Black Pepper Extract (Pieperine 5-6%) : Cambridge Commodities

Black Pepper Extract (Pieperine 5-6%)
Cambridge Commodities Chemwatch Hazard Alert Code: 2

Part Number: P02102 Issue Date: 09/02/2023
Version No: 2.2 Print Date: 25/12/2023
Safety data sheet according to REACH Regulation (EC) No 1907/2006, as amended by UK REACH Regulations SI 2019/758 S.REACH.GB.EN
SECTION 1 Identification of the substance / mixture and of the company / undertaking
1.1. Product Identifier

Product name Black Pepper Extract (Pieperine 5-6%)
Chemical Name Not Applicable

Synonyms Not Available
Proper shipping name ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (contains piperine)
Chemical formula Not Applicable
Other means of
P02102
identification
1.2. Relevant identified uses of the substance or mixture and uses advised against
Relevant identified uses Therapeutic or pharmacologically-active agent.
Uses advised against No specific uses advised against are identified.
1.3. Details of the manufacturer or supplier of the safety data sheet

Registered company name Cambridge Commodities
Address Lancaster Way Business Park, Ely, Cambridgeshire Cambridgeshire CB6 3NX United Kingdom
Telephone +44 1353 667258
Fax Not Available

Website Not Available
Email enquiries@cambridgecommodities.com
1.4. Emergency telephone number

Association / Organisation Not Available
Emergency telephone
Not Available
numbers
Product code: P02102 Version No: 2.2 Page 1 of 25

S.REACH.GB.EN Lancaster Way Business Park
Safety Data Sheet (Conforms to Annex II of REACH (1907/2006) - Regulation 2020/878) Ely, Cambridgeshire, CB6 3NX, UK.
Chemwatch: 9-685419 +44 (0) 1353 667258
Issue Date: 09/02/2023 info@c-c-l.com
Print Date: 25/12/2023 www.c-c-l.com
Other emergency
Not Available
telephone numbers
SECTION 2 Hazards identification
2.1. Classification of the substance or mixture
Classified according to
GB-CLP Regulation, UK SI H317 - Sensitisation (Skin) Category 1, H361f - Reproductive Toxicity Category 2, H412 - Hazardous to the Aquatic Environment
2019/720 and UK SI Long-Term Hazard Category 3
2020/1567 [1]
Legend: 1. Classified by Chemwatch; 2. Classification drawn from GB-CLP Regulation, UK SI 2019/720 and UK SI 2020/1567
2.2. Label elements
Hazard pictogram(s)
Signal word Warning
Hazard statement(s)
H317 May cause an allergic skin reaction.
H361f Suspected of damaging fertility.
H412 Harmful to aquatic life with long lasting effects.
Supplementary statement(s)
Not Applicable
Precautionary statement(s) Prevention

P201 Obtain special instructions before use.
P280 Wear protective gloves and protective clothing.
P261 Avoid breathing dust/fumes.
P273 Avoid release to the environment.

P272 Contaminated work clothing should not be allowed out of the workplace.
Precautionary statement(s) Response

P308+P313 IF exposed or concerned: Get medical advice/ attention.
P302+P352 IF ON SKIN: Wash with plenty of water and soap.
P333+P313 If skin irritation or rash occurs: Get medical advice/attention.

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P362+P364 Take off contaminated clothing and wash it before reuse.
Precautionary statement(s) Storage

P405 Store locked up.
Precautionary statement(s) Disposal

P501 Dispose of contents/container to authorised hazardous or special waste collection point in accordance with any local regulation.
2.3. Other hazards

Ingestion may produce health damage*.
Cumulative effects may result following exposure*.
Limited evidence of a carcinogenic effect*.
REACH - Art.57-59: The mixture does not contain Substances of Very High Concern (SVHC) at the SDS print date.
SECTION 3 Composition / information on ingredients
3.1.Substances
See 'Composition on ingredients' in Section 3.2
3.2.Mixtures
1. CAS No
2.EC No Classified according to GB-CLP Regulation, UK SI SCL / Nanoform Particle
%[weight] Name
3.Index No 2019/720 and UK SI 2020/1567 M-Factor Characteristics
4.REACH No
1. 94-62-2 Acute Toxicity (Oral) Category 4, Sensitisation (Skin)

2.202-348-0 Category 1, Reproductive Toxicity Category 2, Not
5-6 piperine Not Available
3.Not Available Hazardous to the Aquatic Environment Long-Term Available
4.Not Available Hazard Category 2; H302, H317, H361f, H411 [1]
1. 9050-36-6
2.232-940-4 Not
15-20 maltodextrin Not Classified [1] Not Available
3.Not Available Available
4.Not Available
1. Not Available
2.Not Available black pepper Not
70-74 Not Classified [1] Not Available
3.Not Available extract Available
4.Not Available
Legend: 1. Classified by Chemwatch; 2. Classification drawn from GB-CLP Regulation, UK SI 2019/720 and UK SI 2020/1567; 3.
Classification drawn from C&L; * EU IOELVs available; [e] Substance identified as having endocrine disrupting properties
SECTION 4 First aid measures

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4.1. Description of first aid measures

If this product comes in contact with eyes:
Wash out immediately with water.
Eye Contact
If irritation continues, seek medical attention.
Removal of contact lenses after an eye injury should only be undertaken by skilled personnel.
If skin contact occurs:

Immediately remove all contaminated clothing, including footwear.
Skin Contact
Flush skin and hair with running water (and soap if available).
Seek medical attention in event of irritation.
If fumes, aerosols or combustion products are inhaled remove from contaminated area.
Inhalation
Other measures are usually unnecessary.
Immediately give a glass of water.

Ingestion
First aid is not generally required. If in doubt, contact a Poisons Information Centre or a doctor.
4.2 Most important symptoms and effects, both acute and delayed
See Section 11
4.3. Indication of any immediate medical attention and special treatment needed
Treat symptomatically.
SECTION 5 Firefighting measures
5.1. Extinguishing media

Foam.
Dry chemical powder.
BCF (where regulations permit).
Carbon dioxide.
Water spray or fog - Large fires only.
5.2. Special hazards arising from the substrate or mixture

Avoid contamination with oxidising agents i.e. nitrates, oxidising acids, chlorine bleaches, pool chlorine etc. as ignition may
Fire Incompatibility
result
5.3. Advice for firefighters

Alert Fire Brigade and tell them location and nature of hazard.
Wear breathing apparatus plus protective gloves.
Prevent, by any means available, spillage from entering drains or water courses.
Use water delivered as a fine spray to control fire and cool adjacent area.
Fire Fighting
DO NOT approach containers suspected to be hot.
Cool fire exposed containers with water spray from a protected location.
If safe to do so, remove containers from path of fire.
Equipment should be thoroughly decontaminated after use.
For starch/ air mixtures
Starch is a class St1 dust at normal moisture level:
Fire/Explosion Hazard Minimum Ignition Temperature (MIE): >30 mJ at normal moisture level
Pmax 9.5 Bar
Kst 170 bar.m/s

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Layer Ignition Temperature: >450 deg C

