may be intercellular oedema of the spongy layer of the skin (spongiosis) and intracellular
oedema of the epidermis.
Skin Contact
Entry into the blood-stream through, for example, cuts, abrasions, puncture wounds or lesions, may produce systemic injury with harmful
effects. Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
Vapourising liquid causes rapid cooling and contact may cause cold burns, frostbite, even through normal gloves. Frozen skin tissues are
painless and appear waxy and yellow. Signs and symptoms of frost-bite may include "pins and needles", paleness followed by numbness, a
hardening an stiffening of the skin, a progression of colour changes in the affected area, (first white, then mottled and blue and eventually
black; on recovery, red, hot, painful and blistered).

In common with other halogenated aliphatics, fluorocarbons may cause dermal problems due to a tendency to remove natural oils from the
skin causing irritation and the development of dry, sensitive skin. They do not appear to be appreciably absorbed.

Although the material is not thought to be an irritant (as classified by EC Directives), direct contact with the eye may produce transient
Eye discomfort characterised by tearing or conjunctival redness (as with windburn).
Direct contact with the eye may not cause irritation because of the extreme volatility of the gas; however concentrated atmospheres may
produce irritation after brief exposures..

Principal route of occupational exposure to the gas is by inhalation.

It is generally accepted that the fluorocarbons are less toxic than the corresponding halogenated aliphatic based on chlorine. Repeated
inhalation exposure to the fluorocarbon FC-11 does not produce pathologic lesions of the liver and other visceral organs in experimental
animals. There has been conjecture in non-scientific publications that fluorocarbons may cause leukemia, cancer, sterility and birth defects;
Chronic
these have not been verified by current research. The high incidence of cancer, spontaneous abortion and congenital anomalies amongst
hospital personnel, repeatedly exposed to fluorine-containing general anaesthetics, has caused some scientists to call for a lowering of the
fluorocarbon exposure standard to 5 ppm since some are mutagens.
Limited evidence suggests that repeated or long-term occupational exposure may produce cumulative health effects involving organs or
biochemical systems.

TOXICITY IRRITATION
R32
Not Available Not Available

difluoromethane
TOXICITY IRRITATION

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Inhalation (Rat) LC50: >760000 ppm4h[2] Not Available

[2]
Oral (Mouse) LD50; 1810 mg/kg

Legend: 1. Value obtained from Europe ECHA Registered Substances - Acute toxicity 2. Value obtained from manufacturer's SDS. Unless otherwise
specified data extracted from RTECS - Register of Toxic Effect of chemical Substances

Acute Toxicity Carcinogenicity

Skin Irritation/Corrosion Reproductivity
Serious Eye Damage/Irritation STOT - Single Exposure
Respiratory or Skin
STOT - Repeated Exposure
sensitisation
Mutagenicity Aspiration Hazard

Legend: – Data either not available or does not fill the criteria for classification
– Data available to make classification

11.2 Information on other hazards

11.2.1. Endocrine disrupting properties

No evidence of endocrine disrupting properties were found in the current literature.

11.2.2. Other information

See Section 11.1

SECTION 12 Ecological information

12.1. Toxicity

Endpoint Test Duration (hr) Species Value Source

R32 Not Not Not
Not Available Not Available
Available Available Available

Endpoint Test Duration (hr) Species Value Source

EC50 72h Algae or other aquatic plants >114mg/l 2
EC50 48h Crustacea >97.9mg/l 2
difluoromethane
LC50 96h Fish >81.8mg/l 2
EC50 96h Algae or other aquatic plants 142mg/l 2
NOEC(ECx) 96h Fish 10mg/l 2

Legend: Extracted from 1. IUCLID Toxicity Data 2. Europe ECHA Registered Substances - Ecotoxicological Information - Aquatic Toxicity 4. US EPA,
Ecotox database - Aquatic Toxicity Data 5. ECETOC Aquatic Hazard Assessment Data 6. NITE (Japan) - Bioconcentration Data 7. METI (Japan) -
Bioconcentration Data 8. Vendor Data

DO NOT discharge into sewer or waterways.

