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MEDICATION ADHERENCE:
     DEFINING THE PROBLEM

November 7, 2012
Marquila Ferrell & Sarah Hudson
The University of Toledo
Objectives
2


       Define medication adherence
       Explore the differences between medication
        adherence and medication compliance
       Identify associated statistics
       Factors that contribute to medication adherence
       Why medication adherence matters?
Introduction
3


       125,000 people die a year due to failure to take
        medication or taking medications improperly
       Almost 6 out of 10 people are taking at least one
        prescription drug
       More than 1 in 3 medicine-related hospital
        admissions occur due to people not properly
        adhering to their medications



                   Script Your Future. (2012). National Consumers League.
What is Medication Adherence?
4




        “The extent to which patients take
     medications as prescribed by health care
                    providers.”



    Osterberg, L., & Blaschke, T. (2005). Adherence to medication. New England journal of medicine, 353(5), 487-
                                                        97.
Medication Adherence vs. Patient Compliance
5




      “Compliance suggests that the patient is passively
     following the doctor’s orders and that the treatment
    plan is not based on a therapeutic alliance or contract
     established between the patient and the physician.”




        Osterberg, L., & Blaschke, T. (2005). Adherence to medication. New England journal of
                                         medicine, 353(5), 487.
Medication Non-Adherence
6


       Intentional medication non-adherence
          “Active process whereby the patient chooses
           to deviate from the treatment regimen.”

       Unintentional medication non-adherence
         “Passive process in which the patient may be
          careless or forgetful about adhering to
          treatment regimen.”
    Ho, P., Bryson, C., , & Rumsfeld, J. (2009). Medication adherence: Its importance in Cardiovascular Outcomes.
                                               Circulation, 119(23), 3031.
Effects of Medication Non-Adherence
7


       Increased hospital readmission
       Increased disease progression and complications
       Increased health care costs
       Decreased quality of life
       Patient death
Patient Interviews
8




      “Taking my medication helps balance my
      life. If I do not take it, I often get sick or
               have emotional episodes.”
Why Don’t Patients Take Their Medicine?
9


                         Most Common Reported Reasons
         Late Refill
             10%
        Clinical
       Questions
         15%                                                       Missed Dose
                                                                      39%

                High Cost
                  16%
                                             Late Renewal
                                                 20%




               Express Scripts (2012). Retrieved from http://lab.express-scripts.com/wp-
                      content/uploads/2012/07/Americas_317B_Condition.pdf
5 Dimensions of Medication Adherence
10




     Adult Meducation (2006). Overview of Medication Adherence. American Society on Aging and American Society
                                       of Consultant Pharmacists Foundation.
Clinical Case Study
11


        Primary source
          48   year old African American male with low
            socioeconomic status presenting myocardial infarction
            and end-stage renal disease
        Assessment of medication adherence behaviors
          Psychological   screening
          Questionnaires

          Post-discharge phone interview

          Electronic pill bottle


     Ye, Siqin, Krupka, David, & Davidson, Karina. (2012). Diagnosing medication non-adherence in a patient with
                               myocardial infarction. Frontiers In Psychology, 3:267, 1-3.
Post-Discharge Report
12


     Measures                            Details                               Results
     Barriers to adherence               Asks whether Rx were filled No barriers self-reported
                                         , and if not, reasons why
                                         not

     Morisky scale                       8 item self-report         2/8 score
                                         medication adherence scale

     Modified CARDIA scale               For each medication, self-            7/7 for all medications
                                         reported # of days in
                                         week meds were taken
     Electronic pill bottle              # of days pill bottle was             Aspirin 6/31
                                         opened, divided by total #            Statin 3/31
                                         of days monitored                     B-blocker 2/31
                                                                               Clopidogrel 0/31
      Ye, Siqin, Krupka, David, & Davidson, Karina. (2012). Diagnosing medication non-adherence in a patient with
                                 myocardial infarction. Frontiers In Psychology, 3:267, 7.
Study Results
13


        Limitations to medication adherence for Mr. P
          Low  socioeconomic status
          Lived alone

          Distrust in medications efficacy

          Belief medications being overused

        Outcomes
          Hypertension   poorly controlled
          Intermittent chest pain

          Progression of coronary artery disease concern

     Ye, Siqin, Krupka, David, & Davidson, Karina. (2012). Diagnosing medication non-adherence in a patient with
                                myocardial infarction. Frontiers In Psychology, 3:267, 4.
Summary
14


        What medication adherence is
        Significance of adhering to medications
        Barriers to proper medication adherence
        Pharmacists and MTM services
        Health outcomes and pharmacy administrators
Questions
15
Resources
16

        Adult Meducation. (2006). Overview of Medication Adherence. American Society on
                Aging and American Society of Consultant Pharmacists Foundation. Retrieved from
                http://www.adultmeducation.com/OverviewofMedicationAdherence_4.html.
        Express Scripts (2012). Retrieved from http://lab.express-scripts.com/wp-content/uploads/
                2012/07/Americas_317B_Condition.pdf
        Ho, P., Bryson, C., , & Rumsfeld, J. (2009). Medication adherence: its importance in
                 cardiovascular outcomes. Circulation, 119(23), 3028-35. Retrieved from http://
                 www.ncbi.nlm.nih.gov/pubmed/19528344.
        Osterberg, L., & Blaschke, T. (2005). Adherence to medication. New England journal of
                 medicine, 353(5), 487-97. Retrieved from http://www.nejm.org/doi/full/
                 10.1056/NEJMra050100.
        Script Your Future. (2012). National Consumers League. Retrieved from http://
                 scriptyourfuture.org/medication-adherence/.
        Ye, Siqin, Krupka, David, & Davidson, Karina. (2012). Diagnosing medication non-
                 adherence in a patient with myocardial infarction. Frontiers In Psychology, 3:267,
                 1-7. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411184/.