Autoignition Temperature: 170 deg C (above this temperature starch will self-heat)
Dust Explosion Hazard Class 1
Dusts fall into one of three Kst* classes. Class 1 dusts; Kst 1-200 m3/sec; Class 2 dusts; 201-299 m3/sec. Class 3 dusts; Kst 300
or more. Most agricultural dusts (grains, flour etc.) are Class 1; pharmaceuticals and other speciality chemicals are typically
Class 1 or 2; most unoxidised metallic dusts are Class 3. The higher the Kst, the more energetically the dust will burn and the
greater is the explosion risk and the greater is the speed of the explosion..
Standard test conditions, used to derive the Kst, are representative of industrial conditions, but do not represent and absolute
worst case. Increased levels of turbulence increase the speed of the explosion dramatically.
* Kst - a normalised expression of the burning dust pressure rise rate over time.
Dusts with Minimum Ignition Energies (MIEs) ranging between 20 and 100 mJ may be sensitive to ignition. They require that:
· plant is grounded
· personnel might also need to be grounded
· the use of high resistivity materials (such as plastics) should be restricted or avoided during handling or in
packaging
The majority of ignition accidents occur within or below this range.
The MIE of a dust/air mix depends on the particle size the water content and the temperature of the dust. The finer and the dryer
the dust the lower the MIE. Higher temperatures cause lower MIE and an increased risk of dust explosion.
Quoted values for MIE generally are only representative. Characteristics may change depending upon the process and
conditions of use or any changes made to the dust during use, including further grinding or mixing with other products. In order to
obtain more specific data for dust, as used, it is recommended that further characterisation testing.is performed.
Combustible solid which burns but propagates flame with difficulty; it is estimated that most organic dusts are combustible
(circa 70%) - according to the circumstances under which the combustion process occurs, such materials may cause fires
and / or dust explosions.
Organic powders when finely divided over a range of concentrations regardless of particulate size or shape and suspended in
air or some other oxidizing medium may form explosive dust-air mixtures and result in a fire or dust explosion (including
secondary explosions).
Avoid generating dust, particularly clouds of dust in a confined or unventilated space as dusts may form an explosive mixture
with air, and any source of ignition, i.e. flame or spark, will cause fire or explosion. Dust clouds generated by the fine grinding
of the solid are a particular hazard; accumulations of fine dust (420 micron or less) may burn rapidly and fiercely if ignited -
particles exceeding this limit will generally not form flammable dust clouds; once initiated, however, larger particles up to 1400
microns diameter will contribute to the propagation of an explosion.
In the same way as gases and vapours, dusts in the form of a cloud are only ignitable over a range of concentrations; in
principle, the concepts of lower explosive limit (LEL) and upper explosive limit (UEL) are applicable to dust clouds but only
the LEL is of practical use; - this is because of the inherent difficulty of achieving homogeneous dust clouds at high
temperatures (for dusts the LEL is often called the "Minimum Explosible Concentration", MEC).
When processed with flammable liquids/vapors/mists,ignitable (hybrid) mixtures may be formed with combustible dusts.
Ignitable mixtures will increase the rate of explosion pressure rise and the Minimum Ignition Energy (the minimum amount of
energy required to ignite dust clouds - MIE) will be lower than the pure dust in air mixture. The Lower Explosive Limit (LEL) of
the vapour/dust mixture will be lower than the individual LELs for the vapors/mists or dusts.
A dust explosion may release of large quantities of gaseous products; this in turn creates a subsequent pressure rise of
explosive force capable of damaging plant and buildings and injuring people.
Usually the initial or primary explosion takes place in a confined space such as plant or machinery, and can be of sufficient
force to damage or rupture the plant. If the shock wave from the primary explosion enters the surrounding area, it will disturb
any settled dust layers, forming a second dust cloud, and often initiate a much larger secondary explosion. All large scale
explosions have resulted from chain reactions of this type.
Dry dust can be charged electrostatically by turbulence, pneumatic transport, pouring, in exhaust ducts and during transport.
Build-up of electrostatic charge may be prevented by bonding and grounding.
Powder handling equipment such as dust collectors, dryers and mills may require additional protection measures such as
explosion venting.
All movable parts coming in contact with this material should have a speed of less than 1-meter/sec.
A sudden release of statically charged materials from storage or process equipment, particularly at elevated temperatures

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and/ or pressure, may result in ignition especially in the absence of an apparent ignition source.
One important effect of the particulate nature of powders is that the surface area and surface structure (and often moisture
content) can vary widely from sample to sample, depending of how the powder was manufactured and handled; this means
that it is virtually impossible to use flammability data published in the literature for dusts (in contrast to that published for
gases and vapours).
Autoignition temperatures are often quoted for dust clouds (minimum ignition temperature (MIT)) and dust layers (layer
ignition temperature (LIT)); LIT generally falls as the thickness of the layer increases.
Combustion products include:
,
carbon monoxide (CO)
,
carbon dioxide (CO2)
,
other pyrolysis products typical of burning organic material.
SECTION 6 Accidental release measures
6.1. Personal precautions, protective equipment and emergency procedures

See section 8
6.2. Environmental precautions

See section 12
6.3. Methods and material for containment and cleaning up

Environmental hazard - contain spillage.
Clean up waste regularly and abnormal spills immediately.
Avoid breathing dust and contact with skin and eyes.
Wear protective clothing, gloves, safety glasses and dust respirator.
Use dry clean up procedures and avoid generating dust.
Minor Spills
Vacuum up or sweep up. NOTE: Vacuum cleaner must be fitted with an exhaust micro filter (H-Class HEPA type) (consider
explosion-proof machines designed to be grounded during storage and use). H-Class HEPA filtered industrial vacuum
cleaners should NOT be used on wet materials or surfaces.
Dampen with water to prevent dusting before sweeping.
Place in suitable containers for disposal.
Environmental hazard - contain spillage.

Moderate hazard.
CAUTION: Advise personnel in area.
Alert Emergency Services and tell them location and nature of hazard.
Control personal contact by wearing protective clothing.
Major Spills Prevent, by any means available, spillage from entering drains or water courses.
Recover product wherever possible.
IF DRY: Use dry clean up procedures and avoid generating dust. Collect residues and place in sealed plastic bags or other
containers for disposal. IF WET: Vacuum/shovel up and place in labelled containers for disposal.
ALWAYS: Wash area down with large amounts of water and prevent runoff into drains.
If contamination of drains or waterways occurs, advise Emergency Services.
6.4. Reference to other sections

Personal Protective Equipment advice is contained in Section 8 of the SDS.

Chemwatch: 9-685419 +44 (0) 1353 667258
SECTION 7 Handling and storage
7.1. Precautions for safe handling

In general personnel handling this material and all conducting equipment should be electrically earthed or grounded.
Consideration should be given to avoiding the use of insulating plastics.
Bulk bags (FIBC) used to contain this material should be Type C or Type D. Type C bags must be electrically grounded before
powder is charged to or discharged from the bag.
Bag filters used to scavenge dust from material handling processes should be conductive and electrically grounded during use.
If metal or fibre drums are used to contain this product, make certain that the metal parts are bonded to the filling equipment and
grounded.This material can become readily charged in most/ many operations.
Avoid all personal contact, including inhalation.
Wear protective clothing when risk of exposure occurs.
Use in a well-ventilated area.
Prevent concentration in hollows and sumps.
DO NOT enter confined spaces until atmosphere has been checked.
DO NOT allow material to contact humans, exposed food or food utensils.
Avoid contact with incompatible materials.
When handling, DO NOT eat, drink or smoke.
Keep containers securely sealed when not in use.
Avoid physical damage to containers.
Always wash hands with soap and water after handling.
Work clothes should be laundered separately. Launder contaminated clothing before re-use.
Use good occupational work practice.
Observe manufacturer's storage and handling recommendations contained within this SDS.
Atmosphere should be regularly checked against established exposure standards to ensure safe working conditions are
maintained.
Organic powders when finely divided over a range of concentrations regardless of particulate size or shape and suspended in
Safe handling
air or some other oxidizing medium may form explosive dust-air mixtures and result in a fire or dust explosion (including
secondary explosions)
Minimise airborne dust and eliminate all ignition sources. Keep away from heat, hot surfaces, sparks, and flame.
Establish good housekeeping practices.
Remove dust accumulations on a regular basis by vacuuming or gentle sweeping to avoid creating dust clouds.
Use continuous suction at points of dust generation to capture and minimise the accumulation of dusts. Particular attention
should be given to overhead and hidden horizontal surfaces to minimise the probability of a "secondary" explosion. According
to NFPA Standard 654, dust layers 1/32 in.(0.8 mm) thick can be sufficient to warrant immediate cleaning of the area.
Do not use air hoses for cleaning.
Minimise dry sweeping to avoid generation of dust clouds. Vacuum dust-accumulating surfaces and remove to a chemical
disposal area. Vacuums with explosion-proof motors should be used.
Control sources of static electricity. Dusts or their packages may accumulate static charges, and static discharge can be a
source of ignition.
Solids handling systems must be designed in accordance with applicable standards (e.g. NFPA including 654 and 77) and
other national guidance.
Do not empty directly into flammable solvents or in the presence of flammable vapors.
The operator, the packaging container and all equipment must be grounded with electrical bonding and grounding systems.
Plastic bags and plastics cannot be grounded, and antistatic bags do not completely protect against development of static
charges.
Empty containers may contain residual dust which has the potential to accumulate following settling. Such dusts may explode in
the presence of an appropriate ignition source.
Do NOT cut, drill, grind or weld such containers.
In addition ensure such activity is not performed near full, partially empty or empty containers without appropriate workplace
safety authorisation or permit.
Fire and explosion
See section 5
protection

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Store in original containers.

