Universitas Seminar Hasil Penelitian

Padjadjaran
Formulation by Design
Sediaan Tablet Amoksisilin Trihidrat
Ziyad Aslam Ghatafan
260110160035

Dosen Pembimbing:
Dr.apt.Yoga Windhu Wardhana, M.Si.
Dr.apt.Dolih Gozali, M.S.

sarjana.farmasi.unpad.ac.id The Faculty of Excellence

Pokok Bahasan
• Latar Belakang
• Identifikasi Masalah
• Maksud & Tujuan Penelitian
• Hasil & Pembahasan
• Kesimpulan
• Waktu & Tempat Penelitian

1
Latar Belakang

1
Variasi Formula DC PM
Run A (MCC) B (SSG) C (CSD) Y1 (CI) Y2 (Kompaktibilitas) Y3 (Friabilitas) Y4 (Kekerasan) Y5 (Keragaman bobot) Y6 (Uji disolusi)
1 8,48554 1 0,552959 25,4 0,1255 0,63 52,74 2,54 99,4325
2 8,9385 1 0,1 21,7 0,1847 1,27 67,24 0,57 99,2202
3 8,01973 1,01877 1 22,9 0,1638 0,58 56,04 2,18 99,9024
4 8,23512 1,04045 0,762922 21,3 0,1973 0,29 62,66 0,75 99,9328
5 8,69482 1,24368 0,1 21,7 0,1329 0,23 54,68 1,87 99,8873
6 8 1,46852 0,56998 22,9 0,1514 2,39 57,22 0,68 99,675
7 8,70838 1 0,330124 21,3 0,1347 0,22 50,22 0,73 99,4628
8 8,2396 1,6989 0,1 20,68 0,0915 1,97 75,64 2,17 99,2809
9 8,01121 1,69409 0,333198 22,9 0,178 0,17 99,16 0,85 99,6599
10 8,31642 1,31358 0,408503 21,7 0,1038 0,83 104,14 0,52 99,3112
11 8,46783 1,47067 0,1 21,7 0,137 0,21 42,48 2,17 99,3567
12 8 1,9385 0,1 20,33 0,172 0,32 48,44 2,28 99,4143
13 8,31642 1,31358 0,408503 21,3 0,1134 0,32 111,34 0,86 97,2343
14 8,31642 1,31358 0,408503 21 0,1035 0,83 92,5 1,18 97,0676
15 8,31642 1,31358 0,408503 22 0,157 0,28 51,6 0,75 97,2192
16 8 1,46852 0,56998 21,7 0,1042 0,65 102,94 0,26 97,492
17 8,01973 1,01877 1 22,6 0,1751 0,1 60,08 2,09 97,204

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Indeks Kompresibilitas (Y1)

1
Kompaktibilitas

1
Friabilitas Tablet

Sumber SS df Mean Square Nilai F Nilai p

Model 0,0000 0
Residual 2,36 16 0,1475
Lack of not
Fit 1,24 11 0,1131 0,5074 0,8382 significant
Pure
1,11 5 0,2230
Error
Cor
2,36 16
Total

1
Uji Kekerasan Mean
Sumber SS df Nilai F Nilai p
Square
7435,3
Model 1 8 929,41 8,12 0,0038 significant

⁽¹⁾Linear 223,16 2 111,58 0,9752 0,4178

Mixture
AB 11,31 1 11,31 0,0989 0,7612
AC 32,62 1 32,62 0,2851 0,6079
BC 35,99 1 35,99 0,3145 0,5903
A²BC 952,03 1 952,03 8,32 0,0204
1117,2
AB²C 1 1117,29 9,77 0,0141
9
ABC² 742,84 1 742,84 6,49 0,0343
Residual 915,30 8 114,41
Lack of
Fit 720,53 3 240,18 6,17 0,0392 significant

Pure
194,76 5 38,95
Error
8350,6
Cor Total 16
1

1
Keragaman Bobot Mean
Sumber SS df Nilai F Nilai p
Square
not
Model 5,03 6 0,8382 1,80 0,1955 significant
⁽¹⁾Linear 0,7236 2 0,3618 0,7786 0,4850
Mixture
AB 0,8639 1 0,8639 1,86 0,2026
AC 0,4850 1 0,4850 1,04 0,3311
BC 0,3072 1 0,3072 0,6610 0,4351
ABC 2,21 1 2,21 4,75 0,0542
Residual 4,65 10 0,4647
Lack of 2,15 5 0,4297 0,8599 0,5638 not
Fit significant
Pure 2,50 5 0,4997
Error
Cor Total 9,68 16

1
Uji Disolusi Mean
Sumber SS df Nilai F Nilai p
Square
not
Model 7,64 6 1,27 1,07 0,4381 significant
⁽¹⁾Linear 0,9314 2 0,4657 0,3923 0,6854
Mixture
AB 0,0142 1 0,0142 0,0120 0,9150
AC 0,6089 1 0,6089 0,5130 0,4902
BC 0,1587 1 0,1587 0,1337 0,7223
ABC 3,85 1 3,85 3,24 0,1019
Residual 11,87 10 1,19
Lack of 1,98 5 0,3968 0,2007 0,9487 not
Fit significant
Pure 9,89 5 1,98
Error
Cor Total 19,51 16

