Nanofluids are basically nanoparticles in base fluids. Nanofluids have unique features different from conventional solid-liquid mixtures in which nano sized particles of metals and nonmetals are dispersed. Due to improvement of mechanical properties, nanofluids are widely used in heat transfer industries. The coolant is used water-based, with the addition of glycols to prevent freezing and other additives to limit corrosion, erosion and cavitations. In this study 50-50 mixture of Ethylene Glycol with water (EGW) is tested and compared with another mixture by adding 2 percent Copper oxide (CuO). The geometric model of radiator is uploaded in Autodesk CFD software for its computational analysis. It is analyzed up to 100 iterations. Both the results are compared to find the improved heat transfer rate due to the addition of 2% CuO with Ethylene Glycol and water