Keep containers securely sealed.
Store in a cool, dry area protected from environmental extremes.
Store away from incompatible materials and foodstuff containers.
Protect containers against physical damage and check regularly for leaks.
Other information Observe manufacturer's storage and handling recommendations contained within this SDS.
For major quantities:
Consider storage in bunded areas - ensure storage areas are isolated from sources of community water (including
stormwater, ground water, lakes and streams}.
Ensure that accidental discharge to air or water is the subject of a contingency disaster management plan; this may require
consultation with local authorities.
7.2. Conditions for safe storage, including any incompatibilities

Glass container is suitable for laboratory quantities
Suitable container Polyethylene or polypropylene container.
Check all containers are clearly labelled and free from leaks.
Reducing sugar-based material.

Autooxidation of reducing sugars may produce up to 3000 ppm carbon monoxide under moderately alkaline conditions. High pH
aqueous solutions of saccharides (aldoses, ketoses) or polysaccharides based on these sugars may generate hazardous
atmospheres in confined spaces.
Reducing sugars contain an aldehyde or free hemiacetal in the open-chain form. Sugars with ketone groups in their open chain
form are capable of isomerising via a series of tautomeric shifts to produce an aldehyde group in solution. Therefore, ketone-
bearing sugars like fructose are considered reducing sugars but it is the isomer containing an aldehyde group which is reducing
since ketones cannot be oxidized without decomposition of the sugar.
Many disaccharides, like lactose and maltose, also have a reducing form, as one of the two units may have an open-chain form
Storage incompatibility
with an aldehyde group. However, sucrose and trehalose, in which the anomeric carbons of the two units are linked together, are
non-reducing disaccharides since neither of the rings is capable of opening.
In glucose polymers such as starch and starch-derivatives like glucose syrup, maltodextrin and dextrin the macromolecule begins
with a reducing sugar, a free aldehyde. More hydrolysed starch contains more reducing sugars. The percentage of reducing
sugars present in these starch derivatives is called dextrose equivalent (DE).
Dilute solutions of all sugars are subject to fermentation, either by yeast or by other microorganisms or enzymes derived from
these, producing gases which can pressurise and burst sealed containers.
Some microorganisms will produce hydrogen or methane, adding a fire and explosion hazard.
Avoid reaction with oxidising agents
Hazard categories in
accordance with
Not Available
Regulation (EC) No
1272/2008
Qualifying quantity
(tonnes) of dangerous
substances as referred to Not Available
in Article 3(10) for the
application of
7.3. Specific end use(s)

See section 1.2
SECTION 8 Exposure controls / personal protection
8.1. Control parameters

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DNELs PNECs
Ingredient
Exposure Pattern Worker Compartment
Not Available Not Available Not Available
* Values for General Population
Occupational Exposure Limits (OEL)
INGREDIENT DATA
Source Ingredient Material name TWA STEL Peak Notes
Not Available Not Available Not Available Not Available Not Available Not Available Not Available
Not Applicable
Emergency Limits
Ingredient TEEL-1 TEEL-2 TEEL-3
Black Pepper Extract

Not Available Not Available Not Available
(Pieperine 5-6%)
Ingredient Original IDLH Revised IDLH

piperine Not Available Not Available
maltodextrin Not Available Not Available
black pepper extract Not Available Not Available
Occupational Exposure Banding
Ingredient Occupational Exposure Band Rating Occupational Exposure Band Limit

piperine E ≤ 0.01 mg/m³
Notes: Occupational exposure banding is a process of assigning chemicals into specific categories or bands based on a chemical's
potency and the adverse health outcomes associated with exposure. The output of this process is an occupational exposure
band (OEB), which corresponds to a range of exposure concentrations that are expected to protect worker health.
8.2. Exposure controls

Enclosed local exhaust ventilation is required at points of dust, fume or vapour generation.
HEPA terminated local exhaust ventilation should be considered at point of generation of dust, fumes or vapours.
Barrier protection or laminar flow cabinets should be considered for laboratory scale handling.
A fume hood or vented balance enclosure is recommended for weighing/ transferring quantities exceeding 500 mg.
When handling quantities up to 500 gram in either a standard laboratory with general dilution ventilation (e.g. 6-12 air changes
per hour) is preferred. Quantities up to 1 kilogram may require a designated laboratory using fume hood, biological safety
cabinet, or approved vented enclosures. Quantities exceeding 1 kilogram should be handled in a designated laboratory or
8.2.1. Appropriate containment laboratory using appropriate barrier/ containment technology.
engineering controls Manufacturing and pilot plant operations require barrier/ containment and direct coupling technologies.
Barrier/ containment technology and direct coupling (totally enclosed processes that create a barrier between the equipment and
the room) typically use double or split butterfly valves and hybrid unidirectional airflow/ local exhaust ventilation solutions (e.g.
powder containment booths). Glove bags, isolator glove box systems are optional. HEPA filtration of exhaust from dry product
handling areas is required.
Fume-hoods and other open-face containment devices are acceptable when face velocities of at least 1 m/s (200 feet/minute)
are achieved. Partitions, barriers, and other partial containment technologies are required to prevent migration of the material to
uncontrolled areas. For non-routine emergencies maximum local and general exhaust are necessary. Air contaminants

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generated in the workplace possess varying "escape" velocities which, in turn, determine the "capture velocities" of fresh
circulating air required to effectively remove the contaminant.
Type of Contaminant: Air Speed:
0.25-0.5 m/s
solvent, vapours, etc. evaporating from tank (in still air)
(50-100 f/min.)
aerosols, fumes from pouring operations, intermittent container filling, low speed conveyer transfers 0.5-1 m/s (100-200
(released at low velocity into zone of active generation) f/min.)
direct spray, drum filling, conveyer loading, crusher dusts, gas discharge (active generation into zone 1-2.5 m/s (200-500
of rapid air motion) f/min.)
Within each range the appropriate value depends on:
Lower end of the range Upper end of the range

1: Room air currents minimal or favourable to capture 1: Disturbing room air currents
2: Contaminants of low toxicity or of nuisance value only. 2: Contaminants of high toxicity
3: Intermittent, low production. 3: High production, heavy use

