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Life sciences, healthcare and medical technology
Enabling progress in innovation
About us


   ttopstart is a consultancy firm for business generation in the life
   sciences, healthcare and medical technology. We deliver the intelligence
   required for strategic decisions, develop strong business plans and realise
   business and project financing.
   ttopstart is passionate to turn groundbreaking innovations into profitable
   products and services.


   • INTELLIGENCE			 • TRUST			 • QUALITY




                                       3
technology




                healthcare




life sciences
SECTORS


Life Sciences                                                    Medical Technology
Novel medication for cancer patients, reliable diagnoses         Improved MRI scan results, 3D simulation of the human
based on gene profiling, enzymes as catalyst in chemistry:       body, telemonitoring of hearth patients: high-tech research
innovations in the Life sciences bring valuable technolo-        delivers exiting new technologies with a large impact
gies to society. However, successful commercialisation           on existing medical practice. In contrast the market is
of innovations is a major challenge due to hard to raise         highly competitive, products have a short life cycle and the
financing, long development trajectories, strict regula-         transparency in the application areas is not eminent. It is
tions and difficult reimbursement models. We work from           our commitment to identify the challenges that your tech-
the premise that science has to be combined with market          nology will face and anticipate accordingly.
intelligence to optimally leverage valuable innovations in
this challenging sector.

Healthcare
Increasing market force, pressure on reimbursement, an
aging population, demanding patients and automation
threaten the quality of healthcare. Innovations can con-
tribute in many ways to maintain and improve this quality.
In order to successfully introduce and finance healthcare
innovations ttopstart supports healthcare organizations
during the entire innovation process. Doing so, new prod-
ucts, services and processes are successfully implemented
in daily practice.
                                                             5
BUSINESS DEVELOPMENT

The healthcare and life sciences market is highly                  Business Plan
competitive and promising research does not guarantee              ttopstart offers the service to set up a sound and per-
successful commercialisation. Under influence of defiant           suasive business plan for new activities. It is our task to
conditions your business should be cleverly shaped.                visualise your plans, deliver key market insights and assess
ttopstart is specialised in analysing the options for com-         commercial and financial feasibility. Your business plan
mercial activity and in calculating feasibility of different       with ttopstart label will allow you to objectively review
concepts. Based on such crucial information we offer               the concept and to convince investors to provide financial
support in setting up a strong business plan. With our             backup.
support, a number of clients has been able to determine
the best route of commercialisation and to convince stake-         Business Case
holders and investors of their business concept. By sup-           In early stages of commercialisation a business case offers
porting business development activities, ttopstart is able         rapid insight in the added value of innovations. Such docu-
to offer entrepreneurs and organizations the extra tools           ment is helpful to inform third parties on your plans and
to manage a healthy business.                                      allows you to quickly oversee commercial routes. This gives
                                                                   you the essential basis for further development. ttopstart
                                                                   is dedicated to support you in formulating a well-struc-
                                                                   tured business case, built on relevant market information.

                                                                   Project Management
                                                                   During innovation processes it is crucial to initiate and
                                                                   continue management activities in addition to product
                                                                   development. We are able to support you in carrying
                                                                   part of these responsibilities. Please contact us for more
                                                                   information.
                                                               6
“Thanks to ttopstart, DCPrime has
access to market insights and other
intelligence needed for preparation
of its VC and company presentations.”




Prof. Dr. A.M. (Ada) Kruisbeek, CEO/CSO DCPrime B.V.
ttopstart brochure
INTELLIGENCE

Reliable market information is of key importance in set-              Market research
ting up business activities. Strategic decisions have to              In landscaping your market, we use our extensive network
be based on insights in market size, segmentation, the                and consult direct stakeholders and experts. Furthermore,
competitive landscape, the latest state of art and reim-              we dig into proprietary databases and analyse competi-
bursement options. Besides, the IP landscape influences               tive behavior. We present these data in a transparent and
the potential of winning a strong market position. For this           structured report and talk you through the most impor-
reason it is crucial to identify key opportunities and to             tant conclusions. This will not only give you an apprehen-
determine the market impact of your innovation.                       sion of market statistics and trends, but also provides you
By consulting key opinion leaders and market players we               with essential information on potential customers and
are able to map niche markets, identify critical unmet                market opportunities.
medical needs and recognise interesting business oppor-
tunities. Based on the objective market view generated by             IP Landscaping
ttopstart, you will be able to comprehend commercial and              By mapping the IP landscape of your innovation we offer
technological feasibility.                                            you insight into potential prior art and into competitive
                                                                      activities. We are skilled in patent database searches and
                                                                      deliver a lucid IP overview.




