SAFETY DATA SHEET

according to Regulation UK SI 2019/758 and UK SI 2020/1577 as amended

Creation Date 16-Jun-2009 Revision Date 20-Oct-2023 Revision Number 13

SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE

COMPANY/UNDERTAKING

1.1. Product identifier

Product Description: Sodium hydroxide - pellets

Cat No. : S/4920/68, S/4920/65, S/4920/70, S/4920/63, S/4920/60, S/4920/53, S/4920/PC73
Synonyms Caustic soda
Index No 011-002-00-6
CAS No 1310-73-2
EC No 215-185-5
Molecular Formula H Na O
REACH registration number 01-2119457892-27

1.2. Relevant identified uses of the substance or mixture and uses advised against

Recommended Use Laboratory chemicals.

Sector of use SU3 - Industrial uses: Uses of substances as such or in preparations at industrial sites
Product category PC21 - Laboratory chemicals
Process categories PROC15 - Use as a laboratory reagent
Environmental release category ERC6a - Industrial use resulting in manufacture of another substance (use of intermediates)
Uses advised against No Information available

1.3. Details of the supplier of the safety data sheet

Company .
UK entity/business name
Fisher Scientific UK
Bishop Meadow Road, Loughborough,
Leicestershire LE11 5RG, United Kingdom

EU entity/business name
Thermo Fisher Scientific
Janssen Pharmaceuticalaan 3a
2440 Geel, Belgium

E-mail address begel.sdsdesk@thermofisher.com

1.4. Emergency telephone number

Tel: 01509 231166
Chemtrec US: (800) 424-9300
Chemtrec EU: 001-703-527-3887

SECTION 2: HAZARDS IDENTIFICATION

2.1. Classification of the substance or mixture

CLP Classification - According to GB-CLP Regulations UK SI 2019/720 and UK SI 2020/1567

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Physical hazards

Substances/mixtures corrosive to metal Category 1 (H290)

Health hazards

Skin Corrosion/Irritation Category 1 A (H314)

Serious Eye Damage/Eye Irritation Category 1 (H318)

Environmental hazards
Based on available data, the classification criteria are not met

Full text of Hazard Statements: see section 16

2.2. Label elements

Signal Word Danger

Hazard Statements
H290 - May be corrosive to metals
H314 - Causes severe skin burns and eye damage

Precautionary Statements
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P301 + P330 + P331 - IF SWALLOWED: Rinse mouth. Do NOT induce vomiting
P303 + P361 + P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower
P305 + P351 + P338 - IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and
easy to do. Continue rinsing
P310 - Immediately call a POISON CENTER or doctor/physician

2.3. Other hazards

Substance is not considered persistent, bioaccumulative and toxic (PBT) / very persistent and very bioaccumulative (vPvB)

Toxic to terrestrial vertebrates

This product does not contain any known or suspected endocrine disruptors

SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS

3.1. Substances

Component CAS No EC No Weight % CLP Classification - According to

GB-CLP Regulations UK SI 2019/720 and
UK SI 2020/1567
Sodium hydroxide 1310-73-2 215-185-5 100 Met. Corr. 1 (H290)
Skin Corr. 1A (H314)
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Eye Dam. 1 (H318)

Component Specific concentration limits M-Factor Component notes

(SCL's)
Sodium hydroxide Skin Corr. 1A :: C>=5% - -
Skin Corr. 1B :: 2%<=C<5%
Met .Cor r.1: :C≥2%
Eye Irrit. 2 :: 0.5%<=C<2%
Skin Irrit. 2 :: 0.5%<=C<2%

REACH registration number 01-2119457892-27

Full text of Hazard Statements: see section 16

SECTION 4: FIRST AID MEASURES

4.1. Description of first aid measures

General Advice Immediate medical attention is required. Show this safety data sheet to the doctor in
attendance.

Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Immediate medical attention is required. Keep eye wide open while rinsing.

Skin Contact Wash off immediately with soap and plenty of water while removing all contaminated
clothes and shoes. Call a physician immediately.

Ingestion Do NOT induce vomiting. Immediate medical attention is required. Never give anything by
mouth to an unconscious person. Drink plenty of water.