12.2. Persistence and degradability

Ingredient Persistence: Water/Soil Persistence: Air
difluoromethane LOW LOW

12.3. Bioaccumulative potential

Ingredient Bioaccumulation
difluoromethane LOW (LogKOW = 0.2)

12.4. Mobility in soil

Ingredient Mobility
difluoromethane LOW (Log KOC = 23.74)

12.5. Results of PBT and vPvB assessment

P B T
Relevant available data Not Available Not Available Not Available
PBT

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P B T
vPvB

PBT Criteria fulfilled? No

vPvB No

12.6. Endocrine disrupting properties

No evidence of endocrine disrupting properties were found in the current literature.

12.7. Other adverse effects

Global Warming Potential (GWP) values according to "REGULATION (EU) 2024/573 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 7 February 2024 on fluorinated
greenhouse gases, amending Directive (EU) 2019/1937 and repealing Regulation (EU) No 517/2014": 675

SECTION 13 Disposal considerations

13.1. Waste treatment methods

Evaporate or incinerate residue at an approved site.
Product / Packaging disposal Return empty containers to supplier.
Ensure damaged or non-returnable cylinders are gas-free before disposal.
Waste treatment options Not Available
Sewage disposal options Not Available

SECTION 14 Transport information

Labels Required

Marine Pollutant NO

HAZCHEM 2YE

Land transport (ADR-RID)

14.1. UN number or ID
3252
number
14.2. UN proper shipping
DIFLUOROMETHANE; REFRIGERANT GAS R 32
name

14.3. Transport hazard Class 2.1

class(es) Subsidiary Hazard Not Applicable

14.4. Packing group Not Applicable

14.5. Environmental hazard Not Applicable

Hazard identification (Kemler) 23

Classification code 2F

14.6. Special precautions for Hazard Label 2.1

user Special provisions 662
Limited quantity 0
Tunnel Restriction Code B/D

Air transport (ICAO-IATA / DGR)

14.1. UN number 3252
14.2. UN proper shipping
Refrigerant gas R 32; Difluoromethane
name

ICAO/IATA Class 2.1

14.3. Transport hazard
ICAO / IATA Subsidiary Hazard Not Applicable
class(es)
ERG Code 10L

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14.4. Packing group Not Applicable

14.5. Environmental hazard Not Applicable

Special provisions A1
Cargo Only Packing Instructions 200
Cargo Only Maximum Qty / Pack 150 kg
14.6. Special precautions for
Passenger and Cargo Packing Instructions Forbidden
user
Passenger and Cargo Maximum Qty / Pack Forbidden
Passenger and Cargo Limited Quantity Packing Instructions Forbidden
Passenger and Cargo Limited Maximum Qty / Pack Forbidden

Sea transport (IMDG-Code / GGVSee)

14.1. UN number 3252
14.2. UN proper shipping
REFRIGERANT GAS R 32; DIFLUOROMETHANE
name

14.3. Transport hazard IMDG Class 2.1

class(es) IMDG Subsidiary Hazard Not Applicable

14.4. Packing group Not Applicable

14.5 Environmental hazard Not Applicable

EMS Number F-D , S-U

14.6. Special precautions for
Special provisions Not Applicable
user
Limited Quantities 0

Inland waterways transport (ADN)

14.1. UN number 3252
14.2. UN proper shipping
DIFLUOROMETHANE (REFRIGERANT GAS R 32)
name
14.3. Transport hazard
2.1 Not Applicable
class(es)
14.4. Packing group Not Applicable

14.5. Environmental hazard Not Applicable

Classification code 2F
Special provisions 662
14.6. Special precautions for
Limited quantity 0
user
Equipment required PP, EX, A
Fire cones number 1

14.7.1. Transport in bulk according to Annex II of MARPOL and the IBC code
Not Applicable

14.7.2. Transport in bulk in accordance with MARPOL Annex V and the IMSBC Code
Product name Group

difluoromethane Not Available

14.7.3. Transport in bulk in accordance with the IGC Code

Product name Ship Type
difluoromethane Not Available

SECTION 15 Regulatory information

15.1. Safety, health and environmental regulations / legislation specific for the substance or mixture

difluoromethane is found on the following regulatory lists

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UNEP (United Nations Environment Programme) Montreal Protocol Ozone Depletors - Annex F

Additional Regulatory Information

Not Applicable

This safety data sheet is in compliance with the following EU legislation and its adaptations - as far as applicable - : Directives 98/24/EC, - 92/85/EEC, - 94/33/EC, - 2008/98/EC, -
2010/75/EU; Commission Regulation (EU) 2020/878; Regulation (EC) No 1272/2008 as updated through ATPs.

