Geno Germano, President of U.S. and General Manager of Wyeth Pharmaceuticals, presented at the Cowen Health Care Conference on March 13, 2007. He discussed Wyeth's strong financial growth in 2006, new commercial models being implemented, and upcoming FDA submissions including Pristiq for depression and menopausal symptoms. Germano emphasized building a diverse and stronger company through top line growth, cost management, and outpacing revenue growth with bottom line growth.
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wyeth Cowen and Company Annual Health Care Conference
1. Cowen Health Care Conference
Geno Germano
President – U.S. and General Manager
Wyeth Pharmaceuticals
March 13, 2007
2. Forward-Looking Statement
The statements in this presentation that are not historical facts are forward-
looking statements based on current expectations of future events that
involve risks and uncertainties including, without limitation, risks
associated with the inherent uncertainty of pharmaceutical research,
product development, manufacturing, commercialization, economic
conditions including interest and currency exchange rate fluctuations, the
impact of competitive or generic products, product liability and other types
of lawsuits, the impact of legislative and regulatory compliance and
obtaining approvals, and patent, and other risks and uncertainties,
including those detailed from time to time in Wyeth’s periodic reports,
including quarterly reports on Form 10-Q and the annual report on Form 10-
K, filed with the Securities and Exchange Commission. Quarterly results, in
particular, can vary due to issues which include, but are not limited to,
changes in exchange rates, the timing of actions taken by the Company to
ensure long-term improvements to our manufacturing processes, the
timing of regulatory approval of new products and/or facilities and the
timing of promotional programs. Actual results may vary materially from
the forward-looking statements. The Company assumes no obligation to
publicly update any forward-looking statements, whether as a result of new
information, future events or otherwise.
2
3. Wyeth Delivered Strong Growth in 2006
Net Revenue ($B) Net Income* ($B) Earnings Per
Share*
+15%
$4.5 $3.50
$25
+14%
+9% $4.0 $3.00
$4.3B
$20 $3.5 $3.14
$2.50
$20B $3.0
$19B $3.7B $2.75
$15 $2.00
$2.5
$2.0 $1.50
$10
$1.5
$1.00
$1.0
$5
$0.50
$0.5
$0 $0.0 $0.00
FY 05 FY 06 FY 05 FY 06
FY 05 FY 06
* Excludes Certain Significant Items and Reflects the 2005 Pro Forma Effect
3 of Expensing Stock Options
4. Marketed Products
Strong Growth In 2006
+20%
$1,50 M (Wyeth) $4.4B
Enbrel $2,880 M (Amgen)
+8%
Effexor $3.7 B
+30%
Prevnar $2.0 B
Protonix +7%
$1.8 B
+17%
Alliance Rev. $1.3 B
+15%
Nutritionals $1.2 B
FY06 Pharma
+16%
Premarin $1.1 B
Revenue
+9%
Zosyn Growth +10%
$972 M
+4%
BeneFIX $358M
+12%
Rapamune $337M
BMP-2 +30%
$308 M
$0 $1,000 $2,000 $3,000 $4,000 $5,000
(in millions)
4
5. 2006 Wyeth’s Leadership Positions
#1 Antidepressant
#1 RA & Psoriasis Biologic
#1 Vaccine
#1 HT
#1 I.V. Antibiotic
#1 Hemophilia B
#1 Infant Formula (In Aggregate Market Where We Compete)
5
6. Efforts Continue to Contain Cost Structure While
Allowing Support of Key Brands and R&D
2007 Guidance* Project Springboard
• Increase Efficiency of
• Pro Forma EPS +8% to +11%
Marketing/Selling Approach
• Revenue Growth Mid to High
• Commercial Excellence
Single Digit
• Marketing Excellence
• Gross Margin 72% to 74%
• Enhance R&D Technical and
• SG&A Increase at a
Management Processes
Significantly Lower Rate than
Revenue • Learn and Confirm
• Early Clinical Development
• R&D Growth Mid Single Digit
Centers
• Optimize Manufacturing
• Continue to Grow the Bottom Supply Chain
Line at a Meaningfully Faster
• 25 Sites in 2006 vs. 43 in
Rate Than Revenue Growth
2000
6 * Excludes Certain Significant Items
7. New Commercial Model
Recognizing the Need for More Positive Interactions
With Physicians, Consumers, and Payors, Wyeth Sought
to Create a New Commercial Model That Would:
Meet the Needs of the Market, Our Customers,
n
and Shareholders
Increase Effectiveness by Improving Access and
n
Interaction With Physicians
Recognize Alternative Methods to Deliver Product
n
