Serine/threonine kinase 24 (Q21117407)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y6E0

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

1 reference

8 April 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

1 reference

8 April 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

1 reference

8 April 2019

protein binding

9 references

8 April 2019

RHO binding to FAM65A regulates Golgi reorientation during cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

STRIPAK components determine mode of cancer cell migration and metastasis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

Next-generation sequencing to generate interactome datasets

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

Towards a proteome-scale map of the human protein–protein interaction network

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

Structural mechanism of CCM3 heterodimerization with GCKIII kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

3 references

17 October 2017

17 October 2017

Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

17 October 2017

Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

cadherin binding

1 reference

17 October 2017

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

MAP kinase kinase kinase kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

1 reference

17 October 2017

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

4 references

8 April 2019

8 April 2019

Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

cadherin binding

HDA

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

HDA

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

1 reference

8 April 2019

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

1 reference

8 April 2019

nucleolus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

1 reference

8 April 2019

extracellular exosome

3 references

17 October 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

17 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

cytoplasm

RHO binding to FAM65A regulates Golgi reorientation during cell migration

4 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

17 October 2017

17 October 2017

Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

17 October 2017

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

Golgi apparatus

1 reference

8 April 2019

RHO binding to FAM65A regulates Golgi reorientation during cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

cytoplasm

RHO binding to FAM65A regulates Golgi reorientation during cell migration

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

8 April 2019

Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

intrinsic apoptotic signaling pathway in response to oxidative stress

biological process

1 reference

8 April 2019

Mammalian sterile 20-like kinase 3 (MST3) mediates oxidative-stress-induced cell death by modulating JNK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

regulation of axon regeneration

1 reference

8 April 2019

Mst3b, an Ste20-like kinase, regulates axon regeneration in mature CNS and PNS pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

1 reference

8 April 2019

negative regulation of cell migration

response to hydrogen peroxide

1 reference

8 April 2019

Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

signal transduction

1 reference

8 April 2019

Cloning and Characterization of a Human STE20-like Protein Kinase with Unusual Cofactor Requirements

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

1 reference

8 April 2019

cellular response to starvation

1 reference

8 April 2019

RHO binding to FAM65A regulates Golgi reorientation during cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

protein autophosphorylation

RHO binding to FAM65A regulates Golgi reorientation during cell migration

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

8 April 2019

CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

MAPK cascade

1 reference

17 October 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

regulation of mitotic cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

1 reference

17 October 2017

stress-activated protein kinase signaling cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

regulation of apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9Y6E0&geneProductId=UniProtKB:Q9Y6E0

1 reference

17 October 2017

neuron projection morphogenesis

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

MAPK cascade

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

signal transduction

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

activation of protein kinase activity

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9Y6E0

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5710

English

protein kinase, ATP binding site

17 August 2016

has part(s)

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y6E0

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9Y6E0

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

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30 May 2020

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30 May 2020

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30 May 2020

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13 November 2019

1 reference

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016

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1 August 2016