Psychoactive drugs are chemical substances that act on the central nervous system and affect brain function, resulting in changes to perception, mood, consciousness and behavior. They have therapeutic uses such as anesthetics and for treating psychiatric disorders. Historically, psychoactive drugs have been used for medicinal purposes dating back thousands of years. Commonly used psychoactive drugs include stimulants, depressants, hallucinogens, and those used for anxiety, euphoria and pain management. While some have medical uses, psychoactive drugs can also be abused and lead to addiction. Their legal status varies depending on the substance and jurisdiction.
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Addictive and psychotropic drugs
2. A psychoactive
drug,psychopharmaceutical, or psychotropic is
a chemical substance that crosses the blood–brain
barrier and acts primarily upon the central nervous
system where it affects brain function, resulting in
alterations in
perception, mood, consciousness, cognition, and beh
avior
Psychoactive drugs have therapeutic utility, e.g., as
anesthetics, analgesics, or for the treatment
of psychiatric disorders
INTRODUCTION
3. HISTORY
Psychotropic drugs have been used from
prehistoric times
Medicinal use is one of the important facet of
psychoactive drug usage in ancient times
The chewing of coca leaves, dates back over
8000 years ago has been found by archeologist
while studying
4. Dr. Timothy Leary , Ralph
Metzner, and Richard Alpert (Ram Dass) in
the 1960s
Dosage – some compounds are beneficial when consumed in
small amounts, but harmful in higher doses
Set – it is internal attitudes and constitution of a person
including their wishes, fears and expectation
Setting – it pertains to the surroundings, the place, and the
time in which experiences transpire
5. Commonly Used Psychotropic Drugs And
Its Group
Anxiolytics (inhibits anxiety) - Benzodiazepine
Euphoriants (induces relaxation) - MDMA , MDA, Indopan
Stimulants - amphetamine, caffeine, cocaine,
nicotine
Depressants - alcoholic beverages (ethanol),
opioids, barbiturates, benzodiazepines
Hallucinogens - LSD and nitrous oxide
6. PSYCHIATRIC MEDICATION
Psychiatric medications are psychoactive drugs
prescribed for the management of mental and
emotional disorders
There are six major classes of psychiatric
medications :
Antidepressant – clinical depression, anxiety, eating disorders
Stimulants – attention deficit disorder, suppress the appetite
Antipsyhotics – schizophrenia, severe mania
Mood stabilizers – bipolar disorder
Anxiolytics – anexiety disorder
Depressent – hynotics, sedatives, anaesthetics
7. ANESTHESIA – It is a class of psychotropic drugs used on patients
to block pain and other sensations. Most anesthetics
induce unconsciousness, which allows patients to
undergo medical procedures
like surgery without physical pain or emotional trauma
induce unconsciousness, anesthetics affect the GABA and
NMDA systems. For example, halothane is a GABA
agonist, and ketamine an NMDA receptor antagonist
PAIN MANAGEMENT- Psychoactive drugs are often prescribed
to manage pain. The subjective experience of pain is
primarily regulated by endogenous opiod peptides.
Thus, pain can often be managed using psychoactives that
operate on this neurotransmitter system, also known
as opiod receptor agonist. This class of drugs can be
highly addictive, and includes opiate narcotics,
like morphine and codeine.
USES
8. MILITARY
Psychotropic drugs have been used in military as non-
lethal weapon
In World War II 60 million amphetamine pills were used
by soldiers
Brown-brown, a form of cocaine adulterated with gun
powder, has been used in Sierra Leone Civil War
Both military and civilian American intelligence officials
are know to use psychotropic drugs for there
interrogation with captives
9. Administration
For a substance to be psychotropic it must clear
the blood-brain barrier so it can affect
neurochemical function.
Certain drugs such as alcohol and caffeine are
ingested in beverages form.
Nicotine and cannabis are often smoked
Crystalline drugs like cocaine and
methamphetamines are often insufflated (inhaled
or ”snorted”)
Medicines such as lorazepam is ingested orally in
tablet form or capsule form
The efficiency of each method of administration
varies from drug to drug
10. EFFECTS
It affects a person’s neurochemistry, which in turn
causes a change in person’s mood, cognition, perception
and behaviour.
Agonist - Increase the synthesis of one or more
neurotransmitter, by reducing it’s reuptake from
synapses, or by mimicking the action by binding directly
to the postsynaptic receptor.
Antagonist – operate by interfering with synthesis or
blocking postsynaptic receptors so that neurotransmitters
cannot bind to them.
12. Serotonin is a monoamine neurotransmitter
Derived from tryptophan
Found in gastrointestinal tract, platelets and in central nervous system
It contributes to feelings of well being and happiness
It also acts as a growth factor for some cells
13. ADDICTION
It is of two types :-
Psychological Addiction – by which a user feels compelled to use a
drug despite negative physical or societal consequences
Physical Dependence – by which a user must use a drug to avoid
physically uncomfortable or even medically harmful withdrawal
symptoms
Drugs that are most likely to cause addiction are drugs that directly
stimulate the dopaminergic system, like cocaine and amphetamines
Drugs that only indirectly stimulate the dopaminergic system, such
as psychedelics, are not as likely to be addictive
14. LEGALITY
The legality of psychoactive drugs has been controversial
The most influential document regarding the legality of psychoactive
drugs is the Single Convention on Narcotic Drugs, an
international treaty signed in 1961 as an Act of the United Nations
It is signed by 73 nations including United States, USSR, India and
United Kingdom
It established the legality of each drug and laid out an international
agreement to fight addiction to recreational drugs by combatting the
sale, trafficking, and use of scheduled drugs
In the United States, the Food and Drug Administration (FDA) has
authority over all drugs, including psychoactive drugs
Psychotropic drugs are only given with a prescription
However, certain psychoactive drugs, like alcohol, tobacco, and drugs
listed in the Single Convention on Narcotic Drugs are subject to
criminal laws