Messages to Physicians, Payors, and Consumers
Re-establish Our Sales Representative Value
n
Proposition
7
8. New Primary Selling Model
Operational Summary
New Model
Old Model
Physician and Account
Shared Physician Targets n
n
Responsibility
Within POD
Local Empowerment and
n
Headquarters-driven Plan
n
Decision Making
of Action
Individual Accountability
n
Shared Accountability
n
Portfolio Responsibility
n
One Primary Product
n
Custom Resource Allocation
n
Uniform Resource Allocation
n
DM Geographic Ownership
n
District Management Matrix
n
Physician Segmented
n
by Value
Physician Segmented
n
by Volume Rep Incentive Value
n
Generation
Rep Incentive Share/Volume
n
8
9. Early Indications Reflect Favorable
Physician Response
Primary Care
Company
2006 Rank 2005 Rank
Wyeth 71% 1 57% 8
Eli Lilly 69% 2 51% 13
Pfizer 69% 3 77% 1
GlaxoSmithKline 67% 4 64% 5
Forest 66% 5 68% 2
Abbott 63% 6 48% 16
AstraZeneca 63% 7 62% 6
Merck 62% 8 55% 11
Takeda 62% 9 60% 7
Novartis 60% 10 68% 2
Boehringer-Ingelheim 59% 11 56% 10
Sanofi-Aventis 58% 12 51% 13
Schering-Plough 55% 13 66% 4
Bristol-Myers Squibb 50% 14 38% 17
TAP 50% 14 57% 8
Johnson & Johnson 47% 15 52% 12
Procter & Gamble 44% 16 50% 15
Roche 41% 17 N/A N/A
Industry Average 59% N/A 58% N/A
Source: Health Strategies Group “2006 State of the Selling Environment Study”. Question: Overall, how satisfied are you with this pharmaceutical representative?
Rate on a scale from 1-7 where 1 is Not at all satisfied and 7 is Very satisfied.
10. Continuous Learning
Sales Remain on Target With All Brands Achieving
n
or Exceeding Established Goals
Strong Customer Relationships Enhanced or Maintained
n
72% of Physicians Indicated the New Model Would Allow Them to
Establish Stronger Relationships With Their Representatives
Sales Representatives Report Improved Access in Many Offices As
a Result of Account Ownership
Increased Efficiency
n
Approximately 70% of Physicians Say the Current Model Is
an Improvement That Provides More Value for Them/Their Staff
Greater Flexibility for Market and Environmental Changes
n
Local Empowerment to Increase Productivity
n
and Job Satisfaction
10
11. Marketing Excellence Vision
Innovating for Sustainable Advantage in a Changing Marketplace
Build a Customer-focused Organization That:
1. Understands and Meets Our Customers’ Needs
2. Values and Rewards Innovation & Creativity
3. Optimizes Our Structure to Deliver Flawless Execution
in a Cost-efficient Manner
4. Drives Preference for Our Brands
5. Is Recognized As a Leader at the Forefront of Change
Create Sustainable Competitive Advantage
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12. Other Industries Offer Rich Source of
Learning for Wyeth Marketing
Examples
Customer Novel Approaches to Research (E.G., Anthropology,
Insights Ethnography) to Capture Unique Insights
Channel Use Multi-channels to Segment,
Management Acquire and Retain Customers
Payor As Deep Understanding of Payor Behavior
Customer and Business Drivers
Brand Systematic and Rigorous Approach to
Planning Business Planning and Metrics
Marketing Clearly Defined Roles and Rules of Engagement
Organization Between Brand Team and Marketing Support
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13. Marketing Excellence
Build a Customer-focused Marketing Organization That Innovates to Achieve
Sustainable Advantage in a Changing Marketplace
Key Areas of Focus:
Marketing Excellence
Gain Deeper Customer Insights
Enhance Customer-focused Payor
HCP Consumer
Marketing Excellence
Relationship Engagement
Marketing
Increase Rigor to Marketing
Processes and Talent Insights Powerhouse: Building Deep Customer Insights
Powerhouse:
Brand Planning: Creating a “Wyeth Way” of Planning
Planning: Way”
Talent Management: Strengthening Talent and Development
Management:
Focus on U.S. Business
Business Alignment: Balancing Business Management & Demand Generation
Alignment:
13
14. New Pharmaceutical Products Pending
FDA Approval
Project Indication Filed PDUFA
Lybrel™ Contraception June 2005 May 2007
Approvable
Pristiq™ Depression December 2005
January 2007
Pristiq™ Vasomotor June 2006 2Q 2007
Viviant™ Osteo Prevention June 2006 2Q 2007
Bifeprunox Schizophrenia October 2006 3Q 2007
Torisel™ Renal Cell October 2006 2Q 2007*
