Carlo Urbani was the first to identify SARS as a new and contagious disease while working in Bangkok, Thailand in 2003. His early warning to the WHO helped trigger a large response that likely saved millions. SARS is caused by a coronavirus that leads to respiratory illness. An outbreak between 2002-2003 spread to over 30 countries and caused over 800 deaths. Symptoms include fever and pneumonia. Diagnosis involves testing for the virus or antibodies. Treatment is supportive and isolation is key to prevention.
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• Carlo Urbani (Castelplanio, Italy October 19,
1956 – Bangkok, Thailand March 29, 2003) was
an Italian physician and the first to identify
severe acute respiratory syndrome (SARS) as a
new and dangerously contagious disease.
Although he became infected and died, his early
warning to the World Health Organization
(WHO) touched off a massive response that
probably helped save the lives of millions of
people around the world.
4. Definition
• Severe acute respiratory syndrome (SARS) is a
respiratory disease in humans which is caused
by the SARS corona virus .
• It is a viral disease caused by a virus of Corona
respiratory viruses affecting mostly respiratory
organs.
5. Corona virus
• Corona viruses are positive
strand, enveloped RNA viruses
that are important pathogens
of mammals and birds. This
group of viruses causes enteric
or respiratory tract infections
in a variety of animals
including humans, livestock
and pets.
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• Between November 2002 and July 2003 an
outbreak of SARS in Hong Kong nearly became a
pandemic,
• with 8,422 cases and 916 deaths worldwide
(10.9% fatality) according to the WHO. Within
weeks SARS spread from Hong Kong to infect
individuals in 37 countries in early 2003.
9. Causes
• Droplets from coughing and sneezing and close
human contact
• By leaving respiratory droplets on objects, such
as door handles, doorbells, and telephones.
• The virus is likely to remain active in the
environment for several days.
11. • It is also possible to acquire the SARS virus by
touching a surface that has been contaminated
by the droplets projected from a person with
SARS. The person who touches a contaminated
surface must then touch their eyes or nose or
mouth to provide entry to the virus to the body.
12. Suspect SARS
• SARS may be suspected in a patient who
has:Any of the symptoms, including a fever of 38
°C (100.4 °F) or higher, and
• Either a history of:
- Contact (sexual or casual) with someone with a
diagnosis of SARS within the last 10 days OR
-Travel to any of the regions identified by the
WHO as areas with recent local transmission of
SARS (affected regions as of 10 May 2003[13]
were parts of China, Hong Kong, Singapore and
the province of Ontario, Canada).
17. • Pneumonia is a common complication, so a
person who develops unexplained pneumonia
and has a spent time in a place where there is an
outbreak should be suspected of having SARS.
18. Tests
Laboratory tests can help identify SARS-CoV.
• Reverse transcription-polymerase chain
reaction (RT-PCR) testing can detect the virus
in blood, stool, and nasal secretions.
•
• Serologic testing can detect SARS-CoV
antibodies in the blood. If a person has
antibodies, they are also likely to have the
infection.
19. Management
• Treatment of SARS so far has been largely
supportive with antipyretics, supplemental
oxygen and ventilatory support as needed.
• Isolation and Quarantine the best options.
21. • There was initially anecdotal support for
steroids and the antiviral drug ribavirin, but no
published evidence has supported this therapy
22. Prevention
• frequent handwashing
• avoiding touching the eyes, mouth
or
• nose with unclean hands
• covering the mouth and nose with a
tissue
23. Protect Healthcare Personnel During
Aerosol-Generating Procedures
• Limit personnel to those essential for
performing procedure
• Wear appropriate personal protective equipment
• Gowns and gloves
• Sealed eye protection (i.e., goggles)
• Respiratory protection device