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blood and its functions/B.pharmacy 2 semester

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K
Kondal Reddy

Blood consists of plasma, red blood cells, white blood cells, and platelets. Red blood cells contain hemoglobin and transport oxygen throughout the body, while white blood cells help fight infection. Platelets assist in clotting blood when injuries occur. Together these components maintain homeostasis, transport nutrients and waste, and protect the body from pathogens.

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BLOOD • Blood is a fluid connective tissue that consists of plasma, blood cells and platelets. • It circulates throughout our body delivering oxygen and nutrients to various cells and tissues. • It makes up to 8% of our body weight. • An average adult possesses around 5-6 litres of blood. Physical Characteristics and Volume: • Blood is a sticky, opaque fluid with a characteristic metallic taste. • Colour: Depending on the amount of oxygen it is carrying, the color of blood varies from scarlet (oxygen-rich) to a dull red (oxygen-poor). • Weight: Blood is heavier than water and about five times thicker, or more viscous, largely because of its formed elements. • pH: Blood is slightly alkaline, with a pH between 7.35 and 7.45. • Temperature: Its temperature (38 degrees Celsius, or 100.4 degrees Fahrenheit) is always slightly higher than body temperature.
•We have seen blood consist of cells known as formed elements of blood. •These cells have their own functions and roles to play in the body.
Red blood cells (Erythrocytes) • RBCs are biconcave cells and without nucleus in humans; also known as erythrocytes. • RBCs contain the iron-rich protein (heme)called haemoglobin; give blood its red colour. • RBCs are the most copious/plenty blood cells produced in bone marrows. • Their main function is to transport oxygen from and to various tissues and organs. • Red Blood Cells are red due to Haemoglobin, which is a transport molecule and also a pigment. As a result, blood is red.
White blood cells (Leucocytes) • Leucocytes are colourless blood cells. • They are colourless because it is devoid/lacking/absence of haemoglobin. • They are further classified as granulocytes and agranulocytes. • WBCs mainly contribute to immunity and defence mechanism. Types of White Blood Cells: • There are five different types of White blood cells and are classified mainly based on the presence and absence of granules. • Granulocytes • Agranulocytes
Granulocytes • They are leukocytes(WBC), with the presence of granules in their cytoplasm. • The granulated cells include- eosinophils, basophils, and neutrophils. 1.Eosinophils: (2-3%) • They are the cells of leukocytes, which are present in the immune system. • Eosinophil cells are small granulocyte, which are produced in the bone marrow and makes 2 to 3 percent of whole WBCs. • These cells are present in high concentrations in the digestive tract. • These cells are responsible for combating/preventing/reducing infections in parasites of vertebrates and for controlling mechanisms associated with allergy and asthma. 2.Basophils: (0.5-1%) • They are the least common of the granulocytes, ranging from 0.5 to 1 percent of WBCs. • They contain large cytoplasmic granules, which plays a vital role in mounting/increase a non- specific immune response to pathogens, allergic reactions by releasing histamine and dilates the blood vessels. • These white blood cells have the ability to be stained when exposed to basic dyes, hence referred to as basophil. • These cells are best known for their role in asthma and their result in inflammation and bronchoconstriction in the airways. • They secrete serotonin, histamine and heparin.
3.Neutrophils: (60-65%) • They are normally found in the bloodstream. • They are predominant cells, which are present in pus. • Around 60 to 65 per cent of WBCs are neutrophils with a diameter of 10 to 12 micrometres. • The nucleus is 2 to 5 lobed and cytoplasm has very fine granules. • Neutrophils helps in the destruction of bacteria with lysosomes, and it acts as a strong oxidant. • Neutrophils are stained only using neutral dyes. Hence, they are called neutrophils. • Neutrophils are also the first cells of the immune system to respond to an invader/attack/kills the bacteria or a virus.
