MSDS o Xylene(邻二甲苯)
MSDS o Xylene(邻二甲苯)
MSDS o Xylene(邻二甲苯)
1.2. Relevant identified uses of the substance or mixture and uses advised against
Company
UK entity/business name
Fisher Scientific UK
Bishop Meadow Road,
Loughborough, Leicestershire LE11 5RG, United Kingdom
EU entity/business name
Thermo Fisher Scientific
Janssen Pharmaceuticalaan 3a, 2440 Geel, Belgium
Physical hazards
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Health hazards
Environmental hazards
Hazard Statements
H226 - Flammable liquid and vapor
H304 - May be fatal if swallowed and enters airways
H312 + H332 - Harmful in contact with skin or if inhaled
H315 - Causes skin irritation
H319 - Causes serious eye irritation
H335 - May cause respiratory irritation
H412 - Harmful to aquatic life with long lasting effects
Precautionary Statements
P210 - Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking
P280 - Wear protective gloves/protective clothing/eye protection/face protection
P301 + P330 + P331 - IF SWALLOWED: rinse mouth. Do NOT induce vomiting
P303 + P361 + P353 - IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water or shower
P304 + P340 - IF INHALED: Remove person to fresh air and keep comfortable for breathing
P308 + P311 - IF exposed or concerned: Call a POISON CENTER or doctor
Substance is not considered persistent, bioaccumulative and toxic (PBT) / very persistent and very bioaccumulative (vPvB)
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SECTION 3: COMPOSITION/INFORMATION ON INGREDIENTS
3.1. Substances
Eye Contact Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Get
medical attention.
Skin Contact Wash off immediately with plenty of water for at least 15 minutes. If skin irritation persists,
call a physician.
Ingestion Clean mouth with water and drink afterwards plenty of water. Do NOT induce vomiting. Call
a physician or poison control center immediately. If vomiting occurs naturally, have victim
lean forward.
Inhalation Remove to fresh air. If not breathing, give artificial respiration. Get medical attention if
symptoms occur. Risk of serious damage to the lungs (by aspiration).
Self-Protection of the First Aider Ensure that medical personnel are aware of the material(s) involved, take precautions to
protect themselves and prevent spread of contamination.
4.2. Most important symptoms and effects, both acute and delayed
4.3. Indication of any immediate medical attention and special treatment needed
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Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam. Water mist may be used to cool closed containers.
Flammable. Containers may explode when heated. Vapors may form explosive mixtures with air. Vapors may travel to source of
ignition and flash back.
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear.
Use personal protective equipment as required. Ensure adequate ventilation. Remove all sources of ignition. Take precautionary
measures against static discharges.
Should not be released into the environment. See Section 12 for additional Ecological Information. Avoid release to the
environment. Collect spillage. Do not flush into surface water or sanitary sewer system.
Soak up with inert absorbent material. Keep in suitable, closed containers for disposal. Remove all sources of ignition. Use
spark-proof tools and explosion-proof equipment.
Wear personal protective equipment/face protection. Do not get in eyes, on skin, or on clothing. Avoid ingestion and inhalation.
Ensure adequate ventilation. Keep away from open flames, hot surfaces and sources of ignition. Use only non-sparking tools. Take
precautionary measures against static discharges.
Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice. Keep away from food, drink and animal feeding stuffs. Do
not eat, drink or smoke when using this product. Remove and wash contaminated clothing and gloves, including the inside, before
re-use. Wash hands before breaks and after work.
Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat, sparks and flame. Flammables area.
Use in laboratories
Exposure limits
List source(s): EU - Commission Directive (EU) 2019/1831 of 24 October 2019 establishing a fifth list of indicative occupational
exposure limit values pursuant to Council Directive 98/24/EC and amending Commission Directive 2000/39/EC UK - EH40/2005
Work Exposure Limits, Fourth edition. Published 2020. IRE - 2021 Code of Practice for the Chemical Agents Regulations,
Schedule 1. Published by the Health and Safety Authority
Engineering Measures
Ensure that eyewash stations and safety showers are close to the workstation location. Ensure adequate ventilation, especially in
confined areas. Use explosion-proof electrical/ventilating/lighting equipment.
Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or
equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to
control hazardous materials at source
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Glove material Breakthrough time Glove thickness EU standard Glove comments
Viton (R) > 480 minutes 0.3 mm EN 374 As tested under EN374-3 Determination of
PVA > 360 minutes 0.3 mm Resistance to Permeation by Chemicals
Nitrile rubber < 40 minutes 0.38 mm
Neoprene < 37 minutes 0.45 mm
Skin and body protection Long sleeved clothing.
Respiratory Protection When workers are facing concentrations above the exposure limit they must use
appropriate certified respirators.
To protect the wearer, respiratory protective equipment must be the correct fit and be used
and maintained properly
Large scale/emergency use Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits
are exceeded or if irritation or other symptoms are experienced
Recommended Filter type: Organic gases and vapours filter Type A Brown conforming to
EN14387
Small scale/Laboratory use Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure
limits are exceeded or if irritation or other symptoms are experienced.
Recommended half mask:- Valve filtering: EN405; or; Half mask: EN140; plus filter, EN
141
When RPE is used a face piece Fit Test should be conducted
Environmental exposure controls Prevent product from entering drains. Do not allow material to contaminate ground water
system. Local authorities should be advised if significant spillages cannot be contained.
Appearance Colorless
Odor aromatic
Odor Threshold No data available
Melting Point/Range -25 °C / -13 °F
Softening Point No data available
Boiling Point/Range 143 - 145 °C / 289.4 - 293 °F
Flammability (liquid) Flammable On basis of test data
Flammability (solid,gas) Not applicable Liquid
Explosion Limits Lower 1.7 Vol%
Upper 7.6 Vol%
Flash Point 31 °C / 87.8 °F Method - No information available
Autoignition Temperature 465 °C / 869 °F
Decomposition Temperature No data available
pH Not applicable
Viscosity 0.81 mPas @ 20°C
Water Solubility 0.2 g/L (20°C) practically insoluble
Solubility in other solvents No information available
Partition Coefficient (n-octanol/water)
Component log Pow
o-Xylene 3.12
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Vapor Pressure 882 Pa @ 25 °C
Density / Specific Gravity 0.884
Bulk Density Not applicable Liquid
Vapor Density 3.7 (Air = 1.0)
Particle characteristics Not applicable (liquid)
10.1. Reactivity
None known, based on information available
Product Information
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(e) germ cell mutagenicity; Based on available data, the classification criteria are not met
(f) carcinogenicity; Based on available data, the classification criteria are not met
There are no known carcinogenic chemicals in this product
(g) reproductive toxicity; Based on available data, the classification criteria are not met
(i) STOT-repeated exposure; Based on available data, the classification criteria are not met
Symptoms / effects,both acute and Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting.
delayed
Endocrine Disrupting Properties Assess endocrine disrupting properties for human health. This product does not contain any
known or suspected endocrine disruptors.
12.1. Toxicity
Ecotoxicity effects Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic
environment. Do not empty into drains. The product contains following substances which
are hazardous for the environment.
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12.4. Mobility in soil The product is insoluble and floats on water. The product contains volatile organic
compounds (VOC) which will evaporate easily from all surfaces. Spillage unlikely to
penetrate soil. Will likely be mobile in the environment due to its volatility.
12.5. Results of PBT and vPvB Substance is not considered persistent, bioaccumulative and toxic (PBT) / very persistent
assessment and very bioaccumulative (vPvB).
Waste from Residues/Unused Waste is classified as hazardous. Dispose of in accordance with the European Directives
Products on waste and hazardous waste. Dispose of in accordance with local regulations.