4: Large hood or large air mass in motion 4: Small hood-local control only
Simple theory shows that air velocity falls rapidly with distance away from the opening of a simple extraction pipe. Velocity
generally decreases with the square of distance from the extraction point (in simple cases). Therefore the air speed at the
extraction point should be adjusted, accordingly, after reference to distance from the contaminating source. The air velocity at the
extraction fan, for example, should be a minimum of 1-2.5 m/s (200-500 f/min.) for extraction of gases discharged 2 meters
distant from the extraction point. Other mechanical considerations, producing performance deficits within the extraction
apparatus, make it essential that theoretical air velocities are multiplied by factors of 10 or more when extraction systems are
installed or used.
The need for respiratory protection should also be assessed where incidental or accidental exposure is anticipated: Dependent
on levels of contamination, PAPR, full face air purifying devices with P2 or P3 filters or air supplied respirators should be
evaluated.
The following protective devices are recommended where exposures exceed the recommended exposure control guidelines by
factors of:
10; high efficiency particulate (HEPA) filters or cartridges
10-25; loose-fitting (Tyvek or helmet type) HEPA powered-air purifying respirator.
25-50; a full face-piece negative pressure respirator with HEPA filters
50-100; tight-fitting, full face-piece HEPA PAPR
100-1000; a hood-shroud HEPA PAPR or full face-piece supplied air respirator operated in pressure demand or other positive
pressure mode.
Assess operations based upon available dust explosion information to determine the suitability of preventative or protective
systems as precautionary measures against possible dust explosions. If prevention is not possible, consider protection by use of
containment, venting or suppression of dust handling equipment. Where explosion venting is considered to be the most
appropriate method of protection, vent areas should preferably be calculated based on Kst rather than an St value. If nitrogen
purging is considered as the protective system, it must operate with an oxygen level below the limiting oxygen concentration. The
system should include an oxygen monitoring and shut-down facility in the event of excessive oxygen being detected.
The maximum surface temperature of enclosures potentially exposed to this material should be based on values obtained by
taking 2/3 of the minimum ignition temperature (MIE) of the dust cloud. The effect of dust layers should be reviewed.
An isolated (insulated) human body can readily produce electrostatic discharges in excess of 50 mJ, but have been recorded up
to 100 mJ.
8.2.2. Individual protection

measures, such as
personal protective
equipment

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When handling very small quantities of the material eye protection may not be required.
For laboratory, larger scale or bulk handling or where regular exposure in an occupational setting occurs:
Chemical goggles. [AS/NZS 1337.1, EN166 or national equivalent]
Face shield. Full face shield may be required for supplementary but never for primary protection of eyes.
Contact lenses may pose a special hazard; soft contact lenses may absorb and concentrate irritants. A written policy
Eye and face protection document, describing the wearing of lenses or restrictions on use, should be created for each workplace or task. This should
include a review of lens absorption and adsorption for the class of chemicals in use and an account of injury experience.
Medical and first-aid personnel should be trained in their removal and suitable equipment should be readily available. In the
event of chemical exposure, begin eye irrigation immediately and remove contact lens as soon as practicable. Lens should
be removed at the first signs of eye redness or irritation - lens should be removed in a clean environment only after workers
have washed hands thoroughly. [CDC NIOSH Current Intelligence Bulletin 59].
Skin protection See Hand protection below

NOTE:
The material may produce skin sensitisation in predisposed individuals. Care must be taken, when removing gloves and other
protective equipment, to avoid all possible skin contact.
Contaminated leather items, such as shoes, belts and watch-bands should be removed and destroyed.
The selection of suitable gloves does not only depend on the material, but also on further marks of quality which vary from
manufacturer to manufacturer. Where the chemical is a preparation of several substances, the resistance of the glove material
can not be calculated in advance and has therefore to be checked prior to the application.
The exact break through time for substances has to be obtained from the manufacturer of the protective gloves and has to be
observed when making a final choice.
Personal hygiene is a key element of effective hand care. Gloves must only be worn on clean hands. After using gloves, hands
should be washed and dried thoroughly. Application of a non-perfumed moisturiser is recommended.
Suitability and durability of glove type is dependent on usage. Important factors in the selection of gloves include:
· frequency and duration of contact,
· chemical resistance of glove material,
· glove thickness and
· dexterity
Select gloves tested to a relevant standard (e.g. Europe EN 374, US F739, AS/NZS 2161.1 or national equivalent).
· When prolonged or frequently repeated contact may occur, a glove with a protection class of 5 or higher (breakthrough time
greater than 240 minutes according to EN 374, AS/NZS 2161.10.1 or national equivalent) is recommended.
· When only brief contact is expected, a glove with a protection class of 3 or higher (breakthrough time greater than 60 minutes
according to EN 374, AS/NZS 2161.10.1 or national equivalent) is recommended.
Hands/feet protection · Some glove polymer types are less affected by movement and this should be taken into account when considering gloves for
long-term use.
· Contaminated gloves should be replaced.
As defined in ASTM F-739-96 in any application, gloves are rated as:
· Excellent when breakthrough time > 480 min
· Good when breakthrough time > 20 min
· Fair when breakthrough time < 20 min
· Poor when glove material degrades
For general applications, gloves with a thickness typically greater than 0.35 mm, are recommended.
It should be emphasised that glove thickness is not necessarily a good predictor of glove resistance to a specific chemical, as the
permeation efficiency of the glove will be dependent on the exact composition of the glove material. Therefore, glove selection
should also be based on consideration of the task requirements and knowledge of breakthrough times.
Glove thickness may also vary depending on the glove manufacturer, the glove type and the glove model. Therefore, the
manufacturers technical data should always be taken into account to ensure selection of the most appropriate glove for the task.
Note: Depending on the activity being conducted, gloves of varying thickness may be required for specific tasks. For example:
· Thinner gloves (down to 0.1 mm or less) may be required where a high degree of manual dexterity is needed. However, these
gloves are only likely to give short duration protection and would normally be just for single use applications, then disposed of.
· Thicker gloves (up to 3 mm or more) may be required where there is a mechanical (as well as a chemical) risk i.e. where there
is abrasion or puncture potential
Gloves must only be worn on clean hands. After using gloves, hands should be washed and dried thoroughly. Application of a
non-perfumed moisturiser is recommended.

Chemwatch: 9-685419 +44 (0) 1353 667258
Rubber gloves (nitrile or low-protein, powder-free latex, latex/ nitrile). Employees allergic to latex gloves should use nitrile
gloves in preference.
Double gloving should be considered.
PVC gloves.
Change gloves frequently and when contaminated, punctured or torn.
Wash hands immediately after removing gloves.
Protective shoe covers. [AS/NZS 2210]
Head covering.
Experience indicates that the following polymers are suitable as glove materials for protection against undissolved, dry solids,
where abrasive particles are not present.
polychloroprene.
nitrile rubber.
butyl rubber.
fluorocaoutchouc.
polyvinyl chloride.
Gloves should be examined for wear and/ or degradation constantly.
Body protection See Other protection below
For quantities up to 500 grams a laboratory coat may be suitable.

For quantities up to 1 kilogram a disposable laboratory coat or coverall of low permeability is recommended. Coveralls should
be buttoned at collar and cuffs.
For quantities over 1 kilogram and manufacturing operations, wear disposable coverall of low permeability and disposable
shoe covers.
Other protection
For manufacturing operations, air-supplied full body suits may be required for the provision of advanced respiratory
protection.
Eye wash unit.
Ensure there is ready access to an emergency shower.
For Emergencies: Vinyl suit
Respiratory protection
Type -P Filter of sufficient capacity. (AS/NZS 1716 & 1715, EN 143:2000 & 149:2001, ANSI Z88 or national equivalent)
Required Minimum Protection Factor Half-Face Respirator Full-Face Respirator Powered Air Respirator
P1 - PAPR-P1
up to 10 x ES
Air-line* - -
up to 50 x ES Air-line** P2 PAPR-P2
up to 100 x ES - P3 -
Air-line* -
100+ x ES - Air-line** PAPR-P3
* - Negative pressure demand ** - Continuous flow

A(All classes) = Organic vapours, B AUS or B1 = Acid gasses, B2 = Acid gas or hydrogen cyanide(HCN), B3 = Acid gas or hydrogen cyanide(HCN), E = Sulfur
dioxide(SO2), G = Agricultural chemicals, K = Ammonia(NH3), Hg = Mercury, NO = Oxides of nitrogen, MB = Methyl bromide, AX = Low boiling point organic
compounds(below 65 degC)
· Respirators may be necessary when engineering and administrative controls do not adequately prevent exposures.
· The decision to use respiratory protection should be based on professional judgment that takes into account toxicity information, exposure measurement data,
and frequency and likelihood of the worker's exposure - ensure users are not subject to high thermal loads which may result in heat stress or distress due to
personal protective equipment (powered, positive flow, full face apparatus may be an option).
· Published occupational exposure limits, where they exist, will assist in determining the adequacy of the selected respiratory protection. These may be
government mandated or vendor recommended.
· Certified respirators will be useful for protecting workers from inhalation of particulates when properly selected and fit tested as part of a complete respiratory

