Location via proxy:   [ UP ]  
[Report a bug]   [Manage cookies]                
SlideShare a Scribd company logo

Leptin and obesity cycle

•
•
Smruti Patanaik
Smruti Patanaik

How fat is managed in our human body , and how by altering the leptin pathway we can treat bulimia, anorexia and obesity like disorders.

1 of 13
LEPTIN & OBESITY Dr. Smrutiranjan Patanaik
 OBESITY – A GLOBAL HEALTH PROBLEM  RECENT LIPOSTATIC HYPOTHESIS HAS GIVEN ATTENTION TO LEPTIN  DEFECTIVE OB/OB GENE IN MICE REVEALS ASSOCIATION OF LEPTIN WITH OBESITY  KNOCKOUT OF DB/DB GENE PRODUCES DECREASE IN LEPTIN RECEPTORS  LEPTIN RESISTANCE IS ASSOCIATED WITH OBESITY
Leptin and obesity cycle
 A PEPTIDE HORMONE  167 AMINO ACIDS  M.wt. 16kDa  SECRETED BY ADIPOCYTES  DISCOVERED BY FRIEDMAN IN 1994
Leptin and obesity cycle
Leptin and obesity cycle
Leptin and obesity cycle
Leptin and obesity cycle
Leptin and obesity cycle
Leptin and obesity cycle
Leptin and obesity cycle
 LEPTIN OPERATES AS PART OF A FEEDBACK LOOP BY WHICH THE SIZE OF THE BODY FAT DEPOTS CAN OPERATE THROUGH A HUMORAL LINK TO REGULATE FOOD INTAKE
THANK YOU

More Related Content

Leptin and obesity cycle

  • 1. LEPTIN & OBESITY Dr. Smrutiranjan Patanaik
  • 2. OBESITY – A GLOBAL HEALTH PROBLEM  RECENT LIPOSTATIC HYPOTHESIS HAS GIVEN ATTENTION TO LEPTIN  DEFECTIVE OB/OB GENE IN MICE REVEALS ASSOCIATION OF LEPTIN WITH OBESITY  KNOCKOUT OF DB/DB GENE PRODUCES DECREASE IN LEPTIN RECEPTORS  LEPTIN RESISTANCE IS ASSOCIATED WITH OBESITY
  • 4. A PEPTIDE HORMONE  167 AMINO ACIDS  M.wt. 16kDa  SECRETED BY ADIPOCYTES  DISCOVERED BY FRIEDMAN IN 1994
  • 12. LEPTIN OPERATES AS PART OF A FEEDBACK LOOP BY WHICH THE SIZE OF THE BODY FAT DEPOTS CAN OPERATE THROUGH A HUMORAL LINK TO REGULATE FOOD INTAKE