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Cowen Health Care Conference


Geno Germano
President – U.S. and General Manager
Wyeth Pharmaceuticals


March 13, 2007
Forward-Looking Statement

The statements in this presentation that are not historical facts are forward-
looking statements based on current expectations of future events that
involve risks and uncertainties including, without limitation, risks
associated with the inherent uncertainty of pharmaceutical research,
product development, manufacturing, commercialization, economic
conditions including interest and currency exchange rate fluctuations, the
impact of competitive or generic products, product liability and other types
of lawsuits, the impact of legislative and regulatory compliance and
obtaining approvals, and patent, and other risks and uncertainties,
including those detailed from time to time in Wyeth’s periodic reports,
including quarterly reports on Form 10-Q and the annual report on Form 10-
K, filed with the Securities and Exchange Commission. Quarterly results, in
particular, can vary due to issues which include, but are not limited to,
changes in exchange rates, the timing of actions taken by the Company to
ensure long-term improvements to our manufacturing processes, the
timing of regulatory approval of new products and/or facilities and the
timing of promotional programs. Actual results may vary materially from
the forward-looking statements. The Company assumes no obligation to
publicly update any forward-looking statements, whether as a result of new
information, future events or otherwise.

2
Wyeth Delivered Strong Growth in 2006

          Net Revenue ($B)                      Net Income* ($B)                   Earnings Per
                                                                                      Share*
                                                            +15%
                                     $4.5                                $3.50
$25
                                                                                            +14%
                         +9%         $4.0                                $3.00
                                                             $4.3B
$20                                  $3.5                                                   $3.14
                                                                         $2.50
                         $20B        $3.0
           $19B                               $3.7B                               $2.75
$15                                                                      $2.00
                                     $2.5
                                     $2.0                                $1.50
$10
                                     $1.5
                                                                         $1.00
                                     $1.0
$5
                                                                         $0.50
                                     $0.5
$0                                   $0.0                                $0.00
                                               FY 05         FY 06                  FY 05   FY 06
           FY 05          FY 06



           * Excludes Certain Significant Items and Reflects the 2005 Pro Forma Effect
      3      of Expensing Stock Options
Marketed Products

                                Strong Growth In 2006
                                                                                                 +20%
                                                                         $1,50 M (Wyeth) $4.4B
         Enbrel                                    $2,880 M (Amgen)

                                                                                         +8%
        Effexor                                                                $3.7 B

                                                            +30%
       Prevnar                                     $2.0 B

       Protonix                                          +7%
                                                $1.8 B

                                              +17%
Alliance Rev.                          $1.3 B

                                             +15%
    Nutritionals                    $1.2 B
                                                                                   FY06 Pharma
                                          +16%
      Premarin                   $1.1 B
                                                                                     Revenue
                                        +9%
         Zosyn                                                                     Growth +10%
                              $972 M

                             +4%
       BeneFIX      $358M

                             +12%
    Rapamune        $337M

         BMP-2               +30%
                    $308 M


                   $0            $1,000              $2,000           $3,000            $4,000     $5,000
                                                               (in millions)
4
2006 Wyeth’s Leadership Positions


           #1 Antidepressant

           #1 RA & Psoriasis Biologic

           #1 Vaccine

           #1 HT

           #1 I.V. Antibiotic

           #1 Hemophilia B

           #1 Infant Formula (In Aggregate Market Where We Compete)


5
Efforts Continue to Contain Cost Structure While
Allowing Support of Key Brands and R&D

              2007 Guidance*                 Project Springboard
                                           • Increase Efficiency of
• Pro Forma EPS +8% to +11%
                                             Marketing/Selling Approach
• Revenue Growth Mid to High
                                              • Commercial Excellence
  Single Digit
                                              • Marketing Excellence
• Gross Margin 72% to 74%
                                           • Enhance R&D Technical and
• SG&A Increase at a
                                             Management Processes
  Significantly Lower Rate than
  Revenue                                     • Learn and Confirm
                                              • Early Clinical Development
• R&D Growth Mid Single Digit
                                                Centers
                                           • Optimize Manufacturing
• Continue to Grow the Bottom                Supply Chain
  Line at a Meaningfully Faster
                                              • 25 Sites in 2006 vs. 43 in
  Rate Than Revenue Growth
                                                2000