Chemwatch: 9-685419 +44 (0) 1353 667258
protection program.
· Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN143) dust masks. Use respirators and components tested and
approved under appropriate government standards such as NIOSH (US) or CEN (EU)
· Use approved positive flow mask if significant quantities of dust becomes airborne.
· Try to avoid creating dust conditions.
Class P2 particulate filters are used for protection against mechanically and thermally generated particulates or both.
P2 is a respiratory filter rating under various international standards, Filters at least 94% of airborne particles
Suitable for:
· Relatively small particles generated by mechanical processes eg. grinding, cutting, sanding, drilling, sawing.
· Sub-micron thermally generated particles e.g. welding fumes, fertilizer and bushfire smoke.
· Biologically active airborne particles under specified infection control applications e.g. viruses, bacteria, COVID-19, SARS
8.2.3. Environmental exposure controls

See section 12
SECTION 9 Physical and chemical properties
9.1. Information on basic physical and chemical properties

Appearance Not Available
Relative density (Water =

Physical state Divided Solid|Powder Not Available
1)
Partition coefficient
Odour Not Available Not Available
n-octanol / water
Auto-ignition temperature
Odour threshold Not Available Not Available
(°C)
Decomposition
pH (as supplied) Not Available Not Available
temperature (°C)
Melting point / freezing

Not Available Viscosity (cSt) Not Available
point (°C)
Initial boiling point and

Not Available Molecular weight (g/mol) Not Available
boiling range (°C)
Flash point (°C) Not Available Taste Not Available
Evaporation rate Not Available Explosive properties Not Available

Flammability Not Available Oxidising properties Not Available
Surface Tension (dyn/cm

Upper Explosive Limit (%) Not Available Not Applicable
or mN/m)
Lower Explosive Limit (%) Not Available Volatile Component (%vol) Not Available
Vapour pressure (kPa) Not Available Gas group Not Available

Solubility in water Immiscible pH as a solution (1%) Not Available
Vapour density (Air = 1) Not Available VOC g/L Not Available

Nanoform Particle
Nanoform Solubility Not Available Not Available
Characteristics
Particle Size Not Available

Chemwatch: 9-685419 +44 (0) 1353 667258
9.2. Other information

Not Available
SECTION 10 Stability and reactivity
10.1.Reactivity See section 7.2
Unstable in the presence of incompatible materials.

10.2. Chemical stability Product is considered stable.
Hazardous polymerisation will not occur.
10.3. Possibility of
See section 7.2
hazardous reactions
10.4. Conditions to avoid See section 7.2

10.5. Incompatible
See section 7.2
materials
10.6. Hazardous
See section 5.3
decomposition products
SECTION 11 Toxicological information
11.1. Information on toxicological effects

The material is not thought to produce adverse health effects or irritation of the respiratory tract (as classified by EC Directives
using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable control
measures be used in an occupational setting.
The LD50 for inhalation of the methylenedioxyphenol synergist, piperonyl butoxide ( PBO). by rats is greater than 5.9 g/k.
Inhalation of large amounts of PBO may cause tearing, salivation, labored breathing, accumulation of fluids in the lungs, and may
be linked to respiratory problems, including asthma.
Inhaled
Exposure to high concentrations of PBO vapour may cause asthma, inflammation of the nose and mucous membrane irritation.
Persons with impaired respiratory function, airway diseases and conditions such as emphysema or chronic bronchitis, may incur
further disability if excessive concentrations of particulate are inhaled.
If prior damage to the circulatory or nervous systems has occurred or if kidney damage has been sustained, proper screenings
should be conducted on individuals who may be exposed to further risk if handling and use of the material result in excessive
exposures.
Starch is generally of low toxicity. An abnormal craving for starch (amylophagia) during pregnancy has been recognized in certain
areas.
Studies suggest that by interfering with the metabolism of hormones, methylenedioxyphenol synergists such as the piperonyls
(as piperonyl butoxide - PBO) may damage humeral organs such as the thyroid, adrenal, and pituitary glands. PBO has a low to
moderate toxicity based on short-term laboratory animal studies. The acute oral LD50, or dose that kills half the test population,
was determined to be 6.15 g/kg for rats It is predicted that the oral lethal dose for a human is 5.15 g/kg, or between 1 pint and 1
quart for a 150 lb person. Symptoms caused by ingestion of PBO in large doses include nausea, cramps, vomiting, and diarrhea.
Overdoses of PBO have been shown to cause hyperexcitibility, unsteadiness, coma, seizures, and brain damage in animals.
Ingestion Laboratory animals exposed to single, large oral doses exhibit anorexia, vomiting, diarrhoea, unsteadiness, rough coat, watery
eyes, irritability, prostration, haemorrhagic enteritis, inanition, pulmonary haemorrhage, mild central system depression, bloody
discharge from eyes and nose, liver damage, coma and death. Onset may be as early as 20 minutes after dosing and death may
be delayed for a week. Most rat deaths in studies are attributed to hemorrhages in the digestive tract, particularly the large
intestine. Acute exposure in animals has also triggered hepatic (liver) changes and injury, anemia and loss of appetite, as well as
changes in the kidneys, nasal bleeding, loss of muscle coordination, and abdominal swelling.
Methylenedioxybenzene synergists cause loss of appetite, vomiting, diarrhoea, inflamed bowel with bleeding, bleeding from the
lung, wasting and possible central depression.
The material has NOT been classified by EC Directives or other classification systems as "harmful by ingestion". This is because

Chemwatch: 9-685419 +44 (0) 1353 667258
of the lack of corroborating animal or human evidence.

The material is not thought to produce adverse health effects or skin irritation following contact (as classified by EC Directives
using animal models). Nevertheless, good hygiene practice requires that exposure be kept to a minimum and that suitable gloves
be used in an occupational setting.
Acute and repeated dermal (skin) contact with piperonyls (as piperonyl butoxide - PBO) has been shown to be slightly irritating,
but is not linked to long-term damage.
Skin Contact In one study a lethal dose in rabbits by dermal absorption was 200 mg/kg but this result is thought to be anachronistic. A dermal
application of PBO, at the rate of 1880 mg/kg as a 20% solution in dimethyl phthalate, produced hyperexcitability and convulsions
in rabbits.
Open cuts, abraded or irritated skin should not be exposed to this material
Entry into the blood-stream, through, for example, cuts, abrasions or lesions, may produce systemic injury with harmful effects.
Examine the skin prior to the use of the material and ensure that any external damage is suitably protected.
Although the material is not thought to be an irritant (as classified by EC Directives), direct contact with the eye may cause
transient discomfort characterised by tearing or conjunctival redness (as with windburn). Slight abrasive damage may also result.
Eye
Acute and repeated eye contact with piperonyls (as piperonyl butoxide - PBO) has been shown to be slightly irritating, but is not
linked to long-term damage.
Skin contact with the material is more likely to cause a sensitisation reaction in some persons compared to the general
population.
Ample evidence from experiments exists that there is a suspicion this material directly reduces fertility.
The primary effect of long-term exposure to methylenedioxyphenol insect synergists such as the piperonyls (such as piperonyl
butoxide - PBO) in animals is an increase in liver and thyroid weight, liver and kidney damage, and a decrease in body weight.
These symptoms were observed in a diet of 52.8 mg/kg or more a day in a chronic study with dogs.
PBO is a possible human carcinogen. Currently there is no data from accidental exposure available regarding its carcinogenicity
in humans; the only information is from animal studies. Several studies have shown that PBO treatment in rats causes an
increase in liver cancer at high doses. The incidence of hepatocellular carcinoma, in male and female rats given 2.4% piperonyl
butoxide was 80.0% and 57.7% respectively. Preneoplastic hepatic lesions such as nodular hyperplasia, cholangiofibrosis, and
modular hyperplasia were also seen.
Some studies have shown that PBO treatment in rats corresponds with a very slight increase in thyroid cancer.
Rats fed diets containing from 0.6 to 2.4% piperonyl butoxide for approximately two years showed dose-related decreases in
body weight. Roughened hair, lethargy, epistaxis, abdominal swelling, and decreased food consumption were observed at 2.4%.
All dose rates induced skin tumours after about 1 year. Cumulative mortality varied from around 15 to 50%. Caecal haemorrhage
was the cause of death. Dead rats with hepatic tumours were seen from week 74, but caecal haemorrhage or possible leukaemia
was the cause of death. At necroscopy in rats surviving to the end of the study, hepatocellular adenomas and carcinomas
occurred in both sexes in a dose-related manner. A dose-related increase in thrombocythemia was seen in male rats. The
authors * of this study concluded that the primary feature of chronic piperonyl-butoxide toxicity is hepatocarcinogenicity.
Chronic
It is generally accepted that PBO does not demonstrate any significant potential for mutagenicity (genetic damage) but debate
still exists.
PBO weakens the immune system by inhibiting lymphocyte response. Lymphocytes are a class of white blood cells that consume
potentially dangerous pathogens and release antibodies. Inhibiting lymphocyte response weakens the body's ability to defend
against foreign invaders. Preventing the breakdown of toxic chemicals, may exacerbate potentially toxic effects.
PBO has been shown to adversely affect a variety of reproductive functions. Two-generational laboratory studies on rats show
that litter weight and size are less for mothers exposed to high concentrations of PBO, and there is an increase in birth defects
and fetal death. In one study the difference in the average weight of PBO-exposed offspring immediately after birth is negligible,
but 7-14 days post-natal is significantly greater for those mothers that are exposed to PBO than for those that are not. The U.S.
EPA maintains that results for teratogenicity (the ability to produce birth defects) in animals have been mixed, and while some
studies suggest some teratogenicity, most do not. PBO may also interfere with sexual development because the enzymes it
inhibits are responsible not only for the breakdown of toxic chemicals but also for the metabolism of other compounds such as
steroids, which include the sex hormones. Rats exposed to PBO over the course of two years experience an atrophy of the
testes a decrease in weight of the seminal vesicles (sperm producing structures), and an increase in ovarian weights. There is no
evidence that PBO affects fertility.
Data has shown that PBO alone interferes with enzymes that maintain homeostasis of sodium and calcium in the brain and
nervous system, possibly affecting neural response. Additionally, it increases the neurotoxicity of other compounds. Despite this
data, EPA believes that these neurotoxic effects are slight and maintains that PBO poses no neurological risk.
Behavioral changes have been noted with PBO as well. In a laboratory experiment, exposed rats experience more trouble