Agranulocytes • They are leukocytes(WBC), with the absence of granules in their cytoplasm. • Agranulocytes are further classified into monocytes and lymphocytes. 1.Monocytes: (6-8%) • These cells usually have a large bilobed nucleus, with a diameter of 12 to 20 micrometres. • The nucleus is generally of half-moon shaped or kidney-shaped and it occupies 6 to 8 per cent of WBCs. • They are the garbage trucks of the immune system. • The most important functions of monocytes are to migrate into tissues and clean up dead cells, protect against the blood borne pathogens and they move very quickly to the sites of infections in the tissues. • These white blood cells have a single bean-shaped nucleus, hence referred to as Monocytes. 2.Lymphocytes: • Their size ranges from 8 to 10 micrometres. • These white blood cells are colourless cells formed in lymphoid tissue, hence referred to as lymphocytes. • There are two main types of lymphocytes – B lymphocytes and T lymphocytes. • These cells are very important in the immune systems and are responsible for humoral and cell-mediated immunity. • They play a vital role in producing antibodies. • They are commonly known as natural killer cells. • They play an important role in body defence.
Platelets (Thrombocytes) • Thrombocytes are specialized blood cells produced from bone marrow, is the sponge-like tissue inside our bones. • Platelets come into play when there is bleeding or haemorrhage. • They help in clotting and coagulation of blood. • Platelets help in coagulation during a cut or wound.
FUNCTIONS OF BLOOD Blood is responsible for the following body functions: 1. Fluid Connective Tissue: Blood is a fluid connective tissue composed of 55% plasma and 45% formed elements including WBCs, RBCs, and platelets. Since these living cells are suspended/dip/located in plasma, blood is known as a fluid connective tissue and not just fluid. 2. Provides oxygen to the cells: Blood absorbs oxygen from the lungs and transports it to different cells of the body. The waste carbon dioxide moves from the blood to the lungs and exhaled. 3. Transports Hormone and Nutrients: The digested nutrients such as glucose, vitamins, minerals, and proteins are absorbed into the blood through the capillaries in the villi lining the small intestine. The hormones secreted by the endocrine glands are also transported by the blood to different organs and tissues. 4. Homeostasis: Blood helps to maintain the internal body temperature by absorbing or releasing heat.
FUNCTIONS OF BLOOD 5. Blood Clotting at Site of Injury: The platelets help in the clotting of blood at the site of injury. Platelets along with the fibrin form clot at the wound site 6. Transport of waste to the Kidney and Liver: Blood enters the kidney where it is filtered to remove nitrogenous waste out of the blood plasma. The toxins from the blood are also removed by the liver. 7. Protection of body against pathogens: The White Blood Cells fight against infections. They multiply rapidly during the infections.
Blood Vessels Three types of blood vessels are: 1. Arteries 2. Veins 3. Capillaries 1.Arteries: Arteries are strong tubes and muscular in nature. These blood vessels carry oxygen-rich blood from the heart to all the tissues of the body. Aorta is one of the main arteries that arise from the heart and branches further. 2.Veins: Veins are elastic blood vessels which carry deoxygenated blood from all parts of the body to the heart. An exception is the umbilical and pulmonary veins. The Pulmonary vein carries oxygenated blood to the heart from the lungs and umbilical vein carries oxygenated blood from the placenta to the foetus. 3.Capillaries: On reaching tissues, arteries branch further into extremely thin tubes called capillaries. Capillaries bring about the exchange of substances between blood and tissues. Layers of Blood Vessels Both arteries and veins consist of three layers. 1. Tunica Intima: It is one of the innermost and thinnest layers of arteries and veins. It comprises endothelial cells. They are in direct contact with the flow of blood. 2. Tunica Media: It is the middle layer of an artery or vein. Tunica media is made up of smooth muscle cells 3. Tunica Externa: It surrounds tunica media. It is made up of collagen and also supported by the elastic lamina in arteries.
