Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets (Q37028708)

17 August 2017

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets (English)

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17 August 2017

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30

Carrie Sougnez

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Kristian Cibulskis

10

Kristian Cibulskis

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Gad Getz

43

Gad Getz

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Amaro Taylor-Weiner

5

Amaro Taylor-Weiner

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Stacey Gabriel

37

Stacey Gabriel

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17 August 2017

38

Eric S Lander

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41

Jose Baselga

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17 August 2017

Priscilla K Brastianos

Priscilla K Brastianos

1

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Peleg M Horowitz

Peleg M Horowitz

9

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Mara Rosenberg

Mara Rosenberg

21

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Corey M Gill

Corey M Gill

23

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Joan Seoane

Joan Seoane

13

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Matthew Meyerson

Matthew Meyerson

35

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Daniel P Cahill

Daniel P Cahill

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Josep Tabernero Caturla

Josep Tabernero

12

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Levi A Garraway

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Levi Garraway

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28

Toni K Choueiri

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William C Hahn

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39

Rameen Beroukhim

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3

Sandro Santagata

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17 August 2017

Anat Stemmer-Rachamimov

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Anat Stemmer-Rachamimov

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Sun Ha Paek

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2

Scott L Carter

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11

Keith L Ligon

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Paul Van Hummelen

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Aaron R Thorner

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Tracy T Batchelor

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19

Aaron McKenna

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Sabina Signoretti

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Eliezer M Van Allen

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33

Eric P Winer

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32

Nancy U Lin

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Robert T Jones

6

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Michael S Lawrence

8

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Elena Martinez-Saez

14

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William T Curry

15

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Ian F Dunn

16

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Sung-Hye Park

18

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Aaron Chevalier

20

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Frederick G Barker

22

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Bruce E Johnson

26

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Mai P Hoang

27

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Michael S Rabin

31

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David N Louis

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17 August 2017

language of work or name

English

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publication date

26 September 2015

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17 August 2017

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5

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11

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17 August 2017

1164-1177

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Next-Generation Sequencing of Stage IV Squamous Cell Lung Cancers Reveals an Association of PI3K Aberrations and Evidence of Clonal Heterogeneity in Patients with Brain Metastases

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The dual RAF/MEK inhibitor CH5126766/RO5126766 may be a potential therapy for RAS-mutated tumor cells

29 September 2017

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Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

29 September 2017

1 reference

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Src mutation induces acquired lapatinib resistance in ERBB2-amplified human gastroesophageal adenocarcinoma models

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MCL1 and BCL-xL levels in solid tumors are predictive of dinaciclib-induced apoptosis.

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Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target

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Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing

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A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity

29 September 2017

1 reference

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Clinical discussion and review of the management of brain metastases

29 September 2017

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Clonal evolution in hematological malignancies and therapeutic implications

29 September 2017

1 reference

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PD-0332991, a potent and selective inhibitor of cyclin-dependent kinase 4/6, demonstrates inhibition of proliferation in renal cell carcinoma at nanomolar concentrations and molecular markers predict for sensitivity

29 September 2017

1 reference

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Evolution and impact of subclonal mutations in chronic lymphocytic leukemia

29 September 2017

1 reference

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Activating HER2 mutations in HER2 gene amplification negative breast cancer

29 September 2017

1 reference

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Melanoma brain metastases and vemurafenib: need for further investigation

29 September 2017

1 reference

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Epigenetic therapy with 3-deazaneplanocin A, an inhibitor of the histone methyltransferase EZH2, inhibits growth of non-small cell lung cancer cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916970

Mutational processes molding the genomes of 21 breast cancers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916970

Absolute quantification of somatic DNA alterations in human cancer

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916970

Relevance of PTEN loss in brain metastasis formation in breast cancer patients

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916970

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916970

Integrated genomic analyses of ovarian carcinoma

29 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916970

Data mining using the Catalogue of Somatic Mutations in Cancer BioMart

29 September 2017

1 reference

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Multifactorial central nervous system recurrence susceptibility in patients with HER2-positive breast cancer: epidemiological and clinical data from a population-based cancer registry study.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4916970

The biology of brain metastases-translation to new therapies

29 September 2017

1 reference

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A framework for variation discovery and genotyping using next-generation DNA sequencing data

29 September 2017

1 reference

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Tumour evolution inferred by single-cell sequencing

29 September 2017

1 reference

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Distant metastasis occurs late during the genetic evolution of pancreatic cancer

29 September 2017

1 reference

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The patterns and dynamics of genomic instability in metastatic pancreatic cancer

29 September 2017

1 reference

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Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

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1 reference

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Genome remodelling in a basal-like breast cancer metastasis and xenograft

29 September 2017

1 reference

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Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation

29 September 2017

1 reference

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PD 0332991, a selective cyclin D kinase 4/6 inhibitor, preferentially inhibits proliferation of luminal estrogen receptor-positive human breast cancer cell lines in vitro

29 September 2017

1 reference

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Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

29 September 2017

1 reference

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Genes that mediate breast cancer metastasis to the brain

29 September 2017

1 reference

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Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer

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1 reference

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PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR

29 September 2017

1 reference

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Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance

29 September 2017

1 reference

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

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1 reference

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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1 reference

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Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network

29 September 2017

1 reference

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Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts.

29 September 2017

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

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1 reference

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Tracking the clonal origin of lethal prostate cancer

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Genomic sequencing of meningiomas identifies oncogenic SMO and AKT1 mutations

27 June 2018

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Patterns of somatic alterations between matched primary and metastatic colorectal tumors characterized by whole-genome sequencing.

27 June 2018

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Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy

4 September 2018

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Ineffectiveness of crizotinib on brain metastases in two cases of lung adenocarcinoma with EML4-ALK rearrangement

4 September 2018

1 reference

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Metastatic tumors of the brain from a neurosurgical point of view; a follow-up study of 158 cases.

4 September 2018

1 reference

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Postoperative radiotherapy in the treatment of single metastases to the brain: a randomized trial

4 September 2018

1 reference

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A randomized trial of surgery in the treatment of single metastases to the brain

4 September 2018

1 reference

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10.1158/2159-8290.CD-15-0369

4 September 2018

Identifiers

DOI

1 reference

17 August 2017

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17 August 2017

PubMed publication ID

26410082

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