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    Thyroid Crisis

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    Koka Kola
    Thyroid crisis, also known as thyroid storm, is a life-threatening exacerbation of thyrotoxicosis that can have a mortality rate of 10-20%. It is usually precipitated by an underlying cause of hyperthyroidism like Graves' disease interacting with a triggering event like infection, trauma, surgery, or pregnancy. Clinically it presents with tachycardia, fever, gastrointestinal symptoms, tremors, and altered mental status. The diagnosis is based on meeting criteria for symptoms and lab abnormalities that distinguish it from milder thyrotoxicosis. Prompt treatment is needed to avoid potentially fatal complications.

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    Thyroid Crisis

    Uploaded by

    Koka Kola
    93 views11 pages
    Thyroid crisis, also known as thyroid storm, is a life-threatening exacerbation of thyrotoxicosis that can have a mortality rate of 10-20%. It is usually precipitated by an underlying cause of hyperthyroidism like Graves' disease interacting with a triggering event like infection, trauma, surgery, or pregnancy. Clinically it presents with tachycardia, fever, gastrointestinal symptoms, tremors, and altered mental status. The diagnosis is based on meeting criteria for symptoms and lab abnormalities that distinguish it from milder thyrotoxicosis. Prompt treatment is needed to avoid potentially fatal complications.

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    Thyroid crisis, also known as thyroid storm, is a life-threatening exacerbation of thyrotoxicosis that can have a mortality rate of 10-20%. It is usually precipitated by an underlying cause of hyperthyroidism like Graves' disease interacting with a triggering event like infection, trauma, surgery, or pregnancy. Clinically it presents with tachycardia, fever, gastrointestinal symptoms, tremors, and altered mental status. The diagnosis is based on meeting criteria for symptoms and lab abnormalities that distinguish it from milder thyrotoxicosis. Prompt treatment is needed to avoid potentially fatal complications.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    93 views11 pages

    Thyroid Crisis

    Uploaded by

    Koka Kola
    Thyroid crisis, also known as thyroid storm, is a life-threatening exacerbation of thyrotoxicosis that can have a mortality rate of 10-20%. It is usually precipitated by an underlying cause of hyperthyroidism like Graves' disease interacting with a triggering event like infection, trauma, surgery, or pregnancy. Clinically it presents with tachycardia, fever, gastrointestinal symptoms, tremors, and altered mental status. The diagnosis is based on meeting criteria for symptoms and lab abnormalities that distinguish it from milder thyrotoxicosis. Prompt treatment is needed to avoid potentially fatal complications.

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    Thyroid crisis

    An acute, life-threatening exacerbation of


    thyrotoxicosis

    Thyroid Crisis

    Thyroid storm Thyrotoxic crisis


    Incidence: 1 – 2 % among overt
    hyperthyroidism patients

    Epidemiology

    Mortality rates: 10 – 20%

    Karger S, Führer D. Thyroid storm: an update. Deutsch Med Wochenschr. 2008


     Infection
     Trauma
     Surgery
    Predispose  Myocardial Infarction
    Factors
     Diabetic ketoacidosis
     Pregnancy
     Parturition

    Carroll R, Matfin G. Endocrine and Metabolic Emergencies: Thyroid Storm. Ther Adv Endocrinol
    Metab. 2010; 1(3): 139 - 145
    Grave’s disease

    Etiology Toxic Adenoma Hypersecretory thyroid


    carcinoma

    Toxic Multinodular goitre

    Nayak B, Burman K. Thyrotoxicosis and Thyroid Storm. Endocrinol Metab Clin.


    2006:663-686
    T3, Free T4
    sudden increase
    Precipitating
    Pathogenesis Factors
    + Thyroid storm
    Increased target
    organ sensitivity
    Atrial Fibrilation
    Fever
    Tachycardia

    Congestive
    Heart Failure
    Tachypnea
    Clinical
    manifestations Nausea
    Dyspnea
    and vomit

    Diarrhea
    Generalized
    tremors
    CNS: Agitation, delirium, seizure Skin hyperemia
    Warnock, A.Burch, H. Graves’ Disease: Springer; 2015. p. 115-131
    >45 : Thyroid Strom
    25-44 : Impending Strom
    < 25 : Strom Unlikely

    Criteria
    Diagnosis

    Burch and Wartofsky, 1993 (21)


    Hyperthyroidism Management
    Guidelines, Endocr Pract. 2011;17(No. 3)
    THANK YOU

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