endothelin 1 (Q390566)

http://www.ebi.ac.uk/interpro/protein/P05305

G alpha (q) signalling events

0 references

ECE1 cleaves EDN1(53-90)

0 references

EDNRA,EDNRB bind EDNs

0 references

image of molecular model or crystal lattice model

1EDN human endothelin1 02.png
2,400 × 1,673; 557 KB

0 references

1 reference

6 July 2017

1 reference

6 July 2017

signaling receptor binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

cytokine activity

1 reference

8 April 2019

Krüppel-like factor 15 regulates BMPER in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

endothelin B receptor binding

Cloning and functional expression of human cDNA for the ETB endothelin receptor

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

8 April 2019

Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

protein binding

IPI

1 reference

8 April 2019

Inhibition of tumor angiogenesis and growth by a small-molecule multi-FGF receptor blocker with allosteric properties

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

IPI

cell component

cytoplasm

1 reference

8 April 2019

Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

Weibel-Palade body

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

basal part of cell

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

extracellular region

rough endoplasmic reticulum lumen

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

extracellular space

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

8 April 2019

Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

8 April 2019

Ursodeoxycholic acid reduces increased circulating endothelin 2 in primary biliary cirrhosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

8 April 2019

Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

transport vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

1 reference

8 April 2019

skeletal system development

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

response to amino acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of MAP kinase activity

regulation of sensory perception of pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

vasoconstriction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

8 April 2019

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

8 April 2019

Effect of adrenomedullin on the production of endothelin-1 and on its vasoconstrictor action in resistance arteries: evidence for a receptor-specific functional interaction in patients with heart failure

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

body fluid secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of sarcomere organization

1 reference

8 April 2019

Adenovirus-mediated overexpression of caveolin-3 inhibits rat cardiomyocyte hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of cardiac muscle hypertrophy

1 reference

8 April 2019

Adenovirus-mediated overexpression of caveolin-3 inhibits rat cardiomyocyte hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

cell surface receptor signaling pathway

1 reference

8 April 2019

Cloning and functional expression of human cDNA for the ETB endothelin receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

multicellular organism aging

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

artery smooth muscle contraction

Functional and Autoradiographic Studies of Endothelin-1 and Endothelin-2 in Human Bronchi, Pulmonary Arteries, and Airway Parasympathetic Ganglia

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

8 April 2019

Characterization of endothelin receptors in the human umbilical artery and vein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

cellular response to interferon-gamma

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of chemokine-mediated signaling pathway

IC

1 reference

8 April 2019

Endothelins induce CCR7 expression by breast tumor cells via endothelin receptor A and hypoxia-inducible factor-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

phosphatidylinositol 3-kinase signaling

IC

1 reference

8 April 2019

Mechanisms of endothelin 1-stimulated proliferation in colorectal cancer cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

response to leptin

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of mitotic nuclear division

1 reference

8 April 2019

Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

cellular response to hypoxia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

response to muscle stretch

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

cellular response to calcium ion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

cellular response to transforming growth factor beta stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of renal sodium excretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

blood vessel morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

negative regulation of blood coagulation

1 reference

8 April 2019

Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

response to nicotine

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

in utero embryonic development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

neutrophil chemotaxis

1 reference

8 April 2019

The involvement of protein kinase G in stimulation of neutrophil migration by endothelins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

heart development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of prostaglandin secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

vein smooth muscle contraction

1 reference

8 April 2019

Endothelin converting enzyme (ECE) activity in human vascular smooth muscle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

cartilage development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

rhythmic excitation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

protein kinase C-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

cellular response to glucocorticoid stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

branching involved in blood vessel morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

negative regulation of hormone secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of smooth muscle contraction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

negative regulation of nitric-oxide synthase biosynthetic process

1 reference

8 April 2019

Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of prostaglandin-endoperoxide synthase activity

1 reference

8 April 2019

Prostaglandin endoperoxide synthase-2 contributes to the endothelin/sarafotoxin-induced prostaglandin E2 synthesis in mouse osteoblastic cells (MC3T3-E1): evidence for a protein tyrosine kinase-signaling pathway and involvement of protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of urine volume