Inhalation Remove to fresh air. If breathing is difficult, give oxygen. Do not use mouth-to-mouth
method if victim ingested or inhaled the substance; give artificial respiration with the aid of a
pocket mask equipped with a one-way valve or other proper respiratory medical device. Call
a physician or poison control center immediately.

Self-Protection of the First Aider Ensure that medical personnel are aware of the material(s) involved, take precautions to
protect themselves and prevent spread of contamination.

4.2. Most important symptoms and effects, both acute and delayed

Causes burns by all exposure routes. . Product is a corrosive material. Use of gastric
lavage or emesis is contraindicated. Possible perforation of stomach or esophagus should
be investigated: Ingestion causes severe swelling, severe damage to the delicate tissue
and danger of perforation

4.3. Indication of any immediate medical attention and special treatment needed

Notes to Physician Treat symptomatically.

SECTION 5: FIREFIGHTING MEASURES

5.1. Extinguishing media

Suitable Extinguishing Media

Not combustible. Use extinguishing measures that are appropriate to local circumstances and the surrounding environment.

Extinguishing media which must not be used for safety reasons

No information available.
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5.2. Special hazards arising from the substance or mixture

The product causes burns of eyes, skin and mucous membranes. Reacts violently with water. Contact with metals may evolve
flammable hydrogen gas.

Hazardous Combustion Products

Hydrogen, Sodium oxides.

5.3. Advice for firefighters

As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear. Thermal decomposition can lead to release of irritating gases and vapors.

SECTION 6: ACCIDENTAL RELEASE MEASURES

6.1. Personal precautions, protective equipment and emergency procedures

Use personal protective equipment as required. Evacuate personnel to safe areas. Avoid contact with skin, eyes or clothing.

6.2. Environmental precautions

Do not allow material to contaminate ground water system. Should not be released into the environment. Do not flush into surface
water or sanitary sewer system. See Section 12 for additional Ecological Information.

6.3. Methods and material for containment and cleaning up

Avoid dust formation. Sweep up and shovel into suitable containers for disposal.

6.4. Reference to other sections

Refer to protective measures listed in Sections 8 and 13.

SECTION 7: HANDLING AND STORAGE

7.1. Precautions for safe handling

Wear personal protective equipment/face protection. Use only under a chemical fume hood. Do not get in eyes, on skin, or on
clothing. Do not breathe dust. Do not ingest. If swallowed then seek immediate medical assistance.

Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice. Keep away from food, drink and animal feeding stuffs. Do
not eat, drink or smoke when using this product. Remove and wash contaminated clothing and gloves, including the inside, before
re-use. Wash hands before breaks and after work.

7.2. Conditions for safe storage, including any incompatibilities

Keep containers tightly closed in a dry, cool and well-ventilated place. Corrosives area.

Technical Rules for Hazardous Substances (TRGS) 510 Class 8B

Storage Class (LGK) (Germany)

7.3. Specific end use(s)

Use in laboratories
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SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION

8.1. Control parameters

Exposure limits
List source(s): UK - EH40/2005 Work Exposure Limits, Fourth edition. Published 2020. IRE - 2021 Code of Practice for the
Chemical Agents Regulations, Schedule 1. Published by the Health and Safety Authority

Component The United Kingdom European Union Ireland

Sodium hydroxide 2 mg/m3 STEL STEL: 2 mg/m3 15 min

Biological limit values

This product, as supplied, does not contain any hazardous materials with biological limits established by the region specific
regulatory bodies

Derived No Effect Level (DNEL) / Derived Minimum Effect Level (DMEL)

See table for values

Component Acute effects local Acute effects Chronic effects local Chronic effects
(Inhalation) systemic (Inhalation) (Inhalation) systemic (Inhalation)
Sodium hydroxide DNEL = 1mg/m3
1310-73-2 ( 100 )

Predicted No Effect Concentration (PNEC)

No information available.

