In recent years, the growth of scientific data and the increasing need for data sharing and collaboration in the field of environmental chemistry has led to the creation of various software and databases that facilitate research and development into the safety and toxicity of chemicals. The US-EPA Center for Computational Toxicology and Exposure has been developing software and databases that serve the chemistry community for many years. This presentation will focus on several web-based software applications which have been developed at the USEPA and made available to the community. While the primary software application from the Center is the CompTox Chemicals Dashboard which provides access to data for >1.2 million chemicals (https://comptox.epa.gov/dashboard), almost a dozen proof-of-concept applications have been built serving various capabilities. The publicly accessible proof-of-concept Cheminformatics Modules (https://www.epa.gov/chemicalresearch/cheminformatics) provides access to multiple applications in development allowing for hazard comparison for sets of chemicals, structure-substructure-similarity searching, structure alerts and batch QSAR prediction of both physicochemical and toxicity endpoints. A number of other applications, presently in development but not publicly accessible will also be discussed. These include AMOS, the database of Analytical Methods and Open Spectra.
Analytical methods can vary in nature from detailed regulatory methods to more summary in nature. Regulatory method documents can include details of analytes which can be studied, supported matrices, reagents, methodological details, statistical performance, interlaboratory validation and other details. Summary methods provide a general overview of reagents, instrumentation and commonly a short list of analytes. Regulatory bodies including the US Environmental Protection Agency (US-EPA), US Geological Survey (USGS), US Department of Agriculture (USDA) and others provide detailed analytical methods and collections of summary methods from the agrochemical industry, such as the US-EPA Environmental Chemistry Methods (https://www.epa.gov/pesticide-analytical-methods/environmental-chemistry-methods-ecm). Instrument vendors also provide access to many hundreds of application notes which can be considered as summary methods. AMOS presently contains >4,500 methods integrated to their chemical structures and > 230,000 public domain mass spectral data. AMOS allows for filtering of methods based on analyte, chemical class, method source and other related metadata. AMOS is an important facet of the developing Non-Targeted Analysis WebApp presently also in development at the EPA.
This presentation will provide an overview of existing publicly accessible Dashboards and work in progress to support analysis of pesticides, veterinary drug residues, and other chemicals in food, animal feed, and environmental samples.
Giant exoplanets orbiting close to their host stars are unlikely to have formed in
their present confgurations1
. These âhot Jupiterâ planets are instead thought to have
migrated inward from beyond the ice line and several viable migration channels
have been proposed, including eccentricity excitation through angular-momentum
exchange with a third body followed by tidally driven orbital circularization2,3
. The
discovery of the extremely eccentric (eâ=â0.93) giant exoplanet HDâ80606âb (ref.â4)
provided observational evidence that hot Jupiters may have formed through
this high-eccentricity tidal-migration pathway5
. However, no similar hot-Jupiter
progenitors have been found and simulations predict that one factor afecting the
efcacy of this mechanism is exoplanet mass, as low-mass planets are more likely to
be tidally disrupted during periastron passage6â8
. Here we present spectroscopic and
photometric observations of TICâ241249530âb, a high-mass, transiting warm Jupiter
with an extreme orbital eccentricity of eâ=â0.94. The orbit of TICâ241249530âb is
consistent with a history of eccentricity oscillations and a future tidal circularization
trajectory. Our analysis of the mass and eccentricity distributions of the transitingwarm-Jupiter population further reveals a correlation between high mass and high
eccentricity.
We report Bayesian inference of the mass, radius and hot X-ray emitting region properties - using data
from the Neutron Star Interior Composition ExploreR (NICER) - for the brightest rotation-powered
millisecond X-ray pulsar PSR J0437â4715. Our modeling is conditional on informative tight priors
on mass, distance and binary inclination obtained from radio pulsar timing using the Parkes Pulsar
Timing Array (PPTA) (Reardon et al. 2024), and we use NICER background models to constrain
the non-source background, cross-checking with data from XMM-Newton. We assume two distinct
hot emitting regions, and various parameterized hot region geometries that are defined in terms of
overlapping circles; while simplified, these capture many of the possibilities suggested by detailed
modeling of return current heating. For the preferred model identified by our analysis we infer a mass
of M = 1.418 ± 0.037 Mâ (largely informed by the PPTA mass prior) and an equatorial radius of
R = 11.36+0.95
â0.63 km, each reported as the posterior credible interval bounded by the 16% and 84%
quantiles. This radius favors softer dense matter equations of state and is highly consistent with
constraints derived from gravitational wave measurements of neutron star binary mergers. The hot
regions are inferred to be non-antipodal, and hence inconsistent with a pure centered dipole magnetic
field.