Chemwatch: 9-685419 +44 (0) 1353 667258
navigating a maze than unexposed rats. The exposed rats travel longer distances and turned more frequently in the maze. PBO
also induces changes in olfactory behavior of the offspring of exposed mothers. Offspring of exposed mothers are less likely to
enter a compartment that smells like home than unexposed mothers. Exploratory behavior in mice increases as the dose of PBO
they were treated with increased. This data shows that PBO has the ability to affect behaviors in mammals.
Research on rats has found that PBO can cause intestinal ulcers and bleeding. Liver damage is common in studies,and kidney
damage has been found as well. Long-term ingestion of PBO causes anemia, a decrease in the amount of hemoglobin (oxygen-
transporting molecules) in blood, and increases the blood cholesterol level in rats. PBO can also damage the larynx, and there
have been reports that it can cause labored breathing, an accumulation of fluid in the lungs, nasal bleeding, abdominal swelling,
and loss of the ability to coordinate muscle movement. There has been a fair amount of investigation into the effects of dermal
contact with PBO since it is used as a topical agent for lice, but there has been no evidence of it causing any local or systemic
toxicity, and the amount of PBO absorbed from skin contact is characterized by some researchers as low.
ChemicalWatch Fact Sheet
Takahashi, O.,S. et al: Fundamental and Applied Toxicology: Vol 22., pp 293-303, Feb 1994
Some workers may develop chronic occupational dermatitis (generally mild) through the handling of starch products.
When starch is used as a lubricant in surgical gloves, small amounts, released into the patient during the course of surgery, have
resulted in granulomas and peritonitis.
Long term exposure to high dust concentrations may cause changes in lung function i.e. pneumoconiosis, caused by particles
less than 0.5 micron penetrating and remaining in the lung.
There has been some concern that this material can cause cancer or mutations but there is not enough data to make an
assessment.
Black Pepper Extract TOXICITY IRRITATION

(Pieperine 5-6%) Not Available Not Available
TOXICITY IRRITATION
piperine
Oral (Mouse) LD50; 430 mg/kg[2] Not Available
TOXICITY IRRITATION
maltodextrin
Not Available Not Available
TOXICITY IRRITATION
black pepper extract
Legend: 1. Value obtained from Europe ECHA Registered Substances - Acute toxicity 2. Value obtained from manufacturer's SDS.
Unless otherwise specified data extracted from RTECS - Register of Toxic Effect of chemical Substances
Excitement, abortion, fetotoxicity recorded.

1,3-Benzodioxole derivatives are found widely in nature. Certain such derivatives such as as safrole bind to and inhibit
cytochrome P450. Cytochrome P450 enzymes function to metabolize potentially toxic compounds,
A lipophilic substituent placed para to the methylenedioxy group increases this activity, e.g. piperonyl butoxide . Safrole is of
PIPERINE further interest since it produces liver tumors in mice This toxicity is probably mediated via the propenyl side chain, either by
metabolism to 1-hydroxysafrole and the subsequent formation of a reactive ester derivative or by the direct formation of a
reactive epoxide. A particularly interesting example of the separation of two toxicities by structural modification is provided by
estragole which is a mouse liver carcinogen but does not inhibit hepatic cytochrome P450 Equally dramatic is the fact that
substitution of safrole with a methoxy group yields myristicin a reported hallucinogen derived from the nutmeg tree
MALTODEXTRIN No significant acute toxicological data identified in literature search.
Black Pepper Extract The following information refers to contact allergens as a group and may not be specific to this product.
(Pieperine 5-6%) & Contact allergies quickly manifest themselves as contact eczema, more rarely as urticaria or Quincke's oedema. The
PIPERINE pathogenesis of contact eczema involves a cell-mediated (T lymphocytes) immune reaction of the delayed type. Other allergic

Chemwatch: 9-685419 +44 (0) 1353 667258
skin reactions, e.g. contact urticaria, involve antibody-mediated immune reactions. The significance of the contact allergen is not
simply determined by its sensitisation potential: the distribution of the substance and the opportunities for contact with it are
equally important. A weakly sensitising substance which is widely distributed can be a more important allergen than one with
stronger sensitising potential with which few individuals come into contact. From a clinical point of view, substances are
noteworthy if they produce an allergic test reaction in more than 1% of the persons tested.
Acute Toxicity Carcinogenicity
Skin Irritation/Corrosion Reproductivity
Serious Eye
STOT - Single Exposure
Damage/Irritation
Respiratory or Skin
STOT - Repeated Exposure
sensitisation
Mutagenicity Aspiration Hazard
Legend: – Data either not available or does not fill the criteria for classification
– Data available to make classification
11.2 Information on other hazards
11.2.1. Endocrine disrupting properties

No evidence of endocrine disrupting properties were found in the current literature.
11.2.2. Other information

See Section 11.1
SECTION 12 Ecological information
12.1. Toxicity
Endpoint Test Duration (hr) Species Value Source

Black Pepper Extract
Not Not Not
(Pieperine 5-6%) Not Available Not Available
Available Available Available

piperine
LC50 96h Fish 7.04-8.73mg/l 4

maltodextrin Not Not Not

black pepper extract Not Not Not
Legend: Extracted from 1. IUCLID Toxicity Data 2. Europe ECHA Registered Substances - Ecotoxicological Information - Aquatic Toxicity
4. US EPA, Ecotox database - Aquatic Toxicity Data 5. ECETOC Aquatic Hazard Assessment Data 6. NITE (Japan) -
Bioconcentration Data 7. METI (Japan) - Bioconcentration Data 8. Vendor Data
Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