8.2. Exposure controls

Engineering Measures
Use only under a chemical fume hood. Ensure that eyewash stations and safety showers are close to the workstation location.
Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or
equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to
control hazardous materials at source

Personal protective equipment

Eye Protection Goggles (European standard - EN 166)

Hand Protection Protective gloves

Glove material Breakthrough time Glove thickness EU standard Glove comments

Neoprene > 480 minutes 0.45 mm Level 6 As tested under EN374-3 Determination of
Butyl rubber > 480 minutes 0.35 mm EN 374 Resistance to Permeation by Chemicals
Viton (R) > 480 minutes 0.30 mm
Skin and body protection Long sleeved clothing.

Inspect gloves before use.

Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger
of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
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Respiratory Protection When workers are facing concentrations above the exposure limit they must use
appropriate certified respirators.
To protect the wearer, respiratory protective equipment must be the correct fit and be used
and maintained properly

Large scale/emergency use Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits
are exceeded or if irritation or other symptoms are experienced
Recommended Filter type: Particulates filter conforming to EN 143

Small scale/Laboratory use Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure
limits are exceeded or if irritation or other symptoms are experienced.
Recommended half mask:- Valve filtering: EN405; or; Half mask: EN140; plus filter, EN
141
When RPE is used a face piece Fit Test should be conducted

Environmental exposure controls Prevent product from entering drains.

SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES

9.1. Information on basic physical and chemical properties

Physical State Solid

Appearance White
Odor Odorless
Odor Threshold No data available
Melting Point/Range 318 °C / 604.4 °F
Softening Point No data available
Boiling Point/Range 1390 °C / 2534 °F @ 760 mmHg
Flammability (liquid) Not applicable Solid
Flammability (solid,gas) Not flammable
Explosion Limits No data available

Flash Point No information available Method - No information available

Autoignition Temperature No data available
Decomposition Temperature No data available
pH 14 (5 %)
Viscosity Not applicable Solid
Water Solubility Completely soluble
Solubility in other solvents No information available
Partition Coefficient (n-octanol/water)
Vapor Pressure 1 mbar @ 700 °C
Density / Specific Gravity No data available
Bulk Density 2.13 g/cm3
Vapor Density Not applicable Solid
Particle characteristics No data available

9.2. Other information

Molecular Formula H Na O
Molecular Weight 40
Explosive Properties Not explosive
Evaporation Rate Not applicable - Solid

SECTION 10: STABILITY AND REACTIVITY

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10.1. Reactivity
Yes
Contact with metals may evolve flammable hydrogen gas

10.2. Chemical stability

Stable under normal conditions.

10.3. Possibility of hazardous reactions

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

10.4. Conditions to avoid

Incompatible products. Excess heat.

10.5. Incompatible materials

Strong oxidizing agents. Acids. Metals. Water. Alcohols.

10.6. Hazardous decomposition products

Hydrogen. Sodium oxides.

SECTION 11: TOXICOLOGICAL INFORMATION

11.1. Information on hazard classes as defined in Regulation (EC) No 1272/2008

Product Information

(a) acute toxicity;

Oral Based on available data, the classification criteria are not met
Dermal Based on available data, the classification criteria are not met
Inhalation Based on available data, the classification criteria are not met

Component LD50 Oral LD50 Dermal LC50 Inhalation

Sodium hydroxide 140 - 340 mg/kg ( Rat ) 1350 mg/kg ( Rabbit ) -

(b) skin corrosion/irritation; Category 1 A

(c) serious eye damage/irritation; Category 1

(d) respiratory or skin sensitization;

Respiratory Based on available data, the classification criteria are not met
Skin Based on available data, the classification criteria are not met

(e) germ cell mutagenicity; Based on available data, the classification criteria are not met

(f) carcinogenicity; Based on available data, the classification criteria are not met
There are no known carcinogenic chemicals in this product

(g) reproductive toxicity; Based on available data, the classification criteria are not met

(h) STOT-single exposure; Based on available data, the classification criteria are not met

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(i) STOT-repeated exposure; Based on available data, the classification criteria are not met

Target Organs None known.

(j) aspiration hazard; Not applicable

Solid

Symptoms / effects,both acute and Product is a corrosive material. Use of gastric lavage or emesis is contraindicated.
delayed Possible perforation of stomach or esophagus should be investigated. Ingestion causes
severe swelling, severe damage to the delicate tissue and danger of perforation.