COMPONENTS OF BLOOD • There are many cellular structures in the composition of blood. • When a sample of blood is spun in a centrifuge machine, they separate into the following constituents: Plasma, Buffy coat and erythrocytes. 1.Plasma: • The liquid state of blood can be contributed to plasma as it makes up ~55% of blood. • It is pale yellow in colour and when separated, it consists of salts, nutrients, water and enzymes. • Blood plasma also contains important proteins and other components necessary for overall health. • Hence, blood plasma transfusions are given to patients with liver failure and life- threatening injuries. 2.Red Blood Cells (RBC): • Red blood cells consist of Haemoglobin, a protein. They are produced by the bone marrow to primarily carry oxygen to the body and carbon dioxide away from it. 3. Buffy coat: White Blood Cells (WBC): • White blood cells are responsible for fighting foreign pathogens (such as bacteria, viruses, fungi) that enter our body. They circulate throughout our body and originate from the bone marrow. Platelets: • Tiny disc-shaped cells that help regulate blood flow when any part of the body is damaged, thereby aiding in fast recovery through clotting of blood. • The above-stated elements form the composition of blood in humans. The only vertebrate without haemoglobin is the crocodile ice fish. It derives its oxygen requirement directly from the cold, oxygen-rich water where it lives.
RBC – Red Blood Cells WBC – White Blood Cells Red blood cells are called Erythrocytes. White Blood Cells are called Leucocytes or Leukocytes. RBCs have a bi-concave disc shape WBCs have an irregular shape. Size varies from 6 – 8 µm in diameter. Size varies from 12 – 17 µm in diameter. The lifespan of RBC is about 120 days. The lifespan of WBC is around 12-20 days after which they are destroyed in the lymphatic system Red blood cells do not have a nucleus on maturity. WBCs are characterized by the presence of a large central nucleus. Due to the presence of haemoglobin, these cells appear red in colour. These cells are colourless, as they do not have any pigment. Only one type of RBC exists. Different types of WBCs are found in the blood such as neutrophils, B lymphocytes, T lymphocytes, monocytes, basophils, eosinophils. They help in the transport of respiratory gases to different parts of the human body They help in producing antibodies to fight against disease-causing microbes. RBCs are produced in the red bone marrow These cells are produced in the red bone marrow, lymph nodes, and spleen. These cells make up around 36-50% of human blood. They make up around 1% of the human blood. RBC count: 5 million/ mm³ of blood. WBC count: 7000–8000/mm³ of blood. The process of formation of RBC is known as erythropoiesis. The process of formation of WBC is known as Leukopoiesis. These cells move between the cardiovascular systems. These cells move between the cardiovascular and lymphatic systems. Low count of RBCs results in Anaemia. Low count of WBCs results in Leukopenia.

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blood and its functions/B.pharmacy 2 semester

  • 1. BLOOD • Blood is a fluid connective tissue that consists of plasma, blood cells and platelets. • It circulates throughout our body delivering oxygen and nutrients to various cells and tissues. • It makes up to 8% of our body weight. • An average adult possesses around 5-6 litres of blood. Physical Characteristics and Volume: • Blood is a sticky, opaque fluid with a characteristic metallic taste. • Colour: Depending on the amount of oxygen it is carrying, the color of blood varies from scarlet (oxygen-rich) to a dull red (oxygen-poor). • Weight: Blood is heavier than water and about five times thicker, or more viscous, largely because of its formed elements. • pH: Blood is slightly alkaline, with a pH between 7.35 and 7.45. • Temperature: Its temperature (38 degrees Celsius, or 100.4 degrees Fahrenheit) is always slightly higher than body temperature.
  • 2. •We have seen blood consist of cells known as formed elements of blood. •These cells have their own functions and roles to play in the body.
  • 3. Red blood cells (Erythrocytes) • RBCs are biconcave cells and without nucleus in humans; also known as erythrocytes. • RBCs contain the iron-rich protein (heme)called haemoglobin; give blood its red colour. • RBCs are the most copious/plenty blood cells produced in bone marrows. • Their main function is to transport oxygen from and to various tissues and organs. • Red Blood Cells are red due to Haemoglobin, which is a transport molecule and also a pigment. As a result, blood is red.