6   * Excludes Certain Significant Items
New Commercial Model


Recognizing the Need for More Positive Interactions
With Physicians, Consumers, and Payors, Wyeth Sought
to Create a New Commercial Model That Would:
        Meet the Needs of the Market, Our Customers,
    n

        and Shareholders
        Increase Effectiveness by Improving Access and
    n

        Interaction With Physicians
        Recognize Alternative Methods to Deliver Product
    n

        Messages to Physicians, Payors, and Consumers
        Re-establish Our Sales Representative Value
    n

        Proposition

7
New Primary Selling Model
Operational Summary

                                      New Model
    Old Model
                                          Physician and Account
        Shared Physician Targets      n
    n
                                          Responsibility
        Within POD
                                          Local Empowerment and
                                      n
        Headquarters-driven Plan
    n
                                          Decision Making
        of Action
                                          Individual Accountability
                                      n
        Shared Accountability
    n
                                          Portfolio Responsibility
                                      n
        One Primary Product
    n
                                          Custom Resource Allocation
                                      n
        Uniform Resource Allocation
    n
                                          DM Geographic Ownership
                                      n

        District Management Matrix
    n
                                          Physician Segmented
                                      n

                                          by Value
        Physician Segmented
    n

        by Volume                         Rep Incentive Value
                                      n

                                          Generation
        Rep Incentive Share/Volume
    n




8
Early Indications Reflect Favorable
Physician Response
                                                                                                               Primary Care
                                  Company
                                                                                  2006                         Rank         2005                              Rank
                Wyeth                                                              71%                              1                     57%                       8
                Eli Lilly                                                          69%                              2                     51%                       13
                Pfizer                                                             69%                              3                     77%                       1
                GlaxoSmithKline                                                    67%                              4                     64%                       5
                Forest                                                             66%                              5                     68%                       2
                Abbott                                                             63%                              6                     48%                       16
                AstraZeneca                                                        63%                              7                     62%                       6
                Merck                                                              62%                              8                     55%                       11
                Takeda                                                             62%                              9                     60%                       7
                Novartis                                                           60%                             10                     68%                       2
                Boehringer-Ingelheim                                               59%                             11                     56%                       10
                Sanofi-Aventis                                                     58%                             12                     51%                       13
                Schering-Plough                                                    55%                             13                     66%                       4
                Bristol-Myers Squibb                                               50%                             14                     38%                       17
                TAP                                                                50%                             14                     57%                       8
                Johnson & Johnson                                                  47%                             15                     52%                       12
                Procter & Gamble                                                   44%                             16                     50%                       15
                Roche                                                              41%                             17                      N/A                  N/A
                Industry Average                                                   59%                            N/A                     58%                   N/A

 Source: Health Strategies Group “2006 State of the Selling Environment Study”. Question: Overall, how satisfied are you with this pharmaceutical representative?
 Rate on a scale from 1-7 where 1 is Not at all satisfied and 7 is Very satisfied.
Continuous Learning

         Sales Remain on Target With All Brands Achieving
     n

         or Exceeding Established Goals
         Strong Customer Relationships Enhanced or Maintained
     n

           72% of Physicians Indicated the New Model Would Allow Them to
           Establish Stronger Relationships With Their Representatives
           Sales Representatives Report Improved Access in Many Offices As
           a Result of Account Ownership
         Increased Efficiency
     n

           Approximately 70% of Physicians Say the Current Model Is
           an Improvement That Provides More Value for Them/Their Staff
         Greater Flexibility for Market and Environmental Changes
     n


         Local Empowerment to Increase Productivity
     n

         and Job Satisfaction

10
Marketing Excellence Vision
Innovating for Sustainable Advantage in a Changing Marketplace

     Build a Customer-focused Organization That:
     1. Understands and Meets Our Customers’ Needs