11.2. Information on other hazards

Endocrine Disrupting Properties Assess endocrine disrupting properties for human health. This product does not contain any
known or suspected endocrine disruptors.

SECTION 12: ECOLOGICAL INFORMATION

12.1. Toxicity
Ecotoxicity effects Do not empty into drains. Large amounts will affect pH and harm aquatic organisms.

Component Freshwater Fish Water Flea Freshwater Algae

Sodium hydroxide LC50: = 45.4 mg/L, 96h static
(Oncorhynchus mykiss)

12.2. Persistence and degradability

Persistence Soluble in water, Persistence is unlikely, based on information available.
Degradability Not relevant for inorganic substances.
Degradation in sewage Neutralization is normally necessary before waste water is discharged into water treatment
treatment plant plants.

12.3. Bioaccumulative potential Bioaccumulation is unlikely

12.4. Mobility in soil The product is water soluble, and may spread in water systems. Will likely be mobile in the
environment due to its water solubility. Highly mobile in soils

12.5. Results of PBT and vPvB Substance is not considered persistent, bioaccumulative and toxic (PBT) / very persistent
assessment and very bioaccumulative (vPvB).

12.6. Endocrine disrupting

properties
Endocrine Disruptor Information This product does not contain any known or suspected endocrine disruptors

12.7. Other adverse effects

Persistent Organic Pollutant This product does not contain any known or suspected substance
Ozone Depletion Potential This product does not contain any known or suspected substance

SECTION 13: DISPOSAL CONSIDERATIONS

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13.1. Waste treatment methods

Waste from Residues/Unused Waste is classified as hazardous. Dispose of in accordance with the European Directives
Products on waste and hazardous waste. Dispose of in accordance with local regulations.

Contaminated Packaging Dispose of this container to hazardous or special waste collection point.

European Waste Catalogue (EWC) According to the European Waste Catalog, Waste Codes are not product specific, but
application specific.

Other Information Do not flush to sewer. Waste codes should be assigned by the user based on the
application for which the product was used. Do not empty into drains. Large amounts will
affect pH and harm aquatic organisms. Solutions with high pH-value must be neutralized
before discharge.

SECTION 14: TRANSPORT INFORMATION

IMDG/IMO

14.1. UN number UN1823

14.2. UN proper shipping name Sodium hydroxide, solid
14.3. Transport hazard class(es) 8
14.4. Packing group II

ADR

14.1. UN number UN1823

14.2. UN proper shipping name Sodium hydroxide, solid
14.3. Transport hazard class(es) 8
14.4. Packing group II

IATA

14.1. UN number UN1823

14.2. UN proper shipping name Sodium hydroxide, solid
14.3. Transport hazard class(es) 8
14.4. Packing group II

14.5. Environmental hazards No hazards identified

14.6. Special precautions for user No special precautions required.

14.7. Maritime transport in bulk Not applicable, packaged goods

according to IMO instruments

SECTION 15: REGULATORY INFORMATION

15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture

International Inventories
Europe (EINECS/ELINCS/NLP), China (IECSC), Taiwan (TCSI), Korea (KECL), Japan (ENCS), Japan (ISHL), Canada (DSL/NDSL), Australia
(AICS), New Zealand (NZIoC), Philippines (PICCS). US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)

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Component CAS No EINECS ELINCS NLP IECSC TCSI KECL ENCS ISHL
Sodium hydroxide 1310-73-2 215-185-5 - - X X KE-31487 X X

Component CAS No TSCA TSCA Inventory DSL NDSL AICS NZIoC PICCS
notification -
Active-Inactive
Sodium hydroxide 1310-73-2 X ACTIVE X - X X X

Legend: X - Listed '-' - Not Listed KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)

Authorisation/Restrictions according to EU REACH

Component CAS No REACH (1907/2006) - REACH (1907/2006) - REACH Regulation (EC

Annex XIV - Substances Annex XVII - Restrictions 1907/2006) article 59 -
Subject to Authorization on Certain Dangerous Candidate List of
Substances Substances of Very High
Concern (SVHC)
Sodium hydroxide 1310-73-2 - Use restricted. See item -
75.
(see link for restriction
details)

