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TOPIC: Classification of SIZE Reduction& Cutter Mill
PHARMACEUTICAL ENGINEERING
Prepared by kashish Wilson
Assistant Professor,
MM College of Pharmacy,
MM(DU),Mullana Ambala
SIZE REDUCTION:
INTRODUCTION:
 Size reduction is a process of reducing large solid unit masses into small unit
masses, coarse particles or fine particles.
 Size reduction process also termed as comminution or diminution or pulverisation.
 Size reduction may be achieved by TWO methods
 Precipitation process
 Mechanical process
OBJECTIVE OF SIZE REDUCTION :
 It improves appearance.
 It increases surface area.
 It facilitate absorption and bioavailability.
 It improves the stability.
 It facilitate extraction.
 It facilitate mixing.
 In aerosol and inhalation preparation.
 Parental suspension.
 It facilitate drying.
 Ophthalmic suspension.
 Increase in viscosity.
Precipitation process :
• Substances is dissolved in an appropriate solvent. Subsequently, it is finely precipitated by
the addition of another solvent.
• Which is miscible with the first, but in the later substance is insoluble.
• This method is suitable for the production of raw materials and bulk drugs.
Mechanical process:
 The substances is subject to mechanical forces using grinding equipment.
E.g.: ball mill, roller mill.
 Dry grinding or milling is used in the production of tablets, capsules.
 Wet grinding is used in the preparation of suspensions, emulsions and
ointments.
Modes of size reduction:
Cutting: The material is cut by means of a sharp blades
Eg : cutter mill
Compression:
 In this mode material is crushed between roller by the application of
pressure Eg : roller mill
Impact:
 This involve the operation of hammer/bars at high speeds.
 When a lump of material strikes the rotating hammers, the material splits
apart. Eg : fluid energy mill
Attrition: breaking down by the rubbing action between two surfaces.
Eg : fluid energy mill, ball mill
CLASSIFICATON OF SIZE REDUCTION EQUIPMENT:
A. Crushers: ex: edge runner mill, end runner mill.
B. Grinders :
1.impact mill: ex: hammer mill
2. rolling compression: ex: roller mill
3. attrition mill: ex: attrition mill
4. tumbling mill: ex: ball mill
C. Ultrafine grinder: ex: fluid energy mill
D. Cutting machine : ex: cutter mill
The milling or grinding equipment consist of three basic components.
1. Hopper
2. Rotor and stator
3. A discharge chute.
ROTARY CUTTER MILL :
Construction:
contains two types of knives.
 The horizontally mounted rotor disc
consists of 2 to 12 knives spaced uniformly.
 The casing also has several stationary
knives
Working: the rotor disc is allowed to rotate at
speeds from 200 to 900 rpm
 The particle size and shapes are determined
by the rotor size , gap between the rotating
& stationary knives and opening of the sieve
Uses : size reduction of the tough and fibrous
material.
Thank you

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Cutter mill.pptx

  • 1. TOPIC: Classification of SIZE Reduction& Cutter Mill PHARMACEUTICAL ENGINEERING Prepared by kashish Wilson Assistant Professor, MM College of Pharmacy, MM(DU),Mullana Ambala
  • 2. SIZE REDUCTION: INTRODUCTION:  Size reduction is a process of reducing large solid unit masses into small unit masses, coarse particles or fine particles.  Size reduction process also termed as comminution or diminution or pulverisation.  Size reduction may be achieved by TWO methods  Precipitation process  Mechanical process
  • 3. OBJECTIVE OF SIZE REDUCTION :  It improves appearance.  It increases surface area.  It facilitate absorption and bioavailability.  It improves the stability.  It facilitate extraction.  It facilitate mixing.  In aerosol and inhalation preparation.  Parental suspension.  It facilitate drying.  Ophthalmic suspension.  Increase in viscosity.
  • 4. Precipitation process : • Substances is dissolved in an appropriate solvent. Subsequently, it is finely precipitated by the addition of another solvent. • Which is miscible with the first, but in the later substance is insoluble. • This method is suitable for the production of raw materials and bulk drugs. Mechanical process:  The substances is subject to mechanical forces using grinding equipment. E.g.: ball mill, roller mill.  Dry grinding or milling is used in the production of tablets, capsules.  Wet grinding is used in the preparation of suspensions, emulsions and ointments.
  • 5. Modes of size reduction: Cutting: The material is cut by means of a sharp blades Eg : cutter mill Compression:  In this mode material is crushed between roller by the application of pressure Eg : roller mill Impact:  This involve the operation of hammer/bars at high speeds.  When a lump of material strikes the rotating hammers, the material splits apart. Eg : fluid energy mill Attrition: breaking down by the rubbing action between two surfaces. Eg : fluid energy mill, ball mill
  • 6. CLASSIFICATON OF SIZE REDUCTION EQUIPMENT: A. Crushers: ex: edge runner mill, end runner mill. B. Grinders : 1.impact mill: ex: hammer mill 2. rolling compression: ex: roller mill 3. attrition mill: ex: attrition mill 4. tumbling mill: ex: ball mill C. Ultrafine grinder: ex: fluid energy mill D. Cutting machine : ex: cutter mill The milling or grinding equipment consist of three basic components. 1. Hopper 2. Rotor and stator 3. A discharge chute.
  • 7. ROTARY CUTTER MILL : Construction: contains two types of knives.  The horizontally mounted rotor disc consists of 2 to 12 knives spaced uniformly.  The casing also has several stationary knives Working: the rotor disc is allowed to rotate at speeds from 200 to 900 rpm  The particle size and shapes are determined by the rotor size , gap between the rotating & stationary knives and opening of the sieve Uses : size reduction of the tough and fibrous material.