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Leptin

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Leptin is a hormone that affects appetite and metabolic rate. It is produced by fat cells and acts on the hypothalamus in the brain. Leptin signals satiety to reduce appetite and increases energy expenditure. Studies in mice found that leptin treatment cured obesity by regulating weight, and it has been successfully used to treat rare cases of human congenital leptin deficiency and lipodystrophy where fat is improperly deposited.

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VI. LeptinParabiosis: mutant mouse surgically attached to wild type mouseweight loss.Leptin “cures” obesity in leptin deficient mice and in overfed mice.Leptin treatment of human diseases:Congenital leptin deficiency (rare)Lipodystrophy (inability to deposit fat in fat tissue)Leptin action:Hypothalamus (brain)Major area of action-arcuate nucleus Activates pathways that signal satiety and promotes energy expenditure

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VI. LeptinHormone that affects appetite and metabolic rateProduct of the Ob geneFaulty Ob gene may contribute to some human obesity…rareAlso used in treatment of lipodystrophy…improper storageDefective fat tissue, fat is deposited in isolated places…liver…face

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Leptin

  • 1. VI. LeptinParabiosis: mutant mouse surgically attached to wild type mouseweight loss.Leptin “cures” obesity in leptin deficient mice and in overfed mice.Leptin treatment of human diseases:Congenital leptin deficiency (rare)Lipodystrophy (inability to deposit fat in fat tissue)Leptin action:Hypothalamus (brain)Major area of action-arcuate nucleus Activates pathways that signal satiety and promotes energy expenditure
  • 2. VI. LeptinHormone that affects appetite and metabolic rateProduct of the Ob geneFaulty Ob gene may contribute to some human obesity…rareAlso used in treatment of lipodystrophy…improper storageDefective fat tissue, fat is deposited in isolated places…liver…face