     2. Values and Rewards Innovation & Creativity

     3. Optimizes Our Structure to Deliver Flawless Execution
        in a Cost-efficient Manner

     4. Drives Preference for Our Brands

     5. Is Recognized As a Leader at the Forefront of Change


 Create Sustainable Competitive Advantage
11
Other Industries Offer Rich Source of
 Learning for Wyeth Marketing
               Examples
 Customer      Novel Approaches to Research (E.G., Anthropology,
  Insights     Ethnography) to Capture Unique Insights


  Channel      Use Multi-channels to Segment,
Management     Acquire and Retain Customers


 Payor As      Deep Understanding of Payor Behavior
 Customer      and Business Drivers


   Brand       Systematic and Rigorous Approach to
  Planning     Business Planning and Metrics



 Marketing     Clearly Defined Roles and Rules of Engagement
Organization   Between Brand Team and Marketing Support



 12
Marketing Excellence
Build a Customer-focused Marketing Organization That Innovates to Achieve
Sustainable Advantage in a Changing Marketplace



Key Areas of Focus:
                                                        Marketing Excellence
Gain Deeper Customer Insights


Enhance Customer-focused                                                               Payor
                                            HCP                Consumer
Marketing                                                                            Excellence
                                         Relationship         Engagement
                                          Marketing



Increase Rigor to Marketing
Processes and Talent                       Insights Powerhouse: Building Deep Customer Insights
                                                    Powerhouse:

                                            Brand Planning: Creating a “Wyeth Way” of Planning
                                                  Planning:                   Way”

                                         Talent Management: Strengthening Talent and Development
                                                Management:
Focus on U.S. Business
                                  Business Alignment: Balancing Business Management & Demand Generation
                                           Alignment:




13
New Pharmaceutical Products Pending
FDA Approval
      Project               Indication           Filed         PDUFA

      Lybrel™              Contraception       June 2005      May 2007

                                                              Approvable
      Pristiq™              Depression       December 2005
                                                             January 2007

      Pristiq™              Vasomotor          June 2006       2Q 2007

     Viviant™             Osteo Prevention     June 2006       2Q 2007

     Bifeprunox            Schizophrenia     October 2006      3Q 2007

     Torisel™                Renal Cell      October 2006     2Q 2007*


      * Priority Review
14
Pristiq™ – Proven SNRI Pharmacological Impact
for Management of Depression


         Similar to Effexor XR® in Terms of Efficacy,
     n

         Safety and Tolerability

         Very Low Potential for Drug-drug Interaction
     n



         Well-established QTc Safety Profile
     n




15
Women Represent Over 70% of Patients
Treated with an Antidepressant
                                            Treated Patients by Gender


                                                            Female
                                                           <40 Years
                                                             19%          Female
                                                                           71%
                                            Male
                                            29%
                                                               Female
                                                              >40 Years
                                                                 52%




 Source: SDI Longitudinal Patient Data, April 2006 (USA)
16
Transition Through Menopause Can Be Associated With
New Onset or Recurrence of a Major Depressive Episode

         Estrogen Fluctuation or Decline May Diminish
     n

         Serotonin and Norepinephrine Functioning
         Dual Reuptake Inhibitor May Be a Better Fit
     n

         for Depression Associated With Menopause




17
Remission of Depression:
Differential Response With Age
                                                    SSRIs vs. SNRIs
                                           Pooled Analysis of 32 Depression Studies
                                   50
      Remission Rate, Week 8 (%)




                                                                     SSRIs*
                                                                                                 Effexor®/Effexor XR®
                                                                                                   †‡      †‡
                                                                      P≤0.05
                                   40
                                                                †

                                                                36%
                                   30      Placebo
                                                                               30%

                                   20


                                   10


                                   0
                                        <40       >55           <40          >55                        <40       >55
                                        (n=263)   (n=108)      (n=1041)     (n=367)                    (n=1007)   (n=355)

                                                                    Age
     *SSRIs=fluoxetine, fluvoxamine, paroxetine, sertraline, and citalopram.
     †P≤0.05 drug vs. placebo. ‡P≤0.05 vs. SSRIs.
18   Younger women = age ≤40; older women = age >55.
     Cohen LS, et al. Poster presented at ACNP Annual Meeting; San Juan, Puerto Rico; December 2004.
Providing Specific Benefits for Over
35 Million Women
                                                    U.S. Prevalence

