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    Tumores Histiociticos: DR Josue Ivan Leal Ventura R1 Neurocirugia Hospital Civil Fray Antonio Alcalde

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    Josue Ivan Leal
    This document discusses several types of histiocytic tumors including Langerhans cell histiocytosis, Erdheim-Chester disease, Rosai-Dorfman disease, juvenile xanthogranuloma, and histiocytic sarcoma. It provides definitions, epidemiology, clinical features, locations, and microscopic characteristics for each type. The types vary in their etiology, affected age groups, organ involvement, and prognosis. Microscopically they are characterized by infiltrates of histiocytes, lymphocytes, and other inflammatory cells.

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    Tumores Histiociticos: DR Josue Ivan Leal Ventura R1 Neurocirugia Hospital Civil Fray Antonio Alcalde

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    Josue Ivan Leal
    48 views42 pages
    This document discusses several types of histiocytic tumors including Langerhans cell histiocytosis, Erdheim-Chester disease, Rosai-Dorfman disease, juvenile xanthogranuloma, and histiocytic sarcoma. It provides definitions, epidemiology, clinical features, locations, and microscopic characteristics for each type. The types vary in their etiology, affected age groups, organ involvement, and prognosis. Microscopically they are characterized by infiltrates of histiocytes, lymphocytes, and other inflammatory cells.

    Original Title

    TUMORES HISTIOCITICOS

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    This document discusses several types of histiocytic tumors including Langerhans cell histiocytosis, Erdheim-Chester disease, Rosai-Dorfman disease, juvenile xanthogranuloma, and histiocytic sarcoma. It provides definitions, epidemiology, clinical features, locations, and microscopic characteristics for each type. The types vary in their etiology, affected age groups, organ involvement, and prognosis. Microscopically they are characterized by infiltrates of histiocytes, lymphocytes, and other inflammatory cells.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    48 views42 pages

    Tumores Histiociticos: DR Josue Ivan Leal Ventura R1 Neurocirugia Hospital Civil Fray Antonio Alcalde

    Uploaded by

    Josue Ivan Leal
    This document discusses several types of histiocytic tumors including Langerhans cell histiocytosis, Erdheim-Chester disease, Rosai-Dorfman disease, juvenile xanthogranuloma, and histiocytic sarcoma. It provides definitions, epidemiology, clinical features, locations, and microscopic characteristics for each type. The types vary in their etiology, affected age groups, organ involvement, and prognosis. Microscopically they are characterized by infiltrates of histiocytes, lymphocytes, and other inflammatory cells.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 42

    TUMORES HISTIOCITICOS

    D R J O S U E I VA N L E A L V E N T U R A R 1 N E U R O C I R U G I A

    H O S P I T A L C I V I L F R AY A N T O N I O A L C A L D E
    HISTICITOSIS DE CELULAS
    DE LANGERHANS
    Definicion

    proliferación de las
    células
    mononucleares
    dendríticas con
    infiltración local o
    difusa de órganos
    PEDIATRICA
    Louis DN. WHO classification and grading of tumours of central nervous system. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Ellison DW, Branger FD, et al.,
    editors. WHO Classification of Tumours of the Central Nervous System. 4th ed., Revised. Lyon: International Agency for Research Centre; 2016. pp. 12–3
    Etiología
    0.5 – 100,000 (Respuesta
    inmune anormal)

    Localización
    Microscopí
    Clínica
    a

    Microscopi
    Genética
    a
    Pronostico
    EPIDEMIOLOGI
    A

    Local o Libre de
    Sobrevida
    sistémico enfermedad

    mortalidad secuelas
    Enfermedad de Erdheim-Chester
    Definicion

    Forma de
    histoicitosis
    no-Langerhans
    HISTIOCITOSIS
    POLIOSTOTICA SISTÉMICA

    Louis DN. WHO classification and grading of tumours of central nervous system. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Ellison DW, Branger FD, et al.,
    editors. WHO Classification of Tumours of the Central Nervous System. 4th ed., Revised. Lyon: International Agency for Research Centre; 2016. pp. 12–3
    EPIDEMIOLOGI
    A

