Gud Gelanicals
Gud Gelanicals
Gud Gelanicals
Introduction
The term ‘Galenicals’ is derived by ‘Galen’ the name of
Greek Physician.
• Galenicals: Crude medicinal products made from animal
or vegetable drugs.
• Extraction: Treatment of plant or animal tissue with
solvents to saperate soluble active materials from the
insoluble residue like cell tissues and most of inactive or
inert components.
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Importance of Extraction
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• Menstrum: Solvent used for extraction.
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Salient Features of Different Menstrums
1. Water:
• Suitable for extraction of drugs containing proteins,
alkaloidal salts, colouring matters, glycosides, gums
sugars, anthraquinone derivatives and tannins
• Act as menstrum for enzymes, many organic acids and
small proportion of volatile oils
• Not suitable for drugs like waxes, fats, fixed oils, and
alkaloidal bases
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Advantages
• Cheap
• Non-toxic
• It is non-inflammable
• It is plentily available
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Disadvantages
• Hydrolysis is promoted
• Enzymatic degradation
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2. Alcohol:
fixed oils
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Advantages
• Fairly selective
• Non - toxic
Disadvantages
• Costly
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Other Solvents for Extraction of Drugs
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Light Oils, fats, Very volatile, highly Tincture of
petroleum waxes, inflammable, cheaper strophanthus, B.P.
resins and than the chloroform
alkaloidal
based
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Principle:
Crude plant drugs contains several constituents and some of
them are medicinally (therapeutically) active.
The therapeutically active constituents are called active
principles.
Other constituents of the plant materials are considered inert
or undesirable.
The important plant constituents are alkaloids, glycosides,
sugars, starches, mucilages, proteins, cellulose, gums, oils,
resins, tannins, inorganic salts and many other substances.
The principle of extraction is the leaching (withdrawal) of the
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The various processes used for extraction are
• Infusion
• Decoction
• Maceration
• Percolation
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Infusion
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2. Muslin bag can also be used
beaker
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• When the active constituents dissolve water becomes
heavier
• Heavier layers come down
• Fresh water replaces
• Special pots- infusion pots are used
• Consists of loose perforated shelf
• Drug is placed on the perforated shelf
• Pot is filled with water
• Perforated shelf is adjusted below the surface of water
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• Common apparatus used is coffee or tea pot
• Fresh infusions
• Concentrated infusions
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1. Fresh infusions:
• Aqueous solutions of active constituents of a vegetable
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2. Concentrated infusions.
• Prepared by double or triple maceration process
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Decoction
• Used for extracting the hard and woody crude drugs
• Liquid is strained
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Comparison Between ‘Infusion’ and ‘Decoction’
Infusion Decoction
1.Cold or boiling water is used 1.Drug is boiled in water.
as menstruum.
2.Drug having soft tissue is 2.Drug of a hard tissue is used.
used
3.Drug constituents may be 3.Drug constituents should be non-
volatile. volatile.
4.Final volume is not adjusted. 4. Adjustment to volume is done.
5.When boiling water is used 5.No such precaution is required
as menstruum, precautions because the final volume is adjusted
are taken to prevent the at the end.
escape of heat by covering the
vessel with a cloth.
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Maceration:
The meaning of the word maceration is ‘soaking’. The
word’s origin goes back to the Latin word macerare whose
English equivalent is ‘to soak’.
The process of maceration involves soaking of the
powdered crude drug with the menstruum in a closed
vessel for enough time to for the menstruum to penetrate
into the cellular structure of the crude drug and dissolve
the soluble constituents.
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The powdered crude drug (the drug to be extracted) is
placed with the whole of the menstruum in a wide mouthed
closed vessel.
The closed vessel is required to prevent evaporation and
batch to batch variation.
The contents are agitated (shaking or stirring) repeatedly for
a period ranging from 2 to 14 days.
The mixture is then strained, the marc is pressed, and both
liquids are combined.
The combined liquid is then clarified by filtration or
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decantation after standing.