This pdf is about the Structure of Sperm / Spermatozoon.
For more details visit on YouTube; @SELF-EXPLANATORY; https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Types of Hypersensitivity Reactions.pptxIsha Pandey
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Hypersensitivity as an immunological dysfunction is defined as exaggerated or inappropriate response of the immune system. Hypersensitivity can be classified into four types; namely, type I (Immediate), type II (antibody-mediated), type III (immune complex-mediated), and type IV (cell-mediated or delayed-type) hypersensitivity.
Type I hypersensitivity or allergy, the most common immune disorder, is mainly mediated by immunoglobulin (Ig)E and mast cells. It can cause anaphylaxis, food allergy, and asthma.
Type II hypersensitivity can lead to tissue damage by three main mechanisms: (1) direct cellular destruction (e.g., autoimmune hemolytic anemia and immune thrombocytopenia, (2) inflammation (e.g., Goodpasture's syndrome and acute rheumatic fever), and (3) disrupting cellular function (e.g., myasthenia gravis and Gravesâ disease).
Type III hypersensitivity is caused by excess production of immune complexes or impaired clearance of them and includes serum sickness, systemic lupus erythematosus, and post-streptococcal glomerulonephritis.
Type IV hypersensitivity is mediated by T cells and macrophages, causing diseases like multiple sclerosis and rheumatoid arthritis.
Phytoremediation: Harnessing Nature's Power with PhytoremediationGurjant Singh
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This document provides an overview of phytoremediation, which uses plants to remove contaminants from soil, sediment, or water. It discusses the need for new remediation techniques, describes various phytoremediation processes like phytoextraction and rhizofiltration, and covers important concepts like hyperaccumulators, biotechnology applications, case studies, and advantages/limitations. The author aims to explain the mechanisms, history, types of plants used, and future research directions of this eco-friendly approach to environmental cleanup.
PART 1 & PART 2 The New Natural Principles of Newtonian Mechanics, Electromec...Thane Heins
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PART 1
The New Natural Principles of Newtonian Mechanics, Electromechanics, Electrodynamics, Electromagnetism and Electromagnetic Field Energy
PART 2
How Electromagnetic Field Energy is Created and
Destroyed (absorbed)
in a Current Carrying Conductor
We present the second data release (DR2) of the Far-Infrared Polarimetric Large-Area CMZ Exploration (FIREPLACE) survey. This survey utilized the Stratospheric Observatory for Infrared Astronomy (SOFIA) High-resolution Airborne Wideband Camera plus (HAWC+) instrument at 214 ”m
(E-band) to observe dust polarization throughout the Central Molecular Zone (CMZ) of the Milky
Way. DR2 consists of observations that were obtained in 2022 covering the region of the CMZ extending roughly from the Brick to the Sgr C molecular clouds (corresponding to a roughly 1⊠à 0.75âŠ
region
of the sky). We combine DR2 with the first FIREPLACE data release covering the Sgr B2 region to
obtain full coverage of the CMZ (a 1.5⊠Ă0.75âŠ
region of the sky). After applying total and polarized
intensity significance cuts on the full FIREPLACE data set we obtain âŒ65,000 Nyquist-sampled polarization pseudovectors. The distribution of polarization pseudovectors confirms a bimodal distribution
in the CMZ magnetic field orientations, recovering field components that are oriented predominantly
parallel or perpendicular to the Galactic plane. These magnetic field orientations indicate possible
connections between the previously observed parallel and perpendicular distributions. We also inspect
the magnetic fields toward a set of prominent CMZ molecular clouds (the Brick, Three Little Pigs,
50 km sâ1
, Circum-nuclear Disk, CO 0.02-0.02, 20 km sâ1
, and Sgr C), revealing spatially varying
magnetic fields that generally trace the morphologies of the clouds. We find evidence that compression
from stellar winds and shear from tidal forces are prominent mechanisms influencing the structure of
the magnetic fields observed within the clouds.