    Se han descrito
    más de 500 casos
    53 años
    (<15 pediátricos)
    desde 1930
    Localizacion

    Louis DN. WHO classification and grading of tumours of central nervous system. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Ellison DW, Branger FD, et al.,
    editors. WHO Classification of Tumours of the Central Nervous System. 4th ed., Revised. Lyon: International Agency for Research Centre; 2016. pp. 12–3
    Caracateristicas clinicas
    Lesión
    Engrosamient
    infiltrante a Glioma like
    o dural
    parénquima

    Macroscopia
    Louis DN. WHO classification and grading of tumours of central nervous system. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Ellison DW, Branger FD, et al.,
    editors. WHO Classification of Tumours of the Central Nervous System. 4th ed., Revised. Lyon: International Agency for Research Centre; 2016. pp. 12–3
    Microscopia
    • Histiocito
    s
    • Linfocitos

    • Células
    Touton
    • Eosinofilo
    s
    PRONOSTICO

    BRAF V600E VEMURAFENIB

    Seth Love, Herbert Budka, James W. Ironside and Arie Perry Greenfield’s Neuropathology (9th edition)
    Enfermedad de Rosai-
    Dorfman
    Definicion
    Ttrastorno raro
    caracterizado por
    acumulación de
    histiocitos y
    linfadenopatías masivas,
    en particular en la
    cabeza y el cuello SISTEMICA
    Louis DN. WHO classification and grading of tumours of central nervous system. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Ellison DW, Branger FD, et al.,
    editors. WHO Classification of Tumours of the Central Nervous System. 4th ed., Revised. Lyon: International Agency for Research Centre; 2016. pp. 12–3
    EPIDEMIOLOGIA

    21 AÑOS
    Louis DN. WHO classification and grading of tumours of central nervous system. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Ellison DW, Branger FD, et al.,
    editors. WHO Classification of Tumours of the Central Nervous System. 4th ed., Revised. Lyon: International Agency for Research Centre; 2016. pp. 12–3
    Localización
    Nausea Perdida de
    cefalea
    vomito peso

    Sudoració
    Epilepsia
    n nocturna

    Caracateristicas clinicas
    Macroscopia

    Masa dural firme,


    vagamente
    lobulada, amarillo
    grisácea.
    Microscopia

    Hisitocitos
    Emperipolesis

    Masa multinodular

    Celulas plasmáticas
    Fibrosis
    Xantogranuloma Juvenil
    Definicion

    forma más común


    de histiocitosis de
    células no
    Langerhans 22MO
    Louis DN. WHO classification and grading of tumours of central nervous system. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Ellison DW, Branger FD, et al.,
    editors. WHO Classification of Tumours of the Central Nervous System. 4th ed., Revised. Lyon: International Agency for Research Centre; 2016. pp. 12–3
    Localización
    Clínica

    Convulsione Diabetes Alteraciones


    s Insipida visuales
    Microscopia
    Células
    Células
    Histiocitos gigantes
    Touton
    CE

    Linfocitos Eosinófilos
    Sarcoma Histiocítico
    Definicion

    Neoplasia maligna, Rara,


    Agresiva,
    inmunofenotipicamente
    formado por histiocitos
    maduros
    SISTEMICA
    Louis DN. WHO classification and grading of tumours of central nervous system. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Ellison DW, Branger FD, et al.,
    editors. WHO Classification of Tumours of the Central Nervous System. 4th ed., Revised. Lyon: International Agency for Research Centre; 2016. pp. 12–3
    EPIDEMIOLOGIA

    52 AÑOS RADIACIÓN
    Louis DN. WHO classification and grading of tumours of central nervous system. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Ellison DW, Branger FD, et al.,
    editors. WHO Classification of Tumours of the Central Nervous System. 4th ed., Revised. Lyon: International Agency for Research Centre; 2016. pp. 12–3
    Localización
    Nausea Perdida de
    cefalea
    vomito peso

    Sudoració
    Epilepsia
    n nocturna

    Caracateristicas clinicas
    Microscopia
    Hisitocitos
    Con abundante
    mitosis

    Altamente celular

    Fondo de inflamación
    reactiva

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