TNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships. (Q30380968)

20 February 2018

review article

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title

TNNI1, TNNI2 and TNNI3: Evolution, regulation, and protein structure-function relationships. (English)

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20 February 2018

part of the series

Gene Wiki Review Series

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Juan-Juan Sheng

1

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20 February 2018

Jian-Ping Jin

series ordinal

2

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20 February 2018

language of work or name

English

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publication date

22 October 2015

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20 February 2018

published in

Gene

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20 February 2018

volume

576

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20 February 2018

issue

1 Pt 3

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20 February 2018

page(s)

385-394

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20 February 2018

Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs

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Raised serum cardiac troponin I concentrations predict hospital mortality in intensive care unit patients

20 June 2018

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AMP-activated protein kinase phosphorylates cardiac troponin I and alters contractility of murine ventricular myocytes

20 June 2018

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20 June 2018

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S-glutathionylation of troponin I (fast) increases contractile apparatus Ca2+ sensitivity in fast-twitch muscle fibres of rats and humans

20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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20 June 2018

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Pathogenic peptide deviations support a model of adaptive evolution of chordate cardiac performance by troponin mutations.

20 June 2018

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Removal of the cardiac troponin I N-terminal extension improves cardiac function in aged mice

20 June 2018

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20 June 2018

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20 June 2018

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The C terminus of cardiac troponin I stabilizes the Ca2+-activated state of tropomyosin on actin filaments

20 June 2018

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Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling

20 June 2018

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20 June 2018

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Functional effects of a restrictive-cardiomyopathy-linked cardiac troponin I mutation (R145W) in transgenic mice

20 June 2018

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The molecular structures and expression patterns of zebrafish troponin I genes

20 June 2018

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To investigate protein evolution by detecting suppressed epitope structures

20 June 2018

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O-linked GlcNAc modification of cardiac myofilament proteins: a novel regulator of myocardial contractile function

20 June 2018

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Phosphorylation of cardiac troponin I by mammalian sterile 20-like kinase 1

20 June 2018

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Removal of the N-terminal extension of cardiac troponin I as a functional compensation for impaired myocardial beta-adrenergic signaling

20 June 2018

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Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle

20 June 2018

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Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice

20 June 2018

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Impaired relaxation is the main manifestation in transgenic mice expressing a restrictive cardiomyopathy mutation, R193H, in cardiac TnI.

20 June 2018

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Fast skeletal muscle troponin I is a co-activator of estrogen receptor-related receptor alpha

20 June 2018

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Isoform diversity, regulation, and functional adaptation of troponin and calponin

20 June 2018

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The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation

20 June 2018

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Thin filament disinhibition by restrictive cardiomyopathy mutant R193H troponin I induces Ca2+-independent mechanical tone and acute myocyte remodeling

20 June 2018

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Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function

20 June 2018

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20 June 2018

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Impaired diastolic function after exchange of endogenous troponin I with C-terminal truncated troponin I in human cardiac muscle

20 June 2018

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A mutation in the fast skeletal muscle troponin I gene causes myopathy and distal arthrogryposis

20 June 2018

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20 June 2018

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Differential contribution of troponin I phosphorylation sites to the endothelin-modulated contractile response

20 June 2018

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Fast and slow skeletal troponin I in serum from patients with various skeletal muscle disorders: a pilot study

20 June 2018

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Ca(2+)-regulated structural changes in troponin

20 June 2018

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Regulation of cardiac contractile function by troponin I phosphorylation

20 June 2018

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Structural based insights into the role of troponin in cardiac muscle pathophysiology

20 June 2018

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Cardiac troponin I mutations in Australian families with hypertrophic cardiomyopathy: clinical, genetic and functional consequences.