Chemwatch: 9-685419 +44 (0) 1353 667258
Do NOT allow product to come in contact with surface waters or to intertidal areas below the mean high water mark. Do not contaminate water when cleaning
equipment or disposing of equipment wash-waters.
Wastes resulting from use of the product must be disposed of on site or at approved waste sites.
For piperidine :log Kow : 0.84 Half-life (hr) air : 81.6Henry's atm m3 /mol: 4.45E-06Bioaccumulation : not signficant.
Environmental Fate: Terrestrial Fate - Piperidine is expected to have high mobility in soil. However, as this compound primarily exists in the cation form in the
environment it is likely to adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts. While cations do not volatilise from
moist soil surfaces, Piperidine is expected to volatilise from dry soil surfaces and biodegradation may be an important environmental fate process in soil. Aquatic
fate: Piperidine is not expected to adsorb to suspended solids and sediments. Volatilisation from water surfaces is not expected to be an important fate process.
An estimated BCF of 3 suggests the potential for bioconcentration in aquatic organisms is low. Piperidine was found to degrade anaerobically via denitrification in
12-15 days by microbial action in freshwater sediments, estuarine sediments and activated sludge. Atmospheric Fate - Models indicate that piperidine is expected
to exist solely as a vapor in the ambient atmosphere, where it is degraded by reaction with photochemically-produced hydroxyl radicals; the half-life for this
reaction in air is estimated to be 4 hours.
Ecotoxicity: Daphnia magna LC50 948 h): 8.234 mg/l; Fish LC50 (96 h): fathead minnow (Pimephales promelas) 129.6 mg/l
For piperonyls (as piperonyl butoxide - PBO):
Environmental fate:
PBO is relatively short-lived in the environment and has a low to moderate potential to contaminate groundwater. One study found PBO in river water at a
concentration of 9.7 ug/L. It is rapidly degraded when exposed to sunlight, with a degradation half life of about one day in soil exposed to sunlight, and 14 days in
soil without sunlight. The rate of degradation is also affected by how much oxygen is in the environment (particularly in aquatic systems), moisture levels, and
application methods. There is less information available about PBO's persistence indoors, but one study found that PBO persisted for at least two weeks after a
cockroach treatment on toys and in dust in a kindergarten
Ecotoxicity:
Piperonyl is considered moderately toxic to fish, moderately to highly toxic to invertebrates (including crustaceans and insects), and highly toxic to amphibians. In
one study, concentrations of less than one part per million (ppm) killed water fleas, shrimp, and oysters. It is also very toxic to a common type of earthworm.
Ingested PBO has a low to very low toxicity in birds
Not only does PBO kill organisms, it is known to interfere with the reproduction of many types of wildlife at much lower concentrations than those required for
mortality. The bio-concentration potential for PBO is low but can be moderate in some aquatic organisms. PBO also inhibits the breakdown of toxic chemicals in
wildlife and the soil, increasing the concentrations of other, more acutely potent, pesticides.
Chemical Watch Fact Sheet
DO NOT discharge into sewer or waterways.
12.2. Persistence and degradability

Ingredient Persistence: Water/Soil Persistence: Air
piperine HIGH HIGH
12.3. Bioaccumulative potential

Ingredient Bioaccumulation
piperine LOW (LogKOW = 3.6889)
12.4. Mobility in soil

Ingredient Mobility
piperine LOW (KOC = 5867)
12.5. Results of PBT and vPvB assessment

P B T
Relevant available data Not Available Not Available Not Available
PBT

Chemwatch: 9-685419 +44 (0) 1353 667258
P B T
vPvB
PBT Criteria fulfilled? No

vPvB No
12.6. Endocrine disrupting properties

No evidence of endocrine disrupting properties were found in the current literature.
12.7. Other adverse effects

No evidence of ozone depleting properties were found in the current literature.
SECTION 13 Disposal considerations
13.1. Waste treatment methods

Containers may still present a chemical hazard/ danger when empty.
Return to supplier for reuse/ recycling if possible.
Otherwise:
If container can not be cleaned sufficiently well to ensure that residuals do not remain or if the container cannot be used to
store the same product, then puncture containers, to prevent re-use, and bury at an authorised landfill.
Where possible retain label warnings and SDS and observe all notices pertaining to the product.
Legislation addressing waste disposal requirements may differ by country, state and/ or territory. Each user must refer to laws
operating in their area. In some areas, certain wastes must be tracked.
A Hierarchy of Controls seems to be common - the user should investigate:
Product / Packaging Reduction
disposal Reuse
Recycling
Disposal (if all else fails)
This material may be recycled if unused, or if it has not been contaminated so as to make it unsuitable for its intended use. Shelf
life considerations should also be applied in making decisions of this type. Note that properties of a material may change in use,
and recycling or reuse may not always be appropriate. In most instances the supplier of the material should be consulted.
DO NOT allow wash water from cleaning or process equipment to enter drains.
It may be necessary to collect all wash water for treatment before disposal.
In all cases disposal to sewer may be subject to local laws and regulations and these should be considered first.
Where in doubt contact the responsible authority.
Waste treatment options Not Available

Sewage disposal options Not Available
SECTION 14 Transport information
Labels Required

Chemwatch: 9-685419 +44 (0) 1353 667258
Marine Pollutant NO
HAZCHEM 2Z
Land transport (ADR-RID)

14.1. UN number or ID
3077
number
14.2. UN proper shipping

ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. (contains piperine)
name
14.3. Transport hazard Class 9

class(es) Subsidiary Hazard Not Applicable
14.4. Packing group III

14.5. Environmental
Not Applicable
hazard
Hazard identification (Kemler) 90
Classification code M7
14.6. Special precautions Hazard Label 9

for user Special provisions 274 335 375 601
Limited quantity 5 kg
Tunnel Restriction Code Not Applicable
Air transport (ICAO-IATA / DGR)

14.1. UN number 3077
Environmentally hazardous substance, solid, n.o.s. (contains piperine)
name
ICAO/IATA Class 9
14.3. Transport hazard
ICAO / IATA Subsidiary Hazard Not Applicable
class(es)
ERG Code 9L
14.5. Environmental
Not Applicable
hazard
Special provisions A97 A158 A179 A197 A215
Cargo Only Packing Instructions 956

Cargo Only Maximum Qty / Pack 400 kg
14.6. Special precautions
Passenger and Cargo Packing Instructions 956
for user
Passenger and Cargo Maximum Qty / Pack 400 kg
Passenger and Cargo Limited Quantity Packing Instructions Y956
Passenger and Cargo Limited Maximum Qty / Pack 30 kg G

Chemwatch: 9-685419 +44 (0) 1353 667258
Sea transport (IMDG-Code / GGVSee)

name
14.3. Transport hazard IMDG Class 9

class(es) IMDG Subsidiary Hazard Not Applicable
14.5 Environmental hazard Not Applicable
EMS Number F-A , S-F

Special provisions 274 335 966 967 969
for user
Limited Quantities 5 kg
Inland waterways transport (ADN)

name
14.3. Transport hazard
9 Not Applicable
class(es)
14.5. Environmental
Not Applicable
hazard
Classification code M7
Special provisions 274; 335; 375; 601

Limited quantity 5 kg
for user
Equipment required PP, A***
Fire cones number 0
14.7.1. Transport in bulk according to Annex II of MARPOL and the IBC code
Not Applicable
14.7.2. Transport in bulk in accordance with MARPOL Annex V and the IMSBC Code
Product name Group
piperine Not Available
maltodextrin Not Available

black pepper extract Not Available
14.7.3. Transport in bulk in accordance with the IGC Code

Product name Ship Type

Chemwatch: 9-685419 +44 (0) 1353 667258
Product name Ship Type

piperine Not Available
maltodextrin Not Available

black pepper extract Not Available
SECTION 15 Regulatory information
15.1. Safety, health and environmental regulations / legislation specific for the substance or mixture
piperine is found on the following regulatory lists
Not Applicable
maltodextrin is found on the following regulatory lists
Not Applicable
black pepper extract is found on the following regulatory lists
Not Applicable
Additional Regulatory Information

