Sr.

No Percentage Proportion (xi) Mean (x) (x-xi)^2

1 41 40 1
2 37 40 9
3 41 40 1
4 39 40 1
5 45 40 25
6 37 40 9
7 39 40 1
8 40 40 0
9 41 40 1
10 43 40 9
11 40 40 0
12 38 40 4
13 39 40 1
14 37 40 9
15 43 40 9
16 40 40 0

No. of Samples (N) 16

Σ(x-xi)^2 80
Standard Deviation (σ) 2.309401
 For 95% Confidence Level For 90% Confidence Level

CL 0.95 CL 0.9
α = (1-CL)/2 0.025 α = (1-CL)/2 0.05
df = N-1 15 df = N-1 15
χ2(α) 27.488 χ2(α) 24.996
χ (1-α)
2
6.262 χ (1-α)
2
7.261
Upper Limit (σU2) 12.775471095497 Upper Limit (σU2) 11.017766147914
Lower Limit (σL2) 2.9103608847497 Lower Limit (σL2) 3.2005120819331
Size (x)-mm FD(x) FE(x)
420 1 1
355 0.991 1
250 0.982 0.977
190 0.973 0.967
150 0.964 0.946
75 0.746 0.654
53 0.047 0.284
0 0 0

Mass of Sample (kg)

Mean Mass of Drug
Mean Mass of Excipient
Density of Drug (kg/m3)
Density of Excipient (kg/m3)
No. of Particles of Drug (dnD)
No. of Particles of Excipient (dnE)
Total Particles (n)

For Random Mixture

Standard Deviation (σ)
Theoretical Deviation (σR)
Mixing Index (M)
Mixing Extent (1/M)
 0.0001
0.2
0.8
1100
900
8960000000
33700000000
2875200

om Mixture For 95% Samples in 15% Mean

0.005 Standard Deviation (σ) 0.03
0.000235898925 Theoretical Deviation (σR) 0.00023589892481054
21.19551839423 Mixing Index (M) 127.17311036536
0.047179784962 Mixing Extent (1/M) 0.00786329749368453
 Fraction of Sand (xi)
Sr.No
At t=45s At t=87s
1 0.64 0.53
2 0.68 0.54
3 0.74 0.6
4 0.63 0.6 At t=45s
5 0.73 0.6 Sr.No
6 0.81 0.55 1
7 0.59 0.56 2
8 0.65 0.6 3
9 0.62 0.69 4
10 0.7 0.63 5
11 0.66 0.48 6
12 0.64 0.67 7
13 0.77 0.65 8
14 0.7 0.63 9
15 0.67 0.62 10
16 0.58 0.46 11
17 0.6 0.63 12
18 0.65 0.58 13
19 0.87 0.48 14
20 0.6 0.59 15
21 0.49 0.49 16
22 0.52 0.53 17
23 0.49 0.46 18
24 0.54 0.49 19
25 0.64 0.58 20
26 0.38 0.34 21
27 0.32 0.52 22
28 0.34 0.45 23
29 0.49 0.5 24
30 0.52 0.47 25
31 0.25 0.42 26
32 0.32 0.35 27
33 0.33 0.43 28
34 0.35 0.49 29
35 0.48 0.59 30
36 0.23 0.38 31
37 0.16 0.39 32
38 0.32 0.45 33
39 0.44 0.52 34
40 0.39 0.39 35
41 0.26 0.35 36
42 0.26 0.36 37
43 0.21 0.37 38
44 0.32 0.49 39
45 0.38 0.48 40
46 0.22 0.37 41
47 0.24 0.49 42
48 0.22 0.32 43
49 0.15 0.32 44
50 0.36 0.36 45
46
47
48
49
50

At t=87s
Sr.No
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
 At t=45s
Fraction of Sand (xi) Mean Fraction (x45) (x-xi)^2
0.64 0.483 0.024649
0.68 0.483 0.038809
0.74 0.483 0.066049
0.63 0.483 0.021609
0.73 0.483 0.061009
0.81 0.483 0.106929
0.59 0.483 0.011449
0.65 0.483 0.027889
0.62 0.483 0.018769
0.7 0.483 0.047089
0.66 0.483 0.031329
0.64 0.483 0.024649
0.77 0.483 0.082369
0.7 0.483 0.047089
0.67 0.483 0.034969
0.58 0.483 0.009409
0.6 0.483 0.013689
0.65 0.483 0.027889
0.87 0.483 0.149769
0.6 0.483 0.013689
0.49 0.483 4.9E-05
0.52 0.483 0.001369
0.49 0.483 4.9E-05
0.54 0.483 0.003249
0.64 0.483 0.024649
0.38 0.483 0.010609
0.32 0.483 0.026569
0.34 0.483 0.020449
0.49 0.483 4.9E-05
0.52 0.483 0.001369
0.25 0.483 0.054289
0.32 0.483 0.026569
0.33 0.483 0.023409
0.35 0.483 0.017689
0.48 0.483 9E-06
0.23 0.483 0.064009
0.16 0.483 0.104329
0.32 0.483 0.026569
 0.44 0.483 0.001849
0.39 0.483 0.008649
0.26 0.483 0.049729
0.26 0.483 0.049729
0.21 0.483 0.074529
0.32 0.483 0.026569
0.38 0.483 0.010609
0.22 0.483 0.069169
0.24 0.483 0.059049
0.22 0.483 0.069169
0.15 0.483 0.110889
0.36 0.483 0.015129