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of JUN kinase activity

1 reference

8 April 2019

Adenovirus-mediated overexpression of caveolin-3 inhibits rat cardiomyocyte hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

leukocyte activation

1 reference

8 April 2019

Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

membrane depolarization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

negative regulation of transcription by RNA polymerase II

1 reference

8 April 2019

Krüppel-like factor 15 regulates BMPER in endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

response to ozone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

respiratory gaseous exchange by respiratory system

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of heart rate

1 reference

8 April 2019

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

regulation of blood pressure

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

response to lipopolysaccharide

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

response to prostaglandin F

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

regulation of vasoconstriction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

1 reference

8 April 2019

cellular response to interleukin-1

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

response to salt

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of cell size

1 reference

8 April 2019

Adenovirus-mediated overexpression of caveolin-3 inhibits rat cardiomyocyte hypertrophy

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

middle ear morphogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

sensory perception of pain

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

prostaglandin biosynthetic process

1 reference

8 April 2019

Prostaglandin endoperoxide synthase-2 contributes to the endothelin/sarafotoxin-induced prostaglandin E2 synthesis in mouse osteoblastic cells (MC3T3-E1): evidence for a protein tyrosine kinase-signaling pathway and involvement of protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

dorsal/ventral pattern formation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

phospholipase D-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of odontogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

regulation of pH

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of smooth muscle cell proliferation

1 reference

8 April 2019

Endothelin-1 potentiates human smooth muscle cell growth to PDGF: effects of ETA and ETB receptor blockade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

protein kinase C deactivation

1 reference

8 April 2019

Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

histamine secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

maternal process involved in parturition

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

intracellular signal transduction

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

response to hypoxia

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

neural crest cell development

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

regulation of systemic arterial blood pressure by endothelin

1 reference

8 April 2019

The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

nitric oxide transport

1 reference

8 April 2019

Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of cell migration

1 reference

8 April 2019

The involvement of protein kinase G in stimulation of neutrophil migration by endothelins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

response to testosterone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

epithelial fluid transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of nitric oxide biosynthetic process

1 reference

8 April 2019

Permissive role of nitric oxide in endothelin-induced migration of endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

cell-cell signaling

1 reference

8 April 2019

Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

cellular response to tumor necrosis factor

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

response to activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

response to dexamethasone

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

superoxide anion generation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of endothelial cell migration

1 reference

8 April 2019

Permissive role of nitric oxide in endothelin-induced migration of endothelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

cellular response to peptide hormone stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

cellular response to fatty acid

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

peptide hormone secretion

1 reference

8 April 2019

Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

cellular response to mineralocorticoid stimulus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of cell population proliferation

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

8 April 2019

Mechanisms of endothelin 1-stimulated proliferation in colorectal cancer cell lines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

8 April 2019

Effects of endothelins on signal transduction and proliferation in human melanocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

inositol phosphate-mediated signaling

1 reference

8 April 2019

Effects of endothelins on signal transduction and proliferation in human melanocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of hormone secretion

1 reference

8 April 2019

Expression and biological effects of endothelin-1 in human gonadotropin-releasing hormone-secreting neurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

negative regulation of smooth muscle cell apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

response to transforming growth factor beta

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of DNA-binding transcription factor activity

1 reference

8 April 2019

The miR-19a/b family positively regulates cardiomyocyte hypertrophy by targeting atrogin-1 and MuRF-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of cell growth involved in cardiac muscle cell development

positive regulation of neutrophil chemotaxis

IGI

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

regulation of signaling receptor activity

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

regulation of glucose transmembrane transport

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

negative regulation of gene expression

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of NIK/NF-kappaB signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

positive regulation of vascular associated smooth muscle cell proliferation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P05305

https://www.uniprot.org/uniprot/P05305#PRO_0000008060

exact match

0 references

has part(s)

Endothelin-like toxin

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05305

Endothelin-like toxin, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P05305

Identifiers

0 references

0 references

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

8 February 2021

0 references

Endothelin-1

0 references

0 references

0 references

1 reference

22 July 2017

1 reference

22 July 2017

1 reference

22 July 2017

1 reference

22 July 2017

1 reference

22 July 2017

1 reference

22 July 2017

0 references

0 references

1 reference

28 October 2013

Gran Enciclopèdia Catalana ID

endotelina

0 references

Gran Enciclopèdia Catalana ID (former scheme)

0281914

0 references

JSTOR topic ID (archived)

endothelins

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016