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Volume 14 (7); 2024

Research Papers

Graphic abstract

AXL-specific single domain antibodies show diagnostic potential and anti-tumor activity in Acute Myeloid Leukemia
Niels Vandewalle, Hatice Satilmis, Emma Verheye, Rong Fan, Yanmeng Wang, Timo W.M. De Groof, Jessica Bridoux, Tessa Kerre, Nathan De Beule, Ann De Becker, Elke De Bruyne, Eline Menu, Karin Vanderkerken, Karine Breckpot, Nick Devoogdt, Kim De Veirman
Theranostics 2024; 14(7): 2656-2674. doi:10.7150/thno.91456
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Graphic abstract

Albumin-seeking dyes with adjustable assemblies in situ enable programmable imaging windows and targeting tumor imaging
Yijing Du, Jiajun Xu, Tianyang Han, Zijian Jiang, Yuewei Zhang, Jia Li, Xiaoyuan Chen, Shoujun Zhu
Theranostics 2024; 14(7): 2675-2686. doi:10.7150/thno.92991
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Abnormal mitochondrial iron metabolism damages alveolar type II epithelial cells involved in bleomycin-induced pulmonary fibrosis
Min Shao, Haipeng Cheng, Xiaohong Li, Yujia Qiu, Yunna Zhang, Yanfen Chang, Jiafeng Fu, Mengxia Shen, Xinxin Xu, Dandan Feng, Yang Han, ShaoJie Yue, Yan Zhou, Ziqiang Luo
Theranostics 2024; 14(7): 2687-2705. doi:10.7150/thno.94072
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Graphic abstract

Hyperglycemia facilitates EV71 replication: Insights into miR-206-mediated regulation of G3BP2 promoting EV71 IRES activity
Rai-Hua Lai, Yen-Hung Chow, Yi-Wen Lin, Nai-Hsiang Chung, Shu-Wei Nien, Jyh-Lyh Juang
Theranostics 2024; 14(7): 2706-2718. doi:10.7150/thno.93883
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Graphic abstract

Bifidobacterium breve-derived indole-3-lactic acid ameliorates colitis-associated tumorigenesis by directing the differentiation of immature colonic macrophages
Yuke Li, Qingxiang Li, Ruoshui Yuan, Yifei Wang, Chuanbin Guo, Lin Wang
Theranostics 2024; 14(7): 2719-2735. doi:10.7150/thno.92350
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Graphic abstract

Targeting tumor cell-to-macrophage communication by blocking Vtn-C1qbp interaction inhibits tumor progression via enhancing macrophage phagocytosis
Chen Zhang, Yi Liu, Jiayu Jiang, Chong Chen, Zhaojun Duan, Huifang Su, Shijian Wang, Baorui Tian, Yi Shi, Rong Xiang, Yunping Luo
Theranostics 2024; 14(7): 2757-2776. doi:10.7150/thno.94537
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Small extracellular vesicles (sEVs)-based gene delivery platform for cell-specific CRISPR/Cas9 genome editing
Sunil Dubey, Zhe Chen, Yuxiao Jarvan Jiang, Austin Talis, Andrei Molotkov, Alessandra Ali, Akiva Mintz, Fatemeh Momen-Heravi
Theranostics 2024; 14(7): 2777-2793. doi:10.7150/thno.92133
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Graphic abstract

Nicotinamide phosphoribosyltransferase prompts bleomycin-induced pulmonary fibrosis by driving macrophage M2 polarization in mice
Yaling Chen, Tong Wang, Fuxiang Liang, Jia Han, Zhiling Lou, Yifan Yu, Jinsheng Li, Tianwei Zhan, Yuqing Gu, Lingjun Dong, Bo Jiang, Weiping Zhang, Ming Wu, Yunbi Lu
Theranostics 2024; 14(7): 2794-2815. doi:10.7150/thno.94482
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In situ single-cell therapeutic response imaging facilitated by the TRIPODD fluorescence imaging platform
Nathan P. McMahon, Allison Solanki, Lei G. Wang, Antonio R. Montaño, Jocelyn A. Jones, Kimberley S. Samkoe, Kenneth M. Tichauer, Summer L. Gibbs
Theranostics 2024; 14(7): 2816-2834. doi:10.7150/thno.93256
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CRISPR-Cas9 library screening combined with an exosome-targeted delivery system addresses tumorigenesis/TMZ resistance in the mesenchymal subtype of glioblastoma
Jixing Zhao, Xiaoteng Cui, Qi Zhan, Kailiang Zhang, Dongyuan Su, Shixue Yang, Biao Hong, Qixue Wang, Jiasheng Ju, Chunchao Cheng, Chen Li, Chunxiao Wan, Yunfei Wang, Junhu Zhou, Chunsheng Kang
Theranostics 2024; 14(7): 2835-2855. doi:10.7150/thno.92703
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Graphic abstract