              Major                                         Vasomotor
            Depression                                      Symptoms                                     Fibromyalgia




                                                             23 Million2                                      4 Million3
             12 Million1
                                                              Women                                            Women
              Women



1 National Institute of Mental Health. “What To Do When A Friend is Depressed…” Bethesda (MD): National Institute of
  Mental Health, National Institutes of Health, U.S. Department of Health and Human Services, 2001.
2 Wyeth /ICR Patient Study Dec 2005, projected to total population using U.S. census data
3 Patient Base by Decision Resources, August 2005

2006 Syndicated Depression Omnibus shows VMS and depression overlap of ~3M women, 2005 Depression Consumer
Landscape Study shows fibromyalgia and depression overlap of ~1M women
Pristiq™ Differentiation




           With FDA-approval, the First
           Non-hormonal Treatment of
     Moderate-to-severe Vasomotor Symptoms
       (VMS) Associated With Menopause




20
A Small Percentage of the 23 Million
Symptomatic Women Use Available Treatments

       Menopausal Women                                                         Hysterectomized Women
     Experiencing Hot Flushes                                                   Experiencing Hot Flushes

                                             10% Use                                                       30% Use
                                             Hormone                                                       Estrogen
                                             Therapy                                                       Therapy




              15 Million Women                                                               8 Million Women



     Sources: Wyeth/ICR Patient Study Dec 2005, projected to total population using U.S. census data
21
Pristiq™ Product Profile for Major Depression
or VMS

   Can Become the First and Only SNRI Proven
 to Effectively Address the Distinctive Symptoms
      and Therapeutic Needs of Women With
     Depression Associated With Menopause
              or Vasomotor Symptoms

                     MDD Approvable Jan 2007
        Status
                     VMS NDA June 2006
        Peak Sales   > $2 Billion



22
2007 Planned FDA Submissions


      Project           Indication         Proposed Filing

                      Opioid Induced
 Methylnaltrexone                            March 2007
                       Constipation

      Tygacil®           CAP/HAP               Mid 2007

     ReFacto® AF        Hemophilia             Mid 2007

                    Menopausal Symptoms
      Aprela™                                 Late 2007
                       / Osteoporosis

                                            Late 2007/Early
 Methylnaltrexone   Post Operative Ileus
                                                 2008


23
New Product Summary



      7 NCE’s


      11 New Indications


      Competing in Markets Worth >$30B in
      Annual Sales

     Late Stage Pipeline Addressed at 10/5/06 Analyst Meeting
24
Positioning Wyeth To Be A Stronger
Company
     Build Breadth and Diversity Into Every Aspect of the
 n

     Company So Wyeth Will Never Be Dependent on One
     Product or Any One Research Program


     Continue to Improve Profitability by Enhancing Productivity
 n




     Achieve Solid Top Line Growth, Effectively Manage Costs,
 n

     and Grow the Bottom Line at a Meaningfully Faster Rate
     Than the Growth in Revenues


     Position Wyeth to Be a Stronger Company at the End of the
 n

     Decade Then We Are Today and Enter the Next Decade With
     Great Momentum

25
Questions?


Geno Germano
President – U.S. and General Manager
Wyeth Pharmaceuticals

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wyeth Cowen and Company Annual Health Care Conference