* Priority Review
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15. Pristiq™ – Proven SNRI Pharmacological Impact
for Management of Depression
Similar to Effexor XR® in Terms of Efficacy,
n
Safety and Tolerability
Very Low Potential for Drug-drug Interaction
n
Well-established QTc Safety Profile
n
15
16. Women Represent Over 70% of Patients
Treated with an Antidepressant
Treated Patients by Gender
Female
<40 Years
19% Female
71%
Male
29%
Female
>40 Years
52%
Source: SDI Longitudinal Patient Data, April 2006 (USA)
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17. Transition Through Menopause Can Be Associated With
New Onset or Recurrence of a Major Depressive Episode
Estrogen Fluctuation or Decline May Diminish
n
Serotonin and Norepinephrine Functioning
Dual Reuptake Inhibitor May Be a Better Fit
n
for Depression Associated With Menopause
17
18. Remission of Depression:
Differential Response With Age
SSRIs vs. SNRIs
Pooled Analysis of 32 Depression Studies
50
Remission Rate, Week 8 (%)
SSRIs*
Effexor®/Effexor XR®
†‡ †‡
P≤0.05
40
†
36%
30 Placebo
30%
20
10
0
<40 >55 <40 >55 <40 >55
(n=263) (n=108) (n=1041) (n=367) (n=1007) (n=355)
Age
*SSRIs=fluoxetine, fluvoxamine, paroxetine, sertraline, and citalopram.
†P≤0.05 drug vs. placebo. ‡P≤0.05 vs. SSRIs.
18 Younger women = age ≤40; older women = age >55.
Cohen LS, et al. Poster presented at ACNP Annual Meeting; San Juan, Puerto Rico; December 2004.
19. Providing Specific Benefits for Over
35 Million Women
U.S. Prevalence
Major Vasomotor
Depression Symptoms Fibromyalgia
23 Million2 4 Million3
12 Million1
Women Women
Women
1 National Institute of Mental Health. “What To Do When A Friend is Depressed…” Bethesda (MD): National Institute of
Mental Health, National Institutes of Health, U.S. Department of Health and Human Services, 2001.
2 Wyeth /ICR Patient Study Dec 2005, projected to total population using U.S. census data
3 Patient Base by Decision Resources, August 2005
2006 Syndicated Depression Omnibus shows VMS and depression overlap of ~3M women, 2005 Depression Consumer
Landscape Study shows fibromyalgia and depression overlap of ~1M women
20. Pristiq™ Differentiation
With FDA-approval, the First
Non-hormonal Treatment of
Moderate-to-severe Vasomotor Symptoms
(VMS) Associated With Menopause
20
21. A Small Percentage of the 23 Million
Symptomatic Women Use Available Treatments
Menopausal Women Hysterectomized Women
Experiencing Hot Flushes Experiencing Hot Flushes
10% Use 30% Use
Hormone Estrogen
Therapy Therapy
15 Million Women 8 Million Women
Sources: Wyeth/ICR Patient Study Dec 2005, projected to total population using U.S. census data
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22. Pristiq™ Product Profile for Major Depression
or VMS
Can Become the First and Only SNRI Proven
to Effectively Address the Distinctive Symptoms
and Therapeutic Needs of Women With
Depression Associated With Menopause
or Vasomotor Symptoms
MDD Approvable Jan 2007
Status
VMS NDA June 2006
Peak Sales > $2 Billion
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23. 2007 Planned FDA Submissions
Project Indication Proposed Filing
Opioid Induced
Methylnaltrexone March 2007
Constipation
Tygacil® CAP/HAP Mid 2007
ReFacto® AF Hemophilia Mid 2007
Menopausal Symptoms
Aprela™ Late 2007
/ Osteoporosis
Late 2007/Early
Methylnaltrexone Post Operative Ileus
2008
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24. New Product Summary
7 NCE’s
11 New Indications
Competing in Markets Worth >$30B in
Annual Sales
Late Stage Pipeline Addressed at 10/5/06 Analyst Meeting
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25. Positioning Wyeth To Be A Stronger
Company
Build Breadth and Diversity Into Every Aspect of the
n
Company So Wyeth Will Never Be Dependent on One
Product or Any One Research Program
Continue to Improve Profitability by Enhancing Productivity
n
Achieve Solid Top Line Growth, Effectively Manage Costs,
n
and Grow the Bottom Line at a Meaningfully Faster Rate
Than the Growth in Revenues
Position Wyeth to Be a Stronger Company at the End of the
n
Decade Then We Are Today and Enter the Next Decade With
Great Momentum
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