Saturnâs moon Titan was explored by the Cassini spacecraft from 2004 to 2017.
While Cassini revealed a lot about this Earth-like world, its radar observations
could only provide limited information about Titanâs liquid hydrocarbons seas
Kraken, Ligeia and Punga Mare. Here, we show the results of the analysis of the
Cassini mission bistatic radar experiments data of Titanâs polar seas. The dualpolarized nature of bistatic radar observations allow independent estimates of
effective relative dielectric constant and small-scale roughness of sea surface,
which were not possible via monostatic radar data. We find statistically significant variations in effective dielectric constant (i.e., liquid composition),
consistent with a latitudinal dependence in the methane-ethane mixing-ratio.
The results on estuaries suggest lower values than the open seas, compatible
with methane-rich rivers entering seas with higher ethane content. We estimate small-scale roughness of a few millimeters from the almost purely
coherent scattering from the sea surface, hinting at the presence of capillary
waves. This roughness is concentrated near estuaries and inter-basin straits,
perhaps indicating active tidal currents.
Ascertaining the morphology and composition of the icy mantles covering
dust grains in dense, cold regions of the interstellar medium is essential to
developing accurate astrochemical models, determining conditions for
ice formation, constraining chemical interactions in and on icy grains and
understanding how ices withstand space radiation. The widely observed
infrared spectroscopic signature of H2O ice at ~3âÎŒm discriminates crystalline
from amorphous structures in interstellar ices. Weaker bands seen only in
laboratory ice spectra at ~2.7âÎŒm, termed âdangling OHâ (dOH), are attributed
to water molecules not fully bound to neighbouring water molecules and
are often considered as tracing the degree of ice compaction. We exploit
the high sensitivity of JWST NIRCam to detect two dOH features at 2.703 and
2.753âÎŒm along multiple lines of sight probing the dense cloud Chamaeleon
I, attributing these signatures to unbound dOH in cold water ice and dOH in
interaction with other molecular species. These detections open a path to
using the dOH features as tracers of the formation, composition, morphology
and evolution of icy grains during the star and planet formation process.
The All-Domain Anomaly Resolution Office (AARO) sponsored a series of measurements on a layered material
specimen primarily composed of magnesium and zinc, with bands of bismuth and other co-located trace elements.
The material specimen, whose origin and purpose are of long and debated history, is claimed to be recovered
from an unidentified anomalous phenomenon (UAP) crash in or around 1947. Furthermore, the specimenâs
physiochemical properties are claimed to make the material capable of âinertial mass reductionâ (i.e., levitation or
antigravity functionality), possibly attributable to the materialâs bismuth and magnesium layers acting as a terahertz
waveguide
How Race, Age and Gender Shape Attitudes Towards Mental HealthThinkNow
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Mental health has been in the news quite a bit lately. Dozens of U.S. states are currently suing Meta for contributing to the youth mental health crisis by inserting addictive features into their products, while the U.S. Surgeon General is touring the nation to bring awareness to the growing epidemic of loneliness and isolation. The country has endured periods of low national morale, such as in the 1970s when high inflation and the energy crisis worsened public sentiment following the Vietnam War. The current mood, however, feels different. Gallup recently reported that national mental health is at an all-time low, with few bright spots to lift spirits.
To better understand how Americans are feeling and their attitudes towards mental health in general, ThinkNow conducted a nationally representative quantitative survey of 1,500 respondents and found some interesting differences among ethnic, age and gender groups.
Technology
For example, 52% agree that technology and social media have a negative impact on mental health, but when broken out by race, 61% of Whites felt technology had a negative effect, and only 48% of Hispanics thought it did.
While technology has helped us keep in touch with friends and family in faraway places, it appears to have degraded our ability to connect in person. Staying connected online is a double-edged sword since the same news feed that brings us pictures of the grandkids and fluffy kittens also feeds us news about the wars in Israel and Ukraine, the dysfunction in Washington, the latest mass shooting and the climate crisis.
Hispanics may have a built-in defense against the isolation technology breeds, owing to their large, multigenerational households, strong social support systems, and tendency to use social media to stay connected with relatives abroad.
Age and Gender
When asked how individuals rate their mental health, men rate it higher than women by 11 percentage points, and Baby Boomers rank it highest at 83%, saying itâs good or excellent vs. 57% of Gen Z saying the same.
Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation thatâs least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state theyâre comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
As seen in previous research conducted by ThinkNow, Asian Americans lag other groups when it comes to awareness of mental health issues. Twenty-four percent of Asian Americans believe that having a mental health issue is a sign of weakness compared to the 16% average for all groups. Asians are also considerably less likely to be aware of mental health services in their communities (42% vs. 55%) and most likely to seek out information on social media (51% vs. 35%).
AI Trends in Creative Operations 2024 by Artwork Flow.pdfmarketingartwork
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Creative operations teams expect increased AI use in 2024. Currently, over half of tasks are not AI-enabled, but this is expected to decrease in the coming year. ChatGPT is the most popular AI tool currently. Business leaders are more actively exploring AI benefits than individual contributors. Most respondents do not believe AI will impact workforce size in 2024. However, some inhibitions still exist around AI accuracy and lack of understanding. Creatives primarily want to use AI to save time on mundane tasks and boost productivity.
Organizational culture includes values, norms, systems, symbols, language, assumptions, beliefs, and habits that influence employee behaviors and how people interpret those behaviors. It is important because culture can help or hinder a company's success. Some key aspects of Netflix's culture that help it achieve results include hiring smartly so every position has stars, focusing on attitude over just aptitude, and having a strict policy against peacocks, whiners, and jerks.
PEPSICO Presentation to CAGNY Conference Feb 2024Neil Kimberley
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PepsiCo provided a safe harbor statement noting that any forward-looking statements are based on currently available information and are subject to risks and uncertainties. It also provided information on non-GAAP measures and directing readers to its website for disclosure and reconciliation. The document then discussed PepsiCo's business overview, including that it is a global beverage and convenient food company with iconic brands, $91 billion in net revenue in 2023, and nearly $14 billion in core operating profit. It operates through a divisional structure with a focus on local consumers.
Content Methodology: A Best Practices Report (Webinar)contently
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This document provides an overview of content methodology best practices. It defines content methodology as establishing objectives, KPIs, and a culture of continuous learning and iteration. An effective methodology focuses on connecting with audiences, creating optimal content, and optimizing processes. It also discusses why a methodology is needed due to the competitive landscape, proliferation of channels, and opportunities for improvement. Components of an effective methodology include defining objectives and KPIs, audience analysis, identifying opportunities, and evaluating resources. The document concludes with recommendations around creating a content plan, testing and optimizing content over 90 days.
How to Prepare For a Successful Job Search for 2024Albert Qian
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The document provides guidance on preparing a job search for 2024. It discusses the state of the job market, focusing on growth in AI and healthcare but also continued layoffs. It recommends figuring out what you want to do by researching interests and skills, then conducting informational interviews. The job search should involve building a personal brand on LinkedIn, actively applying to jobs, tailoring resumes and interviews, maintaining job hunting as a habit, and continuing self-improvement. Once hired, the document advises setting new goals and keeping skills and networking active in case of future opportunities.
Trends In Paid Search: Navigating The Digital Landscape In 2024Search Engine Journal
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The search marketing landscape is evolving rapidly with new technologies, and professionals, like you, rely on innovative paid search strategies to meet changing demands.
Itâs important that youâre ready to implement new strategies in 2024.
Check this out and learn the top trends in paid search advertising that are expected to gain traction, so you can drive higher ROI more efficiently in 2024.
Youâll learn:
- The latest trends in AI and automation, and what this means for an evolving paid search ecosystem.
- New developments in privacy and data regulation.
- Emerging ad formats that are expected to make an impact next year.
Watch Sreekant Lanka from iQuanti and Irina Klein from OneMain Financial as they dive into the future of paid search and explore the trends, strategies, and technologies that will shape the search marketing landscape.
If youâre looking to assess your paid search strategy and design an industry-aligned plan for 2024, then this webinar is for you.
5 Public speaking tips from TED - Visualized summarySpeakerHub
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From their humble beginnings in 1984, TED has grown into the worldâs most powerful amplifier for speakers and thought-leaders to share their ideas. They have over 2,400 filmed talks (not including the 30,000+ TEDx videos) freely available online, and have hosted over 17,500 events around the world.
With over one billion views in a year, itâs no wonder that so many speakers are looking to TED for ideas on how to share their message more effectively.