There are two types of crude drugs: organized drugs and unorganized
drugs. The organised drugs have definite cellular structure and the
examples include barks, roots etc while unorganised drugs are
without definite cellular structure and the examples include gums,
resins, benzoin, tolu etc. The maceration process varies accordingly.26
Maceration: Organised drugs
Apparatus:
• Wide mouthed bottle of any container with stopper
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Method:
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Explanation:
• Shaking is essential to replace the saturated layers
around the drug
• Marc is pressed in a filter press, hydraulic press or hand
press
• If final adjustments is made, concentration varies
• Filtration removes insoluble cell contents
E.g:
• Compound Tincture of Gentian .
• Tincture of lemon
• Tincture of squill, BPC
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Officially, maceration process is used for:
• Tinctures made from organized drugs
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Maceration Process for Tinctures Made from
Unorganized drugs
• Place unorganised drug + 4/5 of menstruum in a closed
vessel
• Keep for 2 – 7 days
• Shake occasionally
• Filter the liquid
• Make the final volume with 1/5 of the menstruum
• Marc is not pressed
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Explanation
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Ex:-
• Tincture of Benzoin, BPC;
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Maceration Process for Concentrated
Preparations
Example: Concentrated Compound Infusion of Gentian is
prepared by double maceration with alcohol (25%) as menstruum.
Concentrated infusion of Quassia is prepared by triple maceration
using water as menstruum.
Double Maceration:
• Drug is extracted twice by the menstruum, which is
divided into two parts and each part is separately used
for maceration
determined by experiment
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After maceration :
• Strain
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Process
• Drug + menstruum for first maceration
• Macerate again
24 hours
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• Strain the liquid
• Filter it
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Volume for 1st maceration
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Problem:
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Solution:
First of all, find out the volumes of menstruum for first
maceration and second maceration
• Applying the below formula:
700 ml
1200 700
500 ml
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Drug extraction by first maceration
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Drug extraction by second maceration
71.4+20.4=91.8%
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• If the same drug is extracted by a single maceration using
1200 ml menstruum at a time,
• Then, Volume of combined strained and expressed liquid
is 1000 ml representing;
• 1000/1200 x100=83.3% of soluble matter
83.3
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Triple Maceration
• Drug is extracted thrice
• menstruum is divided into three equal parts
• Whole drug + menstruum
• Macerate for 1 hour
• Strain
• Drug + 2nd part of menstruum
• Macerate for 1 hour
• strain
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Triple Maceration
• Drug + 3rd part of menstruum
• Macerate for 1 hour
• strain
• Press the marc lightly
• Combine the liquid obtained from 2nd & 3rd macerations
• Evaporate
• Mix the liquid obtained from 1st maceration
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Triple Maceration
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Triple Maceration
• Drug is extracted trice
• menstruum is divided into three parts
• Equation for calculating the volume of the first part of
menstruum is calculated as:
Vol. for 1st maceration= T.V. of M. - V. R. by D. +V.R.
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T.V of M = Total volume of menstruum
V.R by D = Volume retained by drug
V.R = Volume retained
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Let us take the extraction of same 400g of drug with 1200
menstruum by triple maceration instead of double maceration
Solution
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• Vol. for 1st maceration= T.V. of M. - V. R. by D. +V.R.
3
T.V. of M. = Total volume of menstruum
V.R. by D. = Volume retained by drug
V.R. = Volume retained
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Drug extraction by first maceration
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Drug extraction by second maceration
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Drug extraction by third maceration
• 333 ml menstruum is added to marc already containing 200
ml menstruum.
soluble matter
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Comparative results of extraction of drug by
different maceration processes.
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Comparison of Maceration process for
‘Organised Drugs’ and Unorganised Drugs’
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Comparison between
‘Maceration Process’ and ‘Infusion Process’
Maceration Process Infusion Process
Menstruum used is Cold or boiled water is used as
usually alcohol, but it menstruum.
may be aqueous
Drug is made in contact Drug is made in contact with
with menstruum for 2-7 menstruum for 15minutes.
days.
