This document analyzes the response of regular and irregularly configured multistory buildings in medium soil and various seismic zones. A 30-story building is modeled in ETABS software with both regular and irregular configurations. The models are analyzed using response spectrum analysis in seismic zones II and V. Results show that the irregular building experiences higher story displacements, drifts, forces, and accelerations compared to the regular building. The regular building has higher story stiffness and lower base shear. Therefore, irregular configurations perform poorer under earthquake loading with increased damage potential.