At t=87s
Fraction of Sand (xi) Mean Fraction (x87) (x-xi)^2
0.53 0.4968 0.001102
0.54 0.4968 0.001866
0.6 0.4968 0.01065
0.6 0.4968 0.01065
0.6 0.4968 0.01065
0.55 0.4968 0.00283
0.56 0.4968 0.003994
0.6 0.4968 0.01065
0.69 0.4968 0.037326
0.63 0.4968 0.017742
0.48 0.4968 0.000282
0.67 0.4968 0.029998
0.65 0.4968 0.02347
0.63 0.4968 0.017742
0.62 0.4968 0.015178
0.46 0.4968 0.001354
0.63 0.4968 0.017742
0.58 0.4968 0.006922
0.48 0.4968 0.000282
0.59 0.4968 0.008686
0.49 0.4968 4.624E-05
0.53 0.4968 0.001102
0.46 0.4968 0.001354
0.49 0.4968 4.624E-05
0.58 0.4968 0.006922
0.34 0.4968 0.024586
0.52 0.4968 0.000538
0.45 0.4968 0.00219
0.5 0.4968 1.024E-05
0.47 0.4968 0.000718
0.42 0.4968 0.005898
0.35 0.4968 0.02155
0.43 0.4968 0.004462
0.49 0.4968 4.624E-05
0.59 0.4968 0.008686
0.38 0.4968 0.013642
0.39 0.4968 0.011406
0.45 0.4968 0.00219
0.52 0.4968 0.000538
0.39 0.4968 0.011406
0.35 0.4968 0.02155
0.36 0.4968 0.018714
0.37 0.4968 0.016078
0.49 0.4968 4.624E-05
0.48 0.4968 0.000282
0.37 0.4968 0.016078
0.49 0.4968 4.624E-05
0.32 0.4968 0.031258
0.32 0.4968 0.031258
0.36 0.4968 0.018714
No. of Samples (N45) 50
Σ(x-xi)^2 1.80945
Standard Deviation (σ) 0.192165426183817
No. of Samples (N87) 50
Σ(x-xi)^2 0.500488
Standard Deviation (σ) 0.101064537877173
Mixing Index (M) 2.02170326752854
Mixing Extent (1/M) 0.494632430021477

No. of Particles (n) 100

Composition (μ = x45+x87 / 2) 0.4899
Theoritical Standard Devation(σT) 0.0499897979591836
Sr.No Fraction of Sand (xi) Mean (x) (x-xi)^2
1 0.53 0.59 0.0036
2 0.54 0.59 0.0025
For 90% Confidence Level
3 0.6 0.59 0.0001
4 0.6 0.59 0.0001 Confidence Level (CL)
5 0.6 0.59 0.0001 α = 1-CL
6 0.55 0.59 0.0016 1 - α/2
7 0.56 0.59 0.0009 Critical Value (z)
8 0.6 0.59 0.0001 Margin of Error (z*SE)
9 0.69 0.59 0.01 Confidence Interval
10 0.63 0.59 0.0016

No. of Samples (N)

Σ(x-xi)^2
Standard Deviation (σ)
Standard Error (SE)