  • 4. White blood cells (Leucocytes) • Leucocytes are colourless blood cells. • They are colourless because it is devoid/lacking/absence of haemoglobin. • They are further classified as granulocytes and agranulocytes. • WBCs mainly contribute to immunity and defence mechanism. Types of White Blood Cells: • There are five different types of White blood cells and are classified mainly based on the presence and absence of granules. • Granulocytes • Agranulocytes
  • 5. Granulocytes • They are leukocytes(WBC), with the presence of granules in their cytoplasm. • The granulated cells include- eosinophils, basophils, and neutrophils. 1.Eosinophils: (2-3%) • They are the cells of leukocytes, which are present in the immune system. • Eosinophil cells are small granulocyte, which are produced in the bone marrow and makes 2 to 3 percent of whole WBCs. • These cells are present in high concentrations in the digestive tract. • These cells are responsible for combating/preventing/reducing infections in parasites of vertebrates and for controlling mechanisms associated with allergy and asthma. 2.Basophils: (0.5-1%) • They are the least common of the granulocytes, ranging from 0.5 to 1 percent of WBCs. • They contain large cytoplasmic granules, which plays a vital role in mounting/increase a non- specific immune response to pathogens, allergic reactions by releasing histamine and dilates the blood vessels. • These white blood cells have the ability to be stained when exposed to basic dyes, hence referred to as basophil. • These cells are best known for their role in asthma and their result in inflammation and bronchoconstriction in the airways. • They secrete serotonin, histamine and heparin.
  • 6. 3.Neutrophils: (60-65%) • They are normally found in the bloodstream. • They are predominant cells, which are present in pus. • Around 60 to 65 per cent of WBCs are neutrophils with a diameter of 10 to 12 micrometres. • The nucleus is 2 to 5 lobed and cytoplasm has very fine granules. • Neutrophils helps in the destruction of bacteria with lysosomes, and it acts as a strong oxidant. • Neutrophils are stained only using neutral dyes. Hence, they are called neutrophils. • Neutrophils are also the first cells of the immune system to respond to an invader/attack/kills the bacteria or a virus.
  • 7. Agranulocytes • They are leukocytes(WBC), with the absence of granules in their cytoplasm. • Agranulocytes are further classified into monocytes and lymphocytes. 1.Monocytes: (6-8%) • These cells usually have a large bilobed nucleus, with a diameter of 12 to 20 micrometres. • The nucleus is generally of half-moon shaped or kidney-shaped and it occupies 6 to 8 per cent of WBCs. • They are the garbage trucks of the immune system. • The most important functions of monocytes are to migrate into tissues and clean up dead cells, protect against the blood borne pathogens and they move very quickly to the sites of infections in the tissues. • These white blood cells have a single bean-shaped nucleus, hence referred to as Monocytes. 2.Lymphocytes: • Their size ranges from 8 to 10 micrometres. • These white blood cells are colourless cells formed in lymphoid tissue, hence referred to as lymphocytes. • There are two main types of lymphocytes – B lymphocytes and T lymphocytes. • These cells are very important in the immune systems and are responsible for humoral and cell-mediated immunity. • They play a vital role in producing antibodies. • They are commonly known as natural killer cells. • They play an important role in body defence.
  • 8. Platelets (Thrombocytes) • Thrombocytes are specialized blood cells produced from bone marrow, is the sponge-like tissue inside our bones. • Platelets come into play when there is bleeding or haemorrhage. • They help in clotting and coagulation of blood. • Platelets help in coagulation during a cut or wound.
  • 9. FUNCTIONS OF BLOOD Blood is responsible for the following body functions: 1. Fluid Connective Tissue: Blood is a fluid connective tissue composed of 55% plasma and 45% formed elements including WBCs, RBCs, and platelets. Since these living cells are suspended/dip/located in plasma, blood is known as a fluid connective tissue and not just fluid. 2. Provides oxygen to the cells: Blood absorbs oxygen from the lungs and transports it to different cells of the body. The waste carbon dioxide moves from the blood to the lungs and exhaled. 3. Transports Hormone and Nutrients: The digested nutrients such as glucose, vitamins, minerals, and proteins are absorbed into the blood through the capillaries in the villi lining the small intestine. The hormones secreted by the endocrine glands are also transported by the blood to different organs and tissues. 4. Homeostasis: Blood helps to maintain the internal body temperature by absorbing or releasing heat.
  • 10. FUNCTIONS OF BLOOD 5. Blood Clotting at Site of Injury: The platelets help in the clotting of blood at the site of injury. Platelets along with the fibrin form clot at the wound site 6. Transport of waste to the Kidney and Liver: Blood enters the kidney where it is filtered to remove nitrogenous waste out of the blood plasma. The toxins from the blood are also removed by the liver. 7. Protection of body against pathogens: The White Blood Cells fight against infections. They multiply rapidly during the infections.