Not Applicable
This safety data sheet is in compliance with the following EU legislation and its adaptations - as far as applicable - : Directives 98/24/EC, - 92/85/EEC, - 94/33/EC,
- 2008/98/EC, - 2010/75/EU; Commission Regulation (EU) 2020/878; Regulation (EC) No 1272/2008 as updated through ATPs.
Information according to 2012/18/EU (Seveso III):

Seveso Category Not Available
15.2. Chemical safety assessment

No Chemical Safety Assessment has been carried out for this substance/mixture by the supplier.
National Inventory Status

Australia - AIIC / Australia

Yes
Non-Industrial Use
Canada - DSL Yes
Canada - NDSL No (piperine; maltodextrin)
China - IECSC Yes
Europe - EINEC / ELINCS /

Yes
NLP
Japan - ENCS No (piperine; maltodextrin)
Korea - KECI No (piperine)
New Zealand - NZIoC Yes
Philippines - PICCS Yes

Chemwatch: 9-685419 +44 (0) 1353 667258

USA - TSCA Yes
Taiwan - TCSI Yes

Mexico - INSQ No (piperine)
Vietnam - NCI Yes

Russia - FBEPH Yes
Yes = All CAS declared ingredients are on the inventory

Legend: No = One or more of the CAS listed ingredients are not on the inventory. These ingredients may be exempt or will require
registration.
SECTION 16 Other information
Revision Date 09/02/2023

Initial Date 17/09/2019
Full text Risk and Hazard codes

H302 Harmful if swallowed.
H411 Toxic to aquatic life with long lasting effects.
SDS Version Summary

Date of
Version Sections Updated
Update
Toxicological information - Acute Health (eye), Toxicological information - Acute Health (inhaled), Toxicological
information - Acute Health (skin), Toxicological information - Acute Health (swallowed), Toxicological information -
Chronic Health, Hazards identification - Classification, Exposure controls / personal protection - Engineering
Control, Ecological Information - Environmental, Exposure controls / personal protection - Exposure Standard,
Handling and storage - Handling Procedure, Composition / information on ingredients - Ingredients, Exposure
1.2 09/02/2023
controls / personal protection - Personal Protection (other), Exposure controls / personal protection - Personal
Protection (Respirator), Exposure controls / personal protection - Personal Protection (eye), Exposure controls /
personal protection - Personal Protection (hands/feet), Accidental release measures - Spills (minor), Handling
and storage - Storage (suitable container), Identification of the substance / mixture and of the company /
undertaking - Use
Other information
Classification of the preparation and its individual components has drawn on official and authoritative sources as well as independent review by the Chemwatch
Classification committee using available literature references.
The SDS is a Hazard Communication tool and should be used to assist in the Risk Assessment. Many factors determine whether the reported Hazards are Risks
in the workplace or other settings. Risks may be determined by reference to Exposures Scenarios. Scale of use, frequency of use and current or available
engineering controls must be considered.
For detailed advice on Personal Protective Equipment, refer to the following EU CEN Standards:
EN 166 Personal eye-protection
EN 340 Protective clothing
EN 374 Protective gloves against chemicals and micro-organisms
EN 13832 Footwear protecting against chemicals

Chemwatch: 9-685419 +44 (0) 1353 667258
EN 133 Respiratory protective devices
Definitions and abbreviations

PC−TWA: Permissible Concentration-Time Weighted Average
PC−STEL: Permissible Concentration-Short Term Exposure Limit
IARC: International Agency for Research on Cancer
ACGIH: American Conference of Governmental Industrial Hygienists
STEL: Short Term Exposure Limit
TEEL: Temporary Emergency Exposure Limit。
IDLH: Immediately Dangerous to Life or Health Concentrations
ES: Exposure Standard
OSF: Odour Safety Factor
NOAEL: No Observed Adverse Effect Level
LOAEL: Lowest Observed Adverse Effect Level
TLV: Threshold Limit Value
LOD: Limit Of Detection
OTV: Odour Threshold Value
BCF: BioConcentration Factors
BEI: Biological Exposure Index
DNEL: Derived No-Effect Level
PNEC: Predicted no-effect concentration
AIIC: Australian Inventory of Industrial Chemicals

DSL: Domestic Substances List
NDSL: Non-Domestic Substances List
IECSC: Inventory of Existing Chemical Substance in China
EINECS: European INventory of Existing Commercial chemical Substances
ELINCS: European List of Notified Chemical Substances
NLP: No-Longer Polymers
ENCS: Existing and New Chemical Substances Inventory
KECI: Korea Existing Chemicals Inventory
NZIoC: New Zealand Inventory of Chemicals
PICCS: Philippine Inventory of Chemicals and Chemical Substances
TSCA: Toxic Substances Control Act
TCSI: Taiwan Chemical Substance Inventory
INSQ: Inventario Nacional de Sustancias Químicas
NCI: National Chemical Inventory
FBEPH: Russian Register of Potentially Hazardous Chemical and Biological Substances
Classification and procedure used to derive the classification for mixtures according to Regulation (EC) 1272/2008 [CLP]
Classification according to
regulation (EC) No
Classification Procedure
1272/2008 [CLP] and
amendments
Sensitisation (Skin) Category

Calculation method
1, H317
Reproductive Toxicity
Calculation method
Category 2, H361f
Hazardous to the Aquatic

Environment Long-Term Calculation method

Chemwatch: 9-685419 +44 (0) 1353 667258
Classification according to
regulation (EC) No
Classification Procedure
1272/2008 [CLP] and
amendments
Hazard Category 3, H412
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Black Pepper Extract (Pieperine 5-6%) : Cambridge Commodities

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Black Pepper Extract (Pieperine 5-6%)

Cambridge Commodities Chemwatch Hazard Alert Code: 2

SECTION 1 Identification of the substance / mixture and of the company / undertaking

1.1. Product Identifier

Chemical Name Not Applicable

Uses advised against No specific uses advised against are identified.

1.3. Details of the manufacturer or supplier of the safety data sheet

Fax Not Available

1.4. Emergency telephone number

Product code: P02102 Version No: 2.2 Page 1 of 25

SECTION 2 Hazards identification

2.1. Classification of the substance or mixture

2.2. Label elements

Signal word Warning

H412 Harmful to aquatic life with long lasting effects.

Precautionary statement(s) Prevention

P273 Avoid release to the environment.

Precautionary statement(s) Response

Product code: P02102 Version No: 2.2 Page 2 of 25

P362+P364 Take off contaminated clothing and wash it before reuse.

Precautionary statement(s) Storage

Precautionary statement(s) Disposal

2.3. Other hazards

Cumulative effects may result following exposure*.

Limited evidence of a carcinogenic effect*.

SECTION 3 Composition / information on ingredients

1. 94-62-2 Acute Toxicity (Oral) Category 4, Sensitisation (Skin)

SECTION 4 First aid measures

Product code: P02102 Version No: 2.2 Page 3 of 25

4.1. Description of first aid measures

If skin contact occurs:

Immediately give a glass of water.

SECTION 5 Firefighting measures

5.1. Extinguishing media

5.2. Special hazards arising from the substrate or mixture

5.3. Advice for firefighters

Product code: P02102 Version No: 2.2 Page 4 of 25

Layer Ignition Temperature: >450 deg C

Dust Explosion Hazard Class 1

Product code: P02102 Version No: 2.2 Page 5 of 25

SECTION 6 Accidental release measures

6.1. Personal precautions, protective equipment and emergency procedures

6.2. Environmental precautions

6.3. Methods and material for containment and cleaning up

Environmental hazard - contain spillage.

6.4. Reference to other sections

Product code: P02102 Version No: 2.2 Page 6 of 25

SECTION 7 Handling and storage

7.1. Precautions for safe handling

Product code: P02102 Version No: 2.2 Page 7 of 25

Store in original containers.

7.2. Conditions for safe storage, including any incompatibilities

Reducing sugar-based material.

7.3. Specific end use(s)

SECTION 8 Exposure controls / personal protection

8.1. Control parameters

Product code: P02102 Version No: 2.2 Page 8 of 25

* Values for General Population

Occupational Exposure Limits (OEL)