Phosphatidylinositol 4,5-bisphosphate decreases the concentration of Ca2+, phosphatidylserine and diacylglycerol required for protein kinase C α to reach maximum activity. (Q34852542)

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English	Phosphatidylinositol 4,5-bisphosphate decreases the concentration of Ca2+, phosphatidylserine and diacylglycerol required for protein kinase C α to reach maximum activity.	scientific article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23874859%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Phosphatidylinositol 4,5-bisphosphate decreases the concentration of Ca2+, phosphatidylserine and diacylglycerol required for protein kinase C α to reach maximum activity (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23874859%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

Antonio L Egea-Jiménez

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5 March 2020

Angel Pérez-Lara

2

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5 March 2020

Senena Corbalan

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5 March 2020

Juan C. Gómez-Fernández

4

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5 March 2020

author name string

Antonio L Egea-Jiménez

1

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4 August 2017

Angel Pérez-Lara

2

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Europe PubMed Central

PubMed publication ID

4 August 2017

Senena Corbalán-García

3

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Europe PubMed Central

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4 August 2017

Juan C Gómez-Fernández

4

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4 August 2017

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10 July 2013

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5 March 2020

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5 March 2020

8

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5 March 2020

7

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5 March 2020

e69041

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5 March 2020

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Creative Commons Attribution 4.0 International

10 July 2013

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April 2022 Public Data File from Crossref

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0 references

Crystal Structure and Allosteric Activation of Protein Kinase C βII

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8 July 2018

The distribution and function of phosphatidylserine in cellular membranes

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8 July 2018

A comparison of the membrane binding properties of C1B domains of PKCgamma, PKCdelta, and PKCepsilon.

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8 July 2018

Structural and mechanistic insights into the association of PKC -C2 domain to PtdIns(4,5)P2

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8 July 2018

Diacylglycerols, multivalent membrane modulators.

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8 July 2018

Mechanism of specific membrane targeting by C2 domains: localized pools of target lipids enhance Ca2+ affinity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Phosphoinositides in cell regulation and membrane dynamics

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8 July 2018

The C2 domain of PKCalpha is a Ca2+ -dependent PtdIns(4,5)P2 sensing domain: a new insight into an old pathway.

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8 July 2018

Protein kinase C regulatory domains: the art of decoding many different signals in membranes

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8 July 2018

Specific translocation of protein kinase Calpha to the plasma membrane requires both Ca2+ and PIP2 recognition by its C2 domain

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8 July 2018

The ATP-dependent membrane localization of protein kinase Calpha is regulated by Ca2+ influx and phosphatidylinositol 4,5-bisphosphate in differentiated PC12 cells

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes

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8 July 2018

An infrared spectroscopic study of the secondary structure of protein kinase C alpha and its thermal denaturation

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8 July 2018

Activation mechanisms of conventional protein kinase C isoforms are determined by the ligand affinity and conformational flexibility of their C1 domains

1 reference

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8 July 2018

A new phosphatidylinositol 4,5-bisphosphate-binding site located in the C2 domain of protein kinase Calpha.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

PIP(2) and proteins: interactions, organization, and information flow

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Identification of the phosphatidylserine binding site in the C2 domain that is important for PKC alpha activation and in vivo cell localization.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Roles of ionic residues of the C1 domain in protein kinase C-alpha activation and the origin of phosphatidylserine specificity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Regulation of receptor-mediated protein kinase C membrane trafficking by autophosphorylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Ca(2+) bridges the C2 membrane-binding domain of protein kinase Calpha directly to phosphatidylserine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Determination of the calcium-binding sites of the C2 domain of protein kinase Calpha that are critical for its translocation to the plasma membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Mechanism of the apparent cooperativity in the interaction of protein kinase C with phosphatidylserine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Protein kinase C as a molecular machine for decoding calcium and diacylglycerol signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Protein kinase C and lipid signaling for sustained cellular responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

The asymmetric distribution of phospholipids in the human red cell membrane. A combined study using phospholipases and freeze-etch electron microscopy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Protein kinase C activation in mixed micelles. Mechanistic implications of phospholipid, diacylglycerol, and calcium interdependencies.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Role of substrate in determining the phospholipid specificity of protein kinase C activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

A tumour promoter, 12-O-tetradecanoylphorbol 13-acetate, increases cellular 1,2-diacylglycerol content through a mechanism other than phosphoinositide hydrolysis in Swiss-mouse 3T3 fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

High cooperativity, specificity, and multiplicity in the protein kinase C-lipid interaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Palmitoyl-CoA and the acyl-CoA thioester of the carcinogenic peroxisome-proliferator ciprofibrate potentiate diacylglycerol-activated protein kinase C by decreasing the phosphatidylserine requirement of the enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Expression, separation, and assay of protein kinase C subspecies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Effect of phospholipid unsaturation on protein kinase C activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Interaction of protein kinase C with phosphatidylserine. 2. Specificity and regulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

8 July 2018

Action of highly purified phospholipases on blood platelets. Evidence for an asymmetric distribution of phospholipids in the surface membrane

1 reference

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8 July 2018

The PtdIns(4,5)P2 ligand itself influences the localization of PKCalpha in the plasma membrane of intact living cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0069041

21 January 2018

Additional binding sites for anionic phospholipids and calcium ions in the crystal structures of complexes of the C2 domain of protein kinase calpha.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0069041

21 January 2018

Retinoic acid binds to the C2-domain of protein kinase C(alpha).

1 reference

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21 January 2018

Role of the Ca2+/phosphatidylserine binding region of the C2 domain in the translocation of protein kinase Calpha to the plasma membrane.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0069041

21 January 2018

Membrane docking of the C2 domain from protein kinase Cα as seen by polarized ATR-IR. The role of PIP₂.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0069041

21 January 2018

Use of stopped-flow fluorescence spectroscopy to measure rapid membrane binding by protein kinase C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

26 October 2018

A comparative study of the activation of protein kinase C alpha by different diacylglycerol isomers.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

26 October 2018

Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3707892

26 October 2018

Effect of calcium and phosphatidic acid binding on the C2 domain of PKC alpha as studied by Fourier transform infrared spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23874859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The C2 domains of classical PKCs are specific PtdIns(4,5)P2-sensing domains with different affinities for membrane binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/23874859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The membrane binding kinetics of full-length PKCα is determined by membrane lipid composition

1 reference

https://pubmed.ncbi.nlm.nih.gov/23874859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets

1 reference

https://pubmed.ncbi.nlm.nih.gov/23874859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid purification of protein kinase C from rat brain. A novel method employing protamine-agarose affinity column chromatography

1 reference

https://pubmed.ncbi.nlm.nih.gov/23874859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aminoacridines, potent inhibitors of protein kinase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/23874859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium: a program in BASIC for calculating the composition of solutions with specified free concentrations of calcium, magnesium and other divalent cations

1 reference

https://pubmed.ncbi.nlm.nih.gov/23874859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid-dependent membrane enzymes. Kinetic modelling of the activation of protein kinase C by phosphatidylserine

1 reference

https://pubmed.ncbi.nlm.nih.gov/23874859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential membrane-binding and activation mechanisms of protein kinase C-alpha and -epsilon

1 reference

https://pubmed.ncbi.nlm.nih.gov/23874859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The C2 domain of protein kinase calpha is directly involved in the diacylglycerol-dependent binding of the C1 domain to the membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/23874859

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0069041

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23874859%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

2013PLoSO...869041E

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23874859%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23874859%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

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