20 June 2018

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A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C

20 June 2018

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Proteolytic N-terminal truncation of cardiac troponin I enhances ventricular diastolic function

20 June 2018

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Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function

20 June 2018

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Intracellular localization and functional effects of P21-activated kinase-1 (Pak1) in cardiac myocytes

20 June 2018

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Structure of the core domain of human cardiac troponin in the Ca(2+)-saturated form

20 June 2018

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Mutations in genes encoding fast-twitch contractile proteins cause distal arthrogryposis syndromes

20 June 2018

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Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity

20 June 2018

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Idiopathic restrictive cardiomyopathy is part of the clinical expression of cardiac troponin I mutations

20 June 2018

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Polycystin-2 interacts with troponin I, an angiogenesis inhibitor

20 June 2018

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p21-activated kinase increases the calcium sensitivity of rat triton-skinned cardiac muscle fiber bundles via a mechanism potentially involving novel phosphorylation of troponin I.

20 June 2018

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The slow isoform of Xenopus troponin I is expressed in developing skeletal muscle but not in the heart

20 June 2018

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Effects of T142 phosphorylation and mutation R145G on the interaction of the inhibitory region of human cardiac troponin I with the C-domain of human cardiac troponin C

20 June 2018

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Time-dependent changes in expression of troponin subunit isoforms in unloaded rat soleus muscle

20 June 2018

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New concepts in diastolic dysfunction and diastolic heart failure: Part II: causal mechanisms and treatment

20 June 2018

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Characteristics of the human ocular surface epithelium

20 June 2018

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The highly conserved COOH terminus of troponin I forms a Ca2+-modulated allosteric domain in the troponin complex

20 June 2018

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A proteolytic NH2-terminal truncation of cardiac troponin I that is up-regulated in simulated microgravity

20 June 2018

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The Genetic Basis for Cardiomyopathy

20 June 2018

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Ischemic dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sites

20 June 2018

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Cardiac troponin I is modified in the myocardium of bypass patients

20 June 2018

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Additional PKA phosphorylation sites in human cardiac troponin I

20 June 2018

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Transgenic mouse model of stunned myocardium

20 June 2018

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Preserved close linkage between the genes encoding troponin I and troponin T, reflecting an evolution of adapter proteins coupling the Ca(2+) signaling of contractility

20 June 2018

1 reference

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Troponin I: inhibitor or facilitator

20 June 2018

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Troponin I is present in human cartilage and inhibits angiogenesis

20 June 2018

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Troponin I degradation and covalent complex formation accompanies myocardial ischemia/reperfusion injury

20 June 2018

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Mutations in the cardiac troponin I gene associated with hypertrophic cardiomyopathy

20 June 2018

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Slow skeletal troponin I gene transfer, expression, and myofilament incorporation enhances adult cardiac myocyte contractile function

20 June 2018

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Molecular evolution of the vertebrate troponin I gene family

20 June 2018

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Alternative RNA splicing-generated cardiac troponin T isoform switching: a non-heart-restricted genetic programming synchronized in developing cardiac and skeletal muscles

20 June 2018

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Phosphorylation of both serine residues in cardiac troponin I is required to decrease the Ca2+ affinity of cardiac troponin C.

20 June 2018

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Troponin I gene expression during human cardiac development and in end-stage heart failure

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Structure and expression of the human slow twitch skeletal muscle troponin I gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Specific degradation of troponin T and I by mu-calpain and its modulation by substrate phosphorylation.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Cardiac troponin-I is not expressed in fetal and healthy or diseased adult human skeletal muscle tissue

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

cDNA clone analysis of six co-regulated mRNAs encoding skeletal muscle contractile proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Structure, evolution, and regulation of a fast skeletal muscle troponin I gene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Effects of acidosis on ventricular muscle from adult and neonatal rats

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Troponin I switching in the developing heart

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Troponin T isoform expression in humans. A comparison among normal and failing adult heart, fetal heart, and adult and fetal skeletal muscle