  • 1. Cowen Health Care Conference Geno Germano President – U.S. and General Manager Wyeth Pharmaceuticals March 13, 2007
  • 2. Forward-Looking Statement The statements in this presentation that are not historical facts are forward- looking statements based on current expectations of future events that involve risks and uncertainties including, without limitation, risks associated with the inherent uncertainty of pharmaceutical research, product development, manufacturing, commercialization, economic conditions including interest and currency exchange rate fluctuations, the impact of competitive or generic products, product liability and other types of lawsuits, the impact of legislative and regulatory compliance and obtaining approvals, and patent, and other risks and uncertainties, including those detailed from time to time in Wyeth’s periodic reports, including quarterly reports on Form 10-Q and the annual report on Form 10- K, filed with the Securities and Exchange Commission. Quarterly results, in particular, can vary due to issues which include, but are not limited to, changes in exchange rates, the timing of actions taken by the Company to ensure long-term improvements to our manufacturing processes, the timing of regulatory approval of new products and/or facilities and the timing of promotional programs. Actual results may vary materially from the forward-looking statements. The Company assumes no obligation to publicly update any forward-looking statements, whether as a result of new information, future events or otherwise. 2
  • 3. Wyeth Delivered Strong Growth in 2006 Net Revenue ($B) Net Income* ($B) Earnings Per Share* +15% $4.5 $3.50 $25 +14% +9% $4.0 $3.00 $4.3B $20 $3.5 $3.14 $2.50 $20B $3.0 $19B $3.7B $2.75 $15 $2.00 $2.5 $2.0 $1.50 $10 $1.5 $1.00 $1.0 $5 $0.50 $0.5 $0 $0.0 $0.00 FY 05 FY 06 FY 05 FY 06 FY 05 FY 06 * Excludes Certain Significant Items and Reflects the 2005 Pro Forma Effect 3 of Expensing Stock Options
  • 4. Marketed Products Strong Growth In 2006 +20% $1,50 M (Wyeth) $4.4B Enbrel $2,880 M (Amgen) +8% Effexor $3.7 B +30% Prevnar $2.0 B Protonix +7% $1.8 B +17% Alliance Rev. $1.3 B +15% Nutritionals $1.2 B FY06 Pharma +16% Premarin $1.1 B Revenue +9% Zosyn Growth +10% $972 M +4% BeneFIX $358M +12% Rapamune $337M BMP-2 +30% $308 M $0 $1,000 $2,000 $3,000 $4,000 $5,000 (in millions) 4
  • 5. 2006 Wyeth’s Leadership Positions #1 Antidepressant #1 RA & Psoriasis Biologic #1 Vaccine #1 HT #1 I.V. Antibiotic #1 Hemophilia B #1 Infant Formula (In Aggregate Market Where We Compete) 5
  • 6. Efforts Continue to Contain Cost Structure While Allowing Support of Key Brands and R&D 2007 Guidance* Project Springboard • Increase Efficiency of • Pro Forma EPS +8% to +11% Marketing/Selling Approach • Revenue Growth Mid to High • Commercial Excellence Single Digit • Marketing Excellence • Gross Margin 72% to 74% • Enhance R&D Technical and • SG&A Increase at a Management Processes Significantly Lower Rate than Revenue • Learn and Confirm • Early Clinical Development • R&D Growth Mid Single Digit Centers • Optimize Manufacturing • Continue to Grow the Bottom Supply Chain Line at a Meaningfully Faster • 25 Sites in 2006 vs. 43 in Rate Than Revenue Growth 2000 6 * Excludes Certain Significant Items
  • 7. New Commercial Model Recognizing the Need for More Positive Interactions With Physicians, Consumers, and Payors, Wyeth Sought to Create a New Commercial Model That Would: Meet the Needs of the Market, Our Customers, n and Shareholders Increase Effectiveness by Improving Access and n Interaction With Physicians Recognize Alternative Methods to Deliver Product n Messages to Physicians, Payors, and Consumers Re-establish Our Sales Representative Value n Proposition 7