Activation of the hypoxia-inducible factor pathway protects against acute ischemic stroke by reprogramming central carbon metabolism
Sarah Madai, Pinar Kilic, Rolf M. Schmidt, Carlos Bas-Orth, Thomas Korff, Michael Büttner, Glynis Klinke, Gernot Poschet, Hugo H. Marti, Reiner Kunze
Theranostics 2024; 14(7): 2856-2880. doi:10.7150/thno.88223
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Distinct eLPBChAT projections for methamphetamine withdrawal anxiety and primed reinstatement of conditioned place preference
Wenwen Chen, Hao Guo, Ning Zhou, Yuning Mai, Tao Hu, Xing Xu, Teng He, Jun Wen, Shan Qin, Chengyong Liu, Wenzhong Wu, Hee Young Kim, Yu Fan, Feifei Ge, Xiaowei Guan
Theranostics 2024; 14(7): 2881-2896. doi:10.7150/thno.95383
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Adaptive plasticity of natural interleukin-35-induced regulatory T cells (Tr35) that are required for T-cell immune regulation
Xundong Wei, Jianhua Zhang, Jian Cui, Wei Xu, Gang Zhao, Chang Guo, Wei Yuan, Xuyu Zhou, Jie Ma
Theranostics 2024; 14(7): 2897-2914. doi:10.7150/thno.90608
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Comprehensive multi-omics analysis of pyroptosis for optimizing neoadjuvant immunotherapy in patients with gastric cancer
Jia-Bin Wang, You-Xin Gao, Yin-Hua Ye, Qiao-Ling Zheng, Hua-You Luo, Shuan-Hu Wang, Tao Zhang, Qin-Wen Jin, Chao-Hui Zheng, Ping Li, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Ying-Hong Yang, Chang-Ming Huang, Jian-Wei Xie
Theranostics 2024; 14(7): 2915-2933. doi:10.7150/thno.93124
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Graphic abstract

A non-lipid nucleic acid delivery vector with dendritic cell tropism and stimulation
Hyung Shik Kim, Elias A. Halabi, Noah Enbergs, Rainer H. Kohler, Fan Fei, Christopher S. Garris, Ralph Weissleder
Theranostics 2024; 14(7): 2934-2945. doi:10.7150/thno.95267
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Cancer-associated fibroblast-derived periostin promotes papillary thyroid tumor growth through integrin-FAK-STAT3 signaling
Xiaorui Jin, Qianmei Deng, Shuting Ye, Shuting Liu, Yilong Fu, Yingfu Liu, Guoyang Wu, Gaoliang Ouyang, Tiantian Wu
Theranostics 2024; 14(7): 3014-3028. doi:10.7150/thno.94207
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Reviews

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Prostate-specific membrane antigen-targeted surgery in prostate cancer: Accurate identification, real-time diagnosis, and precise resection
Jianhua Jiao, Jingjing Zhang, Weihong Wen, Weijun Qin, Xiaoyuan Chen
Theranostics 2024; 14(7): 2736-2756. doi:10.7150/thno.95039
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Spatial Transcriptomics: A Powerful Tool in Disease Understanding and Drug Discovery
Junxian Cao, Caifeng Li, Zhao Cui, Shiwen Deng, Tong Lei, Wei Liu, Hongjun Yang, Peng Chen
Theranostics 2024; 14(7): 2946-2968. doi:10.7150/thno.95908
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Graphic abstract

Actinium-225 targeted alpha particle therapy for prostate cancer
Anil P. Bidkar, Luann Zerefa, Surekha Yadav, Henry F. VanBrocklin, Robert R. Flavell
Theranostics 2024; 14(7): 2969-2992. doi:10.7150/thno.96403
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Mitochondrial Sirtuins in Cancer: A Revisited Review from Molecular Mechanisms to Therapeutic Strategies
Hui Shen, Wei Ma, Yue Hu, Yuan Liu, Yaowen Song, Leilei Fu, Zheng Qin
Theranostics 2024; 14(7): 2993-3013. doi:10.7150/thno.97320
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