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    Psilocybin PP

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    Three sentences: Psilocybin, the psychoactive compound in magic mushrooms, has shown promise in treating conditions like depression, anxiety related to terminal cancer diagnoses, and tobacco addiction. Early research in the 1960s found psilocybin helped over 80% of cancer patients and smokers quit, but it was made illegal in the 1970s. More recent clinical trials have found psilocybin helped reduce symptoms of depression and increased well-being even after the effects wore off.

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    Psilocybin PP

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    Three sentences: Psilocybin, the psychoactive compound in magic mushrooms, has shown promise in treating conditions like depression, anxiety related to terminal cancer diagnoses, and tobacco addiction. Early research in the 1960s found psilocybin helped over 80% of cancer patients and smokers quit, but it was made illegal in the 1970s. More recent clinical trials have found psilocybin helped reduce symptoms of depression and increased well-being even after the effects wore off.

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    Three sentences: Psilocybin, the psychoactive compound in magic mushrooms, has shown promise in treating conditions like depression, anxiety related to terminal cancer diagnoses, and tobacco addiction. Early research in the 1960s found psilocybin helped over 80% of cancer patients and smokers quit, but it was made illegal in the 1970s. More recent clinical trials have found psilocybin helped reduce symptoms of depression and increased well-being even after the effects wore off.

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    Download as pptx, pdf, or txt
    92 views8 pages

    Psilocybin PP

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    api-532149591
    Three sentences: Psilocybin, the psychoactive compound in magic mushrooms, has shown promise in treating conditions like depression, anxiety related to terminal cancer diagnoses, and tobacco addiction. Early research in the 1960s found psilocybin helped over 80% of cancer patients and smokers quit, but it was made illegal in the 1970s. More recent clinical trials have found psilocybin helped reduce symptoms of depression and increased well-being even after the effects wore off.

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    PSILOCYBIN

    DRUG
    TREATMENT

    LAKE MICHIGAN COLLEGE


    JAMES NORRIS
    BEGINNING OF
    RESEARCH
     Albert Hoffman, Swiss Chemist, accidently invents
    Lysergic Acid Diethylamide 1938
     Began as research to find chemical that induces psychosis
     Due to effect that LSD had on mental wellbeing, therapists
    began to use it and other psychedelics as treatment for
    patients previously thought of as untreatable

    g ”
    D ru
    ac le
    M ir
    HISTORY CONT.
    LSD, psilocybin, and other psychedelics used to treat:

    Addiction Depression OCD

    Research continued until these drugs were criminalized to give excuse to lock
    up anti-war protesters by Nixon

    LSD, psilocybin, peyote and ayahuasca made into Schedule-1 Narcotics,


    meaning no medicinal value & high potential for abuse
    (even though over 1000 studies published before 1965)
    As marijuana was brought more and more into the
    mainstream, people began to wonder if other Schedule-1
    drugs truly had no medicinal benefit…

     Marijuana legalized for medicinal use California: 1996


     Psilocybin decriminalized Colorado: 2019
    MEDICAL New York University School of Medicine

    BENEFITS Psychological Aspects of Cancer, 2012

    PSILOCYBIN
    MAGIC MUSHROOMS
    DEPRESSION
     Given to patients with terminal cancer who suffered severe depression
    from their diagnosis, affects 30-40% of patients.
     Placebo, crossover study, 90% Caucasian 62% female
     After 8-month study, 70-80% of patients showed significant increases in
    well being
    MEDICAL BENEFITS PSILOCYBIN
    MAGIC MUSHROOMS
    CLINICAL DEPRESSION

    Psilocybin for treatment resistant depression; FMRI measured brain scans

     Small dose given to patients who did not respond to traditional


    pharmaceutical treatment or therapy.
     Every single patients showed better mood after treatment, with
    only one showing no signs of treatment 5 weeks after trial
     Higher amygdala blood flow associated with depression

    F l ow
    l oo d a
    a m yg
    dal

    ra lB
    eb
    = Cer
    CBF
    Pilot Study of the 5-HT2AR Agonist Psilocybin in the
    MEDICAL BENEFITS PSILOCYBIN Treatment of Tobacco Addiction
    MAGIC MUSHROOMS Journal of Psychopharmacology
    TOBACCO ADDICTION

    Categories Mean (SD) Range


    Sex a 10 M, 5 F
    Age (years) 51 (10.5) 26–65  Patients screened who had severe addiction to
    Education b tobacco, had smoked for a long time, and who had
     Some college 4 (26.7) tried to quit to no avail
     Bachelor’s degree 7 (46.7)
     7-months after trial, twelve out of fifteen patients
     Graduate degree 4 (26.7)
    Cigarette dependence (FTCD) c 5.3 (1.3) 3–8 reported to have quit smoking
    Years smoking 31 (9.9) 10–49  80% success rate compared to 35% success rate of
    Previous quit attempts 6 (3.6) 2–12
    traditional cessation methods (patch, behavioral
    Cigarettes/day at intake 19 (2.9) 15–25
    therapy, hypnosis)
    WORKS CITED
     Carhart-Harris, Robin L, et al. “Psilocybin for Treatment-Resistant Depression: FMRI-Measured Brain
    Mechanisms.” Scientific Reports, vol. 7, no. 1, 2017, doi:10.1038/s41598-017-13282-7.
     Grob, Charles S., et al. “Use of the Classic Hallucinogen Psilocybin for Treatment of Existential Distress
    Associated with Cancer.” Psychological Aspects of Cancer, 2012, pp. 291–308., doi:10.1007/978-1-4614-4866-
    2_17.
     Johnson, Matthew W, et al. “Pilot Study of the 5-HT2AR Agonist Psilocybin in the Treatment of Tobacco
    Addiction.” Journal of Psychopharmacology, vol. 28, no. 11, 2014, pp. 983–992.,
    doi:10.1177/0269881114548296.
     “Prologue: A New Door.” How to Change Your Mind: What the New Science of Psychedelics Teaches Us about
    Consciousness, Dying, Addiction, Depression, and Transcendence, by Michael Pollan, Penguin Press, 2019, p. 1.
     Vattano, Anthony J. “Psychedelic Drugs Reconsidered. By Lester Grinspoon and James B. Bakalar. New York:
    Basic Books, 1979. 343 Pp. $15.95 Cloth.” Children & Schools, vol. 4, no. 1, 1981, pp. 71–72.,
    doi:10.1093/cs/4.1.71.

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