Contaminated Packaging Dispose of this container to hazardous or special waste collection point. Empty containers
retain product residue, (liquid and/or vapor), and can be dangerous. Keep product and
empty container away from heat and sources of ignition.
European Waste Catalogue (EWC) According to the European Waste Catalog, Waste Codes are not product specific, but
application specific.
Other Information Do not flush to sewer. Waste codes should be assigned by the user based on the
application for which the product was used. Can be landfilled or incinerated, when in
compliance with local regulations. Do not let this chemical enter the environment. Do not
empty into drains.
IMDG/IMO
ADR
IATA
15.1. Safety, health and environmental regulations/legislation specific for the substance or mixture
International Inventories
Europe (EINECS/ELINCS/NLP), China (IECSC), Taiwan (TCSI), Korea (KECL), Japan (ENCS), Japan (ISHL), Canada (DSL/NDSL), Australia
(AICS), New Zealand (NZIoC), Philippines (PICCS). US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)
Component CAS No EINECS ELINCS NLP IECSC TCSI KECL ENCS ISHL
o-Xylene 95-47-6 202-422-2 - - X X KE-35429 X X
Component CAS No TSCA TSCA Inventory DSL NDSL AICS NZIoC PICCS
notification -
Active-Inactive
o-Xylene 95-47-6 X ACTIVE X - X X X
Legend: X - Listed '-' - Not Listed KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)
REACH links
https://echa.europa.eu/substances-restricted-under-reach
Component CAS No Seveso III Directive (2012/18/EC) - Seveso III Directive (2012/18/EC) -
Qualifying Quantities for Major Accident Qualifying Quantities for Safety Report
Notification Requirements
o-Xylene 95-47-6 Not applicable Not applicable
Regulation (EC) No 649/2012 of the European Parliament and of the Council of 4 July 2012 concerning the export and
import of dangerous chemicals
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Not applicable
Contains component(s) that meet a 'definition' of per & poly fluoroalkyl substance (PFAS)?
Not applicable
Take note of Directive 98/24/EC on the protection of the health and safety of workers from the risks related to chemical agents at
work .
Take note of Directive 2000/39/EC establishing a first list of indicative occupational exposure limit values
National Regulations
UK - Take note of Control of Substances Hazardous to Health Regulations (COSHH) 2002 and 2005 Amendment
Legend
CAS - Chemical Abstracts Service TSCA - United States Toxic Substances Control Act Section 8(b)
Inventory
EINECS/ELINCS - European Inventory of Existing Commercial Chemical DSL/NDSL - Canadian Domestic Substances List/Non-Domestic
Substances/EU List of Notified Chemical Substances Substances List
PICCS - Philippines Inventory of Chemicals and Chemical Substances ENCS - Japanese Existing and New Chemical Substances
IECSC - Chinese Inventory of Existing Chemical Substances AICS - Australian Inventory of Chemical Substances
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KECL - Korean Existing and Evaluated Chemical Substances NZIoC - New Zealand Inventory of Chemicals
ADR - European Agreement Concerning the International Carriage of ICAO/IATA - International Civil Aviation Organization/International Air
Dangerous Goods by Road Transport Association
IMO/IMDG - International Maritime Organization/International Maritime MARPOL - International Convention for the Prevention of Pollution from
Dangerous Goods Code Ships
OECD - Organisation for Economic Co-operation and Development ATE - Acute Toxicity Estimate
BCF - Bioconcentration factor VOC - (Volatile Organic Compound)
Key literature references and sources for data
https://echa.europa.eu/information-on-chemicals
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Training Advice
Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and
hygiene.
Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit
and standards.
First aid for chemical exposure, including the use of eye wash and safety showers.
Chemical incident response training.
Fire prevention and fighting, identifying hazards and risks, static electricity, explosive atmospheres posed by vapours and dusts.
This safety data sheet complies with Regulation UK SI 2019/758 and UK SI 2020/1577 as
amended. .
.
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text
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