ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage (Q34453891)

2 August 2017

title

ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage (English)

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2 August 2017

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M I Aladjem

1

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2 August 2017

B T Spike

2

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2 August 2017

L W Rodewald

3

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2 August 2017

T J Hope

4

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2 August 2017

M Klemm

5

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2 August 2017

R Jaenisch

6

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2 August 2017

G M Wahl

7

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2 August 2017

language of work or name

English

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publication date

1 January 1998

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2 August 2017

number of pages

11

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inferred from page(s)

published in

Current Biology

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2 August 2017

volume

8

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2 August 2017

issue

3

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2 August 2017

page(s)

145-155

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Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells

2 August 2017

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Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles.

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Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

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Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage

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p53-dependent apoptosis suppresses tumor growth and progression in vivo

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Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis.

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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Lack of functional retinoblastoma protein mediates increased resistance to antimetabolites in human sarcoma cell lines.

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7 January 2021

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts

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Delayed reproductive death as a dominant phenotype in cell clones surviving X-irradiation

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Thymocyte apoptosis induced by p53-dependent and independent pathways.

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p53 is required for radiation-induced apoptosis in mouse thymocytes

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mdm2 expression is induced by wild type p53 activity

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Mdm2 promotes the rapid degradation of p53

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Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

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Cellular localization and cell cycle regulation by a temperature-sensitive p53 protein

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Development and characterization of recombinant adenoviruses encoding human p53 for gene therapy of cancer

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The role of DNA fragmentation in apoptosis

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7 January 2021

p53 and E2F-1 cooperate to mediate apoptosis

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Essential role for p53-mediated transcription in E1A-induced apoptosis

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p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens.

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DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

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7 January 2021

Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

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7 January 2021

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

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7 January 2021

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

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7 January 2021

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7 January 2021

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7 January 2021

Cyclin synthesis drives the early embryonic cell cycle

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7 January 2021

Regulation of the Cellular p53 Tumor Antigen in Teratocarcinoma Cells and Their Differentiated Progeny

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7 January 2021

The phosphoprotein p53 is down-regulated post-transcriptionally during embryogenesis in vertebrates

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7 January 2021

Post-Translational Regulation of the 54K Cellular Tumor Antigen in Normal and Transformed Cells

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7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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7 January 2021

A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation

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7 January 2021

The tumorigenic potential and cell growth characteristics of p53-deficient cells are equivalent in the presence or absence of Mdm2.

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7 January 2021

10.1016/S0960-9822(98)70061-2

Identifiers

DOI

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2 August 2017

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