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Structure and developmental expression of troponin I isoforms. cDNA clone analysis of avian cardiac troponin I mRNA.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Elevation of cardiac troponin T, but not cardiac troponin I, in patients with neuromuscular diseases: implications for the diagnosis of myocardial infarction.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Restrictive cardiomyopathy mutations demonstrate functions of the C-terminal end-segment of troponin I.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Hydroxyl radical and glutathione interactions alter calcium sensitivity and maximum force of the contractile apparatus in rat skeletal muscle fibres.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Lys184 deletion in troponin I impairs relaxation kinetics and induces hypercontractility in murine cardiac myofibrils.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Protein kinase D selectively targets cardiac troponin I and regulates myofilament Ca2+ sensitivity in ventricular myocytes.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Alterations in myofilament function contribute to left ventricular dysfunction in pigs early after myocardial infarction

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Phosphorylation and mutation of human cardiac troponin I deferentially destabilize the interaction of the functional regions of troponin I with troponin C.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Protein kinase C and A sites on troponin I regulate myofilament Ca2+ sensitivity and ATPase activity in the mouse myocardium

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Role of cyclic GMP-dependent protein kinase in the contractile response to exogenous nitric oxide in rat cardiac myocytes

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Phosphorylation of troponin I controls cardiac twitch dynamics: evidence from phosphorylation site mutants expressed on a troponin I-null background in mice

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Myofibrillar disruption in hypocontractile myocardium showing perfusion-contraction matches and mismatches.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

RNA expression of cardiac troponin T isoforms in diseased human skeletal muscle.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5798203

Expression of messenger RNA of the cardiac isoforms of troponin T and I in myopathic skeletal muscle

26 November 2018

1 reference

12 December 2020

Biochemical mechanism(s) of stunning in conscious dogs

1 reference

12 December 2020

Chimera analysis of troponin I domains that influence Ca(2+)-activated myofilament tension in adult cardiac myocytes

1 reference

12 December 2020

Pure restrictive cardiomyopathy associated with cardiac troponin I gene mutation: mismatch between the lack of hypertrophy and the presence of disarray

1 reference

12 December 2020

Sequential phosphorylation of adjacent serine residues on the N‐terminal region of cardiac troponin‐I: structure‐activity implications of ordered phosphorylation

1 reference

12 December 2020

Independent prognostic value of cardiac troponin T in patients with confirmed pulmonary embolism

1 reference

12 December 2020

Cardiac troponin T composition in normal and regenerating human skeletal muscle

1 reference

12 December 2020

Functional analysis of troponin I regulatory domains in the intact myofilament of adult single cardiac myocytes

1 reference

12 December 2020

Cardiac troponin I phosphorylation increases the rate of cardiac muscle relaxation

1 reference

12 December 2020

A novel mechanism for myocardial stunning involving impaired Ca(2+) handling

1 reference

12 December 2020

O-LinkedN-Acetylglucosaminylation Is Involved in the Ca2+Activation Properties of Rat Skeletal Muscle

1 reference

12 December 2020

Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure

1 reference

12 December 2020

Protein kinase A (PKA)-dependent troponin-I phosphorylation and PKA regulatory subunits are decreased in human dilated cardiomyopathy

1 reference

12 December 2020

Impaired cardiomyocyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heart

1 reference

12 December 2020

Clinical and mutational spectrum in a cohort of 105 unrelated patients with dilated cardiomyopathy

1 reference

12 December 2020

Absence of Troponin I Degradation or Altered Sarcoplasmic Reticulum Uptake Protein Expression After Reversible Ischemia in Swine

1 reference

12 December 2020

Troponin I phosphorylation in the normal and failing adult human heart

1 reference

12 December 2020

Differential roles of cardiac myosin-binding protein C and cardiac troponin I in the myofibrillar force responses to protein kinase A phosphorylation

1 reference

12 December 2020

C-terminal truncation of cardiac troponin I causes divergent effects on ATPase and force: implications for the pathophysiology of myocardial stunning

1 reference

12 December 2020

PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144

1 reference

12 December 2020

10.1016/J.GENE.2015.10.052

Identifiers

DOI

1 reference

20 February 2018

PMC publication ID

5798203

1 reference

20 February 2018

PubMed publication ID

26526134

1 reference

20 February 2018