The process is The process may or may not
conducted at room be conducted at room
temperature. temperature.
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Marc is pressed after Marc is not pressed.
maceration except in
modified maceration
process.
Volume is not made up in Volume is not made in
simple maceration but infusion process.
adjustment to volume is
done in modified
maceration process.
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Comparison Between
‘Double Maceration’ and ‘Triple Maceration’
Double Maceration Triple Maceration
1. Menstruum is divided 1. Menstruum is divided
into two parts. into three parts.
2.The drug is macerated 2. The drug is macerated
for 48 hours in first thrice having each
maceration followed by maceration of one hour
second maceration. duration.
3. Strain the liquid after 3. Strain the liquid after
each maceration and each maceration and
press the marc. press the marc after the
last maceration.
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4.The pressed liquid is 4. Combine the strained liquid
mixed with the obtained from the second and
strained liquids of the third maceration evaporate
both macerations and it to a specified extent. Mix it
then the volume is with strained liquid obtained
adjusted after adding after first maceration. Add
more of menstruum. ‘alcohol 90%’ equal to 1/4th of
the volume of the finished
product
5. Alcohol 25% is used 5. Water is used as menstruum but
as menstruum. ‘alcohol 90% is added at the end
equal to 1/4th of the volume of
the finished product.
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Comparison
Simple Maceration Multiple Maceration Process
1. The drug is 1. The menstruum is divided into
macerated with the two parts in double maceration
whole of the and into three parts in triple
menstruum. maceration process.
2. The period of 2. In Double Maceration
maceration is 7 The drug is macerated for 48
days. hours in the first maceration
followed by a second maceration
for 24 hours.
In Triple Maceration
The drug is macerated thrice of
one hour duration in each case.
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3. After maceration, 3. In Double Maceration
strain the liquid After each maceration, strain the
and press the liquid and press the marc.
marc. In Triple Maceration
Strain the liquid after each
maceration and press the marc
after the last maceration.
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4. Mix the 4. In Double Maceration
pressed liquid Mix the pressed liquid with the liquid
with the obtained from the two macerations and
strained liquid then the volume is adjusted by adding
and then filter. more of menstruum.
Volume is not In Triple Maceration
made up. Combine the strained liquid of 2nd & 3rd
maceration and evaporate to a specified
extent. Mix it with the liquid obtained
from the first maceration. Add alcohol
90% equal to 1/4th of the volume of the
finished product.
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5. The final 5. The final volume is made up in
made up.
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Percolation
preparations.
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The extraction apparatus or equipment for percolation is called
percolator and the extract obtained of percolation is called
percolate.
Percolators for drug extraction are available in different size,
shape, and utility.
Glass percolators are used for small scale extraction (usually
up to 1 kilogram drug) and are generally cylindrical shaped with
or without tapering downward, or conical or funnel shaped.
On the other hand, percolators used industrially are made of
stainless steel or are glass lined metal vessels.
The special percolators to percolate with hot menstruum are
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Process of percolation is divided into
eight steps
1. Reduction in drug particle size,
2. Moistening or imbibition,
3. Packing,
4. Maceration,
5. Percolation,
7. Adjustment of volume,
8. Clarification.
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1. Reduction in drug particle size:
• Finer the powder.
2. Moistening or imbibition:
• Drug powder is moistened with small quantity of
menstruum.
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Advantages of Moistening or imbibitions
• Drug swells
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3. Packing:
• A filter paper is placed for support, on perforated metallic
plate.
• Imbibed drug lumps are broken, and packed uniformly
layer by layer with moderate pressure.
• Drug should occupy almost two thirds of the column of
the percolator.
• Surface is covered with filter paper or filter cloth.
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Diagrams of:
(a) Incorrect packing of drug showing incorrect flow of
menstruum.
(b) Correct packing of drug showing correct flow of
menstruum.
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The packing of imbibed drug in percolator, with very high or
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Fig: Soxhlet Extractor
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4. Maceration:
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5. Percolation:
• After maceration, opening the stop cock starts
percolation, rate of percolation is adjusted to 30
drops/minute.