Information according to 2012/18/EU (Seveso III):

Seveso Category Not Available

15.2. Chemical safety assessment

No Chemical Safety Assessment has been carried out for this substance/mixture by the supplier.

National Inventory Status

National Inventory Status

Australia - AIIC / Australia Non-

Yes
Industrial Use
Canada - DSL Yes

Canada - NDSL No (difluoromethane)

China - IECSC No (difluoromethane)

Europe - EINEC / ELINCS / NLP Yes

Japan - ENCS Yes

Korea - KECI Yes

New Zealand - NZIoC Yes

Philippines - PICCS Yes

USA - TSCA All chemical substances in this product have been designated as TSCA Inventory ‘Active'

Taiwan - TCSI Yes

Mexico - INSQ Yes

Vietnam - NCI Yes

Russia - FBEPH Yes

Yes = All CAS declared ingredients are on the inventory
Legend:
No = One or more of the CAS listed ingredients are not on the inventory. These ingredients may be exempt or will require registration.

SECTION 16 Other information

Revision Date 21/05/2024

Initial Date 22/01/2016

Full text Risk and Hazard codes

SDS Version Summary

Version Date of Update Sections Updated
8.1 28/10/2021 Hazards identification - Classification

9.1 21/05/2024 Handling and storage - Storage (suitable container)

Other information
Classification of the preparation and its individual components has drawn on official and authoritative sources using available literature references.

The SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors determine whether the reported Hazards are Risks in the workplace
or other settings. Risks may be determined by reference to Exposures Scenarios. Scale of use, frequency of use and current or available engineering controls must be considered.

For detailed advice on Personal Protective Equipment, refer to the following EU CEN Standards:
EN 166 Personal eye-protection
EN 340 Protective clothing
EN 374 Protective gloves against chemicals and micro-organisms
EN 13832 Footwear protecting against chemicals
EN 133 Respiratory protective devices

Definitions and abbreviations

PC TWA: Permissible Concentration-Time Weighted Average
PC STEL: Permissible Concentration-Short Term Exposure Limit

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IARC: International Agency for Research on Cancer

ACGIH: American Conference of Governmental Industrial Hygienists
STEL: Short Term Exposure Limit
TEEL: Temporary Emergency Exposure Limit
IDLH: Immediately Dangerous to Life or Health Concentrations
ES: Exposure Standard
OSF: Odour Safety Factor
NOAEL: No Observed Adverse Effect Level
LOAEL: Lowest Observed Adverse Effect Level
TLV: Threshold Limit Value
LOD: Limit Of Detection
OTV: Odour Threshold Value
BCF: BioConcentration Factors
BEI: Biological Exposure Index
DNEL: Derived No-Effect Level
PNEC: Predicted no-effect concentration

AIIC: Australian Inventory of Industrial Chemicals

DSL: Domestic Substances List
NDSL: Non-Domestic Substances List
IECSC: Inventory of Existing Chemical Substance in China
EINECS: European INventory of Existing Commercial chemical Substances
ELINCS: European List of Notified Chemical Substances
NLP: No-Longer Polymers
ENCS: Existing and New Chemical Substances Inventory
KECI: Korea Existing Chemicals Inventory
NZIoC: New Zealand Inventory of Chemicals
PICCS: Philippine Inventory of Chemicals and Chemical Substances
TSCA: Toxic Substances Control Act
TCSI: Taiwan Chemical Substance Inventory
INSQ: Inventario Nacional de Sustancias Químicas
NCI: National Chemical Inventory
FBEPH: Russian Register of Potentially Hazardous Chemical and Biological Substances

Classification and procedure used to derive the classification for mixtures according to Regulation (EC) 1272/2008 [CLP]
Classification according to
regulation (EC) No 1272/2008 Classification Procedure
[CLP] and amendments

Flammable gases, Hazard

On basis of test data
Category 1A, H220
Gases Under Pressure
On basis of test data
(Liquefied Gas), H280

, EUH044 On basis of test data

end of SDS