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Vitamin B 3 and Nicotinic acid

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M
MANDEEP KAUR

Vitamin B3, also known as niacin, is a water-soluble vitamin that exists in two forms - nicotinamide and nicotinic acid. It is the precursor to the important coenzymes NAD+ and NADP+, which participate in many oxidation-reduction reactions during carbohydrate, lipid, and protein metabolism. As a result, niacin plays a key role in generating energy through the electron transport chain.

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Vitamin B3 & Nicotinic acid
VITAMIN B3 - Niacin •The term Niacin (Vitamin B3) is considered the generic term for nicotinamide (or niacinamide) & Nicotinic acid. •The conversion of Niacin to niacinamide takes place in the kidney, brain slices and liver slices. •PROPERTIES OF NIACIN •Niacin is a white crystalline substance. •It is soluble in water & ethyl alcohol. •Most stable - stable in air & heat. •Resistant to heat, oxidation & alkalis.
STRUCTURE •Niacin (C6H5O2N) is simplest of all the known vitamins. It is pyridine derivative. It has a carboxyl group (COOH) at the 3- position. •In nicotinamide, the carboxyl group is replaced by a carboxamide (CONH2).
CHEMISTRY •Precursor : Dietary tryptophan •Dietary tryptophan contribute to the synthesis of the coenzymes Niacin (NAD⁺ and NADP⁺). •60 mgs tryptophan = 1 mg of niacin.
•Biosynthesis: The conversion of tryptophan to nicotinic acid in the body takes place through a series of intermediate steps, which are represented below:
Vitamin B 3 and Nicotinic acid
Vitamin B 3 and Nicotinic acid
BIOCHEMICAL FUNCTIONS •The coenzymes NAD⁺ and NADP⁺ are involved in a variety of “oxidation-reduction reactions”. •A large number of enzymes belonging to the class “oxidoreductase” are dependent on NAD⁺ or NADP⁺. •NAD⁺ and NADP⁺ participate in almost all the metabolisms (carbohydrate, lipid, protein etc). •Involved in electron transport chain to generate ATP.
Vitamin B 3 and Nicotinic acid
Vitamin B 3 and Nicotinic acid
Vitamin B 3 and Nicotinic acid

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Vitamin B 3 and Nicotinic acid

  • 2. VITAMIN B3 - Niacin •The term Niacin (Vitamin B3) is considered the generic term for nicotinamide (or niacinamide) & Nicotinic acid. •The conversion of Niacin to niacinamide takes place in the kidney, brain slices and liver slices. •PROPERTIES OF NIACIN •Niacin is a white crystalline substance. •It is soluble in water & ethyl alcohol. •Most stable - stable in air & heat. •Resistant to heat, oxidation & alkalis.
  • 3. STRUCTURE •Niacin (C6H5O2N) is simplest of all the known vitamins. It is pyridine derivative. It has a carboxyl group (COOH) at the 3- position. •In nicotinamide, the carboxyl group is replaced by a carboxamide (CONH2).
  • 4. CHEMISTRY •Precursor : Dietary tryptophan •Dietary tryptophan contribute to the synthesis of the coenzymes Niacin (NAD⁺ and NADP⁺). •60 mgs tryptophan = 1 mg of niacin.
  • 5. •Biosynthesis: The conversion of tryptophan to nicotinic acid in the body takes place through a series of intermediate steps, which are represented below:
  • 8. BIOCHEMICAL FUNCTIONS •The coenzymes NAD⁺ and NADP⁺ are involved in a variety of “oxidation-reduction reactions”. •A large number of enzymes belonging to the class “oxidoreductase” are dependent on NAD⁺ or NADP⁺. •NAD⁺ and NADP⁺ participate in almost all the metabolisms (carbohydrate, lipid, protein etc). •Involved in electron transport chain to generate ATP.