• When displacement of saturated solution formed during
maceration period is started with optimum speed, fresh
menstruum is added.
• Drug column should not be allowed to dry up.
• A bottleful of menstruum and carrying a delivery tube, is
inverted over the percolator. So that delivery tube dips
into the menstruum layer.
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Fig: 46.3 Diagram of percolator with an inverted bottleful of
menstruum to avoid drying up of drug column
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• Process is continued till 75% of finished product is
collected.
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6. Pressing of marc:
• After completion of extraction, marc is taken out of the
column and expressed in Tincture press or hydraulic
press to obtain menstruum retained by it.
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7. Adjustment of volume:
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8. Clarification:
• Filtration or by decantation
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Modified Percolation
a) Intermittent percolation,
b) Re-percolation,
c) Reserved percolation,
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Intermittent Percolation
24 hours – maceration
12 hours – maceration
12 hours – percolation .
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Repercolation
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Reserved Percolation
• Preferred when drug : Percolate ratio is 1:1 or 2:1
Advantages
• Economical
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Hot Continuous Extraction
PRINCIPLE:
Small volume of menstruum is made to circulate
through the extractor containing the drug, again and
again by the method of evaporation and subsequent
condensation of menstruum.
DESIGN:
• It consists of main three parts.
1. The flask holding the menstruum.
2. Extractor.
3. Reflux condensor.
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• The extractor, or cylindrical percolator possess a siphon
assembly and a side tube for the passage of vapors of
the menstruum, called the soxhlet extractor.
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Method of working
Disadvantages
• Not suitable for drugs containing thermo labile
constituents.
• Pure solvent is required.
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Soxhlet Extractor
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Introduction to Ayurvedic Dosage Forms
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Introduction to Ayurvedic Dosage Forms
Dhanvantari has classified ayurveda into eight well
defined branches.
• KAYACHIKITSA
• BALACHIKITSA
• GRAHACHIKITSA
• URDVANGACHIKITSA
• SALYATANTRA
• AGADATANTRA
• RASAYANATANTRA
• VRISHYACHIKITSA
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• The crude drugs from
• Vegetable source
• Animal source
• Metals, Minerals
• Ghee, Oil, Stones are
used to prepare dosage forms.
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Ayurvedic Preparations
ANJANS:
• Remedies intended to be used in eyes for their local
effect.
ARAKS or ARAKAS:
• Distilled essences or liquors made by soaking drugs in
water for 24 to 48 hours and extracting their essence by
distillation.
Ex: Ajwan arkas, triphala arkas ,chirata arkas
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ARISTA’S:
• Weak alcoholic preparations prepared by making a
decotion of the drugs.
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ASAVARISHTAS:
• Medicated spirituous liquors.
• Prepared with honey and medicinal substances such as
roots, leaves, barks etc.
AVALEHAS:
• Lehas, linctuses or convections, decoctions, after
straining, boiled to a thick soft consistency.
Eg: Ashtangara lehas : Used in pneumonia and dry cough.
Jirkadiava lehas : Used as tonic, for women.
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BHASMAS:
• Bhasmas are alkaline ashes prepared from vegetable
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BHAVANA:
• Powders are soaked in various fluids ands dried.
CHOORNAS:
• Choornas are powder mixtures prepared by powdering dry
mineral, animal or vegetable substances in a mortar.
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GUTIKAS:
• Gutikas are large pills or boluses less durable and kept
well closed.
Eg: ADITYA GUTIKA :For indigetion and colic pain
RASAYANAS:
• Major medical preparations. Stored in glass bottles to
keep them active and free from atmospheric
contamination.
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TAILAMS:
• Medicated oils.
Eg: BRAHMI AMLA TEL.
VATIKA:
• Pills usually prepared by reducing a decoction of
vegetable substances to a thick consistency, after then
powders are added.
Eg: GUDAD GUTIKA : Used in cough and cold.
MERICHADI GUTIKA : Used as expectorant and
antitussive.
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