1
Optimasi

1
Konfirmasi

1
Variasi Formula DC CP
Run A (MCC) B (SSG) C (CSD) Y1 (CI) Y2 (Kompaktibilitas) Y3 (Friabilitas) Y4 (Kekerasan) Y5 (Keragaman bobot) Y6 (Uji disolusi)
1 8,48554 1 0,552959 23,08 0,1646 0,17 54,02 7,44 99,008
2 8,9385 1 0,1 24,64 0,1328 0,17 76,64 7,17 99,5538
3 8,01973 1,01877 1 23,08 0,1378 0,26 113,84 5,97 98,8413
4 8,23512 1,04045 0,762922 21,54 0,2129 0,43 113,12 7,53 98,9474
5 8,69482 1,24368 0,1 23,19 0,1138 0,91 106,74 7,28 99,6144
6 8 1,46852 0,56998 24,64 0,1414 0,4 86,98 5,56 99,193
7 8,70838 1 0,330124 23,08 0,0685 0,58 110,52 5,79 95,8548
8 8,2396 1,6989 0,1 22,06 0,0707 0,62 84,94 5,63 95,3697
9 8,01121 1,69409 0,333198 21,54 0,1138 0,17 86,34 7,49 95,491
10 8,31642 1,31358 0,408503 21,54 0,1298 0,3 71,06 7,48 95,9306
11 8,46783 1,47067 0,1 23,88 0,1286 0,28 85,34 7,12 95,4152
12 8 1,9385 0,1 22,39 0,1376 0,23 62,66 5,6 95,6122
13 8,31642 1,31358 0,408503 21,54 0,1257 0,12 91,26 5,91 95,9306
14 8,31642 1,31358 0,408503 21,54 0,102 0,21 74,5 5,72 96,1277
15 8,31642 1,31358 0,408503 21,54 0,1444 0,15 77,66 7,45 95,9306
16 8 1,46852 0,56998 24,64 0,1601 0,15 65,82 5,66 95,688
17 8,01973 1,01877 1 23,08 0,1472 0,22 79,88 7,11 95,5061

1
Indeks Kompresibilitas (Y1)
Su

M
⁽¹⁾L
M
AB
AC
BC
A²
AB
AB
Re
La
Fit
Pu
Err
Co

1
Kompaktibilitas

1
Friabilitas Tablet Mean
Sumber SS df Nilai F Nilai p
Square
not
Model 0,2928 6 0,0488 1,13 0,4115 significant
⁽¹⁾Linear 0,0910 2 0,0455 1,05 0,3847
Mixture
AB 0,1161 1 0,1161 2,69 0,1323
AC 0,0089 1 0,0089 0,2064 0,6593
BC 0,0008 1 0,0008 0,0195 0,8917
ABC 0,1214 1 0,1214 2,81 0,1247
Residual 0,4322 10 0,0432
Lack of 0,3813 5 0,0763 7,48 0,0227 significant
Fit
Pure 0,0510 5 0,0102
Error
Cor Total 0,7250 16

1
Uji Kekerasan

Sumber SS df Mean Square Nilai F Nilai p

Model 0,0000 0
Residual 5071,87 16 316,99
Lack of not
Fit 4036,53 11 366,96 1,77 0,2741 significant
Pure
1035,33 5 207,07
Error
Cor
5071,87 16
Total

1
Keragaman Bobot Sumber SS df
Mean
Square
Nilai F Nilai p

not
Model 7,65 9 0,8498 1,59 0,2760 significant
⁽¹⁾Linear
1,71 2 0,8534 1,60 0,2677
Mixture
AB 0,2151 1 0,2151 0,4033 0,5456
AC 0,1701 1 0,1701 0,3188 0,5899
BC 0,2371 1 0,2371 0,4446 0,5263
1,786E 1,786E- 3,349E
ABC -06 1 06 -06 0,9986

AB(A-B) 0,3253 1 0,3253 0,6099 0,4604

AC(A-C) 2,33 1 2,33 4,37 0,0749
BC(B-C) 2,93 1 2,93 5,50 0,0515
Residual 3,73 7 0,5334
Lack of not
Fit 0,3378 2 0,1689 0,2487 0,7889 significant
Pure
3,40 5 0,6792
Error
Cor Total 11,38 16

1
Uji Disolusi
Sumber SS df Mean Square Nilai F Nilai p
not
Model 13,28 2 6,64 2,67 0,1044
significant
⁽¹⁾Linear 13,28 2 6,64 2,67 0,1044
Mixture
Residual 34,87 14 2,49
Lack of not
Fit 23,14 9 2,57 1,10 0,4862 significant
Pure 11,73 5 2,35
Error
Cor
Total 48,15 16

1
Optimasi

1
Konfirmasi

1
Uji Disolusi Terbanding
Uji Disolusi Terbanding
120 DC PM
F2 = 31.63%
100

DC CP
80
F2 = 33.41%
60

40

20

0
0 5 10 15 20 25 30 35 40 45 50 55 60 65 70 75

REF DC PM DC CP

1
Kompaktibilitas

1
 Universitas
Padjadjaran

Hatur Nuhun
Program Studi Sarjana Farmasi
Fakultas Farmasi Universitas Padjadjaran
Jalan Bandung-Sumedang KM 21 Jatinangor 45636
Alamat Surel: kaprodi.s1.farmasi@unpad.ac.id
Situs Web: sarjana.farmasi.unpad.ac.id

sarjana.farmasi.unpad.ac.id The Faculty of Excellence