REACH links
https://echa.europa.eu/substances-restricted-under-reach

Seveso III Directive (2012/18/EC)

Component CAS No Seveso III Directive (2012/18/EC) - Seveso III Directive (2012/18/EC) -
Qualifying Quantities for Major Accident Qualifying Quantities for Safety Report
Notification Requirements
Sodium hydroxide 1310-73-2 Not applicable Not applicable

Regulation (EC) No 649/2012 of the European Parliament and of the Council of 4 July 2012 concerning the export and
import of dangerous chemicals
Not applicable

Contains component(s) that meet a 'definition' of per & poly fluoroalkyl substance (PFAS)?
Not applicable

Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents at
work .

National Regulations

UK - Take note of Control of Substances Hazardous to Health Regulations (COSHH) 2002 and 2005 Amendment

WGK Classification See table for values

Component Germany - Water Classification (AwSV) Germany - TA-Luft Class

Sodium hydroxide WGK1

Component Switzerland - Ordinance on the Switzerland - Ordinance on Switzerland - Ordinance of the

Reduction of Risk from Incentive Taxes on Volatile Rotterdam Convention on the

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handling of hazardous Organic Compounds (OVOC) Prior Informed Consent
substances preparation (SR Procedure
814.81)
Sodium hydroxide Prohibited and Restricted
1310-73-2 ( 100 ) Substances

15.2. Chemical safety assessment

A Chemical Safety Assessment/Report (CSA/CSR) has been conducted by the manufacturer/importer

SECTION 16: OTHER INFORMATION

Full text of H-Statements referred to under sections 2 and 3

H290 - May be corrosive to metals
H314 - Causes severe skin burns and eye damage
H318 - Causes serious eye damage

Legend

CAS - Chemical Abstracts Service TSCA - United States Toxic Substances Control Act Section 8(b)
Inventory
EINECS/ELINCS - European Inventory of Existing Commercial Chemical DSL/NDSL - Canadian Domestic Substances List/Non-Domestic
Substances/EU List of Notified Chemical Substances Substances List
PICCS - Philippines Inventory of Chemicals and Chemical Substances ENCS - Japanese Existing and New Chemical Substances
IECSC - Chinese Inventory of Existing Chemical Substances AICS - Australian Inventory of Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances NZIoC - New Zealand Inventory of Chemicals

WEL - Workplace Exposure Limit TWA - Time Weighted Average

ACGIH - American Conference of Governmental Industrial Hygienists IARC - International Agency for Research on Cancer
DNEL - Derived No Effect Level Predicted No Effect Concentration (PNEC)
RPE - Respiratory Protective Equipment LD50 - Lethal Dose 50%
LC50 - Lethal Concentration 50% EC50 - Effective Concentration 50%
NOEC - No Observed Effect Concentration POW - Partition coefficient Octanol:Water
PBT - Persistent, Bioaccumulative, Toxic vPvB - very Persistent, very Bioaccumulative

ADR - European Agreement Concerning the International Carriage of ICAO/IATA - International Civil Aviation Organization/International Air
Dangerous Goods by Road Transport Association
IMO/IMDG - International Maritime Organization/International Maritime MARPOL - International Convention for the Prevention of Pollution from
Dangerous Goods Code Ships
OECD - Organisation for Economic Co-operation and Development ATE - Acute Toxicity Estimate
BCF - Bioconcentration factor VOC - (Volatile Organic Compound)
Key literature references and sources for data
https://echa.europa.eu/information-on-chemicals
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS

Training Advice
Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and
hygiene.
Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit
and standards.
First aid for chemical exposure, including the use of eye wash and safety showers.
Chemical incident response training.

Creation Date 16-Jun-2009

Revision Date 20-Oct-2023
Revision Summary Not applicable.

This safety data sheet complies with Regulation UK SI 2019/758 and UK SI 2020/1577 as
amended. .
.
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Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text

End of Safety Data Sheet

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