  • 8. New Primary Selling Model Operational Summary New Model Old Model Physician and Account Shared Physician Targets n n Responsibility Within POD Local Empowerment and n Headquarters-driven Plan n Decision Making of Action Individual Accountability n Shared Accountability n Portfolio Responsibility n One Primary Product n Custom Resource Allocation n Uniform Resource Allocation n DM Geographic Ownership n District Management Matrix n Physician Segmented n by Value Physician Segmented n by Volume Rep Incentive Value n Generation Rep Incentive Share/Volume n 8
  • 9. Early Indications Reflect Favorable Physician Response Primary Care Company 2006 Rank 2005 Rank Wyeth 71% 1 57% 8 Eli Lilly 69% 2 51% 13 Pfizer 69% 3 77% 1 GlaxoSmithKline 67% 4 64% 5 Forest 66% 5 68% 2 Abbott 63% 6 48% 16 AstraZeneca 63% 7 62% 6 Merck 62% 8 55% 11 Takeda 62% 9 60% 7 Novartis 60% 10 68% 2 Boehringer-Ingelheim 59% 11 56% 10 Sanofi-Aventis 58% 12 51% 13 Schering-Plough 55% 13 66% 4 Bristol-Myers Squibb 50% 14 38% 17 TAP 50% 14 57% 8 Johnson & Johnson 47% 15 52% 12 Procter & Gamble 44% 16 50% 15 Roche 41% 17 N/A N/A Industry Average 59% N/A 58% N/A Source: Health Strategies Group “2006 State of the Selling Environment Study”. Question: Overall, how satisfied are you with this pharmaceutical representative? Rate on a scale from 1-7 where 1 is Not at all satisfied and 7 is Very satisfied.
  • 10. Continuous Learning Sales Remain on Target With All Brands Achieving n or Exceeding Established Goals Strong Customer Relationships Enhanced or Maintained n 72% of Physicians Indicated the New Model Would Allow Them to Establish Stronger Relationships With Their Representatives Sales Representatives Report Improved Access in Many Offices As a Result of Account Ownership Increased Efficiency n Approximately 70% of Physicians Say the Current Model Is an Improvement That Provides More Value for Them/Their Staff Greater Flexibility for Market and Environmental Changes n Local Empowerment to Increase Productivity n and Job Satisfaction 10
  • 11. Marketing Excellence Vision Innovating for Sustainable Advantage in a Changing Marketplace Build a Customer-focused Organization That: 1. Understands and Meets Our Customers’ Needs 2. Values and Rewards Innovation & Creativity 3. Optimizes Our Structure to Deliver Flawless Execution in a Cost-efficient Manner 4. Drives Preference for Our Brands 5. Is Recognized As a Leader at the Forefront of Change Create Sustainable Competitive Advantage 11
  • 12. Other Industries Offer Rich Source of Learning for Wyeth Marketing Examples Customer Novel Approaches to Research (E.G., Anthropology, Insights Ethnography) to Capture Unique Insights Channel Use Multi-channels to Segment, Management Acquire and Retain Customers Payor As Deep Understanding of Payor Behavior Customer and Business Drivers Brand Systematic and Rigorous Approach to Planning Business Planning and Metrics Marketing Clearly Defined Roles and Rules of Engagement Organization Between Brand Team and Marketing Support 12
  • 13. Marketing Excellence Build a Customer-focused Marketing Organization That Innovates to Achieve Sustainable Advantage in a Changing Marketplace Key Areas of Focus: Marketing Excellence Gain Deeper Customer Insights Enhance Customer-focused Payor HCP Consumer Marketing Excellence Relationship Engagement Marketing Increase Rigor to Marketing Processes and Talent Insights Powerhouse: Building Deep Customer Insights Powerhouse: Brand Planning: Creating a “Wyeth Way” of Planning Planning: Way” Talent Management: Strengthening Talent and Development Management: Focus on U.S. Business Business Alignment: Balancing Business Management & Demand Generation Alignment: 13
  • 14. New Pharmaceutical Products Pending FDA Approval Project Indication Filed PDUFA Lybrel™ Contraception June 2005 May 2007 Approvable Pristiq™ Depression December 2005 January 2007 Pristiq™ Vasomotor June 2006 2Q 2007 Viviant™ Osteo Prevention June 2006 2Q 2007 Bifeprunox Schizophrenia October 2006 3Q 2007 Torisel™ Renal Cell October 2006 2Q 2007* * Priority Review 14