More Related Content

Medication Adherence

  • 1. MEDICATION ADHERENCE: DEFINING THE PROBLEM November 7, 2012 Marquila Ferrell & Sarah Hudson The University of Toledo
  • 2. Objectives 2  Define medication adherence  Explore the differences between medication adherence and medication compliance  Identify associated statistics  Factors that contribute to medication adherence  Why medication adherence matters?
  • 3. Introduction 3  125,000 people die a year due to failure to take medication or taking medications improperly  Almost 6 out of 10 people are taking at least one prescription drug  More than 1 in 3 medicine-related hospital admissions occur due to people not properly adhering to their medications Script Your Future. (2012). National Consumers League.
  • 4. What is Medication Adherence? 4 “The extent to which patients take medications as prescribed by health care providers.” Osterberg, L., & Blaschke, T. (2005). Adherence to medication. New England journal of medicine, 353(5), 487- 97.
  • 5. Medication Adherence vs. Patient Compliance 5 “Compliance suggests that the patient is passively following the doctor’s orders and that the treatment plan is not based on a therapeutic alliance or contract established between the patient and the physician.” Osterberg, L., & Blaschke, T. (2005). Adherence to medication. New England journal of medicine, 353(5), 487.
  • 6. Medication Non-Adherence 6  Intentional medication non-adherence  “Active process whereby the patient chooses to deviate from the treatment regimen.”  Unintentional medication non-adherence  “Passive process in which the patient may be careless or forgetful about adhering to treatment regimen.” Ho, P., Bryson, C., , & Rumsfeld, J. (2009). Medication adherence: Its importance in Cardiovascular Outcomes. Circulation, 119(23), 3031.
  • 7. Effects of Medication Non-Adherence 7  Increased hospital readmission  Increased disease progression and complications  Increased health care costs  Decreased quality of life  Patient death
  • 8. Patient Interviews 8 “Taking my medication helps balance my life. If I do not take it, I often get sick or have emotional episodes.”
  • 9. Why Don’t Patients Take Their Medicine? 9 Most Common Reported Reasons Late Refill 10% Clinical Questions 15% Missed Dose 39% High Cost 16% Late Renewal 20% Express Scripts (2012). Retrieved from http://lab.express-scripts.com/wp- content/uploads/2012/07/Americas_317B_Condition.pdf
  • 10. 5 Dimensions of Medication Adherence 10 Adult Meducation (2006). Overview of Medication Adherence. American Society on Aging and American Society of Consultant Pharmacists Foundation.
  • 11. Clinical Case Study 11  Primary source  48 year old African American male with low socioeconomic status presenting myocardial infarction and end-stage renal disease  Assessment of medication adherence behaviors  Psychological screening  Questionnaires  Post-discharge phone interview  Electronic pill bottle Ye, Siqin, Krupka, David, & Davidson, Karina. (2012). Diagnosing medication non-adherence in a patient with myocardial infarction. Frontiers In Psychology, 3:267, 1-3.
  • 12. Post-Discharge Report 12 Measures Details Results Barriers to adherence Asks whether Rx were filled No barriers self-reported , and if not, reasons why not Morisky scale 8 item self-report 2/8 score medication adherence scale Modified CARDIA scale For each medication, self- 7/7 for all medications reported # of days in week meds were taken Electronic pill bottle # of days pill bottle was Aspirin 6/31 opened, divided by total # Statin 3/31 of days monitored B-blocker 2/31 Clopidogrel 0/31 Ye, Siqin, Krupka, David, & Davidson, Karina. (2012). Diagnosing medication non-adherence in a patient with myocardial infarction. Frontiers In Psychology, 3:267, 7.
  • 13. Study Results 13  Limitations to medication adherence for Mr. P  Low socioeconomic status  Lived alone  Distrust in medications efficacy  Belief medications being overused  Outcomes  Hypertension poorly controlled  Intermittent chest pain  Progression of coronary artery disease concern Ye, Siqin, Krupka, David, & Davidson, Karina. (2012). Diagnosing medication non-adherence in a patient with myocardial infarction. Frontiers In Psychology, 3:267, 4.
  • 14. Summary 14  What medication adherence is  Significance of adhering to medications  Barriers to proper medication adherence  Pharmacists and MTM services  Health outcomes and pharmacy administrators
  • 16. Resources 16  Adult Meducation. (2006). Overview of Medication Adherence. American Society on Aging and American Society of Consultant Pharmacists Foundation. Retrieved from http://www.adultmeducation.com/OverviewofMedicationAdherence_4.html.  Express Scripts (2012). Retrieved from http://lab.express-scripts.com/wp-content/uploads/ 2012/07/Americas_317B_Condition.pdf  Ho, P., Bryson, C., , & Rumsfeld, J. (2009). Medication adherence: its importance in cardiovascular outcomes. Circulation, 119(23), 3028-35. Retrieved from http:// www.ncbi.nlm.nih.gov/pubmed/19528344.  Osterberg, L., & Blaschke, T. (2005). Adherence to medication. New England journal of medicine, 353(5), 487-97. Retrieved from http://www.nejm.org/doi/full/ 10.1056/NEJMra050100.  Script Your Future. (2012). National Consumers League. Retrieved from http:// scriptyourfuture.org/medication-adherence/.  Ye, Siqin, Krupka, David, & Davidson, Karina. (2012). Diagnosing medication non- adherence in a patient with myocardial infarction. Frontiers In Psychology, 3:267, 1-7. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3411184/.

Editor's Notes

  1. Patient stated he could afford his medications and foresaw no difficulties in obtaining and filling medications.Morisky scale-POOR ADHERENCEElectronic pill bottle-POOR ADHERENCE