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Edible vaccines.pptx

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Sujata Koundal

Edible vaccines are engineered vaccines produced in plants or animals that are meant to be eaten. They work by expressing vaccine antigens in plant tissues that are then eaten, triggering an immune response. This avoids issues with traditional vaccine storage and transport. The concept was developed in the 1990s as a cheap, safe alternative that does not require purification or cold storage. When eaten, the vaccine epitopes are absorbed and passed to immune cells, eliciting future protection against the pathogen. Common methods for gene transfer include Agrobacterium and particle guns. Advantages are low cost, easy distribution without refrigeration, but disadvantages include lack of dosage control and potential allergic reactions.

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EDIBLE VACCINES
• Edible vaccines are engineered vaccines that refers to any foods, typically plants that produces vitamins, proteins and develop the immune system to defend the pathogen • These are nothing but transgenic plant that trigger an immune response. • In simple terms, edible vaccine is plant or animal made pharmaceuticals. • The concept of edible vaccines was developed by Amtzen in the 1990s.
• In initial traditional vaccines and later development of newer, safer and highly effective vaccines, such as recombinant vaccines, subunit vaccines, peptide vaccines DNA vaccines or developed but these vaccines have storage and transport problem and also expensive. So, an alternate cheap, safe and efficient production system for vaccine is required, then the concept of edible vaccines arises.
Edible vaccines.pptx
Mode of Action • Epitope present in edible vaccines (fruits) • Recognized and absorbed by M-cells of Intestine and passed through various immune cells like B-cells, T-cells • As a result they elicit a defense mechanism against part of antigen as if real infectious agent has attacked the body
• This in turn produces memory cells which can identify and neutralize the real infectious agent in the future
Methods of Gene Transfer • Agrobacterium tumefaciens method • Particle gun method
Edible vaccines.pptx
Edible vaccines.pptx
Advantages: • These are cheap, these can produce in large quantity. • These can be ingested by eating plant / part of plant, so purification is not required. • Extensive storage facilities like deep freezer cold storage are not required. • Edible vaccines can be produced locally, so need of transportation and distribution can be eliminated. • Edible vaccines trigger immunity at mucosal surface, which is first line of defense.
Disadvantages of edible vaccines: • Dosing of vaccine cannot be controlled. • There is no separate dosing is available for children and adults. • People may develop allergy to fruit or vegetable containing vaccines.
Edible vaccines.pptx

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Edible vaccines.pptx

  • 2. • Edible vaccines are engineered vaccines that refers to any foods, typically plants that produces vitamins, proteins and develop the immune system to defend the pathogen • These are nothing but transgenic plant that trigger an immune response. • In simple terms, edible vaccine is plant or animal made pharmaceuticals. • The concept of edible vaccines was developed by Amtzen in the 1990s.
  • 3. • In initial traditional vaccines and later development of newer, safer and highly effective vaccines, such as recombinant vaccines, subunit vaccines, peptide vaccines DNA vaccines or developed but these vaccines have storage and transport problem and also expensive. So, an alternate cheap, safe and efficient production system for vaccine is required, then the concept of edible vaccines arises.
  • 5. Mode of Action • Epitope present in edible vaccines (fruits) • Recognized and absorbed by M-cells of Intestine and passed through various immune cells like B-cells, T-cells • As a result they elicit a defense mechanism against part of antigen as if real infectious agent has attacked the body
  • 6. • This in turn produces memory cells which can identify and neutralize the real infectious agent in the future
  • 7. Methods of Gene Transfer • Agrobacterium tumefaciens method • Particle gun method
  • 10. Advantages: • These are cheap, these can produce in large quantity. • These can be ingested by eating plant / part of plant, so purification is not required. • Extensive storage facilities like deep freezer cold storage are not required. • Edible vaccines can be produced locally, so need of transportation and distribution can be eliminated. • Edible vaccines trigger immunity at mucosal surface, which is first line of defense.
  • 11. Disadvantages of edible vaccines: • Dosing of vaccine cannot be controlled. • There is no separate dosing is available for children and adults. • People may develop allergy to fruit or vegetable containing vaccines.