         “For the VIRGO consortium, we are continuously looking for new opportunities for which
         a business plan or market analysis is essential. ttopstart has gained our trust by delivering
         high-quality information for decision making.”
         Prof.Dr. E.H.J.H.M (Eric) Claassen, Valorisation Manager VIRGO Consortium and CEO of Vironovative BV

                                                                  9
FINANCING


For every business activity, financing is essential. ttopstart    Subsidies
supports by mapping the financing opportunities and               The ttopstart team has a background in both life sciences/
actively contributes in their raising. It is our expertise to     healthcare and business and is therefore able to rapidly
support the financing of the following activities:                translate scientific concepts into strong propositions. We
                                                                  are specialised in translational and commercially targeted
   • 	Translational research                                      subsidies.
   • 	Commercialisation or valorisation of research
   •	Start an innovative company                                  Subsidy scan
   •	Upscaling and internationalisation of commercial 			         We can provide you with a complete and tailored overview
   	 activities                                                   of subsidies and other financial means for which your
   • 	Targeting new markets                                       company or project is eligible.
   • 	Starting innovative healthcare concepts
   • 	Strengthening of your proposition towards industry          Private capital
                                                                  Venture capital, bank loans and innovation credit: ttopstart
For this, we use a wide variety of financial resources,           provides optimal advice to maximize your finance possi-
including national and international subsidies, patient           bilities.
societies and funds, bank loans, innovation credit, tax
incentives and risk capital.




                                                                 10
“The application for subsidies and grants is extraordinary
complex. ttopstart offered us the most promising opportu-
nities and a realistic outlook on the chance for success. It is
pleasant that they support you during the whole process.
So far we have received all the grants we applied for thanks
to the support of ttopstart.”




Dr. S.A. (Servaas) Morré, CSO Microbiome Ltd.
ttopstart brochure
CLIENT PROFILES


The TU/e Innovation Lab in Eindhoven fulfils an active and             Steef Blok: “For us, ttopstart delivers capacity and profes-
supportive role in relation to knowledge valorisation and              sionalism. They have the brains to deliver high quality
innovation. They encourage entrepreneurship by identifying,            products that make us able to assist promising research
supporting and providing guidance for potential high-tech              even better. Our projects are highly divers. The flexibility
startups and spin-off companies originating at the TU Eind-            of ttopstart makes it possible to join forces on a variety of
hoven. For innovative research in Eindhoven the assistance             projects.”
of the Innovation Lab is probably the most familiar first step
towards commercial success.

The Innovation Lab works together with ttopstart on several
projects to offer promising researchers the tools they need for
optimal valorisation. The role of ttopstart in assisting these
projects is diverse. Depending on the needs of the clients, the
Innovation Lab asks ttopstart to take care of either a business
plan; to carry out market research or to assist in acquiring
public and private capital for a project.

As a team the TU/e Innovation Lab and ttopstart were able
to assist the valorisation of promising research projects in
medical technology and healthcare. The trustworthy relation
has resulted in the successful progress of cutting edge tech-
nology towards society and industry.

                                                                  13
Microbiome Ltd. is a molecular diagnostics company in the              Because setting up a subsidy application is a time consum-
field of infectious diseases. As a spin-off from the VU Univer-        ing task that requires full attention, ttopstart took care of the
sity medical center in Amsterdam, Microbiome is active in the          complete process. To make the proposition as persuasive and
discovery, manufacturing and marketing of microbiological              lucid as possible multiple experts within the field and key
techniques, tools, systems and characterisations. In 2008 the          decision makers where consulted.
company received the Amsterdam Innovation Award for the
groundbreaking research concerning Chlamydia testing and               Microbiome successfully applied for a EuroTransBio grant of
in 2011 they were nominated for the FD-Gazellen award                  660.000 EUR for the development of the diagnostic test. The
                                                                       grant enables the company to further develop the diagnostic
One of the R&D programs of Microbiome is the development               test.
of a certified host genetic based diagnostic test to assess
Chlamydia trachomatis (CT) and other Sexually Transmitted                 Dr. Servaas Morré: “The application for subsidies and
Diseases (STD) associated tubal damage in subfertile women                grants is extraordinary complex. ttopstart offered us the
to triage subfertile better for laparoscopy as compared to CT             most promising opportunities and a realistic outlook on
serology only.                                                            the chance for success. It is pleasant that they support you
                                                                          during the whole process. So far we have received all the
To realise sufficient funding for R&D, Microbiome works                   grants we applied for thanks to the support of ttopstart.”
together with ttopstart. In a close cooperation ttopstart                 Patrick de Boer MSc: “Microbiome has several promising
investigated the possibilities for Microbiome to receive                  R&D projects that are close to market. Therefore, we sup-
funding for the development of the genetic test. After select-            ported Microbiome in attracting funding specifically for
ing the most promising funding possibilities, it was decided              SMEs. With these proceeds, Microbiome is able to validate,
to apply for a European and National subsidy program.                     certify and market their diagnostic test”.