The article â5 Public-Speaking Tips TED Gives Its Speakersâ, by Carmine Gallo for Forbes, gives speakers five practical ways to connect with their audience, and effectively share their ideas on stage.
Whether you are gearing up to get on a TED stage yourself, or just want to master the skills that so many of their speakers possess, these tips and quotes from Chris Anderson, the TED Talks Curator, will encourage you to make the most impactful impression on your audience.
See the full article and more summaries like this on SpeakerHub here: https://speakerhub.com/blog/5-presentation-tips-ted-gives-its-speakers
See the original article on Forbes here:
http://www.forbes.com/forbes/welcome/?toURL=http://www.forbes.com/sites/carminegallo/2016/05/06/5-public-speaking-tips-ted-gives-its-speakers/&refURL=&referrer=#5c07a8221d9b
ChatGPT and the Future of Work - Clark Boyd Clark Boyd
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Everyone is in agreement that ChatGPT (and other generative AI tools) will shape the future of work. Yet there is little consensus on exactly how, when, and to what extent this technology will change our world.
Businesses that extract maximum value from ChatGPT will use it as a collaborative tool for everything from brainstorming to technical maintenance.
For individuals, now is the time to pinpoint the skills the future professional will need to thrive in the AI age.
Check out this presentation to understand what ChatGPT is, how it will shape the future of work, and how you can prepare to take advantage.
The document provides career advice for getting into the tech field, including:
- Doing projects and internships in college to build a portfolio.
- Learning about different roles and technologies through industry research.
- Contributing to open source projects to build experience and network.
- Developing a personal brand through a website and social media presence.
- Networking through events, communities, and finding a mentor.
- Practicing interviews through mock interviews and whiteboarding coding questions.
Google's Just Not That Into You: Understanding Core Updates & Search IntentLily Ray
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1. Core updates from Google periodically change how its algorithms assess and rank websites and pages. This can impact rankings through shifts in user intent, site quality issues being caught up to, world events influencing queries, and overhauls to search like the E-A-T framework.
2. There are many possible user intents beyond just transactional, navigational and informational. Identifying intent shifts is important during core updates. Sites may need to optimize for new intents through different content types and sections.
3. Responding effectively to core updates requires analyzing "before and after" data to understand changes, identifying new intents or page types, and ensuring content matches appropriate intents across video, images, knowledge graphs and more.
A brief introduction to DataScience with explaining of the concepts, algorithms, machine learning, supervised and unsupervised learning, clustering, statistics, data preprocessing, real-world applications etc.
It's part of a Data Science Corner Campaign where I will be discussing the fundamentals of DataScience, AIML, Statistics etc.
Time Management & Productivity - Best PracticesVit Horky
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Here's my presentation on by proven best practices how to manage your work time effectively and how to improve your productivity. It includes practical tips and how to use tools such as Slack, Google Apps, Hubspot, Google Calendar, Gmail and others.
The six step guide to practical project managementMindGenius
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The six step guide to practical project management
If you think managing projects is too difficult, think again.
Weâve stripped back project management processes to the
basics â to make it quicker and easier, without sacrificing
the vital ingredients for success.
âIf youâre looking for some real-world guidance, then The Six Step Guide to Practical Project Management will help.â
Dr Andrew Makar, Tactical Project Management
Unlocking the Power of ChatGPT and AI in Testing - A Real-World Look, present...Applitools
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During this webinar, Anand Bagmar demonstrates how AI tools such as ChatGPT can be applied to various stages of the software development life cycle (SDLC) using an eCommerce application case study. Find the on-demand recording and more info at https://applitools.info/b59
Key takeaways:
âą Learn how to use ChatGPT to add AI power to your testing and test automation
âą Understand the limitations of the technology and where human expertise is crucial
âą Gain insight into different AI-based tools
âą Adopt AI-based tools to stay relevant and optimize work for developers and testers
* ChatGPT and OpenAI belong to OpenAI, L.L.C.
The document discusses various AI tools from OpenAI like GPT-3 and DALL-E 2, as well as ChatGPT. It explores how search engines are using AI and things to consider around AI-generated content. Potential SEO uses of ChatGPT are also presented, such as generating content at scale, conducting topic research, and automating basic coding tasks. The document encourages further reading on using ChatGPT for SEO purposes.