Sr.No Fraction of Sand (xi) Mean (x) (x-xi)^2

1 0.53 0.550667 0.000427
2 0.54 0.550667 0.000114
For 90% Confidence Level
3 0.6 0.550667 0.002434
4 0.6 0.550667 0.002434 Confidence Level (CL)
5 0.6 0.550667 0.002434 α = 1-CL
6 0.55 0.550667 4.449E-07 1 - α/2
7 0.56 0.550667 8.71E-05 Critical Value (z)
8 0.6 0.550667 0.002434 Margin of Error (z*SE)
9 0.69 0.550667 0.019414 Confidence Interval
10 0.63 0.550667 0.006294
11 0.48 0.550667 0.004994
12 0.67 0.550667 0.01424
 13 0.65 0.550667 0.009867
14 0.63 0.550667 0.006294
15 0.62 0.550667 0.004807 No. of Samples (N)
16 0.46 0.550667 0.008221 Σ(x-xi)^2
17 0.63 0.550667 0.006294 Standard Deviation (σ)
18 0.58 0.550667 0.00086 Standard Error (SE)
19 0.48 0.550667 0.004994
20 0.59 0.550667 0.001547
21 0.49 0.550667 0.00368
22 0.53 0.550667 0.000427
23 0.46 0.550667 0.008221
24 0.49 0.550667 0.00368
25 0.58 0.550667 0.00086
26 0.34 0.550667 0.044381
27 0.52 0.550667 0.00094
28 0.45 0.550667 0.010134
29 0.5 0.550667 0.002567
30 0.47 0.550667 0.006507

Sr.No Fraction of Sand (xi) Mean (x) (x-xi)^2

1 0.53 0.4968 0.001102
2 0.54 0.4968 0.001866
For 90% Confidence Level
3 0.6 0.4968 0.01065
4 0.6 0.4968 0.01065 Confidence Level (CL)
5 0.6 0.4968 0.01065 α = 1-CL
6 0.55 0.4968 0.00283 1 - α/2
7 0.56 0.4968 0.003994 Critical Value (z)
8 0.6 0.4968 0.01065 Margin of Error (z*SE)
9 0.69 0.4968 0.037326 Confidence Interval
10 0.63 0.4968 0.017742
11 0.48 0.4968 0.000282
12 0.67 0.4968 0.029998
13 0.65 0.4968 0.02347
14 0.63 0.4968 0.017742
15 0.62 0.4968 0.015178 No. of Samples (N)
16 0.46 0.4968 0.001354 Σ(x-xi)^2
17 0.63 0.4968 0.017742 Standard Deviation (σ)
18 0.58 0.4968 0.006922 Standard Error (SE)
19 0.48 0.4968 0.000282
20 0.59 0.4968 0.008686
21 0.49 0.4968 4.624E-05
22 0.53 0.4968 0.001102
23 0.46 0.4968 0.001354
24 0.49 0.4968 4.624E-05
25 0.58 0.4968 0.006922
26 0.34 0.4968 0.024586
27 0.52 0.4968 0.000538
28 0.45 0.4968 0.00219
29 0.5 0.4968 1.024E-05
30 0.47 0.4968 0.000718
31 0.42 0.4968 0.005898
32 0.35 0.4968 0.02155
33 0.43 0.4968 0.004462
34 0.49 0.4968 4.624E-05
35 0.59 0.4968 0.008686
36 0.38 0.4968 0.013642
37 0.39 0.4968 0.011406
38 0.45 0.4968 0.00219
39 0.52 0.4968 0.000538
40 0.39 0.4968 0.011406
41 0.35 0.4968 0.02155
42 0.36 0.4968 0.018714
43 0.37 0.4968 0.016078
44 0.49 0.4968 4.624E-05
45 0.48 0.4968 0.000282
46 0.37 0.4968 0.016078
47 0.49 0.4968 4.624E-05
48 0.32 0.4968 0.031258
49 0.32 0.4968 0.031258
50 0.36 0.4968 0.018714
0% Confidence Level For 95% Confidence Level

0.9 Confidence Level (CL) 0.95

0.1 α = 1-CL 0.05
0.95 1 - α/2 0.975
1.64 Critical Value (z) 1.96
0.0248116818365 Margin of Error (z*SE) 0.029652985609
0.59 ± 0.0248 Confidence Interval 0.59 ± 0.0297

10
0.0206
0.047842333648
0.0151290742905

0% Confidence Level For 95% Confidence Level

0.9 Confidence Level (CL) 0.95

0.1 α = 1-CL 0.05
0.95 1 - α/2 0.975
1.64 Critical Value (z) 1.96
0.023562493614 Margin of Error (z*SE) 0.028160053344
0.551 ± 0.0236 Confidence Interval 0.551 ± 0.0282
 30
0.1795866528921
0.0786933491674
0.0143673741549

0% Confidence Level For 95% Confidence Level

0.9 Confidence Level (CL) 0.95

0.1 α = 1-CL 0.05
0.95 1 - α/2 0.975
1.64 Critical Value (z) 1.96
0.0234400017831 Margin of Error (z*SE) 0.028013660668
0.4968 ± 0.0234 Confidence Interval 0.4968 ± 0.0280

50
0.500488
0.1010645378772
0.0142926840141