Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53. (Q39777499)

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English	Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53.	scientific article

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31 October 2019

Drug-induced apoptosis in hepatoma cells is mediated by the CD95 (APO-1/Fas) receptor/ligand system and involves activation of wild-type p53 (English)

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31 October 2019

apoptotic process

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hepatocellular carcinoma

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based on heuristic

inferred from title

Wolfgang Stremmel

7

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31 October 2019

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Müller M

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31 October 2019

Strand S

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31 October 2019

Hug H

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31 October 2019

Heinemann EM

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31 October 2019

Walczak H

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31 October 2019

Hofmann WJ

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31 October 2019

Krammer PH

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31 October 2019

Galle PR

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1 February 1997

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31 October 2019

Journal of Clinical Investigation

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31 October 2019

99

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31 October 2019

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31 October 2019

403-413

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31 October 2019

CD95 (APO-1/Fas)-associating signalling proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death--inducing signaling complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

mdm2 expression is induced by wild type p53 activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Apoptosis in cancer therapy: crossing the threshold

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Regulation of apoptosis in the immune system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Lethal effect of the anti-Fas antibody in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Involvement of the CD95 (APO-1/Fas) receptor and ligand in liver damage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

The CTL's kiss of death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Participation of p53 protein in the cellular response to DNA damage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Assignment of the human Fas antigen gene (Fas) to 10q24.1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Wild-type p53 is a cell cycle checkpoint determinant following irradiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

22 September 2017

A license to kill

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

25 September 2017

Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

25 September 2017

APO-1 (CD95)-dependent and -independent antigen receptor-induced apoptosis in human T and B cell lines.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

25 September 2017

Involvement of a Putative Protein-tyrosine Phosphatase and IκB-α Serine Phosphorylation in Nuclear Factor κB Activation by Tumor Necrosis Factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

25 September 2017

Bcl-x and Bcl-2 inhibit TNF and Fas-induced apoptosis and activation of phospholipase A2 in breast carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

25 September 2017

Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

25 September 2017

Involvement of an ICE-like protease in Fas-mediated apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

25 September 2017

Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

25 September 2017

Exploitable mechanisms in combined radiotherapy-chemotherapy: The concept of additivity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

25 September 2017

Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

17 June 2018

Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

17 June 2018

p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

17 June 2018

Hepatocarcinoma-specific mutant p53-249ser induces mitotic activity but has no effect on transforming growth factor beta 1-mediated apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

17 June 2018

Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

17 June 2018

Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

17 June 2018

Monoclonal antibody-mediated tumor regression by induction of apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

17 June 2018

Phenotypical stability of a human hepatoma cell line, HuH-7, in long-term culture with chemically defined medium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

17 June 2018

Thymocyte apoptosis induced by p53-dependent and independent pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507813

20 August 2018

Anti-Fas on nonhematopoietic tumors: levels of Fas/APO-1 and bcl-2 are not predictive of biological responsiveness

1 reference

https://pubmed.ncbi.nlm.nih.gov/9022073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/9022073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/9022073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The humoral immune response to p53 in patients with hepatocellular carcinoma is specific for malignancy and independent of the alpha-fetoprotein status

1 reference

https://pubmed.ncbi.nlm.nih.gov/9022073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 and chemosensitivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/9022073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood

1 reference

https://pubmed.ncbi.nlm.nih.gov/9022073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of cis-diamminedichloroplatinum (II) given as low-dose and high-dose infusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/9022073

12 December 2020

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 activity and chemotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/9022073

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I clinical and pharmacokinetic study of carboplatin and autologous bone marrow support

1 reference

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12 December 2020

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1 reference

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1 reference

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1 reference

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1 reference

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1 reference

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inferred from PubMed ID database lookup

p53 overexpression is frequent in European hepatocellular carcinoma and largely independent of the codon 249 hot spot mutation

1 reference

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inferred from PubMed ID database lookup

p53 tumor suppressor gene: from the basic research laboratory to the clinic--an abridged historical perspective

1 reference

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12 December 2020

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inferred from PubMed ID database lookup

Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents

1 reference

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based on heuristic

inferred from PubMed ID database lookup

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10.1172/JCI119174

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31 October 2019

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31 October 2019

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