                                                                  14
Contact


Bilthoven
P.C. Staalweg 30
3721 TJ Bilthoven
Tel: +31 30 73 70 779

Mailing address
Postbus 7881
1008 AB Amsterdam

info@ttopstart.nl
www. ttopstart.nl
www.ttopstart.nl

More Related Content

ttopstart brochure

  • 1. Life sciences, healthcare and medical technology
  • 2. Enabling progress in innovation
  • 3. About us ttopstart is a consultancy firm for business generation in the life sciences, healthcare and medical technology. We deliver the intelligence required for strategic decisions, develop strong business plans and realise business and project financing. ttopstart is passionate to turn groundbreaking innovations into profitable products and services. • INTELLIGENCE • TRUST • QUALITY 3
  • 4. technology healthcare life sciences
  • 5. SECTORS Life Sciences Medical Technology Novel medication for cancer patients, reliable diagnoses Improved MRI scan results, 3D simulation of the human based on gene profiling, enzymes as catalyst in chemistry: body, telemonitoring of hearth patients: high-tech research innovations in the Life sciences bring valuable technolo- delivers exiting new technologies with a large impact gies to society. However, successful commercialisation on existing medical practice. In contrast the market is of innovations is a major challenge due to hard to raise highly competitive, products have a short life cycle and the financing, long development trajectories, strict regula- transparency in the application areas is not eminent. It is tions and difficult reimbursement models. We work from our commitment to identify the challenges that your tech- the premise that science has to be combined with market nology will face and anticipate accordingly. intelligence to optimally leverage valuable innovations in this challenging sector. Healthcare Increasing market force, pressure on reimbursement, an aging population, demanding patients and automation threaten the quality of healthcare. Innovations can con- tribute in many ways to maintain and improve this quality. In order to successfully introduce and finance healthcare innovations ttopstart supports healthcare organizations during the entire innovation process. Doing so, new prod- ucts, services and processes are successfully implemented in daily practice. 5
  • 6. BUSINESS DEVELOPMENT The healthcare and life sciences market is highly Business Plan competitive and promising research does not guarantee ttopstart offers the service to set up a sound and per- successful commercialisation. Under influence of defiant suasive business plan for new activities. It is our task to conditions your business should be cleverly shaped. visualise your plans, deliver key market insights and assess ttopstart is specialised in analysing the options for com- commercial and financial feasibility. Your business plan mercial activity and in calculating feasibility of different with ttopstart label will allow you to objectively review concepts. Based on such crucial information we offer the concept and to convince investors to provide financial support in setting up a strong business plan. With our backup. support, a number of clients has been able to determine the best route of commercialisation and to convince stake- Business Case holders and investors of their business concept. By sup- In early stages of commercialisation a business case offers porting business development activities, ttopstart is able rapid insight in the added value of innovations. Such docu- to offer entrepreneurs and organizations the extra tools ment is helpful to inform third parties on your plans and to manage a healthy business. allows you to quickly oversee commercial routes. This gives you the essential basis for further development. ttopstart is dedicated to support you in formulating a well-struc- tured business case, built on relevant market information. Project Management During innovation processes it is crucial to initiate and continue management activities in addition to product development. We are able to support you in carrying part of these responsibilities. Please contact us for more information. 6
  • 7. “Thanks to ttopstart, DCPrime has access to market insights and other intelligence needed for preparation of its VC and company presentations.” Prof. Dr. A.M. (Ada) Kruisbeek, CEO/CSO DCPrime B.V.
  • 9. INTELLIGENCE Reliable market information is of key importance in set- Market research ting up business activities. Strategic decisions have to In landscaping your market, we use our extensive network be based on insights in market size, segmentation, the and consult direct stakeholders and experts. Furthermore, competitive landscape, the latest state of art and reim- we dig into proprietary databases and analyse competi- bursement options. Besides, the IP landscape influences tive behavior. We present these data in a transparent and the potential of winning a strong market position. For this structured report and talk you through the most impor- reason it is crucial to identify key opportunities and to tant conclusions. This will not only give you an apprehen- determine the market impact of your innovation. sion of market statistics and trends, but also provides you By consulting key opinion leaders and market players we with essential information on potential customers and are able to map niche markets, identify critical unmet market opportunities. medical needs and recognise interesting business oppor- tunities. Based on the objective market view generated by IP Landscaping ttopstart, you will be able to comprehend commercial and By mapping the IP landscape of your innovation we offer technological feasibility. you insight into potential prior art and into competitive activities. We are skilled in patent database searches and deliver a lucid IP overview. “For the VIRGO consortium, we are continuously looking for new opportunities for which a business plan or market analysis is essential. ttopstart has gained our trust by delivering high-quality information for decision making.” Prof.Dr. E.H.J.H.M (Eric) Claassen, Valorisation Manager VIRGO Consortium and CEO of Vironovative BV 9