  • 11. Blood Vessels Three types of blood vessels are: 1. Arteries 2. Veins 3. Capillaries 1.Arteries: Arteries are strong tubes and muscular in nature. These blood vessels carry oxygen-rich blood from the heart to all the tissues of the body. Aorta is one of the main arteries that arise from the heart and branches further. 2.Veins: Veins are elastic blood vessels which carry deoxygenated blood from all parts of the body to the heart. An exception is the umbilical and pulmonary veins. The Pulmonary vein carries oxygenated blood to the heart from the lungs and umbilical vein carries oxygenated blood from the placenta to the foetus. 3.Capillaries: On reaching tissues, arteries branch further into extremely thin tubes called capillaries. Capillaries bring about the exchange of substances between blood and tissues. Layers of Blood Vessels Both arteries and veins consist of three layers. 1. Tunica Intima: It is one of the innermost and thinnest layers of arteries and veins. It comprises endothelial cells. They are in direct contact with the flow of blood. 2. Tunica Media: It is the middle layer of an artery or vein. Tunica media is made up of smooth muscle cells 3. Tunica Externa: It surrounds tunica media. It is made up of collagen and also supported by the elastic lamina in arteries.
  • 12. COMPONENTS OF BLOOD • There are many cellular structures in the composition of blood. • When a sample of blood is spun in a centrifuge machine, they separate into the following constituents: Plasma, Buffy coat and erythrocytes. 1.Plasma: • The liquid state of blood can be contributed to plasma as it makes up ~55% of blood. • It is pale yellow in colour and when separated, it consists of salts, nutrients, water and enzymes. • Blood plasma also contains important proteins and other components necessary for overall health. • Hence, blood plasma transfusions are given to patients with liver failure and life- threatening injuries. 2.Red Blood Cells (RBC): • Red blood cells consist of Haemoglobin, a protein. They are produced by the bone marrow to primarily carry oxygen to the body and carbon dioxide away from it. 3. Buffy coat: White Blood Cells (WBC): • White blood cells are responsible for fighting foreign pathogens (such as bacteria, viruses, fungi) that enter our body. They circulate throughout our body and originate from the bone marrow. Platelets: • Tiny disc-shaped cells that help regulate blood flow when any part of the body is damaged, thereby aiding in fast recovery through clotting of blood. • The above-stated elements form the composition of blood in humans. The only vertebrate without haemoglobin is the crocodile ice fish. It derives its oxygen requirement directly from the cold, oxygen-rich water where it lives.
  • 13. RBC – Red Blood Cells WBC – White Blood Cells Red blood cells are called Erythrocytes. White Blood Cells are called Leucocytes or Leukocytes. RBCs have a bi-concave disc shape WBCs have an irregular shape. Size varies from 6 – 8 µm in diameter. Size varies from 12 – 17 µm in diameter. The lifespan of RBC is about 120 days. The lifespan of WBC is around 12-20 days after which they are destroyed in the lymphatic system Red blood cells do not have a nucleus on maturity. WBCs are characterized by the presence of a large central nucleus. Due to the presence of haemoglobin, these cells appear red in colour. These cells are colourless, as they do not have any pigment. Only one type of RBC exists. Different types of WBCs are found in the blood such as neutrophils, B lymphocytes, T lymphocytes, monocytes, basophils, eosinophils. They help in the transport of respiratory gases to different parts of the human body They help in producing antibodies to fight against disease-causing microbes. RBCs are produced in the red bone marrow These cells are produced in the red bone marrow, lymph nodes, and spleen. These cells make up around 36-50% of human blood. They make up around 1% of the human blood. RBC count: 5 million/ mm³ of blood. WBC count: 7000–8000/mm³ of blood. The process of formation of RBC is known as erythropoiesis. The process of formation of WBC is known as Leukopoiesis. These cells move between the cardiovascular systems. These cells move between the cardiovascular and lymphatic systems. Low count of RBCs results in Anaemia. Low count of WBCs results in Leukopenia.