G protein subunit alpha i2 (Q21113113)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04899

G-protein alpha subunit, group I

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04899

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04899

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

1 reference

8 April 2019

signal transducer activity

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

1 reference

8 April 2019

protein binding

6 references

8 April 2019

Activation state-dependent interaction between Galphai and p67phox

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

Differential G protein subunit expression by prostate cancer cells and their interaction with CXCR5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

A proteome-scale map of the human interactome network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

Agonist-selective signaling is determined by the receptor location within the membrane domains.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

guanyl nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

1 reference

8 April 2019

G protein-coupled receptor binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

GTP binding

GTPase activity

Right ventricular outflow tract tachycardia due to a somatic cell mutation in G protein subunitalphai2.

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

cell component

cell body

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

extracellular vesicle

1 reference

31 October 2017

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04899&geneProductId=UniProtKB:P04899

centrosome

1 reference

8 April 2019

Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04899&geneProductId=UniProtKB:P04899

3 references

31 October 2017

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04899&geneProductId=UniProtKB:P04899

31 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04899&geneProductId=UniProtKB:P04899

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

1 reference

8 April 2019

microtubule organizing center

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

1 reference

8 April 2019

dendrite

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

midbody

1 reference

8 April 2019

Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

heterotrimeric G-protein complex

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

membrane raft

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

extracellular exosome

5 references

31 October 2017

Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04899&geneProductId=UniProtKB:P04899

31 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04899&geneProductId=UniProtKB:P04899

31 October 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04899&geneProductId=UniProtKB:P04899

31 October 2017

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04899&geneProductId=UniProtKB:P04899

31 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04899&geneProductId=UniProtKB:P04899

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

1 reference

8 April 2019

nucleus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

extracellular exosome

4 references

8 April 2019

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

Proteomic and biochemical analyses of human B cell-derived exosomes. Potential implications for their function and multivesicular body formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

extracellular vesicle

1 reference

8 April 2019

Proteomic analysis of cerebrospinal fluid extracellular vesicles: a comprehensive dataset

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

G protein-coupled acetylcholine receptor signaling pathway

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

4 references

8 April 2019

8 April 2019

Insulin action impaired by deficiency of the G-protein subunit G ialpha2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

negative regulation of adenylate cyclase activity

1 reference

8 April 2019

Right ventricular outflow tract tachycardia due to a somatic cell mutation in G protein subunitalphai2.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

intracellular signal transduction

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04899&geneProductId=UniProtKB:P04899

regulation of calcium ion transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

3 references

1 reference

8 April 2019

Insulin action impaired by deficiency of the G-protein subunit G ialpha2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04899&geneProductId=UniProtKB:P04899

1 reference

31 October 2017

negative regulation of synaptic transmission

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

positive regulation of cell population proliferation

1 reference

31 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04899&geneProductId=UniProtKB:P04899

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

1 reference

8 April 2019

cell population proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

signal transduction

Right ventricular outflow tract tachycardia due to a somatic cell mutation in G protein subunitalphai2.

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

Regulation of cAMP-mediated gene transcription by wild type and mutated G-protein alpha subunits. Inhibition of adenylyl cyclase activity by muscarinic receptor-activated and constitutively activated G(o) alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

8 April 2019

protein folding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

1 reference

8 April 2019

adenylate cyclase-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

positive regulation of cell migration

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

positive regulation of superoxide anion generation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

positive regulation of NAD(P)H oxidase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

positive regulation of urine volume

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

positive regulation of renal sodium excretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

negative regulation of calcium ion-dependent exocytosis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

positive regulation of insulin receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

negative regulation of protein tyrosine phosphatase activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

positive regulation of vascular associated smooth muscle cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

positive regulation of neural precursor cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

negative regulation of apoptotic signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04899

D08.811.277.040.330.300.200.100.200.500

Identifiers

MeSH descriptor ID

D051960

subject named as

GTP-Binding Protein alpha Subunit, Gi2

0 references

MeSH tree code

0 references

D12.776.157.325.332.100.200.500

0 references

D12.776.476.338.200.100.200.500

0 references

D12.776.543.325.100.200.500

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023