  • 15. Pristiq™ – Proven SNRI Pharmacological Impact for Management of Depression Similar to Effexor XR® in Terms of Efficacy, n Safety and Tolerability Very Low Potential for Drug-drug Interaction n Well-established QTc Safety Profile n 15
  • 16. Women Represent Over 70% of Patients Treated with an Antidepressant Treated Patients by Gender Female <40 Years 19% Female 71% Male 29% Female >40 Years 52% Source: SDI Longitudinal Patient Data, April 2006 (USA) 16
  • 17. Transition Through Menopause Can Be Associated With New Onset or Recurrence of a Major Depressive Episode Estrogen Fluctuation or Decline May Diminish n Serotonin and Norepinephrine Functioning Dual Reuptake Inhibitor May Be a Better Fit n for Depression Associated With Menopause 17
  • 18. Remission of Depression: Differential Response With Age SSRIs vs. SNRIs Pooled Analysis of 32 Depression Studies 50 Remission Rate, Week 8 (%) SSRIs* Effexor®/Effexor XR® †‡ †‡ P≤0.05 40 † 36% 30 Placebo 30% 20 10 0 <40 >55 <40 >55 <40 >55 (n=263) (n=108) (n=1041) (n=367) (n=1007) (n=355) Age *SSRIs=fluoxetine, fluvoxamine, paroxetine, sertraline, and citalopram. †P≤0.05 drug vs. placebo. ‡P≤0.05 vs. SSRIs. 18 Younger women = age ≤40; older women = age >55. Cohen LS, et al. Poster presented at ACNP Annual Meeting; San Juan, Puerto Rico; December 2004.
  • 19. Providing Specific Benefits for Over 35 Million Women U.S. Prevalence Major Vasomotor Depression Symptoms Fibromyalgia 23 Million2 4 Million3 12 Million1 Women Women Women 1 National Institute of Mental Health. “What To Do When A Friend is Depressed…” Bethesda (MD): National Institute of Mental Health, National Institutes of Health, U.S. Department of Health and Human Services, 2001. 2 Wyeth /ICR Patient Study Dec 2005, projected to total population using U.S. census data 3 Patient Base by Decision Resources, August 2005 2006 Syndicated Depression Omnibus shows VMS and depression overlap of ~3M women, 2005 Depression Consumer Landscape Study shows fibromyalgia and depression overlap of ~1M women
  • 20. Pristiq™ Differentiation With FDA-approval, the First Non-hormonal Treatment of Moderate-to-severe Vasomotor Symptoms (VMS) Associated With Menopause 20
  • 21. A Small Percentage of the 23 Million Symptomatic Women Use Available Treatments Menopausal Women Hysterectomized Women Experiencing Hot Flushes Experiencing Hot Flushes 10% Use 30% Use Hormone Estrogen Therapy Therapy 15 Million Women 8 Million Women Sources: Wyeth/ICR Patient Study Dec 2005, projected to total population using U.S. census data 21
  • 22. Pristiq™ Product Profile for Major Depression or VMS Can Become the First and Only SNRI Proven to Effectively Address the Distinctive Symptoms and Therapeutic Needs of Women With Depression Associated With Menopause or Vasomotor Symptoms MDD Approvable Jan 2007 Status VMS NDA June 2006 Peak Sales > $2 Billion 22
  • 23. 2007 Planned FDA Submissions Project Indication Proposed Filing Opioid Induced Methylnaltrexone March 2007 Constipation Tygacil® CAP/HAP Mid 2007 ReFacto® AF Hemophilia Mid 2007 Menopausal Symptoms Aprela™ Late 2007 / Osteoporosis Late 2007/Early Methylnaltrexone Post Operative Ileus 2008 23
  • 24. New Product Summary 7 NCE’s 11 New Indications Competing in Markets Worth >$30B in Annual Sales Late Stage Pipeline Addressed at 10/5/06 Analyst Meeting 24
  • 25. Positioning Wyeth To Be A Stronger Company Build Breadth and Diversity Into Every Aspect of the n Company So Wyeth Will Never Be Dependent on One Product or Any One Research Program Continue to Improve Profitability by Enhancing Productivity n Achieve Solid Top Line Growth, Effectively Manage Costs, n and Grow the Bottom Line at a Meaningfully Faster Rate Than the Growth in Revenues Position Wyeth to Be a Stronger Company at the End of the n Decade Then We Are Today and Enter the Next Decade With Great Momentum 25
  • 26. Questions? Geno Germano President – U.S. and General Manager Wyeth Pharmaceuticals