Calcium channel, voltage-dependent, L type, alpha 1C subunit (Q14905748)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01815

Voltage-dependent channel domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q01815

voltage-gated ion channel

1 reference

Transporter Classification Database ID

1.A.1.11.6

2 October 2019

hierarchical database ID heuristic

Voltage-gated calcium channel subunit alpha, C-terminal domain, protein family

1 reference

Ion transport domain, protein family

1 reference

Voltage-dependent calcium channel, alpha-1 subunit, IQ domain, protein family

1 reference

Voltage-dependent L-type calcium channel, IQ-associated domain, protein family

1 reference

voltage-gated calcium channel activity

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 August 2016

calcium channel activity

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

metal ion binding

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

voltage-gated ion channel activity

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

calmodulin binding

1 reference

9 August 2016

ion channel activity

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

protein binding

5 references

9 August 2016

14 February 2019

Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

Localization of cardiac L-type Ca(2+) channels to a caveolar macromolecular signaling complex is required for beta(2)-adrenergic regulation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

CIB1 is a regulator of pathological cardiac hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

high voltage-gated calcium channel activity

5 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

voltage-gated calcium channel activity involved in cardiac muscle cell action potential

IBA

3 references

alpha-actinin binding

voltage-gated calcium channel activity

3 references

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle

12 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

Opposite effects of a single IIIS5 mutation on phenylalkylamine and dihydropyridine interaction with L-type Ca2+ channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

Impaired insulin secretion and glucose tolerance in beta cell-selective Ca(v)1.2 Ca2+ channel null mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

14 February 2019

Cloning and expression of a novel truncated calcium channel from non-excitable cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

Expression of a cDNA for a neuronal calcium channel alpha 1 subunit enhances secretion from adrenal chromaffin cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

Neuronal L-type calcium channels open quickly and are inhibited slowly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

Endogenous cardiac Ca2+ channels do not overcome the E‐C coupling defect in immortalized dysgenic muscle cells: evidence for a missing link

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

protein domain specific binding

IBA

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

translation initiation factor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

transmembrane transporter binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

protein phosphatase 2A binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential

1 reference

14 February 2019

Cav1.2 calcium channels modulate the spiking pattern of hippocampal pyramidal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

cell component

cytoplasm

2 references

9 August 2016

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

integral component of membrane

3 references

postsynaptic density

1 reference

9 August 2016

plasma membrane

6 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

14 February 2019

Coexpression of skeletal muscle voltage-dependent calcium channel alpha 1 and beta cDNAs in mouse Ltk- cells increases the amount of alpha 1 protein in the cell membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

Differential targeting of the L-type Ca2+ channel alpha 1C (CaV1.2) to synaptic and extrasynaptic compartments in hippocampal neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

membrane

1 reference

9 August 2016

T-tubule

1 reference

9 August 2016

L-type voltage-gated calcium channel complex

4 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

voltage-gated calcium channel complex

5 references

9 August 2016

14 February 2019

Functional disorders of the sympathetic nervous system in mice lacking the alpha 1B subunit (Cav 2.2) of N-type calcium channels

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

neuronal cell body

1 reference

9 August 2016

Z discdkac

1 reference

9 August 2016

integral component of plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

1 reference

14 February 2019

cell surface

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

membrane

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

14 February 2019

An essential role of Cav1.2 L-type calcium channel for urinary bladder function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

1 reference

14 February 2019

T-tubule

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01815&geneProductId=UniProtKB:Q01815

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01815&geneProductId=UniProtKB:Q01815

1 January 2018

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q01815&geneProductId=UniProtKB:Q01815

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

presynaptic membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

1 reference

14 February 2019

perikaryon

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

1 reference

14 February 2019

synapse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

1 reference

14 February 2019

postsynaptic membrane

glutamatergic synapse

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

integral component of postsynaptic membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

integral component of presynaptic membrane

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

T-tubule

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

14 February 2019

Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

membrane depolarization during action potential

biological process

1 reference

9 August 2016

positive regulation of cytosolic calcium ion concentration

2 references

9 August 2016

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

regulation of ion transmembrane transport

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

ion transport

3 references

cardiac conduction

calcium ion transmembrane transport

3 references

4 references

9 August 2016

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

transmembrane transport

2 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

transport

1 reference

9 August 2016

calcium ion transport

1 reference

9 August 2016

calcium ion transmembrane transport via high voltage-gated calcium channel

4 references

9 August 2016

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

immune system development

2 references

9 August 2016

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

camera-type eye development

2 references

9 August 2016

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

heart development

2 references

9 August 2016

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

embryonic forelimb morphogenesis

2 references

9 August 2016

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

calcium ion transport

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

Role of hippocampal Cav1.2 Ca2+ channels in NMDA receptor-independent synaptic plasticity and spatial memory

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

An essential role of Cav1.2 L-type calcium channel for urinary bladder function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

14 February 2019

Endogenous cardiac Ca2+ channels do not overcome the E‐C coupling defect in immortalized dysgenic muscle cells: evidence for a missing link

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

IBA

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

1 reference

14 February 2019

positive regulation of adenylate cyclase activity

1 reference

14 February 2019

An improved targeted cAMP sensor to study the regulation of adenylyl cyclase 8 by Ca2+ entry through voltage-gated channels.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

regulation of postsynaptic membrane potential

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

calcium ion transport into cytosol

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

1 reference

14 February 2019

positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q01815

physically interacts with

isradipine

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

4488

IUPHAR/BPS Guide to PHARMACOLOGY

17 August 2016

1 reference

Guide to Pharmacology Ligand ID

2524

Transporter Classification Database ID

17 August 2016

Identifiers

1 reference

20 March 2022

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25 May 2022

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1.A.1.11.6

2 references

Transporter Classification database

13 March 2020

Transporter Classification database