  • 10. FINANCING For every business activity, financing is essential. ttopstart Subsidies supports by mapping the financing opportunities and The ttopstart team has a background in both life sciences/ actively contributes in their raising. It is our expertise to healthcare and business and is therefore able to rapidly support the financing of the following activities: translate scientific concepts into strong propositions. We are specialised in translational and commercially targeted • Translational research subsidies. • Commercialisation or valorisation of research • Start an innovative company Subsidy scan • Upscaling and internationalisation of commercial We can provide you with a complete and tailored overview activities of subsidies and other financial means for which your • Targeting new markets company or project is eligible. • Starting innovative healthcare concepts • Strengthening of your proposition towards industry Private capital Venture capital, bank loans and innovation credit: ttopstart For this, we use a wide variety of financial resources, provides optimal advice to maximize your finance possi- including national and international subsidies, patient bilities. societies and funds, bank loans, innovation credit, tax incentives and risk capital. 10
  • 11. “The application for subsidies and grants is extraordinary complex. ttopstart offered us the most promising opportu- nities and a realistic outlook on the chance for success. It is pleasant that they support you during the whole process. So far we have received all the grants we applied for thanks to the support of ttopstart.” Dr. S.A. (Servaas) Morré, CSO Microbiome Ltd.
  • 13. CLIENT PROFILES The TU/e Innovation Lab in Eindhoven fulfils an active and Steef Blok: “For us, ttopstart delivers capacity and profes- supportive role in relation to knowledge valorisation and sionalism. They have the brains to deliver high quality innovation. They encourage entrepreneurship by identifying, products that make us able to assist promising research supporting and providing guidance for potential high-tech even better. Our projects are highly divers. The flexibility startups and spin-off companies originating at the TU Eind- of ttopstart makes it possible to join forces on a variety of hoven. For innovative research in Eindhoven the assistance projects.” of the Innovation Lab is probably the most familiar first step towards commercial success. The Innovation Lab works together with ttopstart on several projects to offer promising researchers the tools they need for optimal valorisation. The role of ttopstart in assisting these projects is diverse. Depending on the needs of the clients, the Innovation Lab asks ttopstart to take care of either a business plan; to carry out market research or to assist in acquiring public and private capital for a project. As a team the TU/e Innovation Lab and ttopstart were able to assist the valorisation of promising research projects in medical technology and healthcare. The trustworthy relation has resulted in the successful progress of cutting edge tech- nology towards society and industry. 13
  • 14. Microbiome Ltd. is a molecular diagnostics company in the Because setting up a subsidy application is a time consum- field of infectious diseases. As a spin-off from the VU Univer- ing task that requires full attention, ttopstart took care of the sity medical center in Amsterdam, Microbiome is active in the complete process. To make the proposition as persuasive and discovery, manufacturing and marketing of microbiological lucid as possible multiple experts within the field and key techniques, tools, systems and characterisations. In 2008 the decision makers where consulted. company received the Amsterdam Innovation Award for the groundbreaking research concerning Chlamydia testing and Microbiome successfully applied for a EuroTransBio grant of in 2011 they were nominated for the FD-Gazellen award 660.000 EUR for the development of the diagnostic test. The grant enables the company to further develop the diagnostic One of the R&D programs of Microbiome is the development test. of a certified host genetic based diagnostic test to assess Chlamydia trachomatis (CT) and other Sexually Transmitted Dr. Servaas Morré: “The application for subsidies and Diseases (STD) associated tubal damage in subfertile women grants is extraordinary complex. ttopstart offered us the to triage subfertile better for laparoscopy as compared to CT most promising opportunities and a realistic outlook on serology only. the chance for success. It is pleasant that they support you during the whole process. So far we have received all the To realise sufficient funding for R&D, Microbiome works grants we applied for thanks to the support of ttopstart.” together with ttopstart. In a close cooperation ttopstart Patrick de Boer MSc: “Microbiome has several promising investigated the possibilities for Microbiome to receive R&D projects that are close to market. Therefore, we sup- funding for the development of the genetic test. After select- ported Microbiome in attracting funding specifically for ing the most promising funding possibilities, it was decided SMEs. With these proceeds, Microbiome is able to validate, to apply for a European and National subsidy program. certify and market their diagnostic test”. 14
  • 15. Contact Bilthoven P.C. Staalweg 30 3721 TJ Bilthoven Tel: +31 30 73 70 779 Mailing address Postbus 7881 1008 AB Amsterdam info@